Tag: 100-200

Chasing ChEs-MAO B multi-targeting 4-aminomethyl-7-benzyloxy-2H-chromen-2-ones was written by Rullo, Mariagrazia;Catto, Marco;Carrieri, Antonio;de Candia, Modesto;Altomare, Cosimo Damiano;Pisani, Leonardo. And the article was included in Molecules in 2019.Product Details of 95-88-5 The following contents are mentioned in the article:

A series of 4-aminomethyl-7-benzyloxy-2H-chromen-2-ones was investigated with the aim of identifying multiple inhibitors of cholinesterases (acetyl- and butyryl-, AChE and BChE) and monoamine oxidase B (MAO B) as potential anti-Alzheimer mols. Starting from a previously reported potent MAO B inhibitor (3), we studied single-point modifications at the benzyloxy or at the basic moiety. The in vitro screening highlighted triple-acting compounds (6, 8, 9, 16, 20) showing nanomolar and selective MAO B inhibition along with IC50 against ChEs at the low micromolar level. Enzyme kinetics anal. toward AChE and docking simulations on the target enzymes were run in order to get insight into the mechanism of action and plausible binding modes. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Product Details of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Functionalized Phosphonated Half-Cage Molecules as Ligands for Metal Complexes was written by Villemin, Elise;Herent, Marie-France;Marchand-Brynaert, Jacqueline. And the article was included in European Journal of Organic Chemistry in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

Phosphonated mols., featuring a half-cage structure and a N-lateral chain with addnl. metal coordinating groups were designed as ligands of metal cations. These compounds were synthesized by a Diels-Alder (DA) strategy, using 1-diethoxyphosphoryl-1,3-butadiene and a series of N-substituted maleimides as dienophiles. Two cycloadducts, bearing a terminal primary alc. and a terminal iodide, resp., were used as key intermediates for further functionalizations. Metal coordination properties of the ligands equipped with functionalized N-lateral chains were proven by an ESI-HRMS study. The stoichiometry of one selected Eu^III complex with a diphosphonated ligand was determined by photoluminescence spectroscopy in emission mode. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New stable donor-acceptor dyads for molecular electronics was written by Kondratenko, Mykola;Moiseev, Andrey G.;Perepichka, Dmitrii F.. And the article was included in Journal of Materials Chemistry in 2011.Application In Synthesis of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

A series of new donor-bridge-acceptor dyads with high chem., electrochem., thermal and conformational stability were synthesized by Stille coupling of oligo(3,4-ethylenedioxy)thiophenes (nEDOTs) and 1,4,5,8-naphthalenetetracarboxydiimide (NDI) building blocks. The mol. design provides for complete separation of HOMO and LUMO orbitals. A thiol functionality allows for selective anchoring of the dyads to metal electrodes, through either the donor or acceptor sides of the mol. The optoelectronic properties of the dyads, both in solution and in self-assembled monolayers on gold, were characterized by electrochem., spectroelectrochem. and UV-Vis absorption/emission spectroscopy and the results were further supported by DFT calculations This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application In Synthesis of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An expedient one-pot tandem method for the synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones under green conditions was written by Kavitha, K.;Srikrishna, D.;Dubey, Pramod Kumar;Aparna, P.. And the article was included in Journal of the Iranian Chemical Society in 2019.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

This paper describes a facile pathway for the one-pot three-component synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones starting from ethyl-4-chloroacetoacetate by treating it with equimolar amounts of various phenylthioureas and salicylaldehyde. Use of biosynthetically prepared L-proline as an efficient catalyst and naturally extracted renewable polyethylene glycol-600 (PEG-600) as an effective green reaction media are the added advantages of this method. Alternatively, tandem, stepwise methods have been proposed to isolate the intermediate and to study the possible reaction mechanism. These reactions are very simple, rapid, cost effective, industrially viable, which would be applied for various biomass conversions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers was written by Irie, Takayuki;Asami, Tokiko;Sawa, Ayako;Uno, Yuko;Taniyama, Chika;Funakoshi, Yoko;Masai, Hisao;Sawa, Masaaki. And the article was included in Journal of Medicinal Chemistry in 2021.Formula: C6H9ClO3 The following contents are mentioned in the article:

CDC7, a serine-threonine kinase, plays conserved and important roles in regulation of DNA replication and has been recognized as a potential anticancer target. We report here the optimization of a series of furanone analogs starting from compound 1 with a focus on ADME properties suitable for clin. development. By replacing the 2-chlorobenzene moiety in 1 with various aliphatic groups, we identified compound 24 as a potent CDC7 inhibitor with excellent kinase selectivity and favorable oral bioavailability in multiple species. Oral administration of 24 demonstrated robust in vivo antitumor efficacy in a colorectal cancer xenograft model. Compound 24 (AS-0141) is currently in phase I clin. trials for the treatment of solid cancers. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of coumarin derivatives as anti-inflammatory agents was written by Kayal, Gaurav;Kayal, Snehlata;Gokhale, Niharika;Jain, Sanjay. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2016.Related Products of 95-88-5 The following contents are mentioned in the article:

All the newly synthesized Coumarin derivatives have shown considerable anti-inflammatory activity. In the present research work, we synthesized a series of novel Coumarin derivatives The Coumarin derivatives such as substituted 7-hydroxy-4-methyl-2H-chromen-2-one and substituted 6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one were synthesized from substituted benzoyl chloride. The chem. structures of the synthesized compounds were confirmed by means of IR and 1H-NMR. These compounds were screened for anti-inflammatory activity by carrageenan induced paw edema method in rats at a dose of 30 mg/kg body weight All the tested compounds of Coumarin derivatives were found to be more potent when compared to standard drug Diclofenac. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Related Products of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved synthesis of clopidogrel bisulfate was written by Hu, Jia-peng;Lu, Xin;Liu, Zhi-bin. And the article was included in Zhejiang Huagong in 2012.Product Details of 141109-14-0 The following contents are mentioned in the article:

(S)-Me 2-amino-2-(2-chlorophenyl) acetate is obtained from racemic 2-amino-2-(2-chlorophenyl) acetic acid through esterification and optical resolution, which was subjected to condensation reaction with 2-(thiophen-2-yl)ethyl 4-Me benzene sulfonate to afford the critical intermediate (S)-Me 2-(2-chlorophenyl)-2-(2-thiophen-2-yl)ethylamino) acetate. The cyclization of (S)-Me 2-(2-chloropheny)-2-(2-(thiophen-2-yl) ethylamino) acetate with paraformaldehyde in the presence of anhydrous formic acid provided clopidogrel bisulfate. For this synthesis pathway, there are some advantages such as readily available starting material, moderate condition, high yield and good quality. This process is suitable for industrialization. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Novel Inhibitor of the Obesity-Related Protein FTO was written by Qiao, Yan;Zhou, Bin;Zhang, Meizi;Liu, Weijia;Han, Zhifu;Song, Chuanjun;Yu, Wenquan;Yang, Qinghua;Wang, Ruiyong;Wang, Shaomin;Shi, Shuai;Zhao, Renbin;Chai, Jijie;Chang, Junbiao. And the article was included in Biochemistry in 2016.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Fe^II and α-ketoglutarate-dependent fat mass and obesity associated protein (FTO)-dependent demethylation of m⁶A is important for regulation of mRNA splicing and adipogenesis. Developing FTO-specific inhibitors can help probe the biol. of FTO and unravel novel therapeutic targets for treatment of obesity or obesity-associated diseases. In the present paper, we have identified that 4-chloro-6-(6′-chloro-7′-hydroxy-2′,4′,4′-trimethyl-chroman-2′-yl)benzene-1,3-diol (CHTB) is an inhibitor of FTO. The crystal structure of CHTB complexed with human FTO reveals that the novel small mol. binds to FTO in a specific manner. The identification of the novel small mol. offers opportunities for further development of more selective and potent FTO inhibitors. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Highly Regioselective Synthesis of Novel Imidazolidin-2-ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity was written by Gazizov, Almir S.;Smolobochkin, Andrey V.;Kuznetsova, Elizaveta A.;Abdullaeva, Dinara S.;Burilov, Alexander R.;Pudovik, Michail A.;Voloshina, Alexandra D.;Syakaev, Victor V.;Lyubina, Anna P.;Amerhanova, Syumbelya K.;Voronina, Julia K.. And the article was included in Molecules in 2021.Reference of 95-88-5 The following contents are mentioned in the article:

A series of novel 4-(het)arylimidazolidin-2-ones I [R = 5-Cl-2,4-di-HO-C₆H₂, 6-hydroxy-1,3-benzodioxol-5-yl, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl; R¹ = H, Me; R² = Ph, 4-MeC₆H₄, 3-ClC₆H₄, etc.] was obtained by the acid-catalyzed reaction of (2,2-dimethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones I benefited from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chem. calculations and control experiments The anti-cancer activity of the obtained compounds was tested in vitro. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Reference of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manganese-Catalyzed Borylation of Unactivated Alkyl Chlorides was written by Atack, Thomas C.;Cook, Silas P.. And the article was included in Journal of the American Chemical Society in 2016.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

The use of low-cost manganese(II) bromide (MnBr₂) and tetramethylethylenediamine (TMEDA) catalyzes the cross coupling of (bis)pinacolatodiboron with a wide range of alkyl halides, demonstrating the first manganese-catalyzed coupling with alkyl electrophiles. This method allows access to primary, secondary, and tertiary boronic esters from the parent chlorides, which were previously inaccessible as coupling partners. The reaction proceeds in high yield with as little as 1000 ppm catalyst loading, while 5 mol % can provide high yields in as little as 30 min. Finally, radical-clock experiments revealed that at 0 °C direct borylation outcompetes alternative radical processes, thereby providing synthetically useful, temperature-controlled reaction outcomes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics