Tag: 100-200

One-pot synthesis of sulfonylhydrazones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water was written by Luo, Mengqiang;Wang, Hai;Ren, Xiaorong;Lu, Ruijuan;Qi, Chenze;Zhang, Yaohong;Shen, Runpu. And the article was included in Journal of the Iranian Chemical Society in 2021.Product Details of 75-57-0 The following contents are mentioned in the article:

A facile and eco-friendly protocol for the synthesis of sulfonylhydrazones I [R = Ph, 4-MeC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄; R¹ = Me, Ph, 4-MeOC₆H₄, etc.] from sulfonyl chlorides, hydrazine hydrate and vinyl azides was developed. The unique advantage of this approach was that desired products could be obtained efficiently in water, which meets the requirements of green chem. and provided good perspectives for the sustainable production of new drug candidate. Also, this reaction proceeded in moderate to good yields with a wide tolerance of functional groups. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Product Details of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient ultrasonic-assisted synthesis of enol carbamates via oxidative coupling of formamides with 1,3-dicarbonyl compounds was written by Akbari, Jafar;Meyestani, Alireza Akbari. And the article was included in Letters in Organic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Sonochem. oxidative-coupling of N,N-dimethyl/diethylformamide with 1,3-dicarbonyl compounds RC(O)CH(R¹)C(O)OR² (R = Me, chloromethyl, Ph, propyl; R¹ = H, Cl; R² = Me, Bn, prop-2-en-1-yl, etc.) in the corresponding carbamates R²OC(O)C(R¹)=C(R)OC(O)N(R³)(R⁴) (R³ = R⁴ = Me, Et) by CuO nanoparticles as a catalyst and tert-Bu hydroperoxide (TBHP) as an oxidant has been reported. Various derivatives of enol carbamates were synthesized with good to high yields under the optimized reaction conditions. Compared with conventional methods, the main advantage of this method is mild conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Highly Z-Selective Coumarin Annulated Dioxocine, Dioxacindione and Macrocycles Using Grubbs’ Second-Generation Catalyst was written by Goud, E. Yadaiah;Rao, B. Kanakadurga;Thirupahi, G.;Hemasri, Y.;Rao, Ch. Prasad;Kumar, P. Vijay;Rao, Y. Jayaprakash. And the article was included in ChemistrySelect in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The diversity-oriented organic synthesis of novel coumarin annulated dioxocine I [R = Me, Ph], dioxacindione II scaffolds with Z-selectivity and the sym. pentacyclic coumarin macrocyclic derivatives III [R = H, Me; R¹ = H, Cl; n = 1,2,4] is demonstrated from substituted hydroxyl coumarins via ring-closing metathesis in presence of Grubbs’ second-generation catalyst as the facile and efficient route with excellent yields. This synthetic strategy provides a route for the intramol. ring-closing metathesis to access a library of novel tricyclic coumarin heterocycles and pentacyclic coumarin macrocycles having different ring systems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stationary states of systems with intermolecular interactions dominated by electrostatics: Structure of trimethylammonium and tetramethylammonium chlorides and bromides in the gas phase, monomers and dimers was written by Denisov, Gleb S.;Limbach, Hans-Heinrich;Alkorta, Ibon;Elguero, Jose. And the article was included in Chemical Physics Letters in 2021.Product Details of 75-57-0 The following contents are mentioned in the article:

This work reports the theor. study carried out with the M06-2x functional and the aug-cc-pVTZ basis set of four ammonium and two phosphonium salts, Me₃NH⁺Cl^–, Me₃NH⁺Br^–, Me₄N⁺Cl^–, Me₄N⁺Br^–, Me₄P⁺Cl^– and Me₄P⁺Br^–. The structure of the monomeric and dimeric complexes (between 1 and 5 conformations each) has been analyzed in what concern geometries, energies and NH⁺ stretching frequencies. The ammonium geometries were successfully compared with the X-ray structures found in the CSD. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Product Details of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polyacrylonitrile fiber with strongly acidic electrostatic microenvironment: Highly efficient and recyclable heterogeneous catalyst for the synthesis of heterocyclic compounds was written by Xiao, Jian;Xu, Gang;Wang, Lu;Li, Pengyu;Zhang, Wenqin;Ma, Ning;Tao, Minli. And the article was included in Journal of Industrial and Engineering Chemistry in 2019.SDS of cas: 638-07-3 The following contents are mentioned in the article:

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity was investigated by Friedlander reaction, PANEOSF was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent was discussed and a “release-catch-release-catch” catalytic pattern was proposed accordingly. PANEOSF can be easily recycled for 20 times without any decrease of catalytic activity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electron-Deficient Olefin Ligands Enable Generation of Quaternary Carbons by Ni-Catalyzed Cross-Coupling was written by Huang, Chung-Yang;Doyle, Abigail G.. And the article was included in Journal of the American Chemical Society in 2015.Application of 6294-17-3 The following contents are mentioned in the article:

A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, I (Fro-DO), proved crucial for achieving high rates and chemoselectivity for C-C bond formation over β-H elimination. This ligand is easy to access, is stable, and presents a modular framework for reaction discovery and optimization. We expect that these attributes, combined with the fact that the ligands impart distinct electronic properties to a metal, will support the invention of new transformations not previously possible using established ligands. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core was written by Dar’in, Dmitry;Khoroshilova, Olesya;Kantin, Grigory;Krasavin, Mikhail. And the article was included in Synthesis in 2020.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N,S-bis-nucleophiles led to the formation of bicyclic 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazines was presented. The key to the successful realization of the atom-economical synthetic strategy was the initial SN₂ event, which facilitated the subsequent domino 1,2,3-triazole formation via the Wolff reaction. Equally important was the choice of sodium acetate as the base: acetic acid formed in the course of the initial nucleophilic substitution acted as an efficient catalyst for the Wolff reaction, which suppressed the competing, unwanted fragmentation path (observed when other bases were used). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A multipronged QSAR approach to predict algal low-toxic-effect concentrations of substituted phenols and anilines was written by Tugcu, Gulcin;Sacan, Melek Turker. And the article was included in Journal of Hazardous Materials in 2018.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

Environmental risk assessment procedures require acute and chronic toxicity values of hazardous chems. In this respect, the 96-h toxicity bioassays of nitro-, methyl-, methoxy-, chloro-, and nitrile- substituted phenols and anilines to Chlorella vulgaris were performed. Median inhibitory and low-toxic-effect concentrations were reported. Significant correlations between acute and chronic toxicities were found for the chems. in the data set regardless of mode of action. Consequently, linear models employing theor. and empirical descriptors were developed for the prediction of NOEC and IC₂₀. The outcome of the study will be beneficial in the risk assessments of organic chems. and setting water quality standards by the regulators. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists was written by Liu, Peng;Xu, Xing;Chen, Lili;Ma, Lei;Shen, Xu;Hu, Lihong. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Compound I [R = HO] (IC₅₀ = 35.2±7.2 μM), a moderate FXR antagonist was discovered via high-throughput screening. Structure-activity relationship studies indicated that the shape and the lipophilicity of the substituents of the aromatic ring affect the activity dramatically, increasing the shape and the lipophilicity of the substituents of the aromatic ring enhances the potency of FXR antagonists. Especially, when the OH at C2 position of the aromatic ring was replaced by the BnO substituent (analog I [R = PhCH₂O]), its activity could be improved to IC₅₀ = 1.1±0.1 μM. Besides, the length of the linker and the tetrazole structure are essential for retaining the activity. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1-Nicotinoylbenzotriazole: A Convenient Tool for Site-Selective Protection of 5,7-Dihydroxycoumarins was written by Fatykhov, Ramil F.;Khalymbadzha, Igor A.;Chupakhin, Oleg N.;Charushin, Valery N.;Inyutina, Anna K.;Slepukhin, Pavel A.;Kartsev, Victor G.. And the article was included in Synthesis in 2019.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

1-Nicotinoylbenzotriazole (NicBt) was uncovered as an efficient protecting agent for the site-selective acylation of resorcinol-type phenolic groups with almost equal reactivity. The use of NicBt allows selective protection of the 7-OH group in 5,7-dihydroxycoumarins in one simple scalable step, while combination of the nicotinoylation with tosylation-denicotinoylation or silylation-denicotinoylation yields 5-OH-protected 5,7-dihydroxycoumarins. Furthermore, nicotinoylated 5,7-dihydroxycoumarins proved useful in a gram-scale three-step preparation of a 2,2-dimethylpyrano[2,3-f]coumarin, a key intermediate for the synthesis of calanolide A, an HIV reverse transcriptase and Mycobacterium tuberculosis inhibitor, and its active analogs. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics