Tag: 100-200

Synthesis and Characterization of Impurity B of S-(+)-Clopidogrel Bisulfate: An Antiplatelet was written by Reddy, K. Tatendra;Kumar, K. Suneel;Omprakash, G.;Dubey, P. K.. And the article was included in Synthetic Communications in 2013.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

S-(+)-Clopidogrel bisulfate [(S-(+)-Me 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B I·HCl. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new route to functional polymers: Synthesis of functional polymer-supported esters from a weak acid ion exchange resin was written by Hodge, Philip;Houghton, Mark P.;Chakiri, Abdel. And the article was included in Reactive & Functional Polymers in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

Treatment of Amberlite IRC-50, a weak acid cation exchange resin containing methacrylic acid residues, with tetra-n-butylammonium hydroxide or benzyltrimethylammonium hydroxide gives the corresponding polymer-supported quaternary ammonium salts. These react smoothly, in nucleophilic substitution reactions, with a range of alkyl halides or sulfonates to give side chain esters with saturated hydrocarbon groups, with quaternary ammonium or sulfonate salt groups, with halide or alc. groups at the terminus of spacer chains, with 1,2-diol groups, with acetylenic groups or with anthracene residues. These polymer-supported species have a variety of potential applications. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents was written by Templ, Johanna;Schnuerch, Michael. And the article was included in Journal of Organic Chemistry in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The use of Ph trimethylammonium iodide (PhMe₃NI) as an alternative methylating agent for introducing a CH₃ group in α-position to a carbonyl group was described. Compared to conventional methylating agents, quaternary ammonium salts had the advantages of being nonvolatile, noncancerogenic and easy-to-handle solids. This regioselective method was characterized by ease of operational setup, use of anisole as green solvent and yields alkylated aryl ketones RC(O)CH(R¹)R² [R = Ph, 4-BrC₆H₄, 3-MeOC₆H₄, etc.; R¹ = Me, Et, Bn; R² = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.] up to 85%. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Category: chlorides-buliding-blocks).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanistic insights of molecular metal polyselenides for catalytic hydrogen generation was written by Elliott, Alexander;McAllister, James;Masaityte, Liudvika;Segado-Centellas, Mireia;Long, De-Liang;Ganin, Alexey Y.;Song, Yu-Fei;Bo, Carles;Miras, Haralampos N.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Safety of Tetramethylammonium chloride The following contents are mentioned in the article:

Mol. metal chalcogenides have attracted great attention as electrocatalysts for the hydrogen evolution reaction (HER). However, efficient utilization of the active sites and catalytic performance modulation has been challenging. Here we explore the design of immobilized mol. molybdenum polyselenides [Mo₂O₂S₂(Se₂)(Sex)]^2- that exhibit efficient hydrogen evolution at low overpotential and stability over 1000 cycles. D. functional calculations provide evidence of a unimol. mechanism in the HER process via the exploration of viable reaction pathways. The discussed findings are of a broad interest in the development of efficient mol. electrocatalytic materials. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Safety of Tetramethylammonium chloride).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Tetramethylammonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Functionalised Chromonyl-pyrimidines and Their Potential as Antimycobacterial Agents was written by Santoso, Kristiana T.;Brett, Matthew W.;Cheung, Chen-Yi;Cook, Gregory M.;Stocker, Bridget L.;Timmer, Mattie S. M.. And the article was included in ChemistrySelect in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:

Herein, the development of chromonyl-pyrimidines I [R¹ = Me, CH₂Cl, CH₂OMe, Ph, 4-FC₆H₄; R² = H, C(O)Ph; R³ = CO₂H, CO₂Et, Ph, 4-NH₂C₆H₄, 4-O₂NC₆H₄] as a new tuberculosis (TB) drug scaffold was presented. A library of chromonyl-pyrimidines was synthesized, from which lead compounds I [R¹ = Me, R² = H, Ph R³ = Ph; R¹ = Me, R² = R³ = Ph] was identified. From this work, the potential of chromonyl-pyrimidines as therapeutics for TB was demonstrated. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synergetic Effect of Monomer Functional Group Coordination in Catalytic Insertion Polymerization was written by Leicht, Hannes;Goettker-Schnetmann, Inigo;Mecking, Stefan. And the article was included in Journal of the American Chemical Society in 2017.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

PhS- and PhNH-functionalized dienes are copolymerized efficiently with butadiene to stereoregular copolymers by [(mesitylene)Ni(allyl)][BAr^F₄] (Ni-1). Overall polymerization rates and comonomer incorporations depend strongly on the linker length between the diene moiety and functional group, in, e.g., PhS-(CH₂)_xC(=CH₂)-CH=CH₂ (PhS-x-BD, x = 3-7), in particular for certain linker lengths high comonomer reactivity ratios stand out. This effect is related to a favorable binding of the comonomer to the active site comprising coordination of its functional group, which significantly enhances comonomer incorporation in the growing polymer chain. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Isolation of the Elusive Heptavanadate Anion with Trisalkoxide Ligands was written by Fernandez-Navarro, Leticia;Nunes-Collado, Aitor;Artetxe, Benat;Ruiz-Bilbao, Estibaliz;San Felices, Leire;Reinoso, Santiago;San Jose Wery, Ana;Gutierrez-Zorrilla, Juan M.. And the article was included in Inorganic Chemistry in 2021.Electric Literature of C4H12ClN The following contents are mentioned in the article:

The unprecedented heptavanadate cluster has been isolated from reactions between trisalkoxide ligands and vanadate in water at pH = 2 as a series of alkylammonium [H_xV₇O₁₈(H₂O)((OCH₂)₃CR)]^(4-x)- salts (1–3, R = CH₂OH; 4, R = CH₃). Their structures have been determined and the partial stability of 4 in water assessed by a combination of multinuclear NMR spectroscopy and ESI-MS. The heptavanadate unit reported herein could represent an intermediate species in the formation of decavanadate that is blocked by attachment of tripodal ligands. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Electric Literature of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An unusual synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones from ethyl 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate via benzopyran ring opening was written by Kavitha, Kotthireddy;Srikrishna, Devulapally;Sridhar, Balasubramanian;Aparna, Pasula. And the article was included in Molecular Diversity in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

An unusual and unexpected synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones was observed by the reaction of Et 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate with various arylthioureas in ethanol under mild reaction conditions with excellent yields. The ambiguity in the structure of the obtained products was solved by recording its single-crystal X-ray anal. This protocol was found to be a novel approach for the preparation of title compounds via benzopyran ring opening. A systematic plausible mechanism was proposed for the formation of the product. Also, an efficient one-pot three-component method was demonstrated for the formation of title compounds starting from salicylaldehyde. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Category: chlorides-buliding-blocks).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines was written by Ostrovskii, Vladimir A.;Danagulyan, Gevorg G.;Nesterova, Olga M.;Pavlyukova, Yulia N.;Tolstyakov, Vladimir V.;Zarubina, Olga S.;Slepukhin, Pavel A.;Esaulkova, Yana L.;Muryleva, Anna A.;Zarubaev, Vladimir V.;Trifonov, Rostislav E.. And the article was included in Chemistry of Heterocyclic Compounds in 2021.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments were separated by hydrazinocarbonylmethyl I [R = H, Me], methylpyrazolyl II, groups or a sulfur atom III [R¹ = Ph; R² = H; R¹ = CH₂CO₂H, R² = Me] were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which had very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biocatalytic Friedel-Crafts Acylation and Fries Reaction was written by Schmidt, Nina G.;Pavkov-Keller, Tea;Richter, Nina;Wiltschi, Birgit;Gruber, Karl;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to >99 %, and various C- or O-acyl donors, such as DAPG or isopropenyl acetate, are accepted by this enzyme. Furthermore the enzyme enables a Fries-like rearrangement reaction of resorcinol derivatives These findings open an avenue for the development of alternative and selective C-C bond formation methods. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics