Tag: 100-200

Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn_0.925Ti_0.075O NPs: Synthesis of Coumarin was written by Jadhav, Nirajkumar H.;Sakate, Sachin S.;Rasal, Nishant K.;Shinde, Dnyaneshwar R.;Pawar, Ramdas A.. And the article was included in ACS Omega in 2019.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn_0.925Ti_0.075O having a high surface area and good Lewis acidity. The catalyst shows high activity toward a broad spectrum of the substituted phenols with β-ketoesters such as Et acetoacetate, Et butyryl acetate, Et benzoyl acetate, and so forth in good yields over short reaction times during the synthesis of coumarins. The methodol. was further extended for the synthesis of ayapin mols. The catalyst also shows recycle activity up to seven cycles with very good stability. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers was written by Yoritate, Makoto;Londregan, Allyn T.;Lian, Yajing;Hartwig, John F.. And the article was included in Journal of Organic Chemistry in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, author report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of ginger essential oil constituents by simultaneous distillation and solvent extraction combined with GC-MS was written by Luo, Hailin;Lu, Ning. And the article was included in Zhongguo Tiaoweipin in 2010.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Ginger essential oil from hot air dried ginger was extracted by simultaneous distillation and solvent extraction(SDE); qual. anal. and quant. anal. were analyzed by GC-MS. The results showed that ginger essential oil could be extracted effectively by this method; the relative percentages of the constituents were determined by normalization method. The highest content was zingiberene(18.99%), followed by β-sesquiphellandrene(14.35%), α-farnesene(9.95%), α-curcumene(8.77%) and β-bisabolene(5.63%), and this five constituents accounted for 57.69% of the total constituents, initially identified as the main chem. constituents of ginger essential oil. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H₂O: An Expedient Way to Access Alkyl Amides was written by Li, Qiao;Jin, Hongwei;Liu, Yunkui;Zhou, Bingwei. And the article was included in Synthesis in 2020.Application of 6294-17-3 The following contents are mentioned in the article:

Herein, a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanide and water to access alkyl amides I [R = Et, cyclohexyl, CH₂(CH₂)₂Ph, etc.] was described. Bench-stable NiCl₂(dppp) was competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process was proposed based on preliminary experiments and previous literature. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of amine, halide, and pyridinium terminated 2-alkyl-p-tert-butylcalix[4]arenes was written by Hertel, Matthew P.;Behrle, Andrew C.;Williams, Samantha A.;Schmidt, Joseph A. R.;Fantini, Jordan L.. And the article was included in Tetrahedron in 2009.Application of 6294-17-3 The following contents are mentioned in the article:

The synthesis of calix[4]arenes with functional groups tethered to a single methylene bridge has been explored. Mono-lithiated calix[4]arenes react with 1,ω-bromochloroalkanes to give 2-(ω-chloroalkyl)calix[4]arenes, which function as key intermediates in the synthesis of a variety of tether-functionalized calix[4]arenes. Subsequent reactivity of these chloroalkyl species has allowed for successful synthesis of 2-(ω-iodoalkyl)-, 2-(ω-pyridiniumalkyl)-, and 2-(ω-aminoalkyl)-calix[4]arenes. Both alkyl and aryl amines have been incorporated at the end of the tether, and a 2,6-diisopropylaniline derivative has been analyzed by X-ray diffraction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron-catalyzed arene C-H hydroxylation was written by Cheng, Lu;Wang, Huihui;Cai, Hengrui;Zhang, Jie;Gong, Xu;Han, Wei. And the article was included in Science (Washington, DC, United States) in 2021.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

Report of iron coordinated by a bioinspired l-cystine-derived ligand catalyzed undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant to afford aryl alcs. Ar-OH [Ar = Ph, N-(phenyl)acetamide, tert-butyl(phenyl)carbamate, etc.]. The reaction was distinguished by its broad substrate scope, excellent selectivity, good yields, and it showcased compatibility with oxidation-sensitive functional groups, such as alcs., polyphenols, aldehydes and even a boronic acid. This method was well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug mols. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides was written by Cheung, Chi Wai;Hu, Xile. And the article was included in Nature Communications in 2016.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The reductive coupling of nitroarenes RNO₂ (R = 4-OHC₆H₄, OHCH₂CH₂C₆H₄, 1-naphthyl, etc.) with alkyl halides R¹X (R¹ = butan-2-yl, oxolan-3-yl, cyclooctyl, etc.) to yield (hetero)aryl amines, e.g., I has been reported. A simple iron catalyst enables the coupling with numerous primary, secondary and tertiary alkyl halides. Broad scope and high functional group tolerance are demonstrated. Mechanistic study suggests that nitrosoarenes and alkyl radicals are involved as intermediates. This new C-N coupling method provides general and step-economical access to aryl amines. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of substituted ureas possessing alkyl aromatic fragments via the reaction of 1-(3,3-diethoxypropyl)ureas with phenols was written by Smolobochkin, Andrey V.;Gazizov, Almir S.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Synthetic Communications in 2018.HPLC of Formula: 95-88-5 The following contents are mentioned in the article:

In this article, the approach to the substituted ureas based on the reaction of 1-(3,3-diethoxypropyl)ureas I [R¹ = R² = Me, i-Pr, Ph; R¹R² = (CH₂)₂O(CH₂)₂; R³ = R⁴ = OEt] with phenols was reported. Depending on the nature of the phenol and urea the reaction led either to diarylpropanes I [R³ = R⁴ = 5-Cl-2,4-di-HO-C₆H₂, 2,7-di-HO-1-naphthyl] and dibenzoxanthene derivatives or calixarenes. The proposed method benefited from mild reaction conditions, high product yields and operational simplicity. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5HPLC of Formula: 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyl Donors and Additives for the Biocatalytic Friedel-Crafts Acylation was written by Schmidt, Nina G.;Kroutil, Wolfgang. And the article was included in European Journal of Organic Chemistry in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

The Friedel-Crafts acylation is a broadly applied reaction that can be conducted using various types of catalyst. However, a biocatalytic alternative has only been reported recently. In this study, the scope of acetyl donors is described, showing that, in addition to vinyl acetate derivatives, Ph esters are also suitable donors. Furthermore, it was found that various amines enhance the reaction, whereby the effect do not seem to be correlated to the pH but to the structure of the donor. For instance, 1,4-diazabicyclo[2.2.2]octane (DABCO) turned out to be a viable alternative to imidazole; however the former performed best at pH 9.85, whereas the latter performed best at pH 8.3. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates was written by Wang, Jane L.;Aston, Karl;Limburg, David;Ludwig, Cindy;Hallinan, Ann E.;Koszyk, Francis;Hamper, Bruce;Brown, David;Graneto, Matthew;Talley, John;Maziasz, Timothy;Masferrer, Jaime;Carter, Jeffery. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Reference of 89938-53-4 The following contents are mentioned in the article:

In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data. The challenge of a surprisingly long half-life (t _1/2 = 360 h) of the first clin. candidate 1 and human t _1/2 had been difficult to predict based on allometric scaling for this class of highly ppb compounds We used a microdose strategy which led to the discovery of clin. agents 18c-(S), 29b-(S), and 34b-(S) with human half-life of 57, 13, and 11 h. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Reference of 89938-53-4).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 89938-53-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics