Tag: 100-200

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development [Erratum to document cited in CA163:218209] was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Caceres Cortes, Janet;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

Other work on clopidogrel metabolite synthesis was omitted from the reference list; a corrected reference 13 is given. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of acyclic alkanes by metal substitution with extension of the carbon framework was written by Kantchev, E. A. B.;Organ, M. G.. And the article was included in Science of Synthesis in 2009.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

A review of methods to prepare acyclic alkanes by metal substitution with extension of the carbon framework. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Asymmetric synthesis of δ-substituted-β-keto esters and β-substituted ketones via carboxyl-assisted site- and enantio-selective addition reactions was written by Zhu, Huiling;Liu, Peng;Liu, Hongxin;Ahmed, Ebrahim-Alkhalil M. A.;Hu, Xingen;Li, Juan;Xiao, Hong-Ping;Li, Xinhua;Jiang, Jun. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C6H9ClO3 The following contents are mentioned in the article:

Carboxyl-assisted site- and enantio-selective additions of polyfunctional nucleophiles to imines and carbonyls were developed, affording δ-substituted-β-keto esters and β-substituted ketones with good yields and enantioselectivities. Besides, short synthetic routes to bioactive mols. were also achieved. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Electric Literature of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Convenient one-step synthesis of quinoline-3,4-dicarboxylate derivatives was written by Ge, Youjin;Yu, Niefang. And the article was included in Synthetic Communications in 2021.Product Details of 638-07-3 The following contents are mentioned in the article:

Herein a practical and convenient procedure for the one-step synthesis of quinoline-3,4-dicarboxylate derivatives from isatins and β-keto esters in alcs. catalyzed by sulfuric acid was described. This novel protocol offers the advantages of high conversion rates, short reaction times, and easy handling. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Product Details of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Method of splitting key intermediate of clopidogrel was written by Xu, Han-qing. And the article was included in Guangzhou Huagong in 2014.Recommanded Product: 141109-14-0 The following contents are mentioned in the article:

The racemic 2-(2-chlorophenyl)glycine as the starting material, through esterification to give racemic 2-(2-chlorophenyl)glycine Me ester, resolved by (L)-(+)-tartrate, Bu ketone as solvent, (S)-(+)-2-(2-chlorophenyl)glycine Me ester was obtained, and the solvent recovery yield was more than 95%. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acid-catalyzed reaction of 1-(2,2-dimethoxyethyl)ureas with phenols as an effective approach to diarylethanes and dibenzoxanthenes was written by Smolobochkin, A. V.;Gazizov, A. S.;Voronina, J. K.;Rizbayeva, T. S.;Burilov, A. R.;Pudovik, M. A.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2019.Formula: C6H5ClO2 The following contents are mentioned in the article:

A one-pot synthesis of urea-substituted diarylethanes and dibenzoxanthenes starting from 1-(2,2-dimethoxyethyl)ureas and phenols was developed. The approach used readily available reagents and catalysts, requires mild reaction conditions and provides the target compounds in good to high yields. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Formula: C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluating the synthesis of bis-pyrazolines was written by Mahmoodi, Nosrat O.;Sharifzadeh, Bahman;Mamaghani, Manouchehr;Tabatabaeian, Khalil. And the article was included in Journal of Heterocyclic Chemistry in 2014.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The bis-cyclization of chalcone with thiosemicarbazide under basic condition led to the formation of thiocarbamoyl bis-pyrazolines. Bis-chalcones were prepared by a Claisen-Schmidt condensation between 1 mol dialdehyde and 2 mol acetophenones in the presence of NaOH as a catalyst. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A three-photon probe with dual emission colors for imaging of Zn(II) ions in living cells was written by Mandal, Amal Kumar;He, Tingchao;Maji, Swarup Kumar;Sun, Handong;Zhao, Yanli. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

A novel three-photon probe for the imaging of exogenous Zn(II) ions in live cells with varying emission colors under three-photon excitation is developed. The tuning of the charge transfer state and the emission color of the probe was also demonstrated in the presence of acid. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reaction of 4-Chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol with Some Amines was written by Smolobochkin, A. V.;Anikina, E. A.;Gazizov, A. S.;Vagapova, L. I.;Burilov, A. R.;Pudovik, M. A.. And the article was included in Russian Journal of General Chemistry in 2018.Synthetic Route of C6H5ClO2 The following contents are mentioned in the article:

4-Chloro-6-[1-(vinylsulfonyl)pyrrolidin-2-yl]benzene-1,3-diol prepared by the reaction of 2-ethoxypyrrolidine with 4-chlororesorcinol was introduced into the aza-Michael reaction with various amines which led to the formation of new 1-sulfonyl-2-arylpyrrolidines. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Synthetic Route of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Differentiating C-Br and C-Cl Bond Activation by Using Solvent Polarity: Applications to Orthogonal Alkyl-Alkyl Negishi Reactions was written by Hadei, Niloufar;Achonduh, George T.;Valente, Cory;O’Brien, Christopher J.;Organ, Michael G.. And the article was included in Angewandte Chemie, International Edition in 2011.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

Orthogonal reactivity of bifunctional or unactivated bromochloroalkanes was observed in a double Negishi alkyl-alkyl cross-coupling reaction. This was made possible by a relatively simple solvent polarity trigger, lending itself to a one-pot approach. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics