Tag: 100-200

Synthesis, characterization and anti-microbial activity of novel pyrimidine derivatives was written by Kumar, Konda Ravi;Sumanjali, K. N. S. Sneha;Chandana, M. Priya;Srilatha, N.;Rao, P. Koteswara. And the article was included in Journal of Drug Delivery and Therapeutics in 2021.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Chalcones reacted with aminoguanidine to give intermediate compounds which on further reacted with substituted ketones to give pyrimidine derivatives A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for antibacterial activity and anti-fungal activity. They showed significant activity when compared with standard drug Streptomycin and Miconazole resp. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalyst and Sensitizer-Free Visible-Light-Induced C(sp²)-H Chalcogenation of Arenes/Heteroarenes with Dichalcogenides was written by Kumaraswamy, Gullapalli;Ramesh, Vankudoth;Gangadhar, Maram;Vijaykumar, Swargam. And the article was included in Asian Journal of Organic Chemistry in 2018.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

A direct selenation of arenes and heteroarenes at room temperature has been accomplished. This protocol was enabled by a visible-light-promoted single-electron-transfer (SET) pathway without a directing group. An array of arenes and heteroarenes, such as indoles, pyrroles, and functionalized aryl substrates could go through this selenation with high yields and regioselectivity. The salient feature of this protocol is the SET achieved by irradiating one of two organic mols. thereby avoiding a sensitizer to form a radical ion pair. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO₂) was written by Chetty, Lloyd C.;Kruger, Hendrik G.;Arvidsson, Per I.;Naicker, Tricia;Govender, Thavendran. And the article was included in Synthesis in 2022.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols ROH (R = Ph, 3-hydroxyphenyl, 2-methyl-3-hydroxyphenyl, etc.), and indoles I (R¹ = H, Br, nitro) is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel coumarin-based pH sensitive fluorescent probes for the highly alkaline pH region was written by Nguyen, T. Hien;Sun, Tong;Grattan, Kenneth T. V.. And the article was included in Dyes and Pigments in 2020.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

The design, synthesis and spectroscopic properties of novel polymerizable coumarin-based pH indicators are reported. They show a fluorescence response to pH in the highly alk. pH region with calculated pK_a values in the range of 12.2-12.5. Covalent immobilization of the indicators to polymer supports provides novel pH-sensitive materials that possess excellent photostability. The materials are sensitive to pH in a similar range and can be applied in optical pH sensors for measuring pH in various alk. media. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Process Development and Scale-Up of a Protease Inhibitor for the Treatment of HIV Featuring the Preparation of a Neopentyl Grignard Reagent and Development of a One-Pot Curtius Reaction was written by Ischay, Michael A.;Hoang, Brittanie;Steinhuebel, Dietrich P.;Chin, Matthew R.;Dixon, Darryl D.;Elfgren, Danielle;Heumann, Lars;Lew, Willard;Mundal, Devon A.;Neville, Sean T.;Shah, Nisha P.;Shi, Bing;Tripp, Jonathan C.;Wang, Queenie. And the article was included in Organic Process Research & Development in 2022.Computed Properties of C4H12ClN The following contents are mentioned in the article:

Compound I is a densely functionalized iminohydantoin that possesses a quaternary stereocenter and is under development as an HIV protease inhibitor. Key challenges that are discussed include the preparation of a neopentyl Grignard reagent via magnesium insertion, development of a one-pot Curtius reaction that generated a volatile isocyanate and was trapped with an alc., and removal of a CBz protecting group to isolate a succinate salt. This study describes process development efforts that enabled the first scale-up of I. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Computed Properties of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols was written by Chen, Xiaohong;Liu, Xiaoguang;Martinez, Jenny S.;Mohr, Justin T.. And the article was included in Tetrahedron in 2016.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of (αS)-α-amino-2-chlorobenzeneacetic acid methyl ester was written by Ding, Gui-li;Zhao, Min;Wu, Fan-hong;Yu, De-fei;Chen, Jian-zhon. And the article was included in Guangzhou Huagong in 2007.Product Details of 141109-14-0 The following contents are mentioned in the article:

A method for the synthesis of the title compound and a resolution method are reported here. L-(+)-tartaric acid was used as resolving agent. Optimum resolution process conditions were: 30°, 5 h, a mixture of acetone and methanol solvent volume ratio 1:4 and the mol ratio of α-amino-2-chlorobenzeneacetic acid Me ester to L-(+)-tartaric 1:1.1. The resolution process provide a yield above 90% (optical rotation 88°). This process may have industrial applications. The above-mentioned title compound is an intermediate in the synthesis of clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxidation of alcohols to aldehydes and ketones using selenium ionic liquid was written by Cheng, Xian Yi;Li, Kang Feng;Wang, Qiao Jian;Wang, Cong Ying;Ying, Tao Kai. And the article was included in Chinese Chemical Letters in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

A new type of ionic liquid supported selenium reagents was synthesized and was found to be an excellent catalyst in the oxidation of alcs. to aldehydes and ketones in the presence of 30% H₂O₂. The predictable solubility of ionic liquids allows an easy separation of the oxidation products from the reaction mixture Furthermore, the oxidation can be carried out using an ionic liquid as the solvent, and the ionic liquid-supported selenium reagents can be recycled and used 4 times with little decrease in catalytic performance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides was written by Verma, Piyush Kumar;Prasad, K. Sujit;Varghese, Dominic;Geetharani, K.. And the article was included in Organic Letters in 2020.Reference of 6294-17-3 The following contents are mentioned in the article:

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B₂pin₂ or B₂neop₂) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism was written by Kancherla, Rajesh;Muralirajan, Krishnamoorthy;Rueping, Magnus. And the article was included in Chemical Science in 2022.Reference of 6294-17-3 The following contents are mentioned in the article:

The development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides was described. The new methodol. showed broad functional group tolerance and was addnl. be applied in the direct three-component reaction of aldehydes, anilines and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction was proceeded via the inner-sphere electron transfer mechanism. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics