Tag: 100-200

5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment was written by Perrone, Roberto;Berardi, Francesco;Leopoldo, Marcello;Tortorella, Vincenzo;Lograno, Marcello D.;Daniele, Eugenia;Govoni, Stefano. And the article was included in Farmaco in 1994.Reference of 3438-16-2 This article mentions the following:

The synthesis of some arylpiperazines with a benzamide moiety on N-4 was carried out, and their dopaminergic and serotonergic affinity was assayed by in vitro binding to rat brain receptors. The results showed a moderate affinity for D-2 receptors and a lack of 5-HT receptor affinity. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Reference of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzoic esters and electronic affinities of radicals. II. The halogenoalkyl benzoates was written by Zaki, Ahmad. And the article was included in Journal of the Chemical Society in 1930.Computed Properties of C8H7ClO2 This article mentions the following:

In Part I comparison was made between the orienting powers of various alkyl radicals as exhibited in the alkyl benzoates; the effect of a halogen in the alkyl group is now considered. The nitration of the esters, the hydrolysis of the products and the subsequent analyses were carried out as in Part I. BzOCH₂Cl, b₂ 104-6°; nitration gives a 98.2% yield, of which 81.9% is m-isomer. BzOCH₂CH₂Cl, b₁₈ 138.8°, b₇₆₂ 255-7°; nitration, 96.9%, 75.8% m-isomer. γ-Chloropropyl benzoate, b₁₅ 155-6° (75% yield); nitration, 98.5%; 77.3% m-isomer. BzOCH₂CH₂Br, b₁₅ 147-9°; nitration, 98.7%; 71.5% m-isomer. BzOCH₂CH₂CH₂Br, b₁₆ 164.5-5.5°; nitration, 99%; 72.8% m-isomer. β-Iodoethyl benzoate, b₁₇ 161-3° (80% yield); on nitration this liberates I. The effect of Cl is greater the nearer the Cl is to the nucleus; the Br esters occupy a place between the corresponding normal and Cl esters and show the alternation exhibited by the other 2 series. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Computed Properties of C8H7ClO2).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-alkylation and o-alkylation of ethyl 4-(4,6-dimethoxypyrimidin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxylate was written by Li, Yuanxiang. And the article was included in Youji Huaxue in 2013.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Twenty novel N-substituted and O-substituted compounds were prepared starting from Et 4-(4,6-dimethoxypyrimidin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxylate. Various halogenated hydrocarbons were used as resource of alkylation and NaH as base in N,N-dimethylformamide (DMF) at room temperature. The structures of alkylation products were confirmed by ‘H NMR, IR, MS and elemental anal. Two isomer structures were further determined by representative X-ray structures of I and II. The alkylation reaction was performed in mild conditions with a total yield of 89%-98%. Among them, the main product N-alkylation was obtained in 47%-77% yield, and O-alkylation was simultaneously obtained in 21%-49% yield by a simple one-pot reaction. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light-Catalyzed [3 + 1 + 2] Coupling Annulations for the Synthesis of Unsymmetrical Tri-substituted Amino-1,3,5-triazines was written by Guo, Wei;Zhao, Mingming;Du, Chengtang;Zheng, Lvyin;Li, Luo;Chen, Liping;Tao, Kailiang;Tan, Wen;Xie, Zhen;Cai, Liuhuan;Fan, Xiaolin;Zhang, Kai. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 18637-02-0 This article mentions the following:

A visible-light catalyzed [3 + 1 + 2] annulation for the synthesis of unsym. tri-substituted amino-1,3,5-triazines I (R¹ = Me, C₆H₅, 4-FC₆H₄, etc.; R² = 4-FC₆H₄, 4-EtC₆H₄, 2-ClC₆H₄, etc.) from amidines, isothiocyanates and 1,1,3,3-tetramethylguanidines has been developed. The method exhibits the advantages of easily available starting materials, insensitive to air and moisture, wide substrate scopes, high step economy, mild, metal- and ligand-free conditions, which has potential applications in the organic, medicinal and material chem. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Recommanded Product: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance was written by Stotani, Silvia;Gatta, Viviana;Medarametla, Prasanthi;Padmanaban, Mohan;Karawajczyk, Anna;Giordanetto, Fabrizio;Tammela, Paivi;Laitinen, Tuomo;Poso, Antti;Tzalis, Dimitros;Collina, Simona. And the article was included in Journal of Medicinal Chemistry in 2019.Product Details of 1711-11-1 This article mentions the following:

Antibiotic resistance is posing a continuous threat to global public health and represents a huge burden for society as a whole. In the past decade, the interference with bacterial quorum sensing (QS) (i.e., cell-cell communication) mechanisms has extensively been investigated as a valid therapeutic approach in the pursuit of a next generation of antimicrobials. (S)-4,5-Dihydroxy-2,3-pentanedione, commonly known as (S)-DPD, a small signaling mol. that modulates QS in both Gram-neg. and Gram-pos. bacteria, is phosphorylated by LsrK, and the resulting phospho-DPD activates QS. We designed and prepared a small library of DPD derivatives, characterized by five different scaffolds, and evaluated their LsrK inhibition in the context of QS interference. SAR studies highlighted the pyrazole moiety as an essential structural element for LsrK inhibition. Particularly, four compounds were found to be micromolar LsrK inhibitors (IC₅₀ ranging between 100 μM and 500 μM) encouraging further exploration of novel analogs as potential new antimicrobials. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Product Details of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

KMnO₄-mediated oxidative C-N bond cleavage of tertiary amines: Synthesis of amides and sulfonamides was written by Zhang, Zhang;Liu, Yong-Hong;Zhang, Xi;Wang, Xi-Cun. And the article was included in Tetrahedron in 2019.COA of Formula: C8H10ClN This article mentions the following:

KMnO₄-mediated oxidative C-N bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction took placeat mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of novel quinazolin-4(3H)-one derivatives containing the 7-oxo-1,2,4-triazolo[1,5-a]pyrimidine moiety as effective agricultural bactericides against the pathogen Xanthomonas oryzae pv. oryzae was written by Du, Huan;Fan, Zhijiang;Yang, Lan;Bao, Xiaoping. And the article was included in Molecular Diversity in 2018.Related Products of 620-19-9 This article mentions the following:

Abstract: A series of novel quinazolin-4-one derivatives (7a-7n) bearing the 7-oxo-1,2,4-triazolo[1,5-a]pyrimidine moiety were designed, synthesized and evaluated for their inhibition activities against phytopathogenic bacteria and fungi in vitro. All of the target compounds were fully characterized through ¹H NMR, ¹³C NMR, HRMS and IR spectra. Among these compounds, the structure of compound 7e was unambiguously confirmed via single-crystal X-ray diffraction anal. The turbidimetric assays indicated that compounds 7b, 7d, 7g, 7k and 7n exhibited much more potent inhibition activities against the pathogen Xanthomonas oryzae pv. oryzae (Xoo), relative to control Bismerthiazol. Moreover, antibacterial activities of compounds 7j, 7k and 7n against the pathogen Xanthomonas axonopodis pv. citri (Xac) were comparable to that of control Bismerthiazol. As for the pathogen Ralstonia solanacearum (Rs), only compounds 7g and 7i demonstrated inhibition activities similar to control Thiadiazole-copper. Moreover, this class of compounds did not display inhibition activity against three fungi tested. The above findings indicated that quinazolin-4-one derivatives containing the 7-oxo-1,2,4-triazolo[1,5-a]pyrimidine moiety have a potential as promising candidates for the development of new and more efficient agricultural bactericides. Graphical Abstract: [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics