Tag: 100-200

A simple and straightforward protocol to 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids was written by Ramu, Tadikonda;Prasanthi, Sarakula;Mangarao, Nakka;Basha, Gajula Mahaboob;Srinuvasarao, Rayavarapu;Siddaiah, Vidavalur. And the article was included in Chemistry Letters in 2013.Application of 1711-11-1 This article mentions the following:

A convenient one-pot synthesis of 1,2,4-oxadiazoles (e.g. I) is described. The condensation of carboxylic acids and amidoximes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N-methylmorpholine (NMM) has been employed to synthesize a variety of 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields. The methodol. has been applied for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of prodrugs of the rat selective toxicant norbormide was written by Rennison, David;Laita, Olivia;Bova, Sergio;Cavalli, Maurizio;Hopkins, Brian;Linthicum, Darwin S.;Brimble, Margaret A.. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Related Products of 5335-05-7 This article mentions the following:

Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. However, one major drawback of NRB as a viable rodenticide relates to an evolutionary aversion developed by the rat leading to sub-lethal dosing due to either its unpleasant taste or rapid onset of effects. A series of NRB prodrugs were prepared in an effort to mask this acute response. Their synthesis and biol. evaluation (in vitro vasoconstrictory activity, in vitro hydrolytic and enzymic stability and lethality/palatability in vivo) is described. Compound 19 displayed the most promising profile with respect to a delay in the onset of symptoms and was subsequently demonstrated to be significantly more palatable to rats. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Related Products of 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formation of ions of esters of bromomethyl and chloromethyl alcohols in tin tetrabromide solutions studied by electromigration, PMR, and ir spectroscopic methods was written by Lysenko, Yu. A.;Vedmedskaya, A. N.;Kapkan, L. M.;Artemova, V. M.;Pinchuk, V. V.. And the article was included in Zhurnal Obshchei Khimii in 1972.Synthetic Route of C8H7ClO2 This article mentions the following:

The transport data for SnCl4 and SnBr4 in BrCH2OAc, ClCH2OAc and ClCH2OBz were compared with ir and PMR information for these systems. The mixtures underwent a heterolysis of the X-CH2 (X = Br, Cl) bond by the action of SnX4 to form AcOCH2+ ions. The reactivity of SnCl4 was greater than that of SnBr4. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Synthetic Route of C8H7ClO2).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Effects of Substituents on the Geometry of π-π Interactions was written by Snyder, Seth E.;Huang, Bin-Syuan;Chu, Yu W.;Lin, Huei-Shian;Carey, James R.. And the article was included in Chemistry – A European Journal in 2012.HPLC of Formula: 1711-11-1 This article mentions the following:

The authors have designed and used a simple mol. recognition system to study the substituent effects in aromatic interactions. Recently, 3- and 3,5-disubstituted benzoyl leucine diethylamides with aromatic rings of varying electronic character organized into homochiral dimers in the solid state through a parallel displaced π-π interaction and two hydrogen bonds, but no such homochiral dimerization was observed for the unsubstituted case. This phenomenon supports the hypothesis that substituents stabilize π-π interactions regardless of their electronic character. To further study the origin of substituent effects for π-π interactions, the authors synthesized and crystallized 4-substituted benzoyl leucine diethylamides. Surprisingly, only two of the 4-substituted compounds formed homochiral dimers. A comparison among the 4-substituted compounds that crystallized as homochiral dimers and their 3-substituted counterparts revealed that there are differences in regard to the geometry of the aromatic rings with respect to each other, which depend on the electronic nature and location of the substituent. The crystal structures of the homochiral dimers that showed evidence of direct, local interactions between the substituents on the aromatic rings also displayed nonequivalent dihedral angles in the individual monomers. The crystallog. data suggests that such flexing may be the result of the individual mols. orienting themselves to maximize the local dipole interactions on the resp. aromatic rings. The results presented here can potentially have broad applicability towards the development of mol. recognition systems that involve aromatic interactions. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pyrrolobenzodiazepines with antinociceptive activity: synthesis and pharmacological activities was written by Mai, A.;Di Santo, R.;Massa, S.;Artico, M.;Pantaleoni, G. C.;Giorgi, R.;Coppolino, M. F.;Barracchini, A.. And the article was included in European Journal of Medicinal Chemistry in 1995.COA of Formula: C9H9ClO2 This article mentions the following:

The synthesis of some N-[2-(1H-pyrrol-1-yl)benzyl]arylacetamides and 4-(arylmethyl)-5,6-dihydro-4H-pyrrolo[1,2-a]-[1,4]benzodiazepines as their conformationally restricted analogs was reported. The reduction of arylacetamides and N-methylation of pyrrolobenzodiazepines led to the corresponding N-[2-(1H-pyrrol-1-yl)benzyl]arylehylamines and the 4-(arylmethyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines, resp. The new compounds were subjected to pharmacol. tests for evaluation of antinociceptive effects. Neuro-behavioral assays was also carried out on selected compounds to acquire data on neurotoxicity. One of the most active compounds was 4-(4-methoxybenzyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine; it showed high activity in both hot-plate and acetic-acid-induced writhing tests in mice without sedative or myorelaxant effects . In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rubber manufacture: sampling and identification of volatile pollutants was written by Cocheo, Vincenzo;Bellomo, Maria Luisa;Bombi, G. Giorgio. And the article was included in American Industrial Hygiene Association Journal (1958-1999) in 1983.Application of 5335-05-7 This article mentions the following:

Air samples collected in the vulcanization and extrusion areas of a shoe-sole factory contained approx. 100 different volatile organic compounds whose concentrations ranged from 25 to 27000 μg/m³. These compounds included alkanes, cycloalkanes, aromatic hydrocarbons, chlorinated organics, phenols, esters, etc. The highest number and concentrations of pollutants were associated with the vulcanization process. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application of 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Resonant two-photon ionization spectroscopy of the ³⁵Cl and ³⁷Cl isotopomers of cis and trans 3-chloro-4-fluoroanisole was written by Yu, Dan;Dong, Changwu;Zhang, Lijuan;Cheng, Min;Hu, Lili;Du, Yikui;Zhu, Qihe;Zhang, Cunhao. And the article was included in Journal of Molecular Structure in 2011.Name: 2-Chloro-1-fluoro-4-methoxybenzene This article mentions the following:

The effects of conformation and isotopic substitution on the properties of 3-chloro-4-fluoroanisole (3C4FA) were studied by mass-analyzed resonant two-photon ionization (R2PI) technique and theor. calculations In the one color R2PI spectra, the band origins of the S₁ ← S₀ electronic transitions (0⁰ bands) of cis ³⁵Cl-3C4FA and cis ³⁷Cl-3C4FA were found to be equivalent at 34,703 ± 3 cm^-1, while the 0⁰ bands of trans ³⁵Cl-3C4FA and trans ³⁷Cl-3C4FA were found to be equivalent at 34,747 ± 3 cm^-1. Assignments of the observed vibrational bands of R2PI spectra were made mainly based on the 10-electron, 8-orbital CASSCF/6-31g calculations and on conformity with the available data of the similar aromatic mols. in the literature. With the two color R2PI technique, the adiabatic ionization energies (IEs) of cis ³⁵Cl-3C4FA and cis ³⁷Cl-3C4FA were determined to be equivalently 67,349 ± 15 cm^-1, while the IEs of trans ³⁵Cl-3C4FA and trans ³⁷Cl-3C4FA were determined to be equivalently 67,595 ± 15 cm^-1. The conformational effect on the transition energies, ionization energies and vibrational frequencies of 3C4FA is greater than the isotopic effect. The hetero-dihalogen-substitution effect on the transition energies is also discussed. In the experiment, the researchers used many compounds, for example, 2-Chloro-1-fluoro-4-methoxybenzene (cas: 202925-07-3Name: 2-Chloro-1-fluoro-4-methoxybenzene).

2-Chloro-1-fluoro-4-methoxybenzene (cas: 202925-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 2-Chloro-1-fluoro-4-methoxybenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

PEPPSI-type 2-methyl-2-propenyl-functionalized N-heterocyclic carbene-palladium complexes: Synthesis, structural characterization and catalytic activity on Suzuki-Miyaura reaction was written by Sahin, Neslihan. And the article was included in Journal of Molecular Structure in 2019.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

N-Heterocyclic carbenes (NHCs) have been known to be efficient ligands for the Suzuki-Miyaura cross-coupling. In this work, four novel 2-methyl-2-propenyl substituted N-heterocyclic carbene ligands were synthesized. They were used to produce four novel air-stable PEPPSI-type palladium-NHC complexes I (R = Bn, 3-MeC₆H₄CH₂, 1-naphthylmethyl, 9-anthrylmethyl). In addition, prepared complexes I were investigated as catalysts in the Suzuki-Miyaura coupling reaction under very mild conditions using a mixture of i-PrOH/water as a solvent and a base at the room temperature Under optimal reaction conditions, the expected biaryl products were obtained in moderate to high yields. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma was written by Kwong, Ada J.;Pham, Thao N. D.;Oelschlager, Hannah E.;Munshi, Hidayatullah G.;Scheidt, Karl A.. And the article was included in ACS Medicinal Chemistry Letters in 2021.Electric Literature of C4H5ClO2 This article mentions the following:

Growth, division, and development of healthy cells relies on efficient response to environmental survival cues. The conserved mitogen-activated protein kinase (MAPK) family of pathways interface extracellular stimuli to intracellular processes for this purpose. Within these pathways, the MEK family has been identified as a target of interest due to its clin. relevance. Particularly, MEK4 has drawn recent attention for its indications in pancreatic and prostate cancers. Here, we report two potent MEK4 inhibitors demonstrating significant reduction of phospho-JNK and antiproliferative properties against pancreatic cancer cell lines. Furthermore, mol. inhibition of MEK4 pathway activates the MEK1/2 pathway, with the combination of MEK1/2 and MEK4 inhibitors demonstrating synergistic effects against pancreatic cancer cells. Our inhibitors provided insight into the crosstalk between MAPK pathways and new tools for elucidating the roles of MEK4 in disease states, findings which will pave the way for better understanding of the MAPK pathways and development of addnl. probes. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Electric Literature of C4H5ClO2).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C4H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and neuroleptic activity of benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds was written by Iwanami, Sumio;Takashima, Mutsuo;Hirata, Yasufumi;Hasegawa, Osamu;Usuda, Shinji. And the article was included in Journal of Medicinal Chemistry in 1981.HPLC of Formula: 3438-16-2 This article mentions the following:

Fifty-two benzamides were designed and synthesized as potential neuroleptics and were evaluated for their inhibitory effects on apomorphine-induced stereotyped behavior in rats. In the metoclopramide analog (linear benzamides) series, N[2-(N-benzyl-N-methylamino)ethyl]-5-chloro-2-methoxy-4-(methylamino)benzamide-HCl (I) [61694-55-1] was ∼15 times more active than metoclopramide itself. In a cyclic series (benzamides of 1-benzyl-3-aminopyrrolidine), most compounds tested were more active than corresponding linear benzamides. YM-09151-2 (II) [75272-39-8] was the most active compound of all the compounds tested, but it had a high antistereotypic activity-to-cateleptogenicity ratio compared with haloperidol and metoclopramide. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2HPLC of Formula: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics