Tag: 100-200

Synthetic routes to 1,5-diazacyclooctanes via 2,6-dioxo-1,5-diazabicyclo[3.3.1]octanes was written by Kemp, D. S.;Sidell, M. D.;Shortridge, T. J.. And the article was included in Journal of Organic Chemistry in 1979.Recommanded Product: 5335-05-7 This article mentions the following:

Reactions of 3-pyrazolidinones with primary β-chloropropionyl chlorides provide a satisfactory synthetic route to 2,6-dioxo-1,5-diazabicyclo[3.3.0]octanes I (R = H, Me). The corresponding secondary halides cannot be induced to undergo cyclization. The Stetter procedure, reaction of acrylic acid derivatives with hydrazine at 200°, provides an acceptable route to derivatives that bear 4- or 8-alkyl substituents. Reactions of I with NaNH₂ in NH₃ generate sodium enolates that undergo C-alkylation and C-acylation reactions in high yield. Two new procedures are described for reduction of I to 1,5-diazacyclooctanes, treatment with diborane in refluxing THF and Na-NH₃ treatment, followed by reduction by LiAlH₄. Reductions of I with Na-NH₃ or by sodium naphthalenide in dimethoxyethane generate 2,6-dioxo-1,5-diazacyclooctanes in excellent yield. Convenient preparations of 3,6-dibromohexanoic acid and 2-acetyl-3-chloro-2-methylpropionic acid are described. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light-promoted aerobic oxidation of sulfides and sulfoxides in ketone solvents was written by Li, Xiaotong;Wang, Yu;Yang, Liqun;Zhang, Zhaoguo;Xie, Xiaomin. And the article was included in Tetrahedron in 2022.SDS of cas: 85953-29-3 This article mentions the following:

Simple and readily available ketones have been identified to promote the visible-light-promoted aerobic oxidation of sulfides and sulfoxides to sulfones. A simple and environmental-friendly oxidation protocol of sulfides to sulfones is reported. Various sulfides were efficiently oxidized into sulfones with O₂ as sustainable terminate oxidant, readily available thioxanthone as the photocatalyst and 3-pentanone (DEK) as the solvent. The protocol tolerates diverse functional groups, including halogens, ketone, ester, cyano, heterocycle and even cyclopropyl groups. The detection of the aerobic oxidation reaction in DEK by GC and HRMS disclosed that the key active intermediates were generated. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3SDS of cas: 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Phenylbenzimidazoles as potential anthelmintics was written by Sluka, J.;Novak, J.;Budesinsky, Z.. And the article was included in Collection of Czechoslovak Chemical Communications in 1976.Quality Control of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The reaction of o-C6H4(NH2)2 with various 5-chloro-, 3,5-dichloro-, 3,5,6-trichloro-, 5-bromo-, and 3,5-dibromo-substituted 2-ROC6H4CO2H (R = H, Me, Et, Pr, Me2CH, Bu, n-C5H11, n-C6H13, n-C12H25, MeOCH2CH2, PhCH2, o-, m-, and p-ClC6H4CH2, and 3,4-Cl2C6H3CH2) and with 2-RSC6H4CO2H (R = H, Me, Et, Pr, Me2CHCH2) gave the corresponding substituted 2-phenylbenzimidazole (I). Some of these derivatives showed a low anthelmintic activity on Nippostrongylus brasiliensis (9 compounds) and Hymenolepis nana (4 compounds) worms. A low coccidiostatic effect against Eimeria tenella was found only with I substituted at positions 2 and 5 of the Ph group by 2-ClC6H4CH2O and Cl, resp. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Quality Control of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent was written by Zhu, Weixing;Haupenthal, Joerg;Groh, Matthias;Fountain, Michelle;Hartmann, Rolf W.. And the article was included in Antimicrobial Agents and Chemotherapy in 2014.Related Products of 1711-11-1 This article mentions the following:

CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Related Products of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2H-Pyrrolo[3,4-b] [1,5]benzothiazepine derivatives as potential inhibitors of HIV-1 reverse transcriptase was written by Di Santo, Roberto;Costi, Roberta. And the article was included in Farmaco in 2005.Computed Properties of C7H5ClF2 This article mentions the following:

A number of 2H-pyrrolo[3,4-b] [1,5]benzothiazepine derivatives (PBTAs) 7-25 and the related synthetic intermediates 3-pyrrolyl aryl sulfones (PASs) 26-32 were designed, synthesized and tested as potential anti-HIV-1 agents targeted at the reverse transcriptase (RT). The PBTAs were conceived as tricyclic analogs of nevirapine, pyrrolo[1,2-b] [1,2,5]benzothiadiazepine 5 (PBTD) and pyrrolo[2,1-d] [1,2,5]benzothiadiazepine 6, NNRTIs endowed with potent anti-HIV-1 activities. The majority of tested PBTAs were active against HIV-1-induced cytopathicity in MT-4 cells at concentrations ranging from 0.3 to 40 μM. In particular, compound 10 was the most potent derivative with EC₅₀ = 0.3 μM, comparable to that of nevirapine used as reference drug. In the 3-pyrrolyl aryl sulfones (26-32) series only three sulfones were found active against HIV-1 replication cycle. The following preliminary SAR could be depicted for the title derivatives:(i) the conformationally restrained PBTAs are more potent than the corresponding open counterparts (PASs); (ii) the DMA group give the highest anti-HIV-1 potency in the PBTAs series; (iii) PBTAs and the corresponding thiones are equipotent; (iv) an unsubstituted amino group, as part of p-chloroanilino moiety, is a strong determinant for the antiviral activity in the PASs series. The most potent derivatives in cell-based assays were proven to target the RT in enzyme assays. Unfortunately, none of the test compounds inhibited the multiplication of clin. relevant drug-resistant viruses (mutants of HIV-1 carrying K103N and Y181C mutations) at concentrations lower than 30 μM. However, the good results obtained against replication of wt HIV-1, lead us to consider compound 10 as a lead compound for further investigation in this field. In particular, our efforts will be directed to modifications of 10 devoted to obtain new derivatives active against HIV-1 mutant strains. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antimicrobial Evaluation of Calycanthaceous Alkaloid Derivatives was written by Yang, Cheng;Zheng, Shaojun;Tan, Yi;Chen, Xiaoyun;Bai, Hongjin;Zhu, Rui;Gao, Yuhua. And the article was included in Chemistry of Natural Compounds in 2021.Safety of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

To find pesticidal lead compounds with high activity, a series of new chimonanthine derivatives was synthesized via the introduction of the functional group at the N-position to compound I. A preliminary bioassay showed that most of them displayed potent bioactivities. In particular, compound II displayed significant activity and might be a potential novel lead compound for further development of antifungal agent. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Safety of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Antihyperglycemic and Antihyperlipidemic Effects of Newly Synthesized Glibenclamide Analogues on Streptozotocin-diabetic Rats was written by Ahmadi, A.;Khalili, M.;Farsadrooh, M.;Ghiasi, M.;Nahri-Niknafs, B.. And the article was included in Drug Research (Stuttgart, Germany) in 2013.Formula: C8H7ClO3 This article mentions the following:

In this study, new glibenclamide analogs (5a-d) with substituted pharmacol. triethoxysilyl propan, allyl and ethoxyphenyl groups for cyclohexyl moiety have been synthesized by condensing sulfonamide (4) with related isocyanate or isothiocyanate’s compounds The newly synthesized drugs were evaluated for their antihyperglycemic and antihyperlipidemic activities with streptozotocin (STZ)-induced diabetic rats. All showed hypoglycemic and hypolipidemic activities compared to the control animals but 5c and 5d exhibited more and significant lowering blood activities similar to glibenclamide. This was concerned with identical affinities to bind with SUR1 receptor. Moreover, the new drugs displayed high efficiency for reducing serum LDL level which resulted in a high HDL/LDL ratio as a good lipid profile compared to other groups. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Formula: C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly enantioselective synthesis of α-hydroxy phosphonic acid derivatives by Rh-catalyzed asymmetric hydrogenation with phosphine-phosphoramidite ligands was written by Wang, Dao-Yong;Hu, Xiang-Ping;Huang, Jia-Di;Deng, Jun;Yu, Sai-bo;Duan, Zheng-Chao;Xu, Xue-Feng;Zheng, Zhuo. And the article was included in Angewandte Chemie, International Edition in 2007.Name: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Unsym. hybrid phosphine-phosphoramidite ligands, e.g. PhCH₂CH(OBz)P(O)(OMe)₂, with central and axial chirality are applied to the highly enantioselective hydrogenation of various enol ester phosphonates, e.g. PhCH:C(OBz)P(O)(OMe)₂. Enantioselectivities up to 99.9% ee are obtained for all classes of β-aryl, β-alkoxy, and β-alkyl substrates. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Name: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Haloaziridines. 3. Methanolysis of some gem-dichloroaziridines was written by Meilahn, Marcus K.;Pottorf, Richard S.. And the article was included in Journal of Organic Chemistry in 1980.Reference of 7476-66-6 This article mentions the following:

The reaction of gem-dichloroaziridines with methanol in the presence of methoxide gave imino esters, while in the absence of methoxide, esters and amides were the major products. An ortho ester intermediate was proposed to account for the formation of the esters and amides. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Reference of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of BAZ2A bromodomain ligands was written by Spiliotopoulos, Dimitrios;Wamhoff, Eike-Christian;Lolli, Graziano;Rademacher, Christoph;Caflisch, Amedeo. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 39489-79-7 This article mentions the following:

The bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) is implicated in aggressive prostate cancer. The BAZ2A bromodomain is a challenging target because of the shallow pocket of its natural ligand, the acetylated side chain of lysine. Here, we report the successful screening of a library of nearly 1500 small mols. by high-throughput docking and force field-based binding-energy evaluation. For seven of the 20 mols. selected in silico, evidence of binding to the BAZ2A bromodomain is provided by ligand-observed NMR spectroscopy. Two of these compounds show a favorable ligand efficiency of 0.42 kcal/mol per non-hydrogen atom in a competition-binding assay. The crystal structures of the BAZ2A bromodomain in complex with four fragment hits validate the predicted binding modes. The binding modes of compounds 1 and 3 are compatible with ligand growing for optimization of affinity for BAZ2A and selectivity against the close homolog BAZ2B. In the experiment, the researchers used many compounds, for example, 5-Amino-2,4-dichlorophenol (cas: 39489-79-7Related Products of 39489-79-7).

5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 39489-79-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics