Tag: 100-200

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile was written by Stefanowicz, Jacek;Slowinski, Tomasz;Wrobel, Martyna Z.;Slifirski, Grzegorz;Dawidowski, Maciej;Stefanowicz, Zdzislawa;Jastrzebska-Wiesek, Magdalena;Partyka, Anna;Wesolowska, Anna;Turlo, Jadwiga. And the article was included in Medicinal Chemistry Research in 2018.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

This work is a continuation of our previous research, concentrating this time on lead structure modification to increase the 5-HT_1A receptor affinity and water solubility of designed compounds Therefore, the compounds synthesized within the present project included structural analogs of 3β-acylamine derivatives of tropane with the introduction of a Me substituent in the benzyl ring and a 2-quinoline, 3-quinoline, or 6-quinoline moiety. A series of novel 3β-aminotropane derivatives was evaluated for their affinity for 5-HT_1A, 5-HT_2A, and D₂ receptors, which allowed for the identification of compounds I, II, and III as ligands with highest affinity for the tested receptors; they were then subjected to further evaluation in preliminary in vivo studies. Selected compounds II and III displayed antipsychotic properties in the d-amphetamine-induced and MK-801-induced hyperlocomotor activity test in mice. Moreover, compound III showed significant antidepressant-like activity in the forced swim test in mice. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxidation of unsaturated compounds. III. Oxidation of 3-chlorocrotonic acid. Synthesis of dl-threonic acid. Proof of configuration of the dl-1,2-dihydroxybutyric acids was written by Braun, Geza. And the article was included in Journal of the American Chemical Society in 1930.Recommanded Product: 26340-58-9 This article mentions the following:

Oxidation of 3-chlorocrotonic acid, m. 83°, with Ba(ClO₃)₂ in H₂O containing a little osmic acid, gives 78% of dl-threo-1,2-dihydroxy-3-chlorobutyric acid (I), m. 100°; further oxidation, after removing the Cl with AcOAg, with dilute HNO₃, gives dl-(HC(OH)CO₃H)₃ and a small amount of (CO₃H)₃. I, neutralized with BaCO₃, and treated with Ag₂O, gives 46% of dl-threonic acid, m. 98°; with HNO₃ no trace of mesotartaric acid is found, proving that the treatment with HNO₃ causes no inversion. This acid does not form a lactone under the conditions in which the dl-erythronic acid can be isolated only as a lactone. The proof of the configuration of the dl-1,2-dihydroxybutyric acids (II) is based on the fact that the I may be converted into racemic acid and on the other hand it may be catalytically reduced to the II, m. 74-5°, in 70% yield. This shows clearly that the II, m. 74°, has the same configuration as racemic acid and the other possible II, m. 81.5°, has a configuration corresponding to mesotartaric acid. The assignment of the prefixes “threo” and “erythro” for the acids m. 74.5° and 81.5°, resp., is therefore justified. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Recommanded Product: 26340-58-9).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 26340-58-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereoselective α-Tertiary Alkylation of N-(Arylacetyl)oxazolidinones was written by Shim, Eunjae;Zakarian, Armen. And the article was included in Synlett in 2020.Recommanded Product: 6834-42-0 This article mentions the following:

A method was developed for the α-tertiary alkylation of zirconium enolates of N-(arylacetyl)oxazolidinones. This reaction installed directly an all-carbon quaternary center vicinal to a benzylic tertiary carbon in a highly diastereoselective manner. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Easy one-pot synthesis of 1-monosubstituted aliphatic 1,2,3-triazoles from aliphatic halides, sodium azide and propiolic acid by a click cycloaddition/decarboxylation Process was written by Zhang, Zhongkui;Kuang, Chunxiang. And the article was included in Chinese Journal of Chemistry in 2013.Electric Literature of C7H5ClF2 This article mentions the following:

1-Monosubstituted aliphatic 1,2,3-triazoles were synthesized by a one-pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs₂CO₃ at 100° by copper-catalyzed click cycloaddition/decarboxylation. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Electric Literature of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved method of amide synthesis using acyl chlorides was written by Zhang, Li;Wang, Xiao-Jun;Wang, Jing;Grinberg, Nelu;Krishnamurthy, Dhileep Kumar;Senanayake, Chris H.. And the article was included in Tetrahedron Letters in 2009.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A simple, mild and highly efficient condition for amide synthesis from acyl chlorides has been developed to minimize hydrolysis, racemization and other side reactions. This method should expand capabilities in the peptide coupling area. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives was written by Wu, Bowen;Cui, Xinxin;Zhu, Ting;Wang, Shenghui;Lu, Chaofan;Wang, Jinjie;Dang, Hexiang;Zhang, Saiyang;Ding, Li-na;Jin, Chengyun. And the article was included in Youji Huaxue in 2020.Recommanded Product: 620-19-9 This article mentions the following:

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC₆H₄, 4-FC₆H₄, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH₂C₆H₄] showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH₂C₆H₄] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH₂C₆H₄] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of quinoxaline derivatives from benzofuroxan (Part II) was written by Kim, Ho Sik;Hur, Jae Hyuck. And the article was included in Journal of the Korean Chemical Society in 2005.HPLC of Formula: 6834-42-0 This article mentions the following:

Synthesis of 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (I) from benzofuroxan and Et acetoacetate was accomplished. The reaction of compound I with hydrazine hydrate gave 2-hydrazinocarbonyl-3-methylquinoxaline 1,4-dioxide (II). The reactions of compound II with substituted phenylacetyl chlorides, benzyl chloroformate, heteroaryl aldehydes and acid anhydrides afforded 3-methyl-2-(substituted hydrazinocarbonyl)quinoxaline 4-oxides III [R = H, OMe], IV, V [X = O, S] and VI [R = Me, ethyl], resp. The reaction of compound II with isothiocyanates afforded 3-methyl-2-[(N-substituted thiocarbamoyl)hydrazinocarbonyl]quinoxaline 4-oxides VII [e.g., R = methyl], and followed reflux in 2N NaOH resulted in the intramol. cyclization to give 3-methyl-2-(4-substituted-3-thioxo-1,2,4-triazol-5-yl)quinoxaline 4-oxides VIII [e.g., R = methyl]. The herbicidal and fungicidal activities of the synthesized compounds were investigated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0HPLC of Formula: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High-Throughput Catch-and-Release Synthesis of Oxazoline Hydroxamates. Structure-Activity Relationships in Novel Inhibitors of Escherichia coli LpxC: In Vitro Enzyme Inhibition and Antibacterial Properties was written by Pirrung, Michael C.;Tumey, L. Nathan;McClerren, Amanda L.;Raetz, Christian R. H.. And the article was included in Journal of the American Chemical Society in 2003.COA of Formula: C9H9ClO2 This article mentions the following:

LpxC is a zinc amidase that catalyzes the second step of lipid A biosynthesis in Gram-neg. bacteria. Oxazolines incorporating a hydroxamic acid, which is believed to coordinate to the single essential zinc ion, at the 4-position are known inhibitors of this enzyme. Some of these enzyme inhibitors exhibit antibacterial activity through their inhibition of LpxC. A method has been developed for the synthesis of oxazolines using resin capture and ring-forming release that eliminates traditional purification steps and can be used in high-throughput synthesis. Using this method, oxazoline hydroxamates with diverse 2-substituents were prepared in library form as candidate inhibitors for LpxC. Two conventional methods for oxazoline synthesis were also applied to generate more than 70 compounds The groups at the 2-position included a wide variety of substituted aromatic rings and a limited selection of alkyl groups. These compounds were screened against wild-type and LpxC inhibitor-sensitive strains of Escherichia coli, as well as wild-type Pseudomonas aeruginosa. Inhibition of the E. coli LpxC enzyme was also investigated. A broad correlation between enzyme inhibitory and antibacterial activity was observed, and novel compounds were discovered that exhibit antibacterial activity but fall outside earlier-known structural classes. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The synthesis of chiral 3-oxo-6-[(phenylmethoxy)carbonyl]-2-piperazineacetic acid esters designed for the presentation of an aspartic acid side chain. A subsequent novel Friedel Crafts reaction was written by Kogan, Timothy P.;Rawson, Thomas E.. And the article was included in Tetrahedron Letters in 1992.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The synthesis of the title esters (2S,6R)-I and (2S,6S)-I from L– or D-serine and dimethyl D-malate are described. Acylation of (2S,6S)-I with 3-methoxyphenylacetyl chloride, hydrogenolysis of the benzyl ester, followed by treatment with (COCl)₂ then AlCl₃ led to unexpected tricyclic product II into which a C₂O₂ unit had been incorporated. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Construction of axial chirality via asymmetric radical trapping by cobalt under visible light was written by Jiang, Xuan;Xiong, Wei;Deng, Shuang;Lu, Fu-Dong;Jia, Yue;Yang, Qian;Xue, Li-Yuan;Qi, Xiaotian;Tunge, Jon A.;Lu, Liang-Qiu;Xiao, Wen-Jing. And the article was included in Nature Catalysis in 2022.Related Products of 620-19-9 This article mentions the following:

The 3d metals have been identified as economic and sustainable alternatives to palladium, the frequently used metal in transition-metal-catalyzed cross-couplings. However, cobalt has long stood behind its neighboring elements, nickel and copper,in asym. radical couplings owing to its high catalytic activity in the absence of ligands resulting in unfavorable un-asym. background reactions. Here, the authors disclose an asym. metallaphotoredox catalysis (AMPC) strategy for the dynamic kinetic asym. transformation of racemic heterobiaryls, which represents a visible-light-induced, asym. radical coupling for the construction of axial chirality. This success can also extended to the reductive cross-coupling variant featuring the use of more easily available organic halide feedstocks. The keys to these achievements are the rational design of a sustainable AMPC system that merges asym. cobalt catalysis with organic photoredox catalysis in combination with the identification of an efficient chiral polydentate ligand. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics