Tag: 100-200

Ortho effect. IV. Kinetics of the formation of ortho substituted phenyltrimethylammonium iodides in methyl alcoholic solution was written by Evans, David P.;Watson, H. B.;Williams, Reginald. And the article was included in Journal of the Chemical Society in 1939.Product Details of 698-01-1 This article mentions the following:

The velocities of reaction of MeI with o-F, o-PhO, o-MeO, o-NO₂, o-Cl, o-Me and o-Ph derivatives of Me₂NPh have been measured and the results analyzed on the basis of the equation k = PZe^-E/RT. Six of the 7 groups studied caused an increase in both E and PZ, but an o-F leads to no change in PZ. The largest effects are observed with o-Me and o-Ph and it is suggested that, in the transition complex, the group becomes “linked” to the N of NMe₂ by a H bond. Effects of smaller magnitudes are found in the o-PhO, o-MeO, o-NO₂ and o-Cl derivatives and these are regarded as due to an interaction between the unshared electrons of the N and the group in the ortho position whereby, without the formation of an actual “linkage,” the former are subjected to a constraint. The interactions here postulated would raise E by decreasing the electron-reactive portion of the complex. The interaction is not possible in o-FC₆H₄NMe₂, since F cannot expand its valence groups; the lack of any ortho effect in the o-F compounds is, in fact, the key to the interpretation of the observations, as it was in previous work on the hydrolysis of benzoic esters (C. A. 31, 7862.1). In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Product Details of 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light photoredox-catalyzed carboxylation of benzyl halides with CO₂: Mild and transition-metal-free was written by Jing, Ke;Wei, Ming-Kai;Yan, Si-Shun;Liao, Li-Li;Niu, Ya-Nan;Luo, Shu-Ping;Yu, Bo;Yu, Da-Gang. And the article was included in Chinese Journal of Catalysis in 2022.Related Products of 620-19-9 This article mentions the following:

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO₂ has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO₂ and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated Decarboxylative [3+2] Annulation of Ethynyl Benzoxazinanones and Benzimidamides: Synthesis of Imidazole Derivatives was written by Wang, Lan;Jiang, Feng;Gao, Xing;Wang, Wei;Wu, Yongjun;Guo, Hongchao;Zheng, Bing. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18637-02-0 This article mentions the following:

A base-mediated decarboxylative [3+2] annulation of trimethylsilylethynyl benzoxazinanones I (R = H, 6-Me, 5-Cl, 8 -F, etc.; R¹ = H, trimethylsilyl) and benzimidamides hydrochloride R³C(=NH)NH₂•HCl (R³ = H, 2-methylphenyl, 3-chlorophenyl, 6-chloropyridin-3-yl, etc.) was achieved under mild reaction conditions to give various imidazole derivatives II (R⁴ = H, 4-Me, 3-Cl, 2-F, etc.) in high yields. Notably, it demonstrated a new reaction mode of alkynyl benzoxazinanones. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Application of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of acyloxymethyl halides from acylals was written by Grynkiewicz, Grzegorz;Tsien, Roger Y.. And the article was included in Polish Journal of Chemistry in 1987.Recommanded Product: 5335-05-7 This article mentions the following:

Reaction of CH₂(OAc)₂ with Me₃SiBr in the presence of ZnCl₂ gave 81% AcOCH₂Br. Similarly, CH₂(OBz)₂ was treated with Me₃SiR (R = Br, Cl) and ZnCl₂ or AlCl₃ to give 50 and 21%, resp., of BzOCH₂R. In contrast, cleavage of MeOCH₂OAc with Me₃SiBr gave MeOCH₂Br and AcOIMe₃. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses of halogenated methoxybenzophenone derivatives and their cytoprotective activities against H₂O₂-induced injury in HUVECs was written by Zhang, Yuanlin;Feng, Xiue;Gao, Jie;Li, Qingshan. And the article was included in Huaxue Tongbao in 2014.Related Products of 3438-16-2 This article mentions the following:

Twelve kinds of halogenated methoxybenzophenone derivatives were designed and synthesized using methoxy and halogen substituted benzoic acids as starting materials through acylation of carboxylic acid, Friedel-Crafts acylation and halogenation reaction in turn, and their structures were confirmed by ESI-MS, ¹H NMR and ¹³C NMR. Their protective activities against H₂O₂-induced injury in human umbilical vein endothelial cell (HUVECs) were investigated to explore the structure-activity relationships. The results showed that the compounds I and II exhibited high cytoprotective activities at 12.5 μmol/L, the protective rates were over 50%. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Related Products of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic “A-region” was written by Walpole, Christopher S. J.;Wrigglesworth, Roger;Bevan, Stuart;Campbell, Elizabeth A.;Dray, Andy;James, Iain F.;Perkins, Martin N.;Reid, Derek J.;Winter, Janet. And the article was included in Journal of Medicinal Chemistry in 1993.Category: chlorides-buliding-blocks This article mentions the following:

A series of analogs of capsaicin, the pungent principle of chili peppers, was synthesized and tested in assays for capsaicin-like agonism in vitro. The results of these assays were compared with activities in an acute nociceptive model and a correlation was observed which established that the results of these in vitro assays were predictive of analgesia. Using a modular approach the structure-activity profile of specific regions of capsaicin congeners was established using an in vitro assay measuring ⁴⁵Ca²⁺ uptake into neonatal rat dorsal root ganglia neurons. RCH₂NHCO(CH₂)₇Me (I) and RCH₂CONH(CH₂)₇Me (II) (R = substituted Ph) were prepared to test the requirements for activity in the aromatic A-region of the mol. Compounds with the natural substitution pattern, i.e., I and II [R = 3,4-MeO(HO)C₆H₃] and the corresponding catechols I and II [R = 3,4 (HO)₂C₆H₃] were the most potent, although the catechols were less potent in vivo. Other substitution patterns have reduced activity. These results have established stringent structural requirements for capsaicin-like activity in this part of the mol. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Category: chlorides-buliding-blocks).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Anti-HIV-1 Evaluation of New Sonogashira-Modified Emivirine (MKC-442) Analogues was written by Danel, Krzysztof;Joergensen, Per T.;Pedersen, Erik B.;La Colla, Paolo;Collu, Gabriella;Loddo, Roberta. And the article was included in Helvetica Chimica Acta in 2009.Name: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

The MKC-442 analog 6-(3,5-dimethylbenzyl)-5-ethyluracil substituted with a (propargyloxy)methyl group at N(1) has previously been found highly active against HIV-1. The CC bond in the substituent at N(1) is here utilized in a series of chem. reactions in order to develop new agents with higher activity against HIV-1-resistant mutants. The syntheses involved Pd-catalyzed C,C-coupling reactions, addition of disulfides, and click chem. on the terminal CC bond as well as addition of bromine to the so formed internal CC bonds. Sonogashira couplings were performed with silyl-derivatized iodobenzyl alcs. which, after deprotection, were oxidized to aldehydes by means of IBX. The isomeric alc. I was obtained in the Sonogashira reaction of propargyl alc. with the N(1)-substituted (4-iodobenzyloxy)methyl derivative of the above mentioned uracil. Compound I turned out to be the most effective compound against problematic HIV-1 mutants. The general observation in the present work is that a combination of alkyne and aryl in the substituent at N(1) leads to highly active compounds against HIV-1. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Name: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex was written by Liu, Yahuan;Wang, Zheng;Zhao, Ziwei;Gao, Pengxiang;Ma, Ning;Liu, Qingbin. And the article was included in Molecular Catalysis in 2021.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formylation of some sulfides of the furan series was written by Gol’dfarb, Ya. L.;Yakubov, A. P.;Belen’kii, L. I.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1965.Product Details of 3438-16-2 This article mentions the following:

Furfuryl chloride added at 5-10° to Me₃CSH in aqueous alc. KOH and kept 18 hrs. gave 87% α-furfuryl tert-Bu sulfide, b₈ 76-7°, n²⁰_D 1.5012, d₂₀ 0.9944; similarly prepared was 93% α-furfuryl phenyl sulfide, b_0.06 75-6°, 1.5960, 1.1414. Furfuryl mercaptan and PhCH₂Cl gave 89% benzyl α-furfuryl sulfide, b_0.9 111-12° n²⁰_D 1.5825, d₂₀ 1.1402. The products were treated in Me₂NCHO with POCl₃ at 0-20° 2.75 hrs. and after quenching in ice gave the following 5-alkyl(aryl)thiomethyl-2-furancarboxaldehydes (the R of the RS group in the compounds, b.p., n²⁰_D, and d₂₀ shown): Et, b_0.2 90-1°, 1.0575 (sic), 1.1538; iso-Pr, b_1.2 104-6°, 1.6558, 1.1119; Bu, b₂ 130-1°, 1.0550 (sic), 1.0937; Me₃C, b₂ 117° (m. 26-7.5°), -, -; Ph, b_0.1 132-40° (m. 24.5-5°), -, -; PhCH₂, b_0.1 145-6° (m. 35-6° ), -, -. The latter oxidized with Ag₂O to the corresponding carboxylic acid, m. 122-3°. The iso-Pr analog also gave the acid, m 95°. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Product Details of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-catalyzed salt-free double decarboxylative aryl allylation was written by Daley, Ryan A.;Topczewski, Joseph J.. And the article was included in Organic & Biomolecular Chemistry in 2019.SDS of cas: 225104-76-7 This article mentions the following:

This report describes a palladium-catalyzed decarboxylative aryl allylation between unactivated benzoic acids and allylic carbonates. This transformation successfully couples a variety of carbonates and benzoic acids in good yield (up to 94%) using 1 mol% palladium. This salt free allyl-arylation proceeds without added base, copper, or silver. The only stoichiometric byproducts are carbon dioxide and tert-butanol. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7SDS of cas: 225104-76-7).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 225104-76-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics