Tag: 100-200

Benzosuberane-5,8-diones was written by McKay, Roslyn;Proctor, George R.. And the article was included in Journal of Chemical Research, Synopses in 1996.Related Products of 6834-42-0 This article mentions the following:

Oxazolone intermediates were prepared from valine derivatives and converted into 3-methoxy-γ-methyl-γ-oxobenzenepentanoic acid and 3-methoxy-γ-oxobenzenepentanoic acid, resp. The cyclocondensation of these compounds gave the desired benzosuberones i.e., 3-methoxy-5-methyl-5H-benzocyclohepten-6,9-dione 3-methoxy-5H-benzocyclohepten-6,9-dione. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Related Products of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper catalysed alkynylation of tertiary amines with CaC₂ via sp³ C-H activation was written by Teong, Siew Ping;Yu, Dingyi;Sum, Yin Ngai;Zhang, Yugen. And the article was included in Green Chemistry in 2016.HPLC of Formula: 698-01-1 This article mentions the following:

A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide was developed. The reaction proceeds via sp³ C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1HPLC of Formula: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I) was written by Liu, Yan;Haste, Nina M.;Thienphrapa, Wdee;Nizet, Victor;Hensler, Mary;Li, Rongshi. And the article was included in Marine Drugs in 2012.Application of 3438-16-2 This article mentions the following:

Infections caused by drug-resistant pathogens are on the rise. The ongoing spread of methicillin-resistant Staphylococcus aureus (MRSA) strains exemplifies the urgent need for new antibiotics. The marine natural product, marinopyrrole A, was previously shown to have potent antibiotic activity against Gram-pos. pathogens, including MRSA. However, its min. inhibitory concentration (MIC) against MRSA was increased by >500 fold in the presence of 20% human serum, thus greatly limiting therapeutic potential. Here we report our discovery of a novel derivative of marinopyrrole A, designated 1a, featuring a 2-4 fold improved MIC against MRSA and significantly less susceptibility to serum inhibition. Importantly, compound 1a displayed rapid and concentration-dependent killing of MRSA. Compared to the natural product counterpart, compound 1a provides an important natural product based scaffold for further Structure Activity Relationship (SAR) and optimization. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1H-pyrrolo[2,3-b]pyridine: A new scaffold for human neutrophil elastase (HNE) inhibitors was written by Crocetti, Letizia;Giovannoni, Maria Paola;Schepetkin, Igor A.;Quinn, Mark T.;Khlebnikov, Andrei I.;Cantini, Niccolo;Guerrini, Gabriella;Iacovone, Antonella;Teodori, Elisabetta;Vergelli, Claudia. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Application of 1711-11-1 This article mentions the following:

Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family. It is an important target for the development of novel and selective inhibitors for the treatment of inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis and biol. evaluation of a new series of HNE inhibitors with a pyrrolo[2,3-b]pyridine scaffold, which is an isomer of our previously reported indazoles, in order to assess how a shift of the nitrogen from position 2 to position 7 influences activity. The majority of new compounds were effective HNE inhibitors and had IC₅₀ values in the micromolar/submicromolar range, with some compounds active in low nanomolar levels. For example, 2a and 2b inhibited HNE with IC₅₀ values of 15 and 14 nM, resp. Mol. modeling of compounds differing in the position of heteroatom(s) in the bicyclic moiety and in the oxadiazole ring demonstrated that the calculated geometries of enzyme-inhibitor complexes were in agreement with the observed biol. activities. Docking experiments showed that orientation of the active pyrrolo[2,3-b]pyridines in the HNE catalytic triad Ser195-His57-Asp102 correlated with effectiveness of the inhibitor interaction with the enzyme. Thus, the pyrrolo[2,3-b]pyridine scaffold represents a novel scaffold for the development of potent HNE inhibitors. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic contaminants in human breast milk identified by non-targeted analysis was written by Tran, Cuong D.;Dodder, Nathan G.;Quintana, Penelope J. E.;Watanabe, Kayo;Kim, Jae H.;Hovell, Melbourne F.;Chambers, Christina D.;Hoh, Eunha. And the article was included in Chemosphere in 2020.Computed Properties of C8H10ClN This article mentions the following:

Understanding the health implications of human exposure to mixtures of chem. contaminants is aided by anal. methods that can screen for a broad range of both expected and unexpected compounds We performed a proof-of-concept anal. combining human breast milk, a biomonitoring matrix for determining contaminant exposure to mothers and infants, with a non-targeted method based on comprehensive two-dimensional gas chromatog. coupled to time-of-flight mass spectrometry (GCxGC/TOF-MS). A total of 172 presumably anthropogenic halogenated compounds and non-halogenated cyclic and aromatic compounds were tentatively identified in breast milk from San Diego, California through mass spectral database searches. Forty of the compounds were prioritized for confirmation based on halogenation or 100% frequency of detection, and the identities of 30 were verified using authentic standards Thirty-four (85%) of the prioritized contaminants are not typically monitored in breast milk surveys, and 31 (77%) are regulated in at least one market worldwide, indicating breast milk may be a useful biomonitoring matrix for non-targeted anal. and the assessment of human exposure to future emerging or undiscovered contaminants. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Computed Properties of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488 was written by Smith, Victoria C.;Cleghorn, Laura A. T.;Woodland, Andrew;Spinks, Daniel;Hallyburton, Irene;Collie, Iain T.;Mok, N. Yi;Norval, Suzanne;Brenk, Ruth;Fairlamb, Alan H.;Frearson, Julie A.;Read, Kevin D.;Gilbert, Ian H.;Wyatt, Paul G.. And the article was included in ChemMedChem in 2011.Formula: C9H9ClO2 This article mentions the following:

Screening of the Sigma-Aldrich Library of Pharmacol. Active Compounds (LOPAC) against cultured Trypanosoma brucei, the causative agent of African sleeping sickness, resulted in the identification of a number of compounds with selective antiproliferative activity over mammalian cells. These included (+)-(1R,2R)-U50488 (I), a weak opioid agonist with an EC₅₀ value of 59 nM as determined in a T. brucei in vitro assay reported previously. This paper describes the modification of key structural elements of U50488 to investigate structure-activity relationships (SAR) and to optimize the antiproliferative activity and pharmacokinetic properties of this compound In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct arylation (hetero-coupling) of heteroarenes via unsymmetrical palladium-PEPPSI-NHC type complexes was written by Nawaz, Zahid;Gurbuz, Nevin;Naveed Zafar, Muhammad;Nawaz Tahir, Muhammad;Ashfaq, Muhammad;Karci, Huseyin;Ozdemir, Ismail. And the article was included in Polyhedron in 2021.Category: chlorides-buliding-blocks This article mentions the following:

The growing interest of industry in the field of bi(hetero)arenes compounds, motivated to synthesize these compounds via homogeneous catalytic route by using Pd PEPPSI-type complexes through direct arylation. In this work, the five new Pd PEPPSI-type complexes bearing NHC spectator ligands were synthesized and characterized by a bunch of spectroscopic techniques. Further confirmations of structural details were provided by a single-crystal X-ray diffraction study of one pro-ligand and one complex. All these newly synthesized Pd-carbene complexes were found significantly active as catalysts toward direct arylation of five members heterocyclic compounds such as n-propylthaizole, 2-acetylfurane and 2-acetylthiophene with aryl bromides derivatives These catalysts give significantly good results within two hours with just 1 mol % catalyst loading. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Category: chlorides-buliding-blocks).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of hydrolysis of benzoates. II. Alkaline hydrolysis of alkyl benzoates in water was written by Pussa, T.;Nummert, V.;Palm, V.. And the article was included in Reaktsionnaya Sposobnost Organicheskikh Soedinenii in 1972.Quality Control of Chloromethyl benzoate This article mentions the following:

The kinetics of hydrolysis of benzoates was measured spectrophotometrically. The following compounds having the general formula PhCO2X were studied: uncharged benzoates where X is Me, Et, CH2Cl, CH3CH2Cl, CH2Ph, and CH2CH2OMe, and charged benzoate where X is CH2N+Me3, and CH2CH2N+Me3. The BAC2 mechanism was assumed. The kinetics of the alk. hydrolysis of the positively charged choline esters decreased with increasing ionic strength of the solution In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Quality Control of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyloxymethyl as a drug protecting group. Kinetics and mechanism of the hydrolysis of N-acyloxymethylbenzamides was written by Iley, Jim;Moreira, Rui;Rosa, Eduarda. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1991.Safety of Chloromethyl benzoate This article mentions the following:

Acyloxymethyl derivatives of secondary and tertiary amides R¹CONRCH₂O₂CR¹ [R = H, Me; R¹,R² = (un)substituted phenyl] undergo hydrolysis via acid-catalyzed, base-catalyzed and pH-independent processes. The pH-independent pathway involves rate-limiting iminium ion formation and is characterized by the following: a Hammett ρ value for the substituent in the benzamide moiety of ca. -1.2 for both types of substrate; the absence of general-base or nucleophilic catalysis; a common benzoate ion effect; a solvent deuterium isotope effect of ca. 1.6; ΔS^{â€?/sup> values of -4 and -12 J K-1 mol-1 for secondary and tertiary substrates resp.; and higher reactivity of the tertiary amides over their secondary counterparts. The acid-catalyzed process involves protonation of a substrate followed by iminium ion formation, and is characterized by the following: a Hammett ρ value of ca. -1.5 for the substituent effect of the benzamide moiety; a solvent deuterium isotope effect of ca. 0.4; a monotonic rise in the pseudo-first-order rate constant with increasing [H₂SO₄]; ΔSâ€?/sup> values >0 J K-1 mol-1; higher reactivity of the tertiary substrates over their secondary counterparts; and a value of 0.85 for the Broensted coefficient, β_lg, for the carboxylate nucleofuge. The base-catalyzed hydrolysis of tertiary substrates involves normal ester hydrolysis via acyl-oxygen bond cleavage, and is characterized by a Hammett ρ value of +0.38, a solvent deuterium isotope effect of 0.85, and a ΔSâ€?/sup> value of -96 J K-1 mol-1. The corresponding base-catalyzed process for the secondary substrates involves imine formation via an E2 elimination reaction. The secondary acyloxymethylamides are some 7 × 104 times more reactive than their tertiary counterparts in the base-catalyzed region. Hammett ρ values of +1.1 and +0.6 are obtained for the substituents in the ester and amide moieties, resp. Buffer catalysis is observed, and the value of ca. 0.5 for the Broensted β coefficient identifies the amide proton as approx. 50% transferred to the buffer species in the transition state. Heats of formation, ΔH_f, calculated using the AM1 SCF MO package reveal that iminium ion formation is thermodynamically equi-energetic for cyclic and acyclic systems. Iminium ion formation from tertiary substrates is favored by ca. 25 kJ mol-1 over the corresponding secondary analogs. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Safety of Chloromethyl benzoate).}

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of a magnetic hierarchical porous organic polymer: A new platform in heterogeneous phase-transfer catalysis was written by Mouradzadegun, Arash;Ganjali, Mohammad Reza;Mostafavi, Mahsa Alsadat. And the article was included in Applied Organometallic Chemistry in 2018.Computed Properties of C8H9Cl This article mentions the following:

Recyclable phase transfer catalysts containing magnetic nanoparticles (MNPs) have been known as a major trend towards sustainable catalysts. In this study, a novel class of magnetic porous polymer on the basis of calix[4]resorcinarene was synthesized starting from silica-coated Fe₃O₄ core-shell nanoparticles. This compound was found as an efficient phase transfer catalyst for the conversion of benzyl halides into benzyl azides and cyanides in good yields. The catalyst could be used at least for five consecutive cycles without appreciable loss in the catalytic activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Computed Properties of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics