Tag: 100-200

Preparation of 2,4-dichloro-5-hydroxy-phenylhydrazine was written by Liu, Deqiang;Yang, Yanzhao;Lu, Wenjuan. And the article was included in Guangdong Huagong in 2009.Application of 39489-79-7 This article mentions the following:

In the paper, various synthetic routes to obtain 2,4-dichloro-5- hydroxyphenylhydrazine were briefly discussed. 2,4-Dichlorophenol was chosen as starting material, followed by esterification, nitration, hydrolyzation, reduction, diazotization and reduction, and the products were obtained. The products were characterized by m.p. measurement, fourier transform IR(FT-IR) and hydrogen NMR(H¹-NMR). The m.p. of the products was identical with the literature, and the structure was also confirmed by FT-IR and H-NMR. Through optimizing the exptl. parameters, the molar yields of the final products could reach as high as 46.6 %. In the experiment, the researchers used many compounds, for example, 5-Amino-2,4-dichlorophenol (cas: 39489-79-7Application of 39489-79-7).

5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 39489-79-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-Heterocyclic Carbene (NHC)-Stabilized Ru⁰ Nanoparticles: In Situ Generation of an Efficient Transfer Hydrogenation Catalyst was written by Kathuria, Lakshay;Din Reshi, Noor U.;Samuelson, Ashoka G.. And the article was included in Chemistry – A European Journal in 2020.Name: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Tethered and untethered ruthenium half-sandwich complexes I [R = 2,4,6-(CH₃)₃, 4-i-Pr, H, 3-Me, etc.; n = 1, 2] and II were synthesized and characterized spectroscopically. X-ray crystallog. anal. of three untethered I (n = 1, R = 3-OMe; n = 1, R = 4-i-Pr; n = 1, R = 4-NO₂) and two tethered Ru N-heterocyclic carbene (NHC) complexes II (R = 3-OMe, 2,4,6-(CH₃)₃) were also carried out. These RuNHC complexes catalyze transfer hydrogenation of aromatic ketones as acetophenone, 2,3-dihydro-1H-inden-1-one, 1-(furan-2-yl)ethan-1-one, etc. in 2-propanol under reflux, optimally in the presence of (25 mol%) KOH. Under these conditions, the formation of 2-3 nm-sized Ru0 nanoparticles was detected by TEM measurements. A solid-state NMR investigation of the nanoparticles suggested that the NHC ligands were bound to the surface of the Ru nanoparticles (NPs). This base-promoted route to NHC-stabilized ruthenium nanoparticles directly from arene-tethered ruthenium-NHC complexes and from untethered ruthenium-NHC complexes is more convenient than previously known routes to NHC-stabilized Ru nanocatalysts. Similar catalytically active RuNPs were also generated from the reaction of a mixture of [RuCl₂(p-cymene)]₂ and the NHC precursor with KOH in isopropanol under reflux. The transfer hydrogenation catalyzed by these NHC-stabilized RuNPs possess a high turnover number The catalytic efficiency was significantly reduced if nanoparticles were exposed to air or allowed to aggregate and precipitate by cooling the reaction mixtures during the reaction. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Name: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A formal method for the de-N,N-dialkylation of Sommelet-Hauser rearrangement products was written by Tayama, Eiji;Sato, Ryota;Takedachi, Keisuke;Iwamoto, Hajime;Hasegawa, Eietsu. And the article was included in Tetrahedron in 2012.Recommanded Product: Methyl 2-chloro-2-phenylacetate This article mentions the following:

Selective amine de-alkylation enables the conversion of Sommelet-Hauser rearrangement products into 2-aryl-2-bromoacetic acid derivatives These compounds are valuable synthetic intermediates in the synthesis of α-aryl-α-amino or α-aryl-β-amino acid derivatives The method presented herein is a formal de-N,N-dialkylation of Sommelet-Hauser rearrangement products. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro was written by Katane, Masumi;Osaka, Naoko;Matsuda, Satsuki;Maeda, Kazuhiro;Kawata, Tomonori;Saitoh, Yasuaki;Sekine, Masae;Furuchi, Takemitsu;Doi, Issei;Hirono, Shuichi;Homma, Hiroshi. And the article was included in Journal of Medicinal Chemistry in 2013.Synthetic Route of C5H2Cl2O2S This article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Synthetic Route of C5H2Cl2O2S).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C5H2Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Conversion of aromatic ketones into π-arylalkanoic acids. Oxidation by thallium(III) and by halogens was written by Higgins, Stanley D.;Thomas, C. Barry. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.COA of Formula: C9H9ClO2 This article mentions the following:

The mechanism by which Tl(NO₃)₃ oxidizes aromatic ketones to α-arylalkanoic acids was studied, using PhCOMe as substrate. An organothallium intermediate, probably PhCOCH₂-Tl(NO₃)₂, is a significant feature of this reaction and the key factor influencing the efficiency of this reaction is the readiness with which this species is converted into its acetal. Tl(III) is not a unique reagent for this oxidation; any reagent which can act initially as an electrophile and then as a leaving group is suitable, provided acetal formation is possible. The iodine-AgNO₃ system has several advantages over Tl(NO₃)₃ as it gives high specificity and toxicity problems are eliminated. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6COA of Formula: C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Methylation of aniline and its derivatives with dimethyl carbonate in the presence of binder-free micro-, meso-, and macroporous zeolites KNaX, NaY, and HY was written by Khusnutdinov, R. I.;Shchadneva, N. A.;Mayakova, Yu. Yu.;Ardieva, S. I.;Khazipova, A. N.;Kutepov, B. I.. And the article was included in Russian Journal of Organic Chemistry in 2016.Recommanded Product: 2-Chloro-N,N-dimethylaniline This article mentions the following:

Aniline and its derivatives RC₆H₄NH₂ (R = H, 3-CH₃, 4-Br, etc.) which undergo methylation when treated with di-Me carbonate in the presence of binder-free micro-, meso-, and macroporous zeolites KNaX, NaY, and HY and leads to the formation of N-methyl- and N,N-dimethylanilines RC₆H₄NHCH₃, RC₆H₄N(CH₃)₂ have been described. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ligand-Promoted Rh^III-Catalyzed Thiolation of Benzamides with a Broad Disulfide Scope was written by Kang, Yan-Shang;Zhang, Ping;Li, Min-Yan;Chen, You-Ke;Xu, Hua-Jin;Zhao, Jing;Sun, Wei-Yin;Yu, Jin-Quan;Lu, Yi. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 1711-11-1 This article mentions the following:

A ligand-promoted Rh^III-catalyzed C(sp²)-H activation/thiolation of benzamides has been developed. Using bidentate mono-N-protected amino acid ligands led to the first example of Rh^III-catalyzed aryl thiolation reactions directed by weakly coordinating directing amide groups. The reaction tolerates a broad range of amides and disulfide reagents. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of novel (E)-2-(4-(1H-1,2,4-triazol-1-yl)styryl)-4-(alkyl/arylmethyleneoxy)quinazoline derivatives as antimicrobial agents was written by Yang, Lan;Ge, Shijia;Huang, Jian;Bao, Xiaoping. And the article was included in Molecular Diversity in 2018.Safety of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A series of novel (E)-2-(4-(1H-1,2,4-triazol-1-yl)styryl)-4-(alkyl/arylmethyleneoxy)quinazoline derivatives I (R = H, Me, Et, etc.) were synthesized in good to excellent yields. The structure of compound I (R = Me) was further confirmed via single-crystal X-ray diffraction anal. The bioassay results indicated that compounds I (R = 4-t-Bu-C₆H₄, 2,6-(Cl)₂C₆H₃, 4-FC₆H₄) inhibit phytopathogenic bacterium Xanthomonas axonopodis pv. citri (Xac) more potently than com. bactericide bismerthiazol. However, not a single compound effectively inhibited the three pathogenic fungi tested at 50 μg/mL. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Safety of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arylacetonitriles: application in syntheses of 2,1-benzisoxazoles was written by Orlov, V. Y.;Kotov, A. D.;Ganzha, V. V.;Mironov, G. S.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2003.Synthetic Route of C8H5ClFN This article mentions the following:

A series of 2,1-benzisoxazoles, e.g. I (R = Ph, 3-ClC₆H₄, 2-MeC₆H₄, 4-MeOC₆H₄, etc.), was synthesized by cyclocondensation of the corresponding nitrobenzene derivative, e.g. 4-chloronitrobenzene, with arylacetonitriles RCH₂CN, and the substituent effect on the product yield was studied. It is shown that when the aromatic ring of the R fragment contains electron-donating or halogen substituents, the yield of the products depends on the position of these substituents in the aromatic ring. The introduction of electron-accepting substituents partially or completely inhibits the reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Synthetic Route of C8H5ClFN).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H5ClFN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo was written by Fu, Dong-Jun;Song, Jian;Zhu, Ting;Pang, Xiao-Jing;Wang, Sheng-Hui;Zhang, Yan-Bing;Wu, Bo-Wen;Wang, Jun-Wei;Zi, Xiaolin;Zhang, Sai-Yang;Liu, Hong-Min. And the article was included in European Journal of Medicinal Chemistry in 2020.Computed Properties of C9H9ClO2 This article mentions the following:

NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC₅₀ value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Computed Properties of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics