Tag: 100-200

Derisking the Cu-Mediated ¹⁸F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands was written by Taylor, Nicholas J.;Emer, Enrico;Preshlock, Sean;Schedler, Michael;Tredwell, Matthew;Verhoog, Stefan;Mercier, Joel;Genicot, Christophe;Gouverneur, Veronique. And the article was included in Journal of the American Chemical Society in 2017.Reference of 697-73-4 This article mentions the following:

The compatibility of various heterocycles, particularly nitrogen heterocycles, towards the copper-mediated ¹⁸F-fluorination of aryl pinacolboronates with ¹⁸F-fluoride was determined using fluorination reactions of a model substrate in the presence of exogenous heterocycles and the fluorination reactions of substrates possessing heterocycles with fluorination on an attached aromatic ring or directly attached to the heterocycle of interest. Using this information, syntheses of seven ¹⁸F-labeled structurally complex pharmaceutically relevant heterocycle-containing mols. were designed and executed. The method may be useful in designing syntheses of other radiolabeled compounds and delineating the scope of utility of other radiolabeling methods. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Reference of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nonpeptide Inhibitors of Measles Virus Entry was written by Sun, Aiming;Prussia, Andrew;Zhan, Weiqiang;Murray, Ernest E.;Doyle, Joshua;Cheng, Li-Ting;Yoon, Jeong-Joong;Radchenko, Eugene V.;Palyulin, Vladimir A.;Compans, Richard W.;Liotta, Dennis C.;Plemper, Richard K.;Snyder, James P.. And the article was included in Journal of Medicinal Chemistry in 2006.Reference of 6834-42-0 This article mentions the following:

Measles virus (MV) is one of the most infectious pathogens known. Despite the existence of a vaccine, over 500 000 deaths/yr result from MV or associated complications. Antimeasles compounds could conceivably reverse these statistics. Previously, the authors described a homol. model of the MV fusion protein trimer and a putative binding site near the head-neck region. The resulting model permitted the identification of two nonpeptidic entry inhibitors. Here, the authors present the design, synthesis, and bioevaluation of several series of fusion inhibitors and describe their structure-activity relationships (SAR). Five simply substituted anilides show low-μM blockade of the MV, one of which (I, AS-48) exhibits IC₅₀ = 0.6-3.0 μM across a panel of wild-type MV strains found in the field. Mol. field topol. anal. (MFTA), a 2D QSAR approach based on local mol. properties (at. charges, hydrogen-bonding capacity and local lipophilicity), applied to the anilide series suggests structural modifications to improve potency. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Linear relations between thermodynamic parameters. III. Application to solvolysis reactions was written by Lee, Ikchoon. And the article was included in Taehan Hwahakhoe Chi in 1963.Safety of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The general equation for the test of the substituent effect which was derived in the previous paper was extended to correlate thermodn. parameters of solvolysis reactions by modifying the potential energy term to represent the effect of change in solvent composition The linear fits of the new equation, ΔΔH.dbldag. = a’Y + bΔΔS⁼, were tested with 35 examples taken from the literature and an average correlation coefficient of 0.977 was obtained. The equation is generally applicable to solvolysis reactions and helps elucidate some of the difficulties experienced with the Grunwald-Winstein equation (CA 42, 8591a). The linear enthalpy-entropy effect exists only between the external enthalpy and entropy of activation. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Safety of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Expedited access to thieno[3,2-c]quinolin-4(5H)-ones and benzo[h]-1,6-naphthyridin-5(6H)-ones via a continuous flow photocyclization method was written by Fang, Y.;Tranmer, G. K.. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 36157-41-2 This article mentions the following:

Synthesis of thieno[3,2-c]quinolin-4(5H)-ones I [R¹ = H, Me, Cl, OMe; R² = H, Cl; R³ = H, Cl, CF₃, etc.] and benzo[h]-1,6-naphthyridin-5(6H)-ones II [R¹ = H, Cl] via continuous flow photocyclization of phenylthiophene-carboxamides and phenylnicotinamides resp. was described. Overall, the continuous flow method provided access to complex heterocycles in two steps from com. available starting materials in good yields and with greater atom efficiency than traditional batch reactions. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Product Details of 36157-41-2).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 36157-41-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 was written by Buchstaller, Hans-Peter;Eggenweiler, Hans-Michael;Sirrenberg, Christian;Graedler, Ulrich;Musil, Djordje;Hoppe, Edmund;Zimmermann, Astrid;Schwartz, Harry;Maerz, Joachim;Bomke, Joerg;Wegener, Ansgar;Wolf, Michael. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Application of 6834-42-0 This article mentions the following:

Inhibitors of the Hsp90 mol. chaperone are showing considerable promise as potential mol. therapeutic agents for the treatment of cancer. Here we describe the identification of novel small mol. weight inhibitors of Hsp90 using a fragment based approach. Fragments were selected by docking, tested in a biochem. assay and the confirmed hits were crystallized Information gained from X-ray structures of these fragments and other chemotypes was used to drive the fragment evolution process. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity and anti-proliferative effects in different human cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides was written by Liu, Yongzhu;Bao, Zhi-Peng;Qi, Xinxin;Wu, Xiao-Feng. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors was written by Yu, Zhiliang;Zhuang, Chunlin;Wu, Yuelin;Guo, Zizhao;Li, Jin;Dong, Guoqiang;Yao, Jianzhong;Sheng, Chunquan;Miao, Zhenyuan;Zhang, Wannian. And the article was included in International Journal of Molecular Sciences in 2014.COA of Formula: C7H5ClF2 This article mentions the following:

A series of sulfamide I (R₁ = HCCCH₂, 3-FC₆H₄CH₂, NCCH₂, 2,6-F₂C₆H₃CH₂, C₆H₅CH₂; R₂ = HCCCH₂, H₂C:C:CH, H) and triazole benzodiazepines, e.g. II, were obtained with the principle of bioisosterism. The p53-murine double minute 2 (MDM2) inhibitory activity and in vitro antitumor activity were evaluated. Most of the benzodiazepines exhibited moderate protein binding inhibitory activity. The triazole benzodiazepines showed good inhibitory activity and antitumor potency. The compound 8-chloro-4-(4-chloro-phenyl)-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene had promising antitumor activity against the U-2 OS human osteosarcoma cell line with an IC₅₀ value of 4.17 μM, which was much better than that of nutlin-3. The mol. docking model also successfully predicted that this class of compounds mimicked the three critical residues of p53 binding to MDM2. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Additive-Controlled Divergent Synthesis of Indole and 4H-Benzo[d][1,3]oxazine Derivatives: Palladium-Catalyzed Carbonylative Cyclization of 2-Alkynylanilines and Benzyl Chlorides was written by Wang, Qi;Yao, Lingyun;Wang, Jian-Shu;Ying, Jun;Wu, Xiao-Feng. And the article was included in Journal of Organic Chemistry.Formula: C8H9Cl This article mentions the following:

A palladium-catalyzed divergent carbonylative synthesis of indoles and 4H-benzo[d][1,3]oxazines from 2-alkynylanilines and benzyl chlorides with benzene-1,3,5-triyl triformate (TFBen) as the CO source was developed. The reaction using AlCl₃ as the additive produced various indoles in high yields, while a series of 4H-benzo[d][1,3]oxazines were achieved in moderate yields with AcOH as the additive. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Formula: C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rearrangement in the Synthesis of Annulated Lactams Starting from Benzothiazines was written by Stalling, Timo;Saak, Wolfgang;Martens, Juergen. And the article was included in European Journal of Organic Chemistry in 2013.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The conversion of methoxyamides I [R¹ = R² = Me, R¹R² = (CH₂)₅ R³ = H, Me, none, R⁴ = H, 3-Me, 3-MeO, 3-Cl, 2-NO₂, X = (CH)_n, n = 0, 1], based on iminic 1,4-benzothiazines, has led to three different products depending on the substitution pattern. On the one hand, different types of unknown lactam systems with and without a rearrangement under ring contraction of the benzothiazine substructure, e.g., tetracyclic lactams II, were selectively obtained. In this investigation, annulated lactams without ring contraction were formed by oxidation of the sulfide group to a sulfone group in the benzothiazine skeleton. On the other hand, benzothiazoles, which are oxidation products, were isolated. The structures of all types of lactams were verified by X-ray diffraction. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hydrogen Chloride Gas in Solvent-Free Continuous Conversion of Alcohols to Chlorides in Microflow was written by Borukhova, Svetlana;Noel, Timothy;Hessel, Volker. And the article was included in Organic Process Research & Development in 2016.Application of 697-73-4 This article mentions the following:

Chlorides represent a class of valuable intermediates that are utilized in the preparation of bulk and fine chems. An earlier milestone to convert bulk alcs. to corresponding chlorides was reached when hydrochloric acid was used instead of toxic and wasteful chlorinating agents. This paper presents the development of an intensified solvent-free continuous process by using hydrogen chloride gas only. The handling of corrosive hydrogen chloride became effortless when the operating platform was split into dry and wet zones. The dry zone is used to deliver gas and prevent corrosion, while the wet zone is used to carry out the chem. transformation. The use of gas instead of hydrochloric acid allowed a decrease in hydrogen chloride equivalent from 3 to 1.2. In 20 min residence time, full conversion of benzyl alc. yielded 96 weight % of benzyl chloride in the product stream. According to green chem. and engineering principles, the developed process is of an exemplary type due to its truly continuous nature, no use of solvent and formation of water as a sole byproduct. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Application of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics