Tag: 100-200

Catalytic Cycloisomerization-Fluorination Sequence of N-Propargyl Amides by Iodoarene/HF.Pyridine/Selectfluor Systems was written by Asari, Naoki;Takemoto, Yusuke;Shinomoto, Yukino;Yagyu, Takuma;Yoshimura, Akira;Zhdankin, Viktor V.;Saito, Akio. And the article was included in Asian Journal of Organic Chemistry in 2016.Reference of 1711-11-1 This article mentions the following:

As a first example for metal-free and catalytic fluorinative transformations of alkynes, a cycloisomerization-fluorination sequence of N-propargyl amides catalyzed by iodine(III) species was developed. The iodine(III) catalyst was in-situ generated from iodoarene as a precatalyst with Selectfluor as a fluorinating oxidant in the presence of HF·pyridine. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Group IB organometallic chemistry. 20. The role of mixed organocopper cluster compounds RnR’mCun+m in selective carbon-carbon coupling reactions of 2- and 4-(dimethylamino)phenylcopper with copper arylacetylides was written by Van Koten, Gerard;Ten Hoedt, Richard W. M.;Noltes, Jan G.. And the article was included in Journal of Organic Chemistry in 1977.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The 1:1 interaction of ArnCun (Ar = 2-Me2NC6H4) with CuCCR (R = Ph, 4-MeC6H4, 2,4-xylyl, mesityl, 4-ClC6H4, 4-MeCC6H4, 4-O2NC6H4 in DMF at 125° affords the asym. cross-coupling products ArCCR in almost quant. yield. These reactions involve the intermediate formation of well-defined mixed organocopper cluster species Ar4Cu6(CCR)2. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A visit to Wittig and arsa-Wittig reactions was written by Birzan, Liviu;Cristea, Mihaela;Tecuceanu, Victorita;Draghici, Constantin;Hanganu, Anamaria;Razus, Alexandru C.. And the article was included in Revista de Chimie (Bucharest, Romania) in 2020.Related Products of 620-19-9 This article mentions the following:

Some considerations regarding the mechanism of arsa-Wittig condensation have been supplemented with the synthesis of compounds substituted with the nitro to Ph and various alkyl groups to the azulene moiety. For several unknown meta-substituted 1-styrylazulenes Wittig synthesis was used. The obtained products were completely characterized. A look at the behavior of the products in NMR and UV-Vis spectrometry was taken. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s was written by Subasinghe, Nalin L.;Travins, Jeremy M.;Ali, Farah;Huang, Hui;Ballentine, Shelley K.;Marugan, Juan Jose;Khalil, Ehab;Hufnagel, Heather R.;Bone, Roger F.;DesJarlais, Renee L.;Crysler, Carl S.;Ninan, Nisha;Cummings, Maxwell D.;Molloy, Christopher J.;Tomczuk, Bruce E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Safety of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Inhibiting the classical pathway of complement activation by attenuating the proteolytic activity of the serine protease C1s is a potential strategy for the therapeutic intervention in disease states such as hereditary angioedema, ischemia-reperfusion injury, and acute transplant rejection. A series of (arylsulfonyl)-2-thiophene carboxamidine inhibitors of C1s were synthesized and evaluated for C1s inhibitory activity. A potent compound, 4-[[7-bromo-1-[(2,5-difluorophenyl)methyl]-1H-benzimidazol-5-yl]sulfonyl]-5-(methylthio)-2-thiophene-carboximidamide, had a K_i of 10 nM and >1000-fold selectivity over uPA, tPA, FX_a, thrombin, and plasmin. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Safety of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Derivatives of salicylic acid. XIII. Chlorosalicylic acids and their methyl ethers was written by Hirwe, N. W.;Rana, K. N.;Gavankar, K. D.. And the article was included in Proceedings – Indian Academy of Sciences, Section A in 1938.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

3-Chlorosalicylic acid (I), m. 180-2°, is prepared by the action of Cl₂ or nascent Cl (KMnO₄ and concentrated HCl) on 5-sulfosalicylic acid (II) in glacial AcOH, followed by desulfonation with super-heated steam at 160-70°. The yield is 72% in the former case, from 100 g. II. A small amount of chlorophenol is probably also obtained in each case. I gives an intense violet color with FeCl₃. Cl₂ passed into chloralsalicylamide in glacial AcOH below 15° gives chloral-3-chlorosalicylamide (III), m. 159-60°, gives a red color with alc. FeCl₃. III (20 g.) refluxed with 10% NaOH (200 cc.) for 6 h. gives I in 86% yield. K salt of I, needles from water; Ca salt contains 3H₂O; Ag salt is light sensitive. Me 3-chlorosalicylate and aqueous NH₃ give 3-chlorosalicylamide (IV), m. 174-5°, gives a violet-red color with FeCl₃. I (10 g.) and PCl₅ (12 g.) when refluxed 4 h. in low-boiling petroleum ether, and the reaction mixture treated with aqueous NH₃, give IV, m. 174-6°; yield 8.5 g. When 7 g. Cl₂ is passed gradually into 14 g. salicylic acid in ice-cold glacial AcOH, 5-chlorosalicylic acid, m. 172-3°, giving a violet color with alc. FeCl₃, is formed in 15 g. yield; when double the quantity of Cl₂ was used, 3,5-dichlorosalicylic acid (V), m. 219-20°, giving a reddish violet color with alc. FeCl₃, was formed in 16.5 g. yield. Ca salt of V, contains 4H₂O. Me₂SO₄ (100 g.) added to 17 g. I in 75 cc. cold aqueous KOH (40 g. KOH in 150 cc. water) gave 16 g. of 3-chloro-2-methoxybenzoic acid (VI), m. 120-21°, giving no color with alc. FeCl₃. The Na salt of VI is anhydrous; the Ba salt contains 4H₂O, and the Ag salt darkens. VI treated with PCl₅ and aqueous NH₃ gives 3-chloro-2-methoxybenzamide, m. 99-100°, giving no color with alc. FeCl₃. 2-MeOC₆H₄CO₂H (14 g.) chlorinated in ice-cold glacial AcOH with 7 g. Cl₂ gives 5-chloro-2-methoxybenzoic acid (VII), m. 80-1°, giving no color with alc. FeCl₃, in 15.5 g. yield. The Ag salt of VII turns brownish. VII (6 g.) treated with PCl₅ and aqueous NH₃ gives 5-chloro-2-methoxybenzamide, m. 137-8°, giving no color with alc. FeCl₃; yield, 5 g. 2-MeOC₆H₄CO₂H acid (15 g.) chlorinated in glacial AcOH with 15 g. Cl₂, yields 15 g. 3,5-dichloro-2-methoxybenzoic acid (VIII), m. 166-7°, giving no color with alc. FeCl₃. The Na salt of VIII contains 2H₂O; the Ba salt, 5H₂O; the Ag salt turns gray. VIII (20 g.) treated with PCl₅ and aqueous NH₃ yields 19.5 g. 3,5-dichloro-2-methoxybenzamide, m. 152-3° giving no color with alc. FeCl₃. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Arylsulfonamidotetralin inhibitors of the Kv1.5 ion channel was written by Gross, Michael F.;Castle, Neil A.;Zou, Anruo;Wickenden, Alan D.;Yu, Weifeng;Spear, Kerry L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Arylsulfonamidotetralins based on lead compound I were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC₅₀ values less then 0.1 μM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones was written by Zuo, Youpeng;He, Xinwei;Tang, Qiang;Hu, Wangcheng;Zhou, Tongtong;Hu, Wenbo;Shang, Yongjia. And the article was included in Advanced Synthesis & Catalysis in 2021.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

An cascade intramol. 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, Ph hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones I [R = Ph, 2-naphthyl, 2-thienyl, etc.; R¹ = H, 6-Me, 7-Cl, etc.; R² = Me, Et, Ph, OPh; R³ = Me, Et, allyl, Bn] using unexpensive Pd(PPh₃)₄ as catalyst was developed. The protocol enabled the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors was written by Tang, Sheng;Li, Yu-Huan;Cheng, Xin-Yue;Li, Ying-Hong;Wang, Hui-Qiang;Kong, Lan-Ying;Zhang, Xin;Jiang, Jian-Dong;Song, Dan-Qing. And the article was included in Future Medicinal Chemistry in 2016.Category: chlorides-buliding-blocks This article mentions the following:

Materials & methods: Fifty-one novel 12N-substituted matrinic acid derivatives were synthesized and evaluated for their anti-coxsackievirus B3 activities. Results: Structure-activity relationship studies revealed that the 11-side chain could be determinant for the selectivity index by adjusting overall lipophilicity, and 11-butane was the best one for both potency and druggability. The optimized 35d showed the broad-spectrum anti-coxsackieviruse effects, an excellent pharmacokinetics and a good safety profile. More importantly, it displayed a potential effect for the pleconaril-resistant coxsackievirus B3 as well. Its mode of action is targeting on the viral transcription and translation stage, a different mechanism from that of pleconaril. Conclusion: Thus, we considered that 35d is a promising anti-enteroviral candidate for the treatment of various diseases infected with coxsackieviruses. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition was written by Fox, Brian M.;Natero, Reina;Richard, Kevin;Connors, Richard;Roveto, Philip M.;Beckmann, Holger;Haller, Katrin;Golde, Justin;Xiao, Shou-Hua;Kayser, Frank. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.HPLC of Formula: 1711-11-1 This article mentions the following:

We discovered novel pyrrolidine MCHR1 antagonist 1 possessing moderate potency. Profiling of pyrrolidine 1 demonstrated that it was an inhibitor of the hERG channel. Investigation of the structure-activity relationship of this class of pyrrolidines allowed us to optimize the MCHR1 potency and decrease the hERG inhibition. Increasing the acidity of the amide proton by converting the benzamide in lead 1 to an anilide provided single digit nanomolar MCHR1 antagonists while replacing the dimethoxyphenyl ring of 1 with alkyl groups possessing increased polarity dramatically reduced the hERG inhibition. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel sulfone derivatives containing 1,3,4-oxadiazole moiety was written by Su, Shihu;Zhou, Xia;Zhou, Yan;Liao, Guoping;Shi, Li;Yang, Xia;Zhang, Xian;Jin, Linhong. And the article was included in World Journal of Organic Chemistry in 2014.Recommanded Product: 85953-29-3 This article mentions the following:

Series of novel sulfone derivatives containing 1,3,4-oxadiazole moiety I [R¹ = 4-F-2-Me, 2,5-Cl₂, 2-Br-4-F, etc.; R² = Me, Et, CH(CH₃)₂, n-propyl] and II [R² = Me, Et, CH₂Ph] were synthesized. All the target compounds were characterized by ¹H and ¹³C NMR, IR spectroscopy and elemental anal. Their antifungal activities were tested in vitro with six important phytopathogenic fungi, namely, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Phytophthora infestans, Paralepetopsis sasakii and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Their antibacterial activities were tested in vitro with two important phytopathogenic bacteria, namely, Xanthomonas oryzae and Ralstonia solanacearum from tobacco bacterial by the turbid meter test. Compounds I [R¹ = 2-Cl-4-F, 4-CF₃; R² = Me] and II [R² = Me, Et] exhibited the most potent inhibition against R. solanacearum and X. oryzae with 50% inhibition concentration (EC₅₀) from 1.97 to 7.75 μg/mL and 0.45 to 0.52 μg/mL, resp. Their antifungal tests indicated that among target compounds exhibited good antifungal activities against six kinds of fungi, especially against S. sclerotiorum with EC₅₀ from 3.71 to 17.44 μg/mL. In vivo antibacterial activities tests demonstrated that the controlling effect of compound II [R² = Me] (81.9%) against rice bacterial leaf blight were better than that of bismerthiazol (50.8%) and thiodiazole-copper (44.7%). The results also demonstrated that compounds I [R¹ = 2-Cl-4-F; R² = Me] and II [R² = Me, Et] had a better antifungal and antibacterial activity, with good characteristics of broad spectrum. The structure-activity relationships were also discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Recommanded Product: 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics