Tag: 100-200

Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells was written by Landi, Martina;Catelani, Giorgio;D’Andrea, Felicia;Ghidini, Eleonora;Amari, Gabriele;Paola, Puccini;Bianchi, Nicoletta;Gambari, Roberto. And the article was included in European Journal of Medicinal Chemistry in 2009.Reference of 6834-42-0 This article mentions the following:

A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogs and Me 3,4-O-isopropylidene-α- and β-D-galactopyranosides have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythro-leukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pd-Catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates was written by Shang, Rui;Xu, Qing;Jiang, Yuan-Ye;Wang, Yan;Liu, Lei. And the article was included in Organic Letters in 2010.Computed Properties of C7H3ClF2O2 This article mentions the following:

Pd-catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates is achieved by using diglyme as the solvent. The reaction is useful for synthesis of polyfluorobiaryls from readily accessible and nonvolatile polyfluorobenzoate salts. Unlike the Cu-catalyzed decarboxylation cross coupling where oxidative addition is the rate-limiting step, in the Pd-catalyzed version decarboxylation is the rate-limiting step. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Computed Properties of C7H3ClF2O2).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3ClF2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and anticonvulsant activity of 1-substituted benzyl N-substituted 1,2,3-triazole-4-carboxanilides was written by Wang, Junmin;Jun, Changsoo;Chai, Kyuyun;Kwak, Kyungchell;Quan, Zheshan. And the article was included in Progress in Natural Science in 2006.Synthetic Route of C7H5ClF2 This article mentions the following:

Title compounds I [R = (un)substituted phenyl; R¹ = H, Me, Pr] were prepared by heterocyclization of benzyl azides with Et propiolate, followed by amidation of the resulting triazolecarboxylate esters. The anticonvulsant activity of I depended on R and R¹. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Synthetic Route of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense was written by Patrick, Donald A.;Wenzler, Tanja;Yang, Sihyung;Weiser, Patrick T.;Wang, Michael Zhuo;Brun, Reto;Tidwell, Richard R.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.COA of Formula: C8H4ClNO This article mentions the following:

2-(2-Benzamido)ethyl-4-phenylthiazole I was one of 1035 mols. (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6 μM and nontoxic to mammalian (Huh7) cells in a phenotypic high-throughput screen of a 700,000 compound library performed by the Genomics Institute of the Novartis Research Foundation (GNF). Compound I and 72 analogs were synthesized in this laboratory by one of two general pathways. These plus 10 com. available analogs were tested against T. brucei rhodesiense STIB900 and L6 rat myoblast cells (for cytotoxicity) in vitro. Forty-four derivatives were more potent than I, including eight with IC₅₀ values below 100 nM. The most potent and most selective for the parasite was the urea analog 2-(2-piperidin-1-ylamido)ethyl-4-(3-fluorophenyl)thiazole II (IC₅₀ = 9 nM, SI > 18,000). None of 33 compounds tested were able to cure mice infected with the parasite; however, seven compounds caused temporary reductions of parasitemia (â‰?7%) but with subsequent relapses. The lack of in vivo efficacy was at least partially due to their poor metabolic stability, as demonstrated by the short half-lives of 15 analogs against mouse and human liver microsomes. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1COA of Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH was written by Singh, Vinayak;Pacitto, Angela;Donini, Stefano;Ferraris, Davide M.;Boros, Sandor;Illyes, Eszter;Szokol, Balint;Rizzi, Menico;Blundell, Tom L.;Ascher, David B.;Pato, Janos;Mizrahi, Valerie. And the article was included in European Journal of Medicinal Chemistry in 2019.Category: chlorides-buliding-blocks This article mentions the following:

In prior work, (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was identified and showed that its anti-tubercular activity is attributable to inhibition of inosine-5′-monophosphate dehydrogenase (IMPDH) in Mycobacterium tuberculosis. In the present study, the structure-activity relationship around (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone) was explored by synthesizing and evaluating the inhibitory activity of analogs against M. tuberculosis IMPDH in biochem. and whole-cell assays. X-ray crystallog. was performed to elucidate the mode of binding of selected analogs to IMPDH. The importance of the cyclohexyl, piperazine and isoquinoline rings was estabilished for activity and reported the identification of an analog with IMPDH-selective activity against a mutant of M. tuberculosis that is highly resistant to (cyclohexyl(4-(isoquinolin-5-ylsulfonyl)piperazin-1-yl)methanone). It was showed that the nitrogen in urea analogs is required for anti-tubercular activity and identify benzylurea derivatives as promising inhibitors that warrant further investigation. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies on spasmolytics. III. Influence of structural changes in nitrogen-free esters with spasmolytic activity was written by Funcke, A. B. H.;Rekker, R. F.;Ernsting, M. J. E.;Nauta, W. Th.. And the article was included in Arzneimittel-Forschung in 1956.Application In Synthesis of Methyl 2-chloro-2-phenylacetate This article mentions the following:

The following esters of α-chlorophenylacetic acid were prepared from the acyl chloride and resp. alc. (b.°/mm., n_D²⁰ and yield in % are given): Me 123-6/11, 1.4963, 60; Et 132-3/15, 1.5037, 65; Pr 140-2/19, 1.5024, 55; iso-Pr 125-30/8, 1.5010, 55; Bu 143-5/8, 1.4960, 65; iso-Bu 135-40/8, 1.4958, 30; Am 143-5/11 1.5028, 79; 2-Me-1-Bu 144-6/11, 1.5028, 81; 3-Me-1-Bu 145-7/11, 1.5029, 55; 2,2-dimethylpropyl 141-3/11, 1.4983, 68; 2-pentyl 144-5/11, 1.5023, 78; 2-Me-2-Bu 148-50/12, m. 70-2°, 83; 3-Me-2-Bu 146-8/12, 1.5018, 90; 3-pentyl 144-5/11, 1.5035, 69; 3,3,5-trimethyl-1-cyclohexyl 140/0.04, 1.5135, 81. The lower esters of the series have a higher spasmolytic activity than the corresponding mandelates; as the number of C atoms in the ester group increases, however, this relation is inversed. The following esters of phenylglyoxylic acid have little or no spasmolytic activity: 2-Me-1-Bu 118/0.02, 1.5058, 53; 1-heptyl 128/0.03, 1.4980, 61; 2,6-dimethyl-4-heptyl 125/0.05, 1.4900, 55; 3,3,5-trimethyl-1-cyclohexyl 145/0.05, m. 43-4°, 77. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application In Synthesis of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aromatic nucleophilic substitution. XI. Effect of meta substituents was written by Bevan, Cecil W. L.;Hirst, J.;Una, S. J.. And the article was included in Nigerian Journal of Science in 1966.Synthetic Route of C6H3ClFNO2 This article mentions the following:

Variation in the rates and log B factor in the Arrhenius equation K = BE-/RT are recorded and correlated largely with changes in activation energy. The compounds used are 3-(R-substituted)-5-nitrofluorobenzenes with methoxide ion in methanol, R being NH2, CO2-, Me3, tert-Bu, OMe3, H, Ac, F, I, Cl, Br, CF3, SO2Me, or NO2. OMe and NH2 groups induce deactivation whereas Ac induces (-T) effect in the mol. MeSO2 in the para position is 10 times less activating than the NO2 group in the identical position. The trifluoromethyl group is found to induce an inductive effect while the CO2- group is weakly deactivating from the ortho position. As expected the effect of halogens in the meta position is powerfully accelerating. 34 references. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9Synthetic Route of C6H3ClFNO2).

1-Chloro-3-fluoro-5-nitrobenzene (cas: 4815-64-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C6H3ClFNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrochemical Sulfoxidation of Thiols and Alkyl Halides was written by Yu, Yi;Wu, Shao-Fen;Zhu, Xiao-Bin;Yuan, Yaofeng;Li, Zhen;Ye, Ke-Yin. And the article was included in Journal of Organic Chemistry in 2022.Synthetic Route of C8H9Cl This article mentions the following:

A green and efficient electrochem. sulfoxidation via the use of readily available materials, i.e., thiols and alkyl halides was reported. The simple operation, mild conditions and broad substrate scope render this protocol potentially applicable for the preparation of diverse synthetically significant sulfoxides RSOCH₂R¹ [R = i-Pr, 4-FC₆H₄, 4-ClC₆H₄, etc.; R¹ = (CH₂)₂CH₃, Ph, 3-MeOC₆H₄, etc.]. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Synthetic Route of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents was written by Hansa, Raj KC.;Khan, M. M. K.;Frangie, M. M.;Gilmore, D. F.;Shelton, R. S.;Savenka, A. V.;Basnakian, A. G.;Shuttleworth, S. L.;Smeltzer, M. S.;Alam, M. A.. And the article was included in European Journal of Medicinal Chemistry in 2021.Computed Properties of C6H4ClF2N This article mentions the following:

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl Ph derived pyrazoles I [R = HO(O)C, F₃C; R¹ = Ph, 3-bromophenyl, 5-iodopyridin-2-yl, etc.] was synthesized and tested for antibacterial activity. The majority of trifluoromethyl Ph derivatives are highly potent growth inhibitors of Gram-pos. bacteria and showed low toxicity to human cultured cells. In particular, two compounds I [R = F₃C; R¹ = 3-fluoro-5-(trifluoromethyl)phenyl, 3,5-dichloro-4-fluorophenyl] were selected for addnl. studies. These compounds were highly effective against Staphylococcus aureus as shown by a low min. inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Addnl., in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromol. synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Computed Properties of C6H4ClF2N).

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C6H4ClF2N

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chiral Imidodiphosphoric Acid-Catalyzed Highly Diastereo- and Enantioselective Synthesis of Poly-Substituted 3,4-Dihydro-2H-pyrans: [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketoesters and 3-Vinylindoles was written by Guan, Xu-Kai;Liu, Guo-Feng;An, Dong;Zhang, Heng;Zhang, Suo-Qin. And the article was included in Organic Letters in 2019.Safety of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Imidodiphosphoric acids were employed to catalyze inverse-electron-demand hetero-Diels-Alder reaction of β,γ-unsaturated α-ketoesters and 3-vinylindoles. A series of optically active 3,4-dihydro-2H-pyran derivatives with three contiguous stereogenic centers was synthesized in excellent yields (70-99%), diastereoselectivities (>20:1), and enantioselectivities (73-99%). The resulting indole containing 3,4-dihydro-2H-pyran could be converted to tetrahydropyran derivatives, which appear in several biol. active compounds by simple hydrogenation reduction In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Safety of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics