Tag: 100-200

A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts was written by Kong, Xianqiang;Chen, Yiyi;Chen, Xiaohui;Lu, Zheng-Xuan;Wang, Wei;Ni, Shao-Fei;Cao, Zhong-Yan. And the article was included in Organic Letters in 2022.SDS of cas: 698-01-1 This article mentions the following:

By merging electrocatalysis and nickel catalysis, a unified strategy was successfully applied for preparing aryl ketones ArC(O)Ph [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.], amides ArC(O)NR¹R² [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.; R¹ = R² = Me, Et; R¹R² = CH₂(CH₂)₂CH₂, CH₂CH₂OCH₂CH₂], esters ArC(O)OR [Ar = Ph, 2-MeC₆H₄, 4-FC₆H₄, etc.; R = Me, Et] or aldehydes ArCHO [Ar = Ph, 4-MeC₆H₄, 4-PhC₆H₄, etc.] via decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1SDS of cas: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Identification of an aminothiazole series of RORβ modulators was written by Patouret, Remi;Doebelin, Christelle;Garcia-Ordonez, Ruben D.;Chang, Mi Ra;Ruiz, Claudia;Cameron, Michael D.;Griffin, Patrick R.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:

Crystallog. has identified stearic acid, ALRT 1550 and ATRA as ligands that bind RORβ, however, none of these mols. represent good starting points to develop optimized small mol. modulators. Recently, I was identified as a potent dual RORβ and RORγ inverse agonist with no activity towards RORα (Fig. 1). To the knowledge, this is one of only two small mol. RORβ inverse agonists identified in the primary literature from a tractable chem. series and represents an ideal starting point from which to design RORβ-selective modulators. Herein the authors describe the SAR optimization efforts that led to a series of potent neutral antagonists of RORβ. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-Diamines: Preparation of Valuable Nitrogenated Compounds was written by Rios-Lombardia, Nicolas;Busto, Eduardo;Garcia-Urdiales, Eduardo;Gotor-Fernandez, Vicente;Gotor, Vicente. And the article was included in Journal of Organic Chemistry in 2009.Reference of 6834-42-0 This article mentions the following:

A wide range of prochiral 1,3-diamines were first efficiently synthesized and subsequently desymmetrized by using lipase from Pseudomonas cepacia as catalyst and diallyl carbonate as alkoxycarbonylating agent. In all cases, the amino carbamates of R-configuration were recovered. Final selective cleavage of the N-allyloxycarbonyl moiety was carried out under mild reaction conditions, which demonstrates the high versatility and potential of this chemoenzymic route as a source of intermediates in the synthesis of related optically active nitrogenated derivatives In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of small molecule agonists of EphA2 receptor was written by Petty, Aaron;Idippily, Nethrie;Bobba, Viharika;Geldenhuys, Werner J.;Zhong, Bo;Su, Bin;Wang, Bingcheng. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 6834-42-0 This article mentions the following:

Ligand-independent activation of EphA2 receptor kinase promotes cancer metastasis and invasion. Activating EphA2 receptor tyrosine kinase with small mol. agonist is a novel strategy to treat EphA2 overexpressing cancer. In this study, we performed a lead optimization of a small mol. Doxazosin that was identified as an EphA2 receptor agonist. 33 new analogs were developed and evaluated; a structure-activity relationship was summarized based on the EphA2 activation of these derivatives Two new derivative compounds 24 and 27 showed much improved activity compared to Doxazosin. Compound 24 possesses a bulky amide moiety, and compound 27 has a dimeric structure that is very different to the parental compound Compound 27 with a twelve-carbon linker of the dimer activated the kinase and induced receptor internalization and cell death with the best potency. Another dimer with a six-carbon linker has significantly reduced potency compared to the dimer with a longer linker, suggesting that the length of the linker is critical for the activity of the dimeric agonist. To explore the receptor binding characteristics of the new mols., we applied a docking study to examine how the small mol. binds to the EphA2 receptor. The results reveal that compounds 24 and 27 form more hydrogen bonds to EphA2 than Doxazosin, suggesting that they may have higher binding affinity to the receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot synthesis of N,N-dimethylanilines from nitroarenes with skeletal Cu as chemoselective catalyst was written by Rong, Zeming;Zhang, Wenjun;Zhang, Peng;Sun, Zhuohua;Lv, Jinkun;Du, Wenqiang;Wang, Yue. And the article was included in Catalysis Communications in 2013.Electric Literature of C8H10ClN This article mentions the following:

A range of N,N-dimethylanilines were synthesized with excellent yields in one-pot by the hydrogenation and alkylation of nitro arenes with H₂ and CH₂O over quenched skeletal Cu catalyst, which provides a facile, economical, and environmentally benign alternative methodol. for C-N bonds formation. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Electric Literature of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel synthesis of 4H-1,4-benzoxazines was written by Kudo, Noriaki;Furuta, Satoru;Sato, Kazuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1996.Product Details of 85953-29-3 This article mentions the following:

The reaction of Me 2-chloro-5-ethoxycarbonylamino-4-fluorobenzoate (I) and 1-bromo-3,3-dimethyl-2-butanone in the presence of 2.2 equiv of LiN(SiMe₃)₂ afforded the 4H-1,4-benzoxazine II in good yield, instead of the expected 4-oxazolin-2-one III. Similar preparations of 5 addnl. benzoxazines are described. The generality of the reaction and the mechanism are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Product Details of 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo was written by Fu, Dong-Jun;Song, Jian;Zhu, Ting;Pang, Xiao-Jing;Wang, Sheng-Hui;Zhang, Yan-Bing;Wu, Bo-Wen;Wang, Jun-Wei;Zi, Xiaolin;Zhang, Sai-Yang;Liu, Hong-Min. And the article was included in European Journal of Medicinal Chemistry in 2020.Computed Properties of C8H9Cl This article mentions the following:

NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC₅₀ value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Computed Properties of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dithiane-directed Rh(III)-catalyzed amidation of unactivated C(sp³)-H bonds was written by Shi, Heyao;Dixon, Darren J.. And the article was included in Chemical Science in 2019.Related Products of 6834-42-0 This article mentions the following:

An oxidant-free Rh(III)-catalyzed direct amidation of alkyl dithianes I (R¹ = Me, Ph, PhCH₂, MeO₂C, etc., R² = Me; R¹R² = CH₂CH₂NBocCH₂CH₂) via C(sp³)-H bond activation utilizing diverse and robust dioxazolone reagents II (R³ = t-BuCH₂, cyclopropyl, n-undecyl, Ph, PhCH₂, 2-furyl, etc.) is reported. The reaction hinges on use of a Cp*Rh(III) complex in combination with an essential amino-carboxylate additive to generate usefully protected 1,3-aminoaldehyde derivatives III. The scalability of the reaction was demonstrated as was a series of downstream product functionalizations, including dithiane deprotection, anion alkylation and reductive desulfurization, highlighting the general applicability of this transformation in the synthesis of novel scaffolds and building blocks. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Related Products of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer’s disease was written by Gutti, Gopichand;Kakarla, Ramakrishna;Kumar, Devendra;Beohar, Mahima;Ganeshpurkar, Ankit;Kumar, Ashok;Krishnamurthy, Sairam;Singh, Sushil Kumar. And the article was included in European Journal of Medicinal Chemistry in 2019.HPLC of Formula: 3438-16-2 This article mentions the following:

Alzheimer’s disease (AD) is associated with multifactorial neuropathol. conditions, which included cholinergic deficit, amyloid-beta plaques formation, loss of neuronal plasticity and neuronal death. Treating such multifactorial conditions with a single target directed approach was considered to be inadequate. Accordingly, multi-target directed ligand (MTDL) strategy has been evolved as an auspicious approach for the treatment of AD. In light of that, a library of 2-substituted benzo[d]oxazol-5-amine derivatives I [Ar = Ph, pyridin-2-yl, 4-bromophenyl, etc.; n = 0, 1, 2, C(O); X = C, N; Y = N, CH₂, O] was designed using the scaffold hopping guided MTDLs strategy, synthesized and evaluated through various in-vitro and in-vivo biol. studies. The optimal compound I [Ar = 4-bromophenyl, n = C(O); X = N, Y = N] exhibited potent inhibitory activities against AChE (IC₅₀ = 0.052 ± 0.010 μM), BuChE (IC₅₀ = 1.085 ± 0.035 μM) and significant amyloid-beta aggregation (20 μM) inhibition. The compound I [Ar = 4-bromophenyl, n = C(O); X = N, Y = N] possessed better blood-brain barrier permeability (Pe = 10.80 ± 0.055 x 10-6 cm s^-1) in PAMPA assay and neuro protective properties (40 μM) on SH-SY5Y neuroblastoma cell lines. Furthermore, in-vivo behavioral studies were performed on Y-maze test (scopolamine-induced amnesia model) and Morris water maze test (Aβ_1-42 induced ICV rat model). The compound I [Ar = 4-bromophenyl, n = C(O); X = N, Y = N], at a dose of 10 mg/kg oral administration, demonstrated a substantial improvement of the cognitive and special memory impairment. In summary, both in-vitro and in-vivo investigations evidenced that compound I [Ar = 4-bromophenyl, n = C(O); X = N, Y = N] was a potential lead for the discovery of safe and effective disease-modifying agents for AD. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2HPLC of Formula: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor was written by Cho, Nobuo;Harada, Masataka;Imaeda, Toshihiro;Imada, Takashi;Matsumoto, Hirokazu;Hayase, Yoji;Sasaki, Satoshi;Furuya, Shuichi;Suzuki, Nobuhiro;Okubo, Shoichi;Ogi, Kazuhiro;Endo, Satoshi;Onda, Haruo;Fujino, Masahiko. And the article was included in Journal of Medicinal Chemistry in 1998.COA of Formula: C7H5ClF2 This article mentions the following:

The authors describe the design, synthesis, and biol. properties of iso-Pr 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-isobutyrylaminophenyl)-4-oxothieno[2,3-b]pyridine-5-carboxylate hydrochloride (I, T-98475), a hightly potent and orally active nonpeptide antagonist of the human LHRH receptor. The results of in vitro and in vivo studies demonstrate that T-98475 is the first potent and orally effective nonpeptide antagonist of the human LHRH receptor, and should provide a new class of useful therapeutic agents for the treatment of sex hormone-dependent pathologies. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics