Tag: 100-200

Studies on fused-ring mesoionic thiazolo[3,2-a]thiazolo[5,4-d]pyrimidine system was written by Talukdar, P. B.;Sengupta, S. K.;Datta, A. K.. And the article was included in Indian Journal of Chemistry in 1983.Product Details of 7476-66-6 This article mentions the following:

Cyclodehydration of 5-carboxymethylmercaptothiazolo[5,4-d]pyrimidine-7(6H)-ones I (R = SMe, NHPh; R¹ = Me, Ph; R² = Ph) with Ac₂O readily affords new fused-ring mesoionic systems II. I (R² = H) fail to give pure products under similar treatment, but the thiazolium perchlorate, III were acylated to give pure mesoionic ketones II (R = SMe, R¹ = Me, R² = Ac, COC₆H₄NO₂-4). II furnish alc. adducts. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Product Details of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 3-[p-(pyrazolyl)]phenylsydnones was written by Havanur, Shambhuling B.;Badami, Bharati V.;Puranik, Gurubasav S.. And the article was included in Journal of Heterocyclic Chemistry in 1980.Category: chlorides-buliding-blocks This article mentions the following:

Condensation of p-RC₆H₄NH₂ (R = 1-pyrazolyl, 3,5-dimethyl-1-pyrazolyl, 3,4,5-trimethyl-1-pyrazolyl) with R¹ClCHCO₂Me (R¹ = H, Me, Ph) gave 70-5% p-RC₆H₄NHCHR¹CO₂H which on treatment with NaNO₂ gave 75-80% p-RC₆H₄N(NO)CHR¹CO₂H. Cyclizing the last with Ac₂O gave 60-76% title compounds I. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Category: chlorides-buliding-blocks).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alkylation of enaminoketone with a modified carane skeleton. Formation of stable β-diketone monoimines was written by Tkachev, A. V.;Popov, S. A.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 1997.COA of Formula: C7H5ClF2 This article mentions the following:

Alkylation of a bicyclic enaminoketone, 1-[(1R,5R)-3-amino-6,6-dimethylbicyclo[3.1.0]hex-2-en-2-yl]ethanone, with highly reactive alkyl halides (Me iodide, benzyl halides, and allyl halides) in a two-phase system benzene-40% aqueous NaOH in the presence of benzyltriethylammonium chloride (BTEA) as phase-transfer catalyst results in formation of stable β-diketone monoimines, derivatives of the series of 1-[(1R,5R)-2-alkyl-3-imino-6,6-dimethylbicyclo[3.1.0]hex-2-yl]ethanone, in 53-81% yields. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

General catalytic methylation of amines with formic acid under mild reaction conditions was written by Sorribes, Ivan;Junge, Kathrin;Beller, Matthias. And the article was included in Chemistry – A European Journal in 2014.Category: chlorides-buliding-blocks This article mentions the following:

A general catalytic protocol for the methylation of amines was developed applying, for the first time, formic acid as the C₁ building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines was converted to the corresponding tertiary amines including [N-¹³C]-labeled drugs in good to excellent yields under mild conditions. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Category: chlorides-buliding-blocks).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sequential Selective C-H and C(sp³)-⁺P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds was written by Babu, K. Naresh;Massarwe, Fedaa;Shioukhi, Israa;Masarwa, Ahmad. And the article was included in Angewandte Chemie, International Edition in 2021.SDS of cas: 620-19-9 This article mentions the following:

Organophosphonium salts containing C(sp3)-+P bonds are among the most utilized reagents in organic synthesis for constructing C-C double bonds. However, their use as C-selective electrophilic groups is rare. Here, authour explore an efficient and general transition-metal-free method for sequential chemo- and regioselective C-H and C(sp³)-+P bond functionalizations. In the present study, C-H alkylation resulting in the synthesis of benzhydryl triarylphosphonium salts was achieved by one-pot, four-component cross-coupling reactions of simple and com. available starting materials. The utility of the resulting phosphonium salt building blocks was demonstrated by the chemoselective post-functionalization of benzylic C(sp³)-+PPh³ groups to achieve aminations, thiolations, and arylations. In this way, benzhydrylamines, benzhydrylthioethers, and triarylmethanes, structural motifs that are present in many pharmaceuticals and agrochems., are readily accessed. These include the synthesis of two anticancer agents from simple materials in only two to three steps. Addnl., a protocol for late-stage functionalization of bioactive drugs has been developed using benzhydrylphosphonium salts. This new approach should provide novel transformations for application in both academic and pharmaceutical research. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An Atom-Economical Method for the Formation of Amidopyrroles Exploiting the Self-Assembled Resorcinarene Capsule was written by La Manna, Pellegrino;Talotta, Carmen;De Rosa, Margherita;Soriente, Annunziata;Gaeta, Carmine;Neri, Placido. And the article was included in Organic Letters in 2020.HPLC of Formula: 620-19-9 This article mentions the following:

Here is reported the first example of an organocatalyzed coupling between pyrrole and isocyanates in a nanoconfined space. The hexameric resorcinarene capsule C is able to catalyze the direct coupling between isocyanates and pyrroles to give amidopyrroles with excellent yields and selectivities. The reaction catalyzed by C prevents the use of expensive and poorly atom-economical reagents. As in natural enzymes, the cavity of C is able to discriminate between isomeric substrates. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9HPLC of Formula: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Fluoroquinolone Derivatives as Potent α-Glucosidase Inhibitors: In-Vitro Inhibitory Screening with In-Silico Docking Studies was written by Shaheen, Aasia;Ashiq, Uzma;Jamal, Rifat Ara;Khan, Khalid Mohammed;Gul, Sana;Yousuf, Sammer;Ali, Syed Tahir. And the article was included in ChemistrySelect in 2021.COA of Formula: C7H5ClF2 This article mentions the following:

This study was based on synthesis, structure elucidation and biol. evaluation of various fluoroquinolone (enoxacin) analogs with electrophilic substitution of aromatic amine moiety of central enoxacin nucleus by benzyl halides. The synthesized derivatives were characterized on the basis of different chem. and phys. measurements and structures were elucidated by various spectroscopic techniques (NMR, EI-MS), including elemental (CHN) and X-ray diffraction anal. Furthermore these compounds were investigated for their potential α-glucosidase inhibition activities and all synthesized analogs of fluoroquinolones were found to exhibit promising inhibition potential of 45.8±0.2 to 74.5±0.2μM in comparison to IC₅₀ value of 425.6±1.3μM for standard inhibitor of α-glucosidase1-deoxynojirimycin. Further, docking of synthetic compounds were carried out by using α-glucosidase I enzyme of Saccharomyces cerevisiaeas a target. The study provided an insight of the mol. interactions of fluoroquinolone derivatives with the enzyme that were in good agreement with the inhibitory activity of synthesized compounds and can be considered as a valuable tool for designing new drugs. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of substituted 4-[(1H-benzo[d]imidazol-2-yl)methyl]phenol derivatives was written by Chittimalla, Srinivasulu;Pochampally, Jalapathi;Maroju, Sreedhar;Velupula, Ganapathi;Bhdraiah, Veera;Thumma, Vishnu;Nalla, Umapathi. And the article was included in Heterocyclic Letters in 2022.Related Products of 620-19-9 This article mentions the following:

A new set of N-substituted benzimidazole analogs I [R = PhC(O), 2-MeC₆H₄CH₂, cyclohexanecarbonyl, etc.] was prepared by the reaction of resp. benzimidazoles with different acids, acid chlorides and alkyl halides under appropriate conditions. All the structures of compounds were analyzed by FT-IR, ¹H-NMR and Mass spectral data. The synthesized compounds I were evaluated for their in vitro antibacterial and antifungal activity and also studied their mol. docking. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 was written by Biamonte, Marco A.;Shi, Jiandong;Hong, Kevin;Hurst, David C.;Zhang, Lin;Fan, Junhua;Busch, David J.;Karjian, Patricia L.;Maldonado, Angelica A.;Sensintaffar, John L.;Yang, Yong-Ching;Kamal, Adeela;Lough, Rachel E.;Lundgren, Karen;Burrows, Francis J.;Timony, Gregg A.;Boehm, Marcus F.;Kasibhatla, Srinivas R.. And the article was included in Journal of Medicinal Chemistry in 2006.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequently have unacceptably low oral bioavailabilities. We now report that water-solubility can be achieved by inserting an amino functionality in the N(9) side chain. This results in compounds that are potent, soluble in aqueous media, and orally bioavailable. In an HER-2 degradation assay, the highest potency was achieved with the neopentylamine 42 (HER-2 IC₅₀ = 90 nM). In a murine tumor xenograft model (using the gastric cancer cell line N87), the H₃PO₄ salts of the amines 38, 39, and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day. The amines 38, 39, and 42 are the first Hsp90 inhibitors shown to inhibit tumor growth upon oral dosage. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Quality Control of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enzymatic hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media was written by Wang, Pei-Yun;Chen, Teh-Liang;Tsai, Shau-Wei. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2007.Recommanded Product: Methyl 2-chloro-2-phenylacetate This article mentions the following:

A thermally stable carboxyl esterase (SNSM-87) from Klebsiella oxytoca is explored as an enantioselective biocatalyst for the hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media, where the Et ester possessing the highest enantioselectivity (E* = 95) is selected as the best substrate and rationalized from the linear free energy relationships in terms of the logarithms of kinetic constants and enantiomeric ratio varied with the inductive parameter of leaving alc. An expanded Michaelis-Menten mechanism for the rate-limiting acylation step is adopted for the kinetic anal. Two-stage Bronsted slopes of 58.0 and 2.28 for the fast-reacting (R)-esters, as well as only one-stage slope of 4.15 for the slow-reacting (S)-esters, were found and elucidated from the change of rate-limiting step. The replacement of α-chloro substituent to α-Me or α-hydroxy moiety indicates that the α-substituent has profound effects on varying the enzyme activity, enantioselectivity, and optical-preference for SNSM-87 and lipases of pCPL, Lipase MY, NOVO 435 and Lipase PS. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics