Tag: 100-200

Esters of γ-chloro-β-hydroxy- and β,γ-dichlorobutyric acid. Preparation of pure ethyl γ-chlorocrotonate was written by Broche, Andre;Rambaud, Rene. And the article was included in Compt. rend. in 1944.Recommanded Product: (E)-4-Chlorobut-2-enoic acid This article mentions the following:

The action of P₂O₅ on ClCH₂CH (OH) CH₂CO₂Et gives ClCH₂CH:CHCO₂Et (I) contaminated with ClCH:CHCH₂CO₂Et (II), and pure I cannot be obtained by distillation The mixture always shows lines in the ethylenic region of the Raman spectrum at 1666, 1651, and 1607 cm.^-1; the last two are of approx. equal intensity and are weaker than the first. Pure II is obtained by the following series of reactions. The action of SOCl₂ on ClCH₂CH(OH)CH₂CO₂Et gives ClCH₂CHClCH₂CO₂Et, b₁₂ 94-5°, d. 1.217, n_D¹⁹ 1.456; this with dilute NaOH yields trans-ClCH₂CH:CHCO₂H, m. 82.7°, which with SOCl₂ gives ClCH₂CH:CHCOCl, b₁₆ 74-4.5°, d. 1.316, n_D¹¹ 1.501, and this with C₅H₅N and EtOH yields I, b₁₃ 83°, d. 1.118, n_D¹⁴ 1.463. The Raman spectrum of pure I shows lines at only 1666 and 1651 cm.^-1; it is therefore trans, by analogy with the Me and Et fumarates, which show 2 unequal lines. The following esters were prepared From ClCH₂CH(OH)CH₂CO₂H: Me, b₁₃ 104-5°, d. 1.259, n_D^14.5 1.458; Pr, b₈ 114-15°, d. 1.150, n_D²¹ 1.453; Bu, b₄ 123-4.5°, d. 1.121, n_D²⁰ 1.453; iso-Bu, b₉ 122-4°, d. 1.116, n_D²⁴ 1.451. From ClCH₂CHClCH₂CO₂H: Me, b₁₅ 89.5-90°, d. 1.278, n_D²³ 1.459; Pr, b₁₄ 114-15°, d. 1.175, n_D¹⁹ 1.454; Bu, b₁₅ 127-8°, d. 1.143, n_D²⁴ 1.454; iso-Bu, b₁₅ 121-2°, d. 1.138, n_D²⁰ 1.452. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Recommanded Product: (E)-4-Chlorobut-2-enoic acid).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: (E)-4-Chlorobut-2-enoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and herbicidal activities of novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives was written by Xu, Han;Hu, Xu Hong;Zhu, You Quan;Zou, Xiao Mao;Liu, Bin;Hu, Fang Zhong;Yang, Hua Zheng. And the article was included in Science China: Chemistry in 2010.Computed Properties of C7H5ClF2 This article mentions the following:

Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed, synthesized, and evaluated through a Spirodela polyrrhiza test and a greenhouse test. Some compounds show > 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the preemergence treatment at a rate of 150 g/ha. Moreover, the study of the structure-activity relationship (SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities, which may be useful for the future design of new compounds In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 1-Indanones from Benzoic Acids was written by Huang, Yun-Sheng;Liu, Jian-Qiang;Zhang, Lang-Jun;Lu, He-Lin. And the article was included in Industrial & Engineering Chemistry Research in 2012.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

An improved process for the preparation of 1-indanones, e.g., I, from various benzoic acids is described. This process involves a Friedel-Crafts acylation between a substituted benzoyl chloride and ethylene, followed by an intramol. Friedel-Crafts alkylation in the presence of aluminum chloride. The described process combines three steps into a one-pot process, is scalable, is cost-effective, and thus has a general applicability in manufacturing production of various 1-indanones. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity was written by Karimi, Nafiseh;Roudsari, Rouhollah Vahabpour;Movahed, Mahsa Azami;Hajimahdi, Zahra;Zarghi, Afshin. And the article was included in Iranian Journal of Pharmaceutical Research in 2021.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC₆H₄, 2-FC₆H₄, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC₆H₄] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organometallic Silver(I) Supramolecular Complexes Generated from Multidentate Furan-Containing Symmetric and Unsymmetric Fulvene Ligands and Silver(I) Salts was written by Dong, Yu-Bin;Geng, Yan;Ma, Jian-Ping;Huang, Ru-Qi. And the article was included in Inorganic Chemistry in 2005.Category: chlorides-buliding-blocks This article mentions the following:

One new conjugated sym. fulvene ligand L1 (I, R = 2-furyl) and two new unsym. fulvene ligands L2 and L3 (I, R = 4- and 3-cyanophenyl, resp.) were synthesized. Five new supramol. complexes, Ag₂(L1)₃(SO₃CF₃)₃ (1, monoclinic, space group P2₁/c; a 12.702(3), b 26.118(7), c 13.998(4) Å, β 96.063(4)°, Z = 4), [Ag(L1)]ClO₄ (2, monoclinic, space group C2/c; a 17.363(2), b 13.2794(18), c 13.4884(18) Å, β 100.292(2)°, Z = 8), [Ag(L1)(C₆H₆)SbF₆]·0.5C₆H₆·H₂O (3, monoclinic, P2₁/c; a 6.8839(11), b 20.242(3), c 18.934(3) Å, β 91.994(3)°, Z = 4), Ag(L2)(SO₃CF₃) (4, triclinic, P1̅; a 8.629(3), b 10.915(3), c 11.178(3) Å, α 100.978(4), β 91.994(3), γ 105.652(4)°, Z = 2), and Ag(L3)(H₂O)(SO₃CF₃) (5, triclinic, P1̅; a 8.914(5), b 10.809(6), c 11.283(6) Å, α 69.255(8), β 87.163(9), γ 84.993(8)°, Z = 2) were obtained through self-assembly based on these three new fulvene ligands in a benzene/toluene mixed-solvent system. Compounds 1–5 were fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The coordination chem. of new fulvene ligands is versatile. They can adopt either cis- or trans-conformation to bind soft acid Ag(I) ion through not only the terminal -CN and furan functional groups but also the fulvene carbon atoms into organometallic coordination polymers or discrete complexes. The luminescent properties of L1-L3 and their Ag(I) complexes were studied preliminarily in EtOH and solid state. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient 4,5-dihydro-1H-imidazol-5-one formation from amidines and ketones under transition-metal free conditions was written by Xie, Yanjun;Cheng, Xiufang;Liu, Saiwen;Chen, Hui;Zhou, Wang;Yang, Luo;Deng, Guo-Jun. And the article was included in Green Chemistry in 2015.Related Products of 18637-02-0 This article mentions the following:

An efficient procedure for 4,5-dihydro-1H-imidazol-5-one preparation from aryl amidines and ketones under transition-metal free conditions is described. When cyclic ketones were employed, various spiro-fused 4,5-dihydro-1H-imidazol-5-ones were formed in high yields via rearrangement reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Related Products of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-/Silver-Mediated Arylation of C(sp²)-H Bonds with 2-Thiophenecarboxylic Acids was written by Zhao, Sheng;Liu, Yue-Jin;Yan, Sheng-Yi;Chen, Fa-Jie;Zhang, Zhuo-Zhuo;Shi, Bing-Feng. And the article was included in Organic Letters in 2015.Category: chlorides-buliding-blocks This article mentions the following:

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. E.g., in presence of CuOAc, AgNO₃, and Li₂CO₃ in DMF, arylation of I with 2-thiophenecarboxylic acid gave 67% 2-fluoro-N-(2-(pyridin-2-yl)propan-2-yl)-2-(thiophen-2-yl)benzamide (II). The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Category: chlorides-buliding-blocks).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase was written by Milkiewicz, Karen L.;Weinberg, Linda R.;Albom, Mark S.;Angeles, Thelma S.;Cheng, Mangeng;Ghose, Arup K.;Roemmele, Renee C.;Theroff, Jay P.;Underiner, Ted L.;Zificsak, Craig A.;Dorsey, Bruce D.. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Quality Control of 2,5-Difluorophenylacetyl chloride This article mentions the following:

Dysregulation of the anaplastic lymphoma kinase (ALK) is implicated in a variety of cancers. A series of tetrahydropyrido[2,3-b]pyrazines was constructed as ring-constrained analogs of a known aminopyridine kinase scaffold. Chem. was developed to rapidly elaborate the SAR, structural elements impacting ALK inhibitory activity were exploited, and kinase selective analogs were identified that inhibit ALK with IC₅₀ values âˆ?0 nM (enzyme) and âˆ?50 nM (cell). In the experiment, the researchers used many compounds, for example, 2,5-Difluorophenylacetyl chloride (cas: 157033-23-3Quality Control of 2,5-Difluorophenylacetyl chloride).

2,5-Difluorophenylacetyl chloride (cas: 157033-23-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 2,5-Difluorophenylacetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas was written by Tan, Davin;Strukil, Vjekoslav;Mottillo, Cristina;Friscic, Tomislav. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Recommanded Product: 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The authors demonstrate the first application of mechanochem. to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalyzed coupling of sulfonamides and iso(thio)cyanates. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of homo-bivalent GnRHR ligands was written by Bonger, Kimberly M.;van den Berg, Richard J. B. H. N.;Heitman, Laura H.;IJzerman, Ad P.;Oosterom, Julia;Timmers, Cornelis M.;Overkleeft, Herman S.;van der Marel, Gijsbert A.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.SDS of cas: 697-73-4 This article mentions the following:

G protein coupled receptors (GPCRs) are important drug targets in pharmaceutical research. Traditionally, most research efforts have been devoted towards the design of small mol. agonists and antagonists. An interesting, yet poorly investigated class of GPCR modulators comprise the bivalent ligands, in which two receptor pharmacophores are incorporated. Here, we set out to develop a general strategy for the synthesis of bivalent compounds based on the imidazopyrimidinone I that are projected to bind to the human gonadotropin-releasing hormone receptor (GnRHR). Our results on the dimerization of a known GnRHR antagonist, with as key step the Huisgen 1,3-cycloaddition, and their ability to bind to and antagonize GnRH-induced GnRHR stimulation, are presented here. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics