Tag: 100-200

Using choline nitrate as solvent and oxidant in direct oxidation of organic halides and alcohols to aldehyde and its derivatives was written by Jafari, Mohammadreza;Heydari, Akbar. And the article was included in Journal of Molecular Structure in 2022.Product Details of 620-19-9 This article mentions the following:

Choline nitrate was prepared by the anion exchange of choline chloride and sodium nitrate. Also, choline chloride gave a low m.p. mixture in the presence of aluminum nitrate. The use of choline nitrate as a safe and environmentally friendly solvent and reagent provided an efficient procedure, simple and mild for oxidizing alcs. and organic halides to aldehydes and ketones R-R¹ [R = Ph, 3-MeC₆H₄, 2-ClC₆H₄, etc.; R¹ = CHO, C(O)Me]. Aldehydes using choline nitrate and trimethylsilyl chloride mixture as a selective oxidant and without using catalysts were synthesized from alcs. and the relevant halides. Benzyl chloride in the presence of choline nitrate and trimethylsilyl chloride at 70°C produced the corresponding aldehyde product with 87% efficiency, while benzyl alc. at 50°C with 90% efficiency performed this conversion. The prepared aldehyde was easily separated from the reaction medium by vacuum distillation or extraction by organic solvent without the need for further purification In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Product Details of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed meta-Selective C-H Alkenylation and Acetoxylation of Arylacetic Acid Using a Pyrimidine Template was written by Jiao, Bo;Peng, Zhen;Dai, Zhen-Hua;Li, Lei;Wang, He;Zhou, Ming-Dong. And the article was included in European Journal of Organic Chemistry in 2019.Application of 6834-42-0 This article mentions the following:

In the presence of Pd(OAc)₂ and N-acetylglycine, pyrimidinylphenyl esters of arylacetic acids such as I underwent regioselective meta-selective alkenylation reactions with electron-deficient alkenes such as Et acrylate mediated by Ag₂CO₃ in hexafluoroisopropanol to yield alkenylarylacetate esters such as II. Using PhI(OAc)₂ as oxidant and Ac₂O, four of the pyrimidinylphenyl esters underwent regioselective acetoxylation to yield acetoxyphenylacetates. The pyrimidinylphenyl moiety was readily removable from the products and recovered. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type was written by Kapkova, Petra;Stiefl, Nikolaus;Suerig, Ulf;Engels, Bernd;Baumann, Knut;Holzgrabe, Ulrike. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2003.Synthetic Route of C7H5ClF2 This article mentions the following:

A novel series of acetylcholinesterase (AChE) inhibitors of the bispyridinium type was synthesized and the inhibitory activity against AChE and butyrylcholinesterase (BChE) measured. In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. Hence, the bisbenzyl ether of TMB-4 was further investigated. In order to obtain diverse lipophilic and electronic properties for these bisbenzyl bispyridinium derivatives (so-called DUO series), the lateral ring substitution was systematically varied. The lowest IC₅₀ value against AChE found thus far in the DUO series was 0.34 μM. Docking studies were carried out to elucidate the differences in biol. activity. A general binding mode for nearly all compounds could be identified by these investigations. In this binding mode, the docked ligands span the narrow, deeply buried active-site gorge, interacting with Trp84 at the bottom of the gorge, Tyr334 or Phe331 halfway down the gorge, and Trp279 at the peripheral anionic site at the mouth of the gorge. For specific ligands, addnl. interactions were found which helped to explain their deviating activity. Based on the promising characteristics of the novel acetylcholinesterase inhibitors presented, a series of structurally related, optimized candidates will be developed. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Synthetic Route of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological activity of substituted 1,2,4-triazolo[1,5-c]pyrimidine derivatives was written by Chen, Chaonan;Chen, Qiong;Yang, Guangfu. And the article was included in Youji Huaxue in 2009.Recommanded Product: 697-73-4 This article mentions the following:

A method for the synthesis of the title compounds is reported here. Several 2-(benzyloxy)-7-chloro-5-(methylthio)[1,2,4]triazolo[1,5-c]pyrimidine derivatives and 2-phenoxy[1,2,4]triazolo[1,5-c]pyrimidine derivatives were designed and synthesized using substituted 4-(hydrazinyl)pyrimidine as starting material. All compounds were confirmed by elemental anal., MS, NMR. A preliminary bioassay indicated that some compounds display good herbicidal and fungicidal activity. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reaction of phenylmagnesium bromide with halomethyl and α-bromobenzyl benzoates was written by Mizuch, K. G.;Gel’fer, Ts. M.. And the article was included in Doklady Akademii Nauk SSSR in 1950.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

Addition of 4.25 g. ClCH₆OBz to cold PhMgBr (from 2.9 g. Mg and 18.8 g. PhBr) in Et₂O below 5°, followed by standing in an ice bath 1 hr. and refluxing 30 min. gave, after the usual treatment with NH₄Cl solution, 1.5 g. Ph₂, 2.5 g. (92%) PhCH₂OH, b₁₅ 97-100°, and 5.95 g. (91.5%) Ph₃COH; no BzOH was isolated. Similarly, BrCH₂OBz gave 86% PhCH₂OH and 87.5% Ph₃COH, without any BzOH. PhMgBr (from 30.2 g. PhBr and 4.7 g. Mg) in Et₂O with 11.64 g. PhCHBrOBz gave 60% Ph₃COH, 1.6 g. Ph₂, 3.2 g. Ph₂CHOH (43.5%), 1.0 g. (10.4%) Ph₃CH, 1.47 g. (11%) tetraphenolethane, m. 209.6-10.6° (from AcOH), and 0.61 g. (12.6%) BzOH. Similar reaction of PhMgBr (from 1.76 g. Mg and 12.3 g. PhBr) with 5.76 g. Ph₂CHOBz gave 3.25 g. (88.2%) Ph₂CHOH and 4.73 g. Ph₃COH (90.9%), as well as 0.9 g. Ph₂. The results are explained, at least in part, by the reaction of RMgX with the 1st C atom of the ROH involved in the ester structure, caused principally by the presence of sufficiently electrophilic groups in the vicinity of the ester link. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D₂ dopaminergic ligands was written by Parraga, Javier;Cabedo, Nuria;Andujar, Sebastian;Piqueras, Laura;Moreno, Laura;Galan, Abraham;Angelina, Emilio;Enriz, Ricardo D.;Ivorra, Maria Dolores;Sanz, Maria Jesus;Cortes, Diego. And the article was included in European Journal of Medicinal Chemistry in 2013.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Dopamine-mediated neurotransmission plays an important role in relevant psychiatric and neurol. disorders. Nowadays, there is an enormous interest in the development of new dopamine receptors (DR) acting drugs as potential new targets for the treatment of schizophrenia or Parkinson’s disease. Previous studies have revealed that isoquinoline compounds such as tetrahydroisoquinolines (THIQs) and tetrahydroprotoberberines (THPBs) can behave as selective D₂ dopaminergic alkaloids since they share structural similarities with dopamine. In the present study we have synthesized eleven 2,3,9- and 2,3,11-trisubstituted THPB compounds (six of them are described for the first time) and evaluated their potential dopaminergic activity. Binding studies on rat striatal membranes were used to evaluate their affinity and selectivity towards D₁ and D₂ DR and establish the structure-activity relation (SAR) as dopaminergic agents. In general, all the tested THPBs with protected phenolic hydroxyls showed a lower affinity for D₁ and D₂ DR than their corresponding homologues with free hydroxyl groups. In previous studies in which dopaminergic affinity of 1-benzyl-THIQs (BTHIQs) was evaluated, the presence of a Cl into the A-ring resulted in increased affinity and selectivity towards D₂ DR. This is in contrast with the current study since the existence of a chlorine atom into the A-ring of the THPBs caused increased affinity for D₁ DR but dramatically reduced the selectivity for D₂ DR. An OH group in position 9 of the THPB (9f) resulted in a higher affinity for DR than its homolog with an OH group in position 11 (9e) (250 fold for D₂ DR). None of the compounds showed any cytotoxicity in freshly isolated human neutrophils. A mol. modeling study of three representative THPBs was carried out. The combination of MD simulations with DFT calculations provided a clear picture of the ligand binding interactions from a structural and energetic point of view. Therefore, compound I (2,3,9-trihydroxy-THPB) behave as D₂ DR agonist since serine residues cluster are crucial for agonist binding and receptor activation. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reaction of substituted benzenes and chloral. VIII. Fluorescent substances, by-products of reduction of DDT-type compounds with zinc dust and glacial acetic acid was written by Yasue, Masaichi;Takai, Yoshiharu. And the article was included in Yakugaku Zasshi in 1959.Electric Literature of C8H7ClO3 This article mentions the following:

[5,2-Me(MeO)C₆H₃]₂CHCl₃ (10 g.) in 200 ml. AcOH treated portionwise with 50 g. Zn, heated 3 hrs., the solution filtered, the filtrate concentrated in vacuo, the residue extracted with Et₂O, the Et₂O removed, and the residue in petr. ether cooled gave 4.1 g. [5,2-Me(MeO)C₆H₃]₂CHMe, m. 56-7°, and the mother liquor concentrated gave 0.3 g. fluorescent substance (I), columns, m. 157°. Oxidation of I with KMnO₄ yielded 5,2-Me(MeO)C₆H₃CO₂H, m. 67°, suggesting that the I is a stilbene derivative The reduction product of [5,2-Cl(MeO)C₆H₃]₂CHCCl₃ also showed fluorescence but the fluorescent compound was not isolated. KMnO₄ oxidation of the crude product yielded a nonfluorescent ethane compound and 5,2-Cl(MeO)C₆H₃CO₂H. The same treatment of Ph₂CHCCl₃ yielded a small amount of stilbene as the by-product. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Electric Literature of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor was written by Maloney, Patrick R.;Khan, Pasha;Hedrick, Michael;Gosalia, Palak;Milewski, Monika;Li, Linda;Roth, Gregory P.;Sergienko, Eduard;Suyama, Eigo;Sugarman, Eliot;Nguyen, Kevin;Mehta, Alka;Vasile, Stefan;Su, Ying;Stonich, Derek;Nguyen, Hung;Zeng, Fu-Yue;Novo, Arianna Mangravita;Vicchiarelli, Michael;Diwan, Jena;Chung, Thomas D. Y.;Smith, Layton H.;Pinkerton, Anthony B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: chlorides-buliding-blocks This article mentions the following:

The recently discovered apelin/APJ system has emerged as a critical mediator of cardiovascular homeostasis and is associated with the pathogenesis of cardiovascular disease. A role for apelin/APJ in energy metabolism and gastrointestinal function has also recently emerged. We disclose the discovery and characterization of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221), a potent APJ functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. ML221 was derived from an HTS of the âˆ?30,600 compound MLSMR collection. This antagonist showed no significant binding activity against 29 other GPCRs, except to the κ-opioid and benzodiazepinone receptors (<50/<70%I at 10 μM). The synthetic methodol., development of structure-activity relationship (SAR), and initial in vitro pharmacol. characterization are also presented. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans was written by Yang, Pengfei;Xu, Weiyan;Wang, Rongchao;Zhang, Min;Xie, Chunsong;Zeng, Xiaofei;Wang, Min. And the article was included in Organic Letters in 2019.COA of Formula: C8H9Cl This article mentions the following:

An efficient and facile method to synthesize valuable disubstituted 2-aryl indoles and benzofurans in good yields has been demonstrated, based on a tert-butoxide-mediated condensation reaction involving a vinyl sulfoxide intermediate. Products are obtained from N- or O-benzyl benzaldehydes using DMSO as a carbon source. The methodol. features a wide functional group tolerance and transition metal-free environment. Preliminary mechanistic studies suggest that the reaction involves a tandem aldol reaction/Michael addition/dehydrosulfenylation/isomerization sequence through an ionic protocol. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9COA of Formula: C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO₃)₃·9H₂O was written by Thurow, Samuel;Fernandes, Alessandra A. G.;Quevedo-Acosta, Yovanny;de Oliveira, Matheus F.;de Oliveira, Marcelo G.;Jurberg, Igor D.. And the article was included in Organic Letters in 2019.Recommanded Product: 6834-42-0 This article mentions the following:

A thermal protocol is reported for the formal insertion of nitric acid into aryldiazoacetates using Fe(NO₃)₃·9H₂O. This strategy is mild and high yielding and gave a large variety of members of an unprecedented family of organic nitrates. The nitrate group can be also readily transformed into other functional groups and heterocyclic moieties and can possibly allow new biol. explorations of untapped potential associated with their NO-releasing ability. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics