Tag: 100-200

The design and synthesis of purine inhibitors of CDK2. III was written by Shum, P. W.;Peet, N. P.;Weintraub, P. M.;Le, T. B.;Zhao, Z.;Barbone, F.;Cashman, B.;Tsay, J.;Dwyer, S.;Loos, P. C.;Powers, E. A.;Kropp, K.;Wright, P. S.;Bitonti, A.;Dumont, J.;Borcherding, D. R.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2001.Related Products of 697-73-4 This article mentions the following:

Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biol. effects. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Related Products of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis was written by Pistritto, Vincent A.;Schutzbach-Horton, Megan E.;Nicewicz, David A.. And the article was included in Journal of the American Chemical Society in 2020.Product Details of 202925-07-3 This article mentions the following:

Nucleophilic aromatic substitution (S_NAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics. In the experiment, the researchers used many compounds, for example, 2-Chloro-1-fluoro-4-methoxybenzene (cas: 202925-07-3Product Details of 202925-07-3).

2-Chloro-1-fluoro-4-methoxybenzene (cas: 202925-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 202925-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactions of ketene acetals, ketene thioacetals, and ketene aminals with ethyl benzoylazocarboxylate was written by Hall, J. Herbert;Wojciechowska, Magdalena. And the article was included in Journal of Organic Chemistry in 1978.Electric Literature of C9H9ClO2 This article mentions the following:

Et benzoylazocarboxylate (I) reacts regiospecifically at room temperature with ketene acetals [e.g. PhCH:C(OMe)₂] to give 2-phenyl-4-carboethoxy-6,6-dialkoxy-5,6-dihydrooxadiazines (e.g. II) together with 1,1-dialkoxy-2-(N-carboethoxy-N‘-benzoylhydrazinyl)ethylenes. Treating ketene thioacetals similarly gives only the hydrazinylketene dialkyl thioacetals. 1,1-Di(N-morpholinyl)ethylene reduces I to the dianion and a paramagnetic species, probably the cation radical of the aminal. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Electric Literature of C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective synthesis of N,N-dimethyl aniline derivatives using dimethyl carbonate as a methylating agent and onium salt as a catalyst was written by Shivarkar, Anand B.;Gupte, Sunil P.;Chaudhari, Raghunath V.. And the article was included in Journal of Molecular Catalysis A: Chemical in 2005.COA of Formula: C8H10ClN This article mentions the following:

N-Alkylation of anilines by di-Me carbonate (DMC) catalyzed by onium salts has been demonstrated. The work shows that a simple catalytic system consisting of onium salts in the presence of a small amount of water is extremely effective in enhancing the DMC mediated N-alkylation of anilines to dialkylated products. The effect of reaction conditions, on the synthesis of N,N-di-methylaniline (NNDMA) from aniline and DMC has been investigated. Under the optimized conditions highest yield of NNDMA obtained was 99.8%, which is the best reported for liquid phase N-alkylation of aniline using DMC. The role of water in enhancing the yield of NNDMA is explained and a reaction-networking scheme is constructed, which summarizes the chem. behind liquid phase N-alkylation of anilines by DMC. The catalyst has been shown to recycle up to five times and at the end of fifth recycle almost 98% of NNDMA yields were obtained. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of calycanthaceous alkaloid analogs was written by Zheng, Shaojun;Zhu, Rui;Zhou, Xinping;Chen, Lizhuang;Bai, Hongjin;Zhang, Jiwen. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Starting from 9-methyl-1,2,3,4,9,9a-hexahydro-4aH-pyrido[2,3-b]indol-4a-ol, or indole-3-acetonitrile, 40 new calycanthaceous alkaloid analogs were synthesized in excellent yields. The prepared compounds were evaluated for biol. activity against acetylcholinesterase and a broad range of plant pathogen fungi. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity than the pos. control. Notably, compounds I and II showed higher activity against Verticillium dahlia than chlorothalonil, with MIC values of 62.5 and 7.81μg mL^-1, resp. Compound III had a higher activity against Bacillus cereus, with a MIC value of 15.63μg mL^-1. Compounds IV and V revealed potent activity against acetylcholinesterase, with MIC values of 0.01 and 0.1 ng mL^-1, resp. Anal. of the mol. docking modes of IV and V with Torpedo californica acetylcholinesterase indicated a medium strong hydrogen bond interaction between the hydroxyl groups of both the ligands and the phenolic hydroxyl of Try121 at a distance of approx. 2.4 Å. The results obtained in this study will be useful for the further design and structural optimization of calycanthaceous alkaloids as potential agrochem. lead compounds for plant disease control. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of Novel Substituted N-(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors was written by Xu, Jimin;Berastegui-Cabrera, Judith;Ye, Na;Carretero-Ledesma, Marta;Pachon-Diaz, Jeronimo;Chen, Haiying;Pachon-Ibanez, Maria Eugenia;Sanchez-Cespedes, Javier;Zhou, Jia. And the article was included in Journal of Medicinal Chemistry in 2020.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. Herein the synthesis and evaluation of a series of novel substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogs, e.g., I (R¹ = H, R² = H, MeCO, Et, cyclopentyl, PhCH₂, 4-pyridylmethyl, etc.; R¹ = R² = Me, Et, N-Pr, cyclopropylmethyl; etc.), as potent HAdV inhibitors are reported. Compounds I (R¹ = H; R² = cyclopentyl, 1-methylcyclopentyl, 4-HOC₆H₄CH₂, 2-hydroxy-5-pyridylmethyl, HOCH₂CH₂CMe₂, HOCH₂CH₂CHMe, N-Boc-piperidin-4-ylmethyl) and I (R¹ = PhCH₂CMe₂O; R² = PhCH₂CMe₂) exhibited increased selectivity indexes (SI > 100) compared to the lead compound niclosamide, while maintaining sub-micromolar to low micromolar potency against HAdV. The preliminary mechanistic studies indicated that compounds I (R¹ = H; R² = cyclopentyl) and I (R¹ = PhCH₂CMe₂O; R² = PhCH₂CMe₂) possibly target the HAdV DNA replication process, while compounds I (R¹ = H; R² = HOCH₂CH₂CHMe, HOCH₂CH₂CMe₂) suppress later steps of HAdV life cycle. Notably, among these derivatives, compound I (R¹ = H; R² = 1-methylcyclopentyl) showed improved anti-HAdV activity (IC₅₀ = 0.27μM), significantly decreased cytotoxicity (CC₅₀ = 156.8μM), and low in vivo toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further in vivo efficacy studies for the treatment of HAdV infections. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Multifunctional donepezil analogues as cholinesterase and BACE1 inhibitors was written by Green, Keith D.;Fosso, Marina Y.;Garneau-Tsodikova, Sylvie. And the article was included in Molecules in 2018.Recommanded Product: 697-73-4 This article mentions the following:

A series of 22 donepezil analogs were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes responsible for the hydrolysis of the neurotransmitter acetylcholine in Alzheimer’s disease patient brains. Many of them displayed lower inhibitory concentrations of EeAChE (IC₅₀ = 0.016 ± 0.001 μM to 0.23 ± 0.03 μM) and EfBChE (IC₅₀ = 0.11 ± 0.01 μM to 1.3 ± 0.2 μM) than donepezil. One of the better compounds was tested against HsAChE and was found to be even more active than donepezil and inhibited HsAChE better than EeAChE. The analogs with the aromatic substituents were generally more potent than the ones with aliphatic substituents. Five of the analogs also inhibited the action of β-secretase (BACE1) enzyme. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists was written by Wendt, John A.;Deeter, Susan D.;Bove, Susan E.;Knauer, Christopher S.;Brooker, Rachel M.;Augelli-Szafran, Corinne E.;Schwarz, Roy D.;Kinsora, Jack J.;Kilgore, Kenneth S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application In Synthesis of 3-Cyanobenzoyl chloride This article mentions the following:

A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists I (R = Me, X = 2-methoxy, 3-cyano, 3,5-Cl₂, etc.; R = H, X = 3-cyano, 3-bromo, 3-methyl-5-fluoro, etc.) are described. The synthesis and pharmacol. activities of these analogs are discussed. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application In Synthesis of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and herbicidal activities of 2-[3-(2-substituted phenyl)-1H-pyrazol-1-yl]-4,6-dimethoxypyrimidine derivatives was written by Li, Yuanxiang;Lin, Long;Chen, Qiong. And the article was included in Youji Huaxue in 2011.SDS of cas: 697-73-4 This article mentions the following:

Twenty two novel 2-[3-(2-substitutedphenyl)-1H-pyrazol-1-yl]-4,6-dimethoxypyrimidine derivatives have been designed and synthesized using 1-(2-hydroxyphenyl)ethanone as starting material. All synthesized compounds were confirmed by ¹H NMR, MS techniques and elemental anal. The preliminary bioassay showed that some of them exhibited certain herbicidal activities. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds was written by Kong, Xianqiang;Wang, Yuchang;Chen, Yiyi;Chen, Xiaohui;Lin, Long;Cao, Zhong-Yan. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C8H10ClN This article mentions the following:

A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Electric Literature of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics