Tag: 100-200

Cu-Catalyzed intermolecular [3 + 3] annulation involving oxidative activation of an unreactive C(sp³)-H bond: access to pyrimidine derivatives from amidines and ketones was written by Guo, Wei;Liu, Dongqing;Liao, Jianhua;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Organic Chemistry Frontiers in 2017.HPLC of Formula: 18637-02-0 This article mentions the following:

A facile and efficient approach for the synthesis of various pyrimidine derivatives, e.g., I from amidines RC(NH₂)=NH (R = Me, Ph, 4-pyridyl, cyclopropyl, etc.) and ketones, e.g., 4-CH₃OC₆H₄C(O)CH₂CH₃ via a Cu-catalyzed intermol. oxidative coupling process using TEMPO/O₂ as a co-oxidant has been developed. This novel protocol features unreactive C(sp³)-H bond amination, a wide range of substrates, good functional group tolerance and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of fluorine substitution of α- and β-hydrogen atoms in ethyl phenylacetate and phenylpropionate on their stereoselective hydrolysis by cultured cancer cells was written by Yamazaki, Yoshimitsu;Yusa, Shiro;Kageyama, Yu-ichi;Tsue, Hirohito;Hirao, Ken-ichi;Okuno, Hiroaki. And the article was included in Journal of Fluorine Chemistry in 1996.Recommanded Product: 7476-66-6 This article mentions the following:

(±)-Et 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The stereoselectivity increased for (±)-Et 2-fluoro-2-phenylpropionate (I) with all present cell lines and for (±)-Et 2-phenyl-3,3,3-trifluoropropionate with rat hepatoma McA-RH7777 cell line. The stereoselectivity was different for the different cell lines, as McA-RH7777 cells preferred (R)-I in contrast with the preference towards (S)-I by other cells such as ras oncogene-transformed rat liver Anr4 cells. These stereoselectivities were different from those for non-fluorinated (±)-Et 2-phenylpropionate. Thus fluorine atoms are recognized by ester hydrolases of cancer cells, and fluorine substitution on the acyl group will be useful for making ester-type anticancer prodrugs more specific to cancer cells. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and in vitro anti-Helicobacter pylori activity of 2-(substituted benzylthio)-5-(5-nitro-2-furyl)-1,3,4-thiadiazole derivatives was written by Mohammadhosseini, Negar;Asadipour, Ali;Letafat, Bahram;Vosooghi, Mohsen;Siavoshi, Farideh;Shafiee, Abbas;Foroumadi, Alireza. And the article was included in Turkish Journal of Chemistry in 2009.Product Details of 697-73-4 This article mentions the following:

Starting from (5-nitrofuran-2-yl)methylene diacetate, a series of 2-[(substituted benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles were synthesized and characterized. The in vitro anti-Helicobacter pylori activity of the synthesized compounds was evaluated by the disk diffusion method against the clin. isolates of Helicobacter pylori. The results indicated that most of the synthesized compounds exhibited significant inhibitory activity against H. pylori with respect to standard drug metronidazole. Compound I, containing the 2-chloro-6-fluorobenzylthio moiety, was the most potent compound tested. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A facile total synthesis of estrogens was written by Daniewski, Andrzej Robert;Kiegiel, Jaroslaw. And the article was included in Journal of Organic Chemistry in 1988.Application of 6834-42-0 This article mentions the following:

Indandione I, obtained by the stereoselective addition of 3-MeOC₆H₄CH₂CHO to 5,6,7,7a-tetrahydro-7a-methyl-1,5-indandione, was transformed into 3-Me ethers of equilenin, 7-hydroxyequilenin, and 9(11)-dehydroestrone, as well as its 7β and 7α hydroxy derivatives II. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-(acyloxymethyl)sulfonamide prodrugs was written by Calheiros, Teresa;Iley, Jim;Lopes, Francisca;Moreira, Rui. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1995.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

Tertiary N-(acyloxymethyl)sulfonamide prodrugs R¹SO₂NR²CH₂OCOR³ (R¹ = 4-MeC₆H₄, 4-ClC₆H₄, 4-O₂NC₆H₄, 4-H₂NC₆H₄, R² = Me, Et, Pr CHMe₂, Bu, Q, Q¹, R³ = Ph, CMe₃, Q²), encompassing penicillin and sulfonamide antibiotics, have been synthesized. The pH-independent hydrolysis of these compounds occurs via the rate-determining formation of an N-sulfonyl iminium ion. SCF-MO calculations using the PM3 method indicate that iminium ion formation is slightly favored, when compared with the corresponding amides, by ca. 10 kJmol^-1. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trichloroisocyanuric acid oxidation of 2-chloro aldehyde acetals to 2-chloro acid esters was written by Boni, Monica;Ghelfi, Franco;Pagnoni, Ugo Maria;Pinetti, Adriano. And the article was included in Bulletin of the Chemical Society of Japan in 1994.Application In Synthesis of Methyl 2-chloro-2-phenylacetate This article mentions the following:

2-Chloro acid Me esters were prepared in good yields by treating 2-chloro aldehyde di-Me acetals with trichloroisocyanuric acid in DMF. Aldehyde di-Me acetals with the 2-halogen on a tertiary carbon atom were poorly reactive and could be oxidized efficiently only after their transformation into 1,3-dioxolanes. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application In Synthesis of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Multistep Solvent-Free 3 m² Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor was written by Escriba-Gelonch, Marc;de Leon Izeppi, Gerardo Antonio;Kirschneck, Dirk;Hessel, Volker. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.SDS of cas: 697-73-4 This article mentions the following:

The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. Complex steps such as Taylor-flow, segmented flow, and high-temperature processing at high pressure (high-p,T) are successfully combined, overcoming the mixing and heat transfer issues of the scale-up. The cascaded multistep process operates essentially solvent-free in just 3 m² giving a productivity of 47 g/h (>400 kg/yr), which increases by a factor of 7 the lab-scale productivity previously reported as a scale-up proof-of-concept. This publication also includes an economic study of the feasible implementation of this technol. for a possible manufacturer, as well as an outline on business development strategies of how to implement such a disruptive technol. The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAA C “click” chemistry as potential anticancer agents was written by Jin, Xin;Yan, Tian-Hua;Yan, Lan;Li, Qian;Wang, Rui-Lian;Hu, Zhen-Lin;Jiang, Yuan-Ying;Sun, Qing-Yan;Cao, Yong-Bing. And the article was included in Drug Design, Development and Therapy in 2014.HPLC of Formula: 697-73-4 This article mentions the following:

A series of novel derivatives of phenyl-substituted berberine triazolyls has been designed and synthesized via copper-catalyzed azide-alkyne cycloaddition click chem. in an attempt to develop antitumor agents. All of the compounds were evaluated for anticancer activity against a panel of three human cancer cell lines, including MCF-7 (breast), SW-1990 (pancreatic), and SMMC-7721 (liver) and the noncancerous human umbilical vein endothelial cell (HUVEC) cell lines. The results indicated that most of the compounds displayed notable anticancer activities against the MCF-7 cells compared with berberine. Among these derivatives, compound 16 showed the most potent inhibitory activity against the SW-1990 and SMMC-7721 cell lines, with half-maximal inhibitory concentration (IC₅₀) values of 8.54±1.97 μM and 11.87±1.83 μM, resp. Compound 36 exhibited the most potent inhibitory activity against the MCF-7 cell line, with an IC₅₀ value of 12.57±1.96 μM. Compound 16 and compound 36 exhibited low cytotoxicity in the HUVEC cell line, with IC₅₀ values of 25.49±3.24 μM and 30.47±3.47 μM. Furthermore, compounds 14, 15, 16, 17, 18, 32, and 36 exhibited much better selectivity than berberine toward the normal cell line HUVEC. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4HPLC of Formula: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile synthesis of a series of non-symmetric thioethers including a benzothiazole moiety and their use as efficient in vitro anti-Trypanosoma cruzi agents was written by Avila-Sorrosa, Alcives;Tapia-Alvarado, Jazz D.;Nogueda-Torres, Benjamin;Chacon-Vargas, Karla Fabiola;Diaz-Cedillo, Francisco;Vargas-Diaz, Maria Elena;Morales-Morales, David. And the article was included in Molecules in 2019.Reference of 697-73-4 This article mentions the following:

A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives I (R = H, 4-MeO, 4-F, etc.) were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Reference of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing was written by Nagaki, Aiichiro;Sasatsuki, Kengo;Ishiuchi, Satoshi;Miuchi, Nobuyuki;Takumi, Masahiro;Yoshida, Jun-ichi. And the article was included in Chemistry – A European Journal in 2019.HPLC of Formula: 3438-16-2 This article mentions the following:

Synthesis of ketones containing various functional groups from acid halides bearing electrophilic functional groups and functionalized organolithiums was achieved using a flow microreactor system. Extremely fast mixing was important for high chemoselectivity. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2HPLC of Formula: 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics