Tag: 100-200

Preparation, characterization and catalytic study of a nano-inorganic composite of CuO/NiO for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water was written by Beni, Zohreh Hashemi;Albadi, Jalal;Kiyani, Hamzeh. And the article was included in Inorganic and Nano-Metal Chemistry.Application of 620-19-9 This article mentions the following:

In this research, a nano-inorganic composite of CuO/NiO is prepared by co-precipitation method as an efficient recyclable nanocatalyst for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water. The catalyst was characterized by several techniques such as the field emission SEM (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), x-ray fluorescence, inductively coupled plasma at. emission spectroscopy (ICP-OES), and brunauer-emmett-teller (BET) surface area anal. The regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles was carried out from reaction of various benzyl halides or alkyl halides with Ph acetylene and sodium azide in water under reflux condition in high yields. The CuO/NiO nanocatalyst can be simply recovered and reused 6 runs without a significant slight in activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular reactions of N-nitrenes: oxidation of 3-amino-2-(arylalkyl)quinazolin-4(3H)-ones was written by Atkinson, Robert S.;Malpass, John R.;Woodthorpe, Katherine L.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:

Oxidation of quinazolines I (R = OMe; R¹ = H, OMe; R² = NH₂; n = 2) with Pd(OAc)₄ in CH₂Cl₂ at room temperature gave I (same R, R¹, n; R² = H) (II) and the diazepines III (R = H, OMe; R¹ ≠ R² = H, OMe) via the corresponding N-nitrene intermediates. On oxidation under analogous conditions I (n = 2, R = H, R¹ = OMe; n = 1, R ≠ R¹ = H, OMe; R² = NH₂) gave only the deamination products II. Azepine formation involves electrophilic aromatic substitution by the nitrene on the aromatic ring via a 7-membered transition state. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents was written by Singh, Meenakshi;Singh, Sudhir K.;Gangwar, Mayank;Nath, Gopal;Singh, Sushil K.. And the article was included in RSC Advances in 2014.Synthetic Route of C8H7ClO3 This article mentions the following:

In this study ten benzothiazole derivatives bearing the amide moiety were designed, synthesized and evaluated for their antibacterial activity and possible mode of action. Structures of the synthesized compounds were elucidated by spectral data. Four different Gram-neg. and two different Gram-pos. bacterial strains were used in antibacterial activity tests. Among all the synthesized compounds, compound A07 displayed the most potent inhibitory activity with min. inhibitory concentration (MIC) values of 15.6, 7.81, 15.6, 3.91 μg ml^-1 against S. aureus, E. coli, S. typhi and K. pneumoniae resp. Structure-activity relationship (SAR) studies revealed that electronic and lipophillic factors of the Ph ring had a significant effect on the antimicrobial activity of the designed compounds The benzothiazole bearing amide (A01-A10) series exhibited different modes of action based on aryl group substitution as revealed by studies on intact bacterial cells and plasmid DNA. The present study provides us two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode of action due to binding with DNA along with potent activity against clin. relevant pathogens E. coli and S. aureus. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Synthetic Route of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic reduction of organic halogen compounds was written by Rosenmund, Karl W.;Zetzsche, Fritz. And the article was included in Berichte der Deutschen Chemischen Gesellschaft in 1918.Synthetic Route of C4H5ClO2 This article mentions the following:

Colloidal Pd protected with gum arabic or palladinized BaSO₄ is an efficient catalyst in the removal of halogen from organic compounds with H and it is usually advisable to have an alkali present to neutralize the halogen acid as it is formed. Many substances react even if merely suspended in aqueous alkalies. In halogen derivatives of ethylenic compounds the halogen may sometimes be removed without saturating the C:C linking or the halogen derivative of the saturated compound may be formed. Frequently the reaction proceeds smoothly to hydrogenation and removal of the halogen. With dihalogen compounds it is apparently impossible to obtain mono-derivatives As illustrations the following reductions are described: PhBr to C₆H₆, o-BrC₆H₄CO₂H, to BzOH, p-BrC₆H₄NO₂ to PhNH₂, chlorocaffeine to caffeine, chlorocrotonic to crotonic acid, o-ClC₆H₄CH:CHCO₂H to PhCH₂-CH₂CO₂H, (CHBrCO₂H)₂ to (CH₂CO₂H)₂. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Synthetic Route of C4H5ClO2).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C4H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial evaluation of nitazoxanide-based analogs: Identification of selective and broad spectrum activity was written by Ballard, T. Eric;Wang, Xia;Olekhnovich, Igor;Koerner, Taylor;Seymour, Craig;Salamoun, Joseph;Warthan, Michelle;Hoffman, Paul S.;MacDonald, Timothy L.. And the article was included in ChemMedChem in 2011.Synthetic Route of C5H2Cl2O2S This article mentions the following:

A library composed of nitazoxanide-based analogs was synthesized and assayed for increased antibacterial efficacy against the pyruvate-ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organism,s and select analogs were tested for their ability to disrupt the PFOR enzyme directly. The library was also screened for activity against staphylococci and resulted in the identification of analogs capable of inhibiting both staphylococci and all PFOR organisms at low micromolar min. inhibitory concentrations with low toxicity to human foreskin cells. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Synthetic Route of C5H2Cl2O2S).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C5H2Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cu(OTf)₂ catalyzed three component strategy for the synthesis of thienopyridine containing spirooxindoles and their cytotoxic evaluation was written by Parthasarathy, K.;Praveen, C.;Kumar, P. Senthil;Balachandran, C.;Perumal, P. T.. And the article was included in RSC Advances in 2015.Name: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Synthesis of novel spirooxindoles e.g., I [R¹ = R² = H; Z = C(O)OCH₃; R = 2,5-F₂C₆H₃CH₂] via a three component reaction of thienopyridines, isatins and malononitriles under copper catalysis was accomplished. This one-pot, room temperature protocol allowed the synthesis of diversely substituted spirooxindoles I in excellent yield. Cytotoxicity towards COLO320 cells revealed that compound I possessing a 2,6-difluorobenzyl group (IC₅₀ of 49.1 μM) was found to be highly potent among the screened compounds In addition, mol. docking of compound I into caspase-3 receptors exhibited the largest binding energy (-10.5 kcal mol^-1) compared to other compounds The formation of a DNA ladder for compound I also supports the exptl. results. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Name: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biocatalytic Enantioselective Oxidative C-C Coupling by Aerobic C-H Activation was written by Schrittwieser, Joerg H.;Resch, Verena;Sattler, Johann H.;Lienhart, Wolf-Dieter;Durchschein, Katharina;Winkler, Andreas;Gruber, Karl;Macheroux, Peter;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2011.Computed Properties of C9H9ClO2 This article mentions the following:

The berberine bridge enzyme (BBE) was employed for the first preparative oxidative biocatalytic C-C coupling that leads to a new intramol. bond. This unique transformation requires O₂ as sole stoichiometric oxidant and gives access to novel optically pure (S)-berbine and (R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloid derivatives by kinetic resolution In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Computed Properties of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

H₂O₂ production at gas-diffusion cathodes made from agarose-derived carbons with different textural properties for acebutolol degradation in chloride media was written by Zhang, Yanyu;Daniel, Giorgia;Lanzalaco, Sonia;Isse, Abdirisak Ahmed;Facchin, Alessandro;Wang, Aimin;Brillas, Enric;Durante, Christian;Sires, Ignasi. And the article was included in Journal of Hazardous Materials in 2022.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

The excessive cost, unsustainability or complex production of new highly selective electrocatalysts for H2O2 production, especially noble-metal-based ones, is prohibitive in the water treatment sector. To solve this conundrum, biomass-derived carbons with adequate textural properties were synthesized via agarose double-step pyrolysis followed by steam activation. A longer steam treatment enhanced the graphitization and porosity, even surpassing com. carbon black. Steam treatment for 20 min yielded the greatest surface area (1248 m2 g-1), enhanced the mesopore/micropore volume distribution and increased the activity (E1/2 = 0.609 V) and yield of H2O2 (40%) as determined by RRDE. The upgraded textural properties had very pos. impact on the ability of the corresponding gas-diffusion electrodes (GDEs) to accumulate H2O2, reaching Faradaic current efficiencies of ∼95% at 30 min. Acidic solutions of β-blocker acebutolol were treated by photoelectro-Fenton (PEF) process in synthetic media with and without chloride. In urban wastewater, total drug disappearance was reached at 60 min with almost 50% mineralization after 360 min at only 10 mA cm-2. Up to 14 degradation products were identified in the Cl–containing medium. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases was written by Ghidini, Eleonora;Marchini, Gessica;Capelli, Anna Maria;Carnini, Chiara;Cenacchi, Valentina;Fioni, Alessandro;Facchinetti, Fabrizio;Rancati, Fabio. And the article was included in Journal of Medicinal Chemistry in 2018.Name: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Inhaled corticosteroids (ICSs) represent the first line therapy for the treatment of asthma and are also extensively utilized in chronic obstructive pulmonary disease. Our goal was to develop a new ICS with a basic group, which can allow solid state feature modulation, achieving at the same time high local anti-inflammatory effect and low systemic exposure. Through a rational drug design approach, a new series of pyrrolidine derivatives of budesonide was identified. Within the series, several compounds showed nanomolar binding affinity (K_i) with GR that mostly correlated with the effect in inducing GR nuclear translocation in CHO cells and anti-inflammatory effects in macrophagic cell lines. Binding and functional cell-based assays allowed identifying compound 17 as a potent ICS agonist with a PK profile showing an adequate lung retention and low systemic exposure in vivo. Finally, compound 17 proved to be more potent than budesonide in a rat model of acute pulmonary inflammation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Name: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents was written by Dong, Shiyang;Liu, Yanhua;Xu, Jun;Hu, Yue;Huang, Limin;Wang, Zengtao. And the article was included in CNS & Neurological Disorders: Drug Targets in 2019.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Background: Epilepsy is a serious and common neurol. disorder threatening the health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present many limitations. These limitations prompted the development of more safer and effective AEDs. Methods: A series of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)- 2-thioxothiazolidin-4- one derivatives and 5-substituted-thioxothiazolidindione derivatives were designed, synthesized and tested for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ). Neurotoxicity was determined by the rotarod test. Results: Among them, the most potent 4e displayed high protection against MES-induced seizures with an ED50 value of 9.7 mg/kg and TD50 value of 263.3 mg/kg, which provided 4e with a high protective index (TD50/ED50) of 27.1 comparable to reference antiepileptic drugs. 4e clearly inhibits the NaV1.1 channel in vitro. The mol. docking study was conducted to exploit the results. Conclusion: Stiripentol is a good lead compound for further structural modification. Compound 4e was synthesized, which displayed remarkable anticonvulsant activities, and the NaV1.1 channel inhibition was involved in the mechanism of action of 4e. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics