Tag: 100-200

Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by benzoate modified β-cyclodextrin derivatives: switching of product chirality by solvent was written by Li, Guangxun;Wang, Zhizhong;Lu, Runhua;Tang, Zhuo. And the article was included in Tetrahedron Letters in 2011.COA of Formula: C8H4ClNO This article mentions the following:

Solvent effect upon asym. photosensitization was studied in the enantiodifferentiating photoisomerization of cyclooctene(1Z), sensitized by benzoate modified β-cyclodextrin derivatives bearing nitrogen, oxygen or sulfur substituents. The enantiomeric excess (ee) and E/Z ratio of reaction products were susceptible to the concentration of methanol in the aqueous solution, which could switch to the chirality of product unprecedentedly. Further the conformation of the modified CDs in aqueous methanol solutions with 1Z were highly sensitive to both the substituent(s) on benzoate moiety of the modified CDs and the concentration of methanol. Solvent content represents a new versatile tool to efficiently manipulate the asym. photochem. reactions, in which the chirality of products can be switched by simply changing the methanol content of reaction solvent rather than synthesizing the antipodal sensitizers. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1COA of Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Novel Insecticides Based on the Serotonergic Ligand 1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) was written by Cai, Mingyi;Li, Zhong;Fan, Feng;Huang, Qingchun;Shao, Xusheng;Song, Gonghua. And the article was included in Journal of Agricultural and Food Chemistry in 2010.SDS of cas: 697-73-4 This article mentions the following:

1-[(4-Aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP) is a 5-HT_1A agonist and was reported to display high affinity for serotonin (5-HT) receptor from the parasitic nematode Haemonchus contortus. The present investigation explored the possibility of using PAPP as a lead compound of new insecticides with novel mode of action. On the basis of the PAPP scaffold, a series of 1-arylmethyl-4-[(trifluoromethyl)pyridin-2-yl]piperazine derivatives were designed, synthesized, and evaluated for biol. activities against the armyworm Pseudaletia separata (Walker). Bioassays showed that most of the target compounds displayed certain growth-inhibiting activities or larvicidal activities against armyworm. The quant. structure-activity relationship (QSAR) for growth-inhibiting activities was also analyzed and established. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis was written by Madaiah, Malavalli;Prashanth, Maralekere K.;Revanasiddappa, Hosakere D.;Veeresh, Bantal. And the article was included in New Journal of Chemistry in 2016.Recommanded Product: 3-Cyanobenzoyl chloride This article mentions the following:

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacol. activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg^-1 body weight In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives was written by Li, Xu-Jun;Zhang, Wei;Zhao, Chi-Na;Wu, Qing-Lai;Li, Jun-Kai;Xu, Zhi-Hong. And the article was included in Journal of Asian Natural Products Research in 2021.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Concise synthesis of 3,4-dihydro-1,4-benzoxazines by three-component reactions of acyl chlorides, o-aminophenols and 1,2-dichloroethane was written by Liu, Yunyun;Chen, Xuwen. And the article was included in Tetrahedron in 2018.Product Details of 6834-42-0 This article mentions the following:

The Cu(OAc)₂-catalyzed three-component reactions of o-aminophenols R¹-2-NH₂C₆H₃OH (R¹ = H, 4-CH₃, 5-CH₃), acyl chlorides R²C(O)Cl (R² = C₆H₅, furan-2-yl, (E)-C₆H₅CH=CH, etc.) and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines) I (R³ = H, 6-CH₃, 7-CH₃). This method features advantages of the one-pot operation enabling N-acylation, C-Cl bond amidation and etherification, as well as the structural divergence of the synthesized products. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Product Details of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation, characterization and catalytic study of a nano-inorganic composite of CuO/NiO for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water was written by Beni, Zohreh Hashemi;Albadi, Jalal;Kiyani, Hamzeh. And the article was included in Inorganic and Nano-Metal Chemistry.Application of 620-19-9 This article mentions the following:

In this research, a nano-inorganic composite of CuO/NiO is prepared by co-precipitation method as an efficient recyclable nanocatalyst for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles in water. The catalyst was characterized by several techniques such as the field emission SEM (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), x-ray fluorescence, inductively coupled plasma at. emission spectroscopy (ICP-OES), and brunauer-emmett-teller (BET) surface area anal. The regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles was carried out from reaction of various benzyl halides or alkyl halides with Ph acetylene and sodium azide in water under reflux condition in high yields. The CuO/NiO nanocatalyst can be simply recovered and reused 6 runs without a significant slight in activity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular reactions of N-nitrenes: oxidation of 3-amino-2-(arylalkyl)quinazolin-4(3H)-ones was written by Atkinson, Robert S.;Malpass, John R.;Woodthorpe, Katherine L.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:

Oxidation of quinazolines I (R = OMe; R¹ = H, OMe; R² = NH₂; n = 2) with Pd(OAc)₄ in CH₂Cl₂ at room temperature gave I (same R, R¹, n; R² = H) (II) and the diazepines III (R = H, OMe; R¹ ≠ R² = H, OMe) via the corresponding N-nitrene intermediates. On oxidation under analogous conditions I (n = 2, R = H, R¹ = OMe; n = 1, R ≠ R¹ = H, OMe; R² = NH₂) gave only the deamination products II. Azepine formation involves electrophilic aromatic substitution by the nitrene on the aromatic ring via a 7-membered transition state. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and mode of action of some benzothiazole derivatives bearing an amide moiety as antibacterial agents was written by Singh, Meenakshi;Singh, Sudhir K.;Gangwar, Mayank;Nath, Gopal;Singh, Sushil K.. And the article was included in RSC Advances in 2014.Synthetic Route of C8H7ClO3 This article mentions the following:

In this study ten benzothiazole derivatives bearing the amide moiety were designed, synthesized and evaluated for their antibacterial activity and possible mode of action. Structures of the synthesized compounds were elucidated by spectral data. Four different Gram-neg. and two different Gram-pos. bacterial strains were used in antibacterial activity tests. Among all the synthesized compounds, compound A07 displayed the most potent inhibitory activity with min. inhibitory concentration (MIC) values of 15.6, 7.81, 15.6, 3.91 μg ml^-1 against S. aureus, E. coli, S. typhi and K. pneumoniae resp. Structure-activity relationship (SAR) studies revealed that electronic and lipophillic factors of the Ph ring had a significant effect on the antimicrobial activity of the designed compounds The benzothiazole bearing amide (A01-A10) series exhibited different modes of action based on aryl group substitution as revealed by studies on intact bacterial cells and plasmid DNA. The present study provides us two active compounds (A07 and A10) with a membrane perturbing mode of action, and an intracellular mode of action due to binding with DNA along with potent activity against clin. relevant pathogens E. coli and S. aureus. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Synthetic Route of C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic reduction of organic halogen compounds was written by Rosenmund, Karl W.;Zetzsche, Fritz. And the article was included in Berichte der Deutschen Chemischen Gesellschaft in 1918.Synthetic Route of C4H5ClO2 This article mentions the following:

Colloidal Pd protected with gum arabic or palladinized BaSO₄ is an efficient catalyst in the removal of halogen from organic compounds with H and it is usually advisable to have an alkali present to neutralize the halogen acid as it is formed. Many substances react even if merely suspended in aqueous alkalies. In halogen derivatives of ethylenic compounds the halogen may sometimes be removed without saturating the C:C linking or the halogen derivative of the saturated compound may be formed. Frequently the reaction proceeds smoothly to hydrogenation and removal of the halogen. With dihalogen compounds it is apparently impossible to obtain mono-derivatives As illustrations the following reductions are described: PhBr to C₆H₆, o-BrC₆H₄CO₂H, to BzOH, p-BrC₆H₄NO₂ to PhNH₂, chlorocaffeine to caffeine, chlorocrotonic to crotonic acid, o-ClC₆H₄CH:CHCO₂H to PhCH₂-CH₂CO₂H, (CHBrCO₂H)₂ to (CH₂CO₂H)₂. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Synthetic Route of C4H5ClO2).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C4H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial evaluation of nitazoxanide-based analogs: Identification of selective and broad spectrum activity was written by Ballard, T. Eric;Wang, Xia;Olekhnovich, Igor;Koerner, Taylor;Seymour, Craig;Salamoun, Joseph;Warthan, Michelle;Hoffman, Paul S.;MacDonald, Timothy L.. And the article was included in ChemMedChem in 2011.Synthetic Route of C5H2Cl2O2S This article mentions the following:

A library composed of nitazoxanide-based analogs was synthesized and assayed for increased antibacterial efficacy against the pyruvate-ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organism,s and select analogs were tested for their ability to disrupt the PFOR enzyme directly. The library was also screened for activity against staphylococci and resulted in the identification of analogs capable of inhibiting both staphylococci and all PFOR organisms at low micromolar min. inhibitory concentrations with low toxicity to human foreskin cells. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Synthetic Route of C5H2Cl2O2S).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C5H2Cl2O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics