Tag: 100-200

《Synthesis, characterization and biological evaluation of novel series of [2-(benzylamino)-2-oxoethyl]-2-oxo-2H-1-benzopyran-3-carboxamide derivatives》 was published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 2020. These research results belong to Naik, Mamata Devendra; Bodke, Yadav D.; Ajeesh Kumar, A. K.; Naik, Jayanth K.; Shastri, Sudhesh L.. COA of Formula: C7H7ClFN The article mentions the following:

A novel series of benzopyran-3-carboxamide derivatives I (R = Ph, 2-chlorophenyl, 4-methoxyphenyl, 2-chloro-3-fluorophenyl, etc.) have been designed and synthesized using a smooth and linear multistep synthesis. Amidation of coumarin-3-carboxylic acid with glycine Et ester in the presence of EDC.HCl and HOBt as coupling agent followed by the hydrolysis results in the formation of key synthon, [(2-oxo-2H-1-benzopyran-3-carbonyl) amino] acetic acid which is further coupled with substituted aryl amines RCH2NH2 using HATU in combination with Hunig’s base to get the target compounds I. The synthesized compounds I have been screened for their in vitro antibacterial and antioxidant activity and the results are expressed as MIC and IC 50 values resp. Further, the binding ability of synthesized compounds I with different proteins have been examined by mol. docking studies. In the experiment, the researchers used many compounds, for example, (2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2COA of Formula: C7H7ClFN)

(2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.COA of Formula: C7H7ClFN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 150444-93-2On May 21, 1995 ,《Directed lithiation of unprotected benzoic acids》 appeared in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The author of the article were Bennetau, Bernard; Mortier, Jacques; Moyroud, Joeel; Guesnet, Jean-Luc. The article conveys some information:

Benzoic acid gives the ortho-lithiated species (2-carboxyphenyl)lithium (lithium salt) under standard conditions. Reaction of (2-carboxyphenyl)lithium (lithium salt) at -78 °C with either Me iodide, di-Me disulfide, hexachloroethane, or 1,2-dibromotetrachloroethane gives the ortho-substituted product. Intramol. competition between the carboxylic acid and methoxy, chloro, fluoro, or diethylamino functions in ortho- and para-substituted benzoic acids establishes the carboxylic acid group to be of intermediate capacity in directing metalation. Complimentarity of directing effects is observed with the chloro and fluoro groups in the meta-substituted benzoic acids but not with the methoxy and trifluoromethyl groups. Electrophile introduction into meta- and para-lithiated benzoates occurs with equal efficacy and comparable scope. The 2,4-dihalobenzoic acids undergo hydrogen/metal exchange at the position flanked by both halogen substituents. 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid undergoes lithiation adjacent to the oxygen atom. By use of such methods, routes to benzoic acids contiguously tri- and tetra-substituted with a variety of functionalities have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2HPLC of Formula: 150444-93-2)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. HPLC of Formula: 150444-93-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alpturk, Onur; Rusin, Oleksandr; Fakayode, Sayo O.; Wang, Weihua; Escobedo, Jorge O.; Warner, Isiah M.; Crowe, William E.; Kral, Vladimir; Pruet, Jeff M.; Strongin, Robert M. published an article in Proceedings of the National Academy of Sciences of the United States of America. The title of the article was 《Lanthanide complexes as fluorescent indicators for neutral sugars and cancer biomarkers》.Quality Control of 2-(2-Chloroethoxy)ethyl acetate The author mentioned the following in the article:

Simple water-soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glycolipids and phospholipids. In solutions at physiol. relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. Interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathol. conditions including ovarian cancer, is selectively detected by the europium complex. LPA is also detected via a fluorescence increase in human plasma samples. The 2-sn-OH moiety of LPA plays a key role in promoting binding to the metal center. Other mols. found in common brain ganglioside and phospholipid extracts do not interfere in the ganglioside or LPA fluorescence assays.2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Quality Control of 2-(2-Chloroethoxy)ethyl acetate) was used in this study.

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Quality Control of 2-(2-Chloroethoxy)ethyl acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Yen-Shan; Gleaton, Jeremy; Yang, Yanwu; Dhayalan, Balamurugan; Phillips, Nelson B.; Liu, Yule; Broadwater, Laurie; Jarosinski, Mark A.; Chatterjee, Deepak; Lawrence, Michael C.; Hattier, Thomas; Michael, M. Dodson; Weiss, Michael A. published an article in 2021. The article was titled 《Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation》, and you may find the article in Proceedings of the National Academy of Sciences of the United States of America.COA of Formula: C6H6BFO2 The information in the text is summarized as follows:

Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to structural reorganization. To test the functional coupling between insulins hinge opening and receptor activation, we inserted an artificial ligand-dependent switch into the insulin mol. Ligand-binding disrupts an internal tether designed to stabilize the hormone native closed and inactive conformation, thereby enabling productive receptor engagement. This scheme exploited a diol sensor (meta-fluoro-phenylboronic acid at GlyA1) and internal diol (3,4-dihydroxybenzoate at LysB28). The sensor recognizes monosaccharides (fructose > glucose). Studies of insulin-signaling in human hepatoma-derived cells (HepG2) demonstrated fructose-dependent receptor autophosphorylation leading to appropriate downstream signaling events, including a specific kinase cascade and metabolic gene regulation (gluconeogenesis and lipogenesis). Addition of glucose (an isomeric ligand with negligible sensor affinity) did not activate the hormone. Similarly, metabolite-regulated signaling was not observed in control studies of 1) an unmodified insulin analog or 2) an analog containing a diol sensor without internal tethering. Although secondary structure (as probed by CD) was unaffected by ligand-binding, heteronuclear NMR studies revealed subtle local and nonlocal monosaccharide-dependent changes in structure. Insertion of a synthetic switch into insulin has thus demonstrated coupling between hinge-opening and allosteric holoreceptor signaling. In addition to this foundational finding, our results provide proof of principle for design of a mechanism-based metabolite-responsive insulin. In particular, replacement of the present fructose sensor by an analogous glucose sensor may enable translational development of a smart insulin analog to mitigate hypoglycemic risk in diabetes therapy. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4COA of Formula: C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.COA of Formula: C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Solid polymer electrolytes from polyesters with diester sidechains for lithium metal batteries》 was written by Rosenbach, Dominic; Krimalowski, Alexander; Erabhoina, Harimohan; Thelakkat, Mukundan. Application In Synthesis of Methyl 2-chloro-2-oxoacetateThis research focused ontitanium oxide polyester solid polymer electrolyte lithium metal battery. The article conveys some information:

A series of polymethacrylates and polyacrylates carrying diester side chain moieties with varying alkyl spacer lengths are designed, synthesized, and evaluated as solid polymer electrolytes (SPEs) in lithium metal batteries (LMBs). These amorphous polymers with glass transition temperatures in the range of -58 to +32 °C are tested as SPEs in combination with LiTFSI or LiFSI. At an optimum salt concentration of 25 wt%, ionic conductivities up to 10-4 S cm-1 at 70 °C are achieved. These SPEs reveal high lithium transport numbers (0.5-0.7) and high electrochem. stability (5.4 V vs. Li/Li+) as determined by LSV. In combination with an ultrathin polyimide membrane and 10 wt% TiO2 nanoparticles, dendrite-free plating/stripping at 40 and 70 °C is realized in sym. Li|SPE|Li cells. Detailed extended distribution of relaxation times (eDRT) anal. of impedance measurements is employed for understanding the diverse cell processes. In solvent-free LMBs comprising a polyimide membrane soaked with the nanocomposite polyester electrolyte, lithium metal foil as the anode and an optimized LiFePO4 cathode, a very high initial specific discharge capacity of 152 mA h g- 1 (at 0.2C, 70 °C), excellent capacity retention of 94% after 100 cycles (at 1C, 70 °C) and negligible capacity fading even at 2C (96% retention after 300 cycles) are demonstrated. These novel polyester-based SPEs exhibit high cycling stability at 40 °C, making them highly attractive for room temperature applications. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application In Synthesis of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Bangjin; Tong, Kai-Ning; Chen, Xing; He, Jian-Li; Liu, Han; Fung, Man-Keung; Fan, Jian published an article in 2021. The article was titled 《A universal thermally activated delayed fluorescent host with short triplet lifetime for highly efficient phosphorescent OLEDs with extremely low efficiency roll-off》, and you may find the article in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices.Product Details of 768-35-4 The information in the text is summarized as follows:

Triplet-involved quenching processes lead to significant efficiency roll-off in phosphorescent organic light-emitting diodes (OLEDs). Thermally activated delayed fluorescent (TADF) materials can reduce the triplet exciton d. in the emitting layer (EML) via the up-conversion of triplet into singlet exciton. However, the effect of the triplet lifetime of TADF hosts on efficiency roll-off is still under-researched. Inspired by the fast spin-flip process in TADF with a small singlet-triplet energy gap, we herein reported a triazine-carbazole hybrid (Trz-PhCz) with a short triplet lifetime, and extremely low efficiency roll-offs were achieved for green, yellow, orange and red OLEDs with external quantum efficiencies (EQEs) over 20% at 10 000 cd m-2. Particularly, the optimized orange device showed a record-high maximum EQE of 31.4%, and 25.5% at 10 000 cd m-2. Furthermore, unprecedented high PEmaxs of 111.8 lm W-1 and 98.9 lm W-1 were obtained for Ir(ppy)2(acac)- and PO-01-based devices, resp. Notably, a two-color white OLED based on a single host Trz-PhCz also showed a remarkably high maximum power efficiency (PEmax) of 102.5 lm W-1 with the Commission Internationale de l’Eclairage (CIE) of (0.42, 0.48). So, the Trz-PhCz-hosted phosphorescent OLEDs showed state-of-the-art device performance, and this work provided insight into the design of efficient TADF host materials via controlling their triplet lifetime for practical applications. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis, characterization and antioxidant activity of 2-aryl benzimidazole derivatives》 was published in Asian Journal of Pharmaceutical Research and Development in 2020. These research results belong to Vineet Kumar Singh, Amrita Parle. Category: chlorides-buliding-blocks The article mentions the following:

In the present study 19 benzimidazole derivatives were synthesized by reacting O-phenylenediamine as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatog. technique, and the newly synthesized derivatives were characterized by ATIR and 1HNMR techniques. The antioxidant assay was performed using ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] method and DPPH [2,2-diphenyl-1-picrylhydrazyl] method. The experimental process involved the reaction of 2-Chloroisonicotinic acid(cas: 6313-54-8Category: chlorides-buliding-blocks)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Fluorination of the tetraphenylethene core: synthesis, aggregation-induced emission, reversible mechanofluorochromism and thermofluorochromism of fluorinated tetraphenylethene derivatives》 were Zhang, Hao; Nie, Yong; Miao, Jinling; Zhang, Dengqing; Li, Yexin; Liu, Guangning; Sun, Guoxin; Jiang, Xuchuan. And the article was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019. Synthetic Route of C6H6BFO2 The author mentioned the following in the article:

The Suzuki-Miyaura cross-coupling reactions of bromoalkenes R(X)C=C(R1)R2 (R = C6H5, Br; R1 = C6H5, 4-FC6H4; R2 = C6H5, 4-FC6H4; X = Br) with fluorophenylboronic acids R3C6H4B(OH)2 (R3 = 2-F, 3,4-(F)2, 2,4,6-(F)3, etc.) afforded 17 fluorinated tetraphenylethene (FTPE) compounds RC(R3)=C(R1)R2 that have only fluorine substituent(s) directly on the tetraphenylethene (TPE) core with different numbers and substitution positions of the fluorine atom(s). The X-ray structures of four FTPEs show that these FTPE derivatives have C-H…F and C-H…π hydrogen bonds in the crystal packing. DFT calculations indicate that both the HOMOs and LUMOs of the FTPEs essentially have lower energy levels than those of the parent TPE, and the energy gaps are highly dependent on the substitution pattern. These FTPEs exhibit aggregation-induced emission characteristics similar to most TPE derivatives but the aggregation process was found to be gradual and time-dependent. The emission wavelengths of both aggregates from tetrahydrofuran/H2O and solids, and the corresponding emission quantum yields of the solid samples vary with different substitution patterns. In addition, two examples of these FTPEs show reversible mechanofluorochromic and thermofluorochromic properties (the latter was only shown on silica gel), while the parent TPE does not exhibit mechanochromism under the same conditions. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Abdel-Rahman, Adel A.-H.; Zeid, Ibrahim F.; Barakat, Hussien A.; El-Sayed, Wael A. published their research in Zeitschrift fuer Naturforschung, C: Journal of Biosciences on December 31 ,2009. The article was titled 《Anti-hepatitis B virus activity of new substituted pyrimidine acyclic nucleoside analogues》.Electric Literature of C6H11ClO3 The article contains the following contents:

A number of N-substituted pyrimidine acyclic nucleosides were synthesized by coupling reaction of 2-(2-chloroethoxy)ethyl acetate or (2,2-dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzenesulfonate with the corresponding base followed by deprotection. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV). The plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the synthesized compounds which showed moderate to high anti-viral activities. The experimental process involved the reaction of 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Electric Literature of C6H11ClO3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Electric Literature of C6H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Chi-Ta;Lee, Kuan-Lin;Wang, Sea-Fue;Chen, Lung-Chien published 《Effect of a Rubidium Chloride Carrier Confinement Layer on the Characteristics of CsPbBr₃ Perovskite Light-Emitting Diodes》. The research results were published in《Nanoscale Research Letters》 in 2022.Recommanded Product: Rubidiumchloride The article conveys some information:

This work describes the effect of a rubidium chloride (RbCl) interlayer in CsPbBr₃ perovskite light-emitting diode (LED) structures. RbCl crystallites exhibited polyhedral structures and lattice parameters similar to those of CsPbBr₃ perovskite crystallites. The lattice mismatch between the RbCl interlayer and CsPbBr₃ active layer was only approx. 2%. The devices exhibited the best quality and performance when RbCl was used as the nucleation and carrier confinement layer. The crystallite sizes of CsPbBr₃ with 0.2-, 0.5-, and 1-nm-thick RbCl bottom layers were 55.1, 65.4, and 55.1 nm, resp. The full width at half maximum (FWHM) of the photoluminescence (PL) emission peak for CsPbBr₃ with the RbCl bottom layer was 0.096 eV. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Rubidium chloride(cas: 7791-11-9) can increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.Recommanded Product: Rubidiumchloride Pharmaceutical compositions have been used as antidepressants in Europe. It is employed in biochemistry to induce cells to take up DNA.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics