Tag: 100-200

Poirot, Alexandre; Saffon-Merceron, Nathalie; Leygue, Nadine; Benoist, Eric; Fery-Forgues, Suzanne published an article in 2021. The article was titled 《Crystal structure of methyl 1,3-benzoxazole-2-carboxylate》, and you may find the article in Acta Crystallographica, Section E: Crystallographic Communications.Product Details of 5781-53-3 The information in the text is summarized as follows:

The title compound, C9H7NO3, crystallizes in the monoclinic (P21) space group. In the crystal, the almost planar mols. display a flattened herringbone arrangement. Stacking mols. are slipped in the lengthwise and widthwise directions and are linked by π interactions [d(Cg…Cg = 3.6640 (11)) Å]. The structure is characterized by strong C-H…N and weak C-H…O hydrogen bonds, and further stabilized by C-O…π interactions. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Miki, Ryotaro; Yamaki, Tsutomu; Uchida, Masaki; Natsume, Hideshi published an article in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The title of the article was 《Hydrogen peroxide-responsive micellar transition from spherical to worm-like in cetyltrimethylammonium bromide/3-fluorophenylboronic acid/fructose system》.SDS of cas: 768-35-4 The author mentioned the following in the article:

In this study, we successfully prepared a novel hydrogen peroxide (H2O2)-responsive micellar system, whose viscosity drastically changes depending on H2O2 levels. The cationic surfactant cetyltrimethylammonium bromide (CTAB)/3-fluorophenol (3FPhOH) and CTAB/3-fluorophenylboronic acid (3FPBA) systems exhibited high viscosity. The viscosity of the CTAB/3FPBA system significantly decreased with the addition of fructose (Fru). The zero-shear viscosity of the CTAB/3FPBA/Fru system with 40 mM H2O2 increased 4 x 104-fold in comparison to that without H2O2. We confirmed that both the CTAB/3FPhOH and CTAB/3FPBA/Fru with H2O2 systems form worm-like micelle (WLM) structures based on their rheol. properties. The results of dynamic light scattering measurements supported the micellar transition with the addition of H2O2. We successfully demonstrated H2O2-responsive micellar transition from spherical/shorter rod-like micelles to long WLMs. We utilized the two reactions in the CTAB-based micellar system to control micellar transitions and viscosities: (i) Phenylboronic acid (PBA) forms a reversible cyclic ester structure with Fru and (ii) PBA reacts with H2O2to convert phenol. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4SDS of cas: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.SDS of cas: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Khalili Arjomandi, Omid; Kavoosi, Mahboubeh; Adibi, Hadi. Related Products of 620-20-2 The article mentions the following:

The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are increasingly prevalent and have become a major worldwide threat to human health. These bacteria are resistant to β-lactam antibiotics and MBL-inhibitor/β-lactam antibiotic combination therapy can be a strategy to overcome this problem. So far, no clin. available inhibitors of metallo-β-lactamases (MBLs) have been reported. In this study, L-benzyl tyrosine thiol carboxylic acid analogs (I) were synthesized after the study of computational simulation by adding of Me, chloro, bromo, and nitro groups to the benzyl ring for investigation of SAR anal. Although the synthesized mols. shows the potent inhibitory effects against metallo-β-lactamase (IMP-1) with the range of Kic values of 1.044.77 μM, they are not as potent as the candidate inhibitor.3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H2S release profiles》 were Bhattacherjee, Debojit; Sufian, Abu; Mahato, Sulendar K.; Begum, Samiyara; Banerjee, Kaustav; De, Sharmistha; Srivastava, Hemant Kumar; Bhabak, Krishna P.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Related Products of 620-20-2 The author mentioned the following in the article:

Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na2S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H2S and potent anti-cancer activities. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Jun; Yang, Tianjiao; Wang, Jiayi; Song, Gonghua published an article on January 31 ,2021. The article was titled 《Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Safety of 3-Chlorobenzylchloride The information in the text is summarized as follows:

Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones I [R = H, 5-F, 6-MeO, 5-Cl; R1 = Me, benzyl, 4-chlorobenzyl, etc.; R2 = tert-Bu, cyclohexyl, 2-MeOC6H4, etc.] which derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds I were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for I [R = 5-Cl, R1= Me, R2 = tert-butyl] and serious nervous curl effect against pinewood nematodes B. xylophilus for I [R = H, R1= Me, R2 = tert-butyl] were observed at 10 mg/l. The inhibition activities of I [R = H, R1= Me, R2 = 2-MeOC6H4, etc.] against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in-vitro test and test tube test, resp. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2004,Bulletin of the Faculty of Pharmacy (Cairo University) included an article by El-Shemy, Khaled; El-Badry, Ossama; Roshdy, Sameha; El-Enany, Mervat. Product Details of 66662-48-4. The article was titled 《Synthesis of certain novel pyridothiopyranoindazoles as potential DNA intercalators in cancer chemotherapy》. The information in the text is summarized as follows:

A series of 5-chloro-8,10-dimethyl-2-(aminoethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole, e.g., I, was obtained by reacting 5-chloro-8,10-dimethyl-2-(2-chloroethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole with certain primary or secondary amines. The in vitro cytotoxic effect of selected samples of the synthesized compounds were also achieved. The two synthesized series have structural relationship to certain anthrapyrazoles and benzothiopyranoindazoles which have been reported as potent antitumor agents. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Product Details of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

de Vasconcelos, Alana; Zulian Boeira, Ana Julia; Drawanz, Bruna Bento; Pedra, Nathalia Stark; Bona, Natalia Pontes; Stefanello, Francieli Moro; Cunico, Wilson published an article in Medicinal Chemistry (Sharjah, United Arab Emirates). The title of the article was 《2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Anti-glioma Activities in C6 and GL261 Cells》.HPLC of Formula: 620-20-2 The author mentioned the following in the article:

Thiazolidinediones (TZDs) represent an important class of heterocyclic compounds that have versatile biol. activities, including anticancer activity. Glioma is one of the most common primary brain tumors, and it is responsible for most of the deaths caused by primary brain tumors. In the present work, 2,4-thiazolidinediones were synthesized via a multicomponent microwave one-pot procedure. The cytotoxicity of compounds was analyzed in vitro using rat (C6) and mouse (GL261) glioblastoma cell lines and primary cultures of astrocytes. This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. TZDs were synthesized from three components: 2,4-thiazolidinedione, arene-aldehydes, and aryl chlorides. The reactions were carried out inside a microwave and monitored using thinlayer chromatog. (TLC). Compounds were identified and characterized using gas chromatog. coupled to mass spectrometry (CG-MS) and hydrogen (1H-NMR) and carbon NMR spectroscopy (13C-NMR). The antitumor activity was analyzed using the 3-(4,5- dimethyl)-2,5-diphenyltetrazolium bromide (MTT) reduction test, in which cell viability was verified in the primary cultures of astrocytes and in rat and mouse glioblastoma cells exposed to the synthesized compounds The cytotoxicity of all derivatives was analyzed at the 100 μM concentration, both in astrocytes and in the mouse and rat glioblastoma cell lines. The compounds that showed the best results, 4CI and 4DI, were also tested at concentrations 25, 50, 100, 175, and 250 μM to obtain the IC50. Seventeen TZD derivatives were easily obtained through one-pot reactions in 40 min with yields ranging from 12% to 49%. All compounds were cytotoxic to both glioblastoma cell lines without being toxic to the astrocyte primary cell line at 100 μM, thus demonstrating a selective activity. Compounds 4CI and 4DI showed the best results in the C6 cells: IC50 of 28.51 μM and 54.26 μM, resp. The compounds were not cytotoxic in astrocyte culture, demonstrating selectivity for malignant cells. Changes in both rings are important for anti-glioma activity in the cell lines tested. TZD 4CI had the best anti-glioma activity. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2HPLC of Formula: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.HPLC of Formula: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《A visible light-mediated, decarboxylative, desulfonylative Smiles rearrangement for general arylethylamines syntheses》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Whalley, David M.; Duong, Hung A.; Greaney, Michael F.. Synthetic Route of C4H3ClO2S2 The article mentions the following:

A decarboxylative, desulfonylative Smiles rearrangement is presented that employs activated-ester/energy transfer catalysis to decarboxylate β-amino acid derived starting materials at room-temperature under visible light irradiation The radical Smiles rearrangement gives a range of biol. active arylethylamine products highly relevant to the pharmaceutical industry, chem. biol. and materials science. The reaction is then applied to the synthesis of a chiral unnatural amino acid, 2-thienylalanine, used in the treatment of phenylketonuria. It was also shown how the reaction can proceed under metal-free and catalyst-free conditions. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and biological activity of certain pyridobenzodiazepine derivatives》 were Botros, Samir; El-Gendy, Adel A.; Said, Mohamed M.; Oma, Adel H.. And the article was published in Bulletin of the Faculty of Pharmacy (Cairo University) in 2001. Recommanded Product: 66662-48-4 The author mentioned the following in the article:

The present work comprises the synthesis of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine-5-one derivatives by condensation of 2-chloro-4,6-dimethylnicotinic acid with 1,2-phenylenediamines using 1-butoxyethanol as solvent. Monoalkylation of the products using one equivalent of the appropriate alkyl halide and 30% NaOH in DMSO gave the 6-alkyl derivatives. Some of the prepared compounds were screened for CNS depressant and anticonvulsant activities. After reading the article, we found that the author used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thirupataiah, B.; Reddy, Gangireddy Sujeevan; Mounika, Guntipally; Kumar, Jetta Sandeep; Hossain, Kazi Amirul; Mudgal, Jayesh; Mathew, Jessy E.; Shenoy, Gautham G.; Rajadurai, Marina; Parsa, Kishore V. L.; Pal, Manojit published an article in 2021. The article was titled 《Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C4H3ClO2S2 The information in the text is summarized as follows:

A Pd-catalyzed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C-C bond formation of 2-(1-alkynyl)phenylacetamide. The ligand/additive free cascade reaction proceeded in the presence of PdCl2 in aqueous MeCN when the sep. and individual use of Me vinyl ketone and allyl bromide generally afforded an O- and N-heterocycle, resp. The pharmacol. assay was performed to identify the first example of a 1H-benzo[d]azepin-2(3H)-one based novel inhibitor of PDE4B. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics