Tag: 100-200

《Synthesis of di(hetero)aryl sulfides by defluorinative sulfenylation of polyfluoroalkyl ketones with sodium sulfinates or arylsulfonyl chlorides》 was written by Chu, Xue-Qiang; Xie, Ting; Wang, Ya-Wen; Li, Xiang-Rui; Rao, Weidong; Xu, Haiyan; Shen, Zhi-Liang. Application of 16629-19-9 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A facile incorporation of a privileged sulfide, naphthofurans e.g., 2-(perfluoroethyl)-3-(p-tolylthio)naphtho[1,2-b]furan framework, and a perfluoroalkyl moiety in one mol. was successfully accomplished through tandem defluorinative sulfenylation of α-perfluoroalkyl ketones e.g., 2-(Perfluorobutyl)-3,4-dihydronaphthalen-1(2H)-one with a sulfur source RS(O)ONa/RS(O)OCl (R = Ph, naphthalen-1-yl, thiophen-2-yl, etc.). The reaction presumably proceeds via a sequence involving defluorination, reductive sulfenylation, autoaromatization, and annulation, accompanied by the simultaneous cleavage of four C(sp3)-F bonds and the formation of new C-S and C-O bonds. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-catalyzed amidation of 1,3-diketones with CO and azides via a nitrene intermediate》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Gu, Zheng-Yang; Chen, Jie; Xia, Ji-Bao. Computed Properties of C4H3ClO2S2 The article mentions the following:

An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce β-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through an in situ generated isocyanate intermediate. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Green synthesis of 1,2,3-triazoles via Cu2O NPs on hydrogen trititanate nanotubes promoted 1,3-dipolar cycloadditions》 were Bhoomireddy, Rajendra Prasad Reddy; Narla, L. G. Bhavani; Peddiahgari, Vasu Govardhana Reddy. And the article was published in Applied Organometallic Chemistry in 2019. Formula: C7H6Cl2 The author mentioned the following in the article:

Cu2O nanoparticles supported on hydrogen trititanate nanotubes (Cu2O/HTNT) catalysts have been efficiently catalyzed the multicomponent synthesis of 1,2,3-triazoles in water at room temperature from different azide precursors, for example organic halides, sulfonates and anilines. The catalysts were synthesized by hydrothermal & wet-impregnation methods and was characterized by HR-TEM, EDS, XRD, XPS, N2-adsorption desorption and ICP-MS anal. The catalyst could be recycled by centrifugation and reused up to seven cycles. The 1-benzyl-4-(4-chlorophenyl)-1H-1,2,3-triazole structure was proven by single crystal X-ray diffraction studies. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents》 were Shen, Qing-Kun; Gong, Guo-Hua; Li, Gao; Jin, Mei; Cao, Li-Hua; Quan, Zhe-Shan. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Name: 3-Chlorobenzylchloride The author mentioned the following in the article:

To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesized, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesized compounds were determined using 1H NMR, 13 C NMR, and HRMS. All the compounds were screened for anti-inflammatory activity based on their inhibitory effects against LPS-induced NO release. Among them, 5-(3,4,5-trimethoxybenzyl)-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide () showed the highest anti-inflammatory activity and inhibited NO release more potently than the lead compound . Further studies revealed that compound reduced the levels of NO, TNF-α, and IL-6, and that its anti-inflammatory activity involves the inhibition of COX-2 and iNOS and downregulation of the mitogen-activated protein kinases (MAPK) signal pathway. Notably, compound displayed more prominent anti-inflammatory activity than and the pos. control ibuprofen in the in vivo acute inflammatory model. Overall, these findings indicate that compound is a therapeutic candidate for the treatment of inflammation. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Name: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Name: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Hwang, Soo-Yeon; Park, Soo-Yeon; Hong, Jung Yeon; Lee, Soo Yeon; Shin, Jae-Ho; Na, Younghwa; Sohn, Myung Hyun; Yoon, Ho-Geun; Kwon, Youngjoo. Safety of 3-Chlorobenzylchloride The article mentions the following:

(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Yi-Min; Yu, Yi; Wu, Shao-Fen; Yan, Hong; Yuan, Yaofeng; Ye, Ke-Yin published an article in 2021. The article was titled 《Electrochemical fluorosulfonylation of styrenes》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Quality Control of Thiophene-2-sulfonyl chloride The information in the text is summarized as follows:

An environmentally friendly and efficient electrochem. fluorosulfonylation of styrenes were developed. With the use of sulfonylhydrazides and triethylamine trihydrofluoride, a diverse array of β-fluorosulfones were readily obtained. This reaction featured mild conditions and a broad substrate scope, which was conveniently extended to a gram-scale preparation In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Quality Control of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Quality Control of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Donnelly, Kian; Baumann, Marcus published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives》.Synthetic Route of C3H3ClO3 The article contains the following contents:

A continuous flow process to generate [1.1.1]propellane on demand is presented rendering solutions of [1.1.1]propellane that can directly be derivatized into various bicyclo[1.1.1]pentane (BCP) species I [R = H, I, phenylsulfanyl, (butan-2-yloxy)carbonyl, etc.; R1 = I, (4-tert-butylphenyl)sulfanyl, N-(4-fluorophenyl)carbamoyl, etc.]. This was realized in throughputs up to 8.5 mmol h-1 providing an attractive and straightforward access to gram quantities of selected BCP building block I (R = R1 = I). Lastly, a continuous photochem. transformation of [1.1.1]propellane into valuable BCPs bearing mixed ester/acyl chloride moieties II (R2 = Me, Et, i-Pr, dodecyl, butan-2-yl) was developed. In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Analytical Chemistry (Washington, DC, United States) included an article by Tian, Zhenhao; Ding, Lele; Li, Kun; Song, Yunqing; Dou, Tongyi; Hou, Jie; Tian, Xiangge; Feng, Lei; Ge, Guangbo; Cui, Jingnan. Recommanded Product: Methyl 2-chloro-2-oxoacetate. The article was titled 《Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems》. The information in the text is summarized as follows:

Rational design of practical probes with excellent specificity and improved optical properties for a particular enzyme is always a big challenge. Herein, a practical and highly specific fluorescent probe for carboxylesterase 1 (CES1) was rationally designed using meso-carboxyl-BODIPY as the basic fluorophore based on the substrate preference and catalytic properties of CES1. Following mol. docking-based virtual screening combined with reaction phenotyping-based exptl. screening, we found that MMB (probe 7) exhibited the optimal combination of sensitivity and specificity toward human CES1 in contrast to other ester derivatives Under physiol. conditions, MMB could be readily hydrolyzed by CES1 and release MCB; such biotransformation brought great changes in the electronic properties at the meso position of the fluorophore and triggered a dramatic increase in fluorescence emission around 595 nm. Moreover, MMB was cell membrane permeable and was successfully applied to monitor the real activities of CES1 in various biol. samples including living cells, tissue slices, organs, and zebrafish. In summary, this study showed a good example for constructing specific fluorescent probe(s) for a target enzyme and also provided a practical and sensitive tool for real-time sensing of CES1 activities in complicated biol. samples. All these findings would strongly facilitate high-throughput screening of CES1 modulators and the studies on CES1-associated physiol. and pathol. processes. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Recommanded Product: Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and apoptosis-promoting effect evaluation of novel pyrazole with benzo[d]thiazole derivatives containing aminoguanidine units》 were Liu, Da Chuan; Gao, Mei Jia; Huo, Qiang; Ma, Tao; Wang, Ying; Wu, Cheng Zhu. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Application In Synthesis of 3-Chlorobenzylchloride The author mentioned the following in the article:

New pyrazole with benzo[d]thiazoles containing hydrazinecarboximidamide substituent was synthesized and evaluated for cytotoxicity and apoptotic activity using the MTT assay, flow cytometry, and Western blot anal. Among the compounds studied, (E)-2-((1-(6-((4-fluorobenzyl)oxy)benzo[d]thiazol-2-yl)-3-phenyl-1H-pyrazol-4-yl)methylene) hydrazinecarboximidamide (8l) was potent, with IC50 values of 2.41 μM, 2.23 μM, 3.75 μM and 2.31 μM in vitro anti-proliferative activity testing against triple-neg. breast cancer cell line MDA-MB-231, non-triple-neg. breast cancer MCF-7 cells, and human hepatocarcinoma HepG2 cells, and SMMC-7721 cells, resp. Especially, the activity against MDA-MB-231 was similar to that of Doxorubicin, which was used as a pos. control in this study. Next, the Annexin V/PI flow cytometry assay was used at different concentrations of compound 8l to demonstrate that compound 8l induced apoptosis of MDA-MB-231 cells in a concentration-dependent manner. Finally, these results were further verified by Western blot anal. Taken together, the results of this study revealed that compound 8l may be a potential anticancer compound play a significant role in the subsequent researches. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2Application In Synthesis of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Application In Synthesis of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Electrochemical heterodifunctionalization of α-CF3 alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols》 was written by Ye, Zhi-Peng; Gao, Jie; Duan, Xin-Yu; Guan, Jian-Ping; Liu, Fang; Chen, Kai; Xiao, Jun-An; Xiang, Hao-Yue; Yang, Hua. Application In Synthesis of Thiophene-2-sulfonyl chlorideThis research focused ontrifluoromethyl sulfonyl tertiary alc green preparation; benzenesulfonyl hydrazide trifluoromethyl alkene electrochem heterodifunctionalization. The article conveys some information:

An unprecedented electrochem. heterodifunctionalization of α-CF3 alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcs. RSOOCH2C(OH)(CF3)R1 [R = i-Pr, Ph, 2-thienyl, etc.; R1 = Ph, 2-naphthyl, 3-thienyl, etc.] were assembled under mild conditions. Electrochem.-driven oxidative 1,2-difunctionalization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics