Tag: 100-200

The author of 《4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity》 were Karimi, Nafiseh; Roudsari, Rouhollah Vahabpour; Movahed, Mahsa Azami; Hajimahdi, Zahra; Zarghi, Afshin. And the article was published in Iranian Journal of Pharmaceutical Research in 2021. Category: chlorides-buliding-blocks The author mentioned the following in the article:

Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC6H4, 2-FC6H4, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC6H4] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C7H7ClFNOn November 25, 2020 ,《X-ray Structure and Molecular Docking Guided Discovery of Novel Chitinase Inhibitors with a Scaffold of Dipyridopyrimidine-3-carboxamide》 appeared in Journal of Agricultural and Food Chemistry. The author of the article were Yuan, Pengtao; Jiang, Xi; Wang, Siyu; Shao, Xusheng; Yang, Qing; Qian, Xuhong. The article conveys some information:

Chitinases are the glycosyl hydrolase for catalyzing the degradation of chitin and play an indispensable role in bacterial pathogenesis, fungal cell wall remodeling, and insect molting. Thus, chitinases are attractive targets for therapeutic drugs and pesticides. Here, we present a strategy of developing a novel chemotype of chitinase inhibitors by the construction of planar heterocycles that can stack with conserved aromatic residues. The rational design, guided by crystallog. anal. and docking results, leads to a series of dipyridopyrimidine-3-carboxamide derivatives as chitinase inhibitors. Among them, compound 6t showed the most potent activity against bacterial chitinase SmChiB and insect chitinase OfChi-h, with a Ki value of 0.14 and 0.0056μM, resp. The strong stacking interaction of compound 6p with Trp99 and Trp220 found in the SmChiB-6p co-crystal structure verifies the feasibility of our design. Our results provide novel insights into developing potent chitinase inhibitors for pathogen and pest control. After reading the article, we found that the author used (2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2Computed Properties of C7H7ClFN)

(2-Chloro-3-fluorophenyl)methanamine(cas: 72235-54-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C7H7ClFN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6313-54-8On May 11, 2022 ,《Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids》 appeared in Journal of the American Chemical Society. The author of the article were Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; Rosko, Michael C.; Danilov, Evgeny O.; Blakemore, David C.; Dechert-Schmitt, Anne-Marie; Knauber, Thomas; Castellano, Felix N.; MacMillan, David W. C.. The article conveys some information:

A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies.2-Chloroisonicotinic acid(cas: 6313-54-8Related Products of 6313-54-8) was used in this study.

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 6313-54-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 350-30-1On September 20, 2019 ,《Development and Scale-up of Continuous Electrocatalytic Hydrogenation of Functionalized Nitro Arenes, Nitriles, and Unsaturated Aldehydes》 was published in Organic Process Research & Development. The article was written by Egbert, Jonathan D.; Thomsen, Edwin C.; O’Neill-Slawecki, Stacy A.; Mans, Douglas M.; Leitch, David C.; Edwards, Lee J.; Wade, Charles E.; Weber, Robert S.. The article contains the following contents:

Electrolysis flow reactors based on the filter-press architecture of redox flow batteries have proven to be effective and scalable toward the production of com. relevant, pharmaceutical quantities of anilines ( > 500 kg/yr) from halogen-, hydroxyl-, and carbonyl-substituted nitroarenes. Turbulent flow through the carbon felts on which the catalysts were supported facilitated scaling toward production levels because it conferred on the reactors scale-independent, plug flow-like residence time distributions and high mass transfer coefficients Equipping the cells with microreference electrodes made it possible to transfer reaction conditions first developed in batch systems to the continuous flow reactors. The catalysts prepared by incipient wetness impregnation of metal salts into lightly oxidized carbon felt supports were readily generalizable. In the experiment, the researchers used many compounds, for example, 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Product Details of 350-30-1)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 350-30-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety》 was written by Al-Sa’Doni, Haitham Husein; Delmani, Fatima-Azzahra; Al Balushi, Abdullah Mohammed; Al-Ahmad, Ala’A. Hamed; Alsawakhneh, Sondos Omar; Al-Soud, Yaseen Ahmad. HPLC of Formula: 16629-19-9This research focused ontriazolyl carbohydrazide preparation antibacterial activity; thione triazolyl preparation antibacterial activity. The article conveys some information:

In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives like 3-methoxy-benzoic acid N'[2-(1,5-diethyl-1H-[1,2,4]triazole3-yl)-acetyl]-hydrazide, 3,5-dinitro-benzoic acid N'[2-(1, 5-diethyl-1H-[1, 2, 4]triazole-3-yl)-acetyl]-hydrazide and compound of 1,2,4- triazole-3-(4H)-thion I (R = C6H5, 2-thienyl, 7-methoxy-4-methyl-2-oxo-2H-chromen-6-yl; R1 = Me, Et; R2 = Et) have been synthesized. Structures and purity of the new compounds I were confirmed by the use of their chromatog. and spectral data besides microanal. Four different bacterial stains for the study of the biol. activity of compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 3-CF3C6H4, R1 = Et, R2 = Et; R = 2,5-(Cl)2C6H3, R1 = Et, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et); two Gram-pos. strains, and two Gram-neg. strains have been used. Compound I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et) was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, with an inhibition zone diameter of 16, 9, and 10 mm, resp. Calculating the minimal inhibitory concentration value (MIC) for the pos. drugs which formed an inhibition zone in the agar well diffusion method, it was found that both I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) were the most active of the four tested compounds against Pseudomonas aeruginosa and Bacillus cereus with an MIC value of 0.5μg/mL for both bacteria. These results suggest that these two compounds I (R = 2,5-(Cl)2C6H3, R1 = Me, R2 = Et; R = 2-thienyl, R1 = Et, R2 = Et) could be considered as potential antibacterial agents against a range of bacteria. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Controlled synthesis of N,N-dimethylarylsulfonamide derivatives as nematicidal agents》 was published in Journal of Asian Natural Products Research in 2020. These research results belong to Chen, Gen-Qiang; Xia, Yan-Fei; Yang, Jin-Ming; Che, Zhi-Ping; Sun, Di; Li, Shen; Tian, Yue-E.; Liu, Sheng-Ming; Jiang, Jia; Lin, Xiao-Min. HPLC of Formula: 16629-19-9 The article mentions the following:

Gramine could be intelligently and efficiently supplied with N,N-dimethylamino group and then reacted with the corresponding sulfonyl chlorides to synthesize N,N-dimethylarylsulfonamides I [R = Ph, 4-FC6H4, 2-thienyl, etc.]. Herein designed and controlled synthesis of N,N-dimethylarylsulfonamide derivatives and first reported the results of the nematicidal activity of N,N-dimethylarylsulfonamide compounds against Meloidogyne incongnita in vitro, resp. Among all of the N,N-dimethylarylsulfonamide derivatives, compounds I [R = Ph, 4-MeOC6H4, 4-O2NC6H4, 8-quinolyl] exhibited potent nematicidal activity with median lethal concentration (LC50) values ranging from 0.22 to 0.26 mg/L. Most noteworthy, compounds I [R = 4-MeOC6H4, 8-quinolyl] showed the best promising and pronounced nematicidal activity, with LC50 values of 0.2381 and 0.2259 mg/L, resp. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Friese, Florian W.; Studer, Armido. Synthetic Route of C3H3ClO3. The article was titled 《Deoxygenative Borylation of Secondary and Tertiary Alcohols》. The information in the text is summarized as follows:

Two different approaches for the deoxygenative radical borylation of secondary and tertiary alcs. are presented. These transformations either proceed through a metal-free silyl-radical-mediated pathway or utilize visible-light photoredox catalysis. Readily available xanthates or Me oxalates are used as radical precursors. The reactions show broad substrate scope and high functional-group tolerance, and are conducted under mild and practical conditions. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Synthetic Route of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Synthetic Route of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Makane, Vitthal B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Shukla, Manjulika; Mahizhaveni, B.; Misra, Sunil; Chopra, Sidharth; Sriram, Dharmarajan; Dusthackeer, V. N. Azger; Rode, Haridas B. published an article on February 15 ,2019. The article was titled 《Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 2-Chloroisonicotinic acid The information in the text is summarized as follows:

Synthesis, SAR and evaluation of α-aminoacyl amides R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2-pyrrolyl, 2-furyl, 2-thienyl, etc.; R2 = Ph, 4-MeC6H4, 2-HOC6H4, etc.; R3 = Ph, 3-ClC6H4, 4-MeOC6H4, etc.; R4 = t-Bu, cyclohexyl, Bn, 2-naphthyl] as antitubercular agents were reported via Ugi reaction of benzaldehydes, isocyanides, anilines and carboxylic acids. The systematic medicinal chem. approach led to identification of optimal substitutions required for the activity. Compound R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2,4-di-methylthiazol-5-yl; R2 = 2,4-di-MeC6H3; R3 = 3-pyridyl; R4 = cyclohexyl] was identified as antitubercular lead with drug like properties. Further, R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2,4-di-methylthiazol-5-yl; R2 = 2,4-di-MeC6H3; R3 = 3-pyridyl; R4 = cyclohexyl] selectively inhibited M. tuberculosis H37Rv with MIC value of 0.78 μM and was found to be non-toxic to CHO-K1 cells. The lead compound inhibited multi drug resistant and Pre-Extensively drug resistant strains of Mycobacterium at 2 μg/mL and 8 μg/mL resp. In the experiment, the researchers used 2-Chloroisonicotinic acid(cas: 6313-54-8Reference of 2-Chloroisonicotinic acid)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of 2-Chloroisonicotinic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Joshi, Bhuwan C.; Tyagi, R. P.; Dobhal, M.P.; Rawat, Ratna; Chauhan, Madhu published an article in Indian Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis of some new sulfide, sulfone and triazolo derivatives of pyridobenzodiazepines》.Recommanded Product: 66662-48-4 The author mentioned the following in the article:

Synthesis of some new sulfide derivatives of 2,4-dimethyl-5,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-5-thione (2) was carried out by reacting 2 with benzyl chloride and 2-bromobutane, resp. On oxidizing the benzyl sulfide derivative with oxone, the corresponding sulfone was obtained. 3,11,13-Trimethylpyridobenzo[2,3-b]-1,2,4-triazolo[4,3-d][1,4]diazepine was synthesized from 2. In the experiment, the researchers used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Chigurupati, Sridevi; Wadood, Abdul; Rehman, Ashfaq Ur; Venugopal, Vijayan; Salar, Uzma; Taha, Muhammad; Khan, Khalid Mohammed published their research in European Journal of Medicinal Chemistry on December 1 ,2019. The article was titled 《Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in-vitro: Structure-activity relationship, molecular docking and kinetic studies》.Quality Control of 2-Chloro-3,4-difluorobenzoic acid The article contains the following contents:

Benzotriazoles were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives I [R1 = R2 = H, Me, Cl; R3 = H, 4-Br, 3-Me-4-NO2, etc.] and II [R4 = R5 = H, Me, Cl; R6 = H, 2-OH, 4-Ph, etc.]. The synthetic compounds I and II were characterized via different spectroscopic techniques including EI-MS, HREI-MS, 1H- and 13C-NMR. These mols. were examined for their anti-hyperglycemic potential hence were evaluated for α-glucosidase and α-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 μM against α-glucosidase and α-amylase enzymes, resp. The synthetic compounds were divided into two categories “”A”” and “”B””, in order to understand the structure-activity relationship. Compounds II [R4 = R5 = H; R6 = 4-Cl] (IC50 = 2.41 ± 1.31 μM), (IC50 = 2.5 ± 1.21 μM), II [R4 = R5 = Me; R6 = 3,4-di-Cl] (IC50 = 2.12 ± 1.35 μM), (IC50 = 2.21 ± 1.08 μM) and II [R4 = R5 = Me; R6 = 4-Cl] (IC50 = 2.00 ± 1.22 μM), (IC50 = 2.04 ± 1.4 μM) with chloro substitution/s at aryl ring were found to be most active against α-glucosidase and α-amylase enzymes. Mol. docking studies on all compounds were performed which revealed that chloro substitutions were playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic mols. showed competitive mode of inhibition against α-amylase and non-competitive mode of inhibition against α-glucosidase enzyme. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2Quality Control of 2-Chloro-3,4-difluorobenzoic acid)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of 2-Chloro-3,4-difluorobenzoic acid The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics