Tag: 100-200

Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2 was written by Takeuchi, Kumiko;Holloway, William G.;Mitch, Charles H.;Quimby, Steven J.;McKinzie, Jamie H.;Suter, Todd M.;Statnick, Michael A.;Surface, Peggy L.;Emmerson, Paul J.;Thomas, Elizabeth M.;Siegel, Miles G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of macrosporin and related 9,10-anthraquinones by biomimetic polyketide aromatization and cyclization of 6-benzylresorcylates was written by Cordes, Jens;Barrett, Anthony G. M.. And the article was included in European Journal of Organic Chemistry in 2013.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

The synthesis of an array of 1-hydroxy-3-methoxy-9,10-anthraquinones by initial preparation of 6-benzylresorcylates from oxo-dioxinone precursors and their subsequent conversion to anthrones by cyclization and oxidn was described. The resorcylates were obtained by an improved 2-step procedure from 6-(4-allyloxy-2,4-dioxobutyl)-2,2-dimethyl-2,4-dihydro-1,3-dioxin-4-one and benzeneacetyl chlorides. These methods were applied in a 7-step synthesis of the fungal natural product macrosporin. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Specific substituent effects in the dehalogenation of halobenzene derivatives by the gaseous Broensted acid CH₅⁺ was written by Leung, Hei-Wun;Harrison, Alex G.. And the article was included in Journal of the American Chemical Society in 1980.Synthetic Route of C8H10ClN This article mentions the following:

In the methane chem. ionization mass spectra of chlorobenzene derivatives containing an electron-donating substituent meta to the chlorine, the protonated mol. ions, MH⁺, formed in the initial protonation reaction undergo extensive loss of HCl to form substituted Ph cations. This dehalogenation reaction is not observed when the substituent is ortho or para to the chlorine (except for the p-dimethylamino substituent) nor for electron-withdrawing substituents. For fluorobenzene derivatives loss of HF from MH⁺ is observed when the substituent is meta or para to the fluorine but not when it is ortho to the fluorine. The origin of these unusual substituent effects is discussed and it is concluded that the substituents act to alter the carbon-halogen bond dipole. This bond dipole in turn exerts a kinetic effect which either alters the activation energy for elimination of the neutral hydrogen halide from MH⁺ or, more likely, influences the extent of protonation at the halogen through localized ion-bond dipole interactions in the collision complex. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Synthetic Route of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The rate of N-demethylation of N,N-dimethylanilines and N-methylanilines by rat liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor was written by Galliani, G.;Nali, M.;Rindone, B.;Tollari, S.;Rocchetti, M.;Salmona, M.. And the article was included in Xenobiotica in 1986.Recommanded Product: 2-Chloro-N,N-dimethylaniline This article mentions the following:

The N-demethylation of a series of 12 p-substituted N,N-dimethylanilines [e.g., 4-fluoro-N,N-dimethylaniline (I) [403-46-3]], 9 m-substituted N,N-dimethylanilines, 1 o-substituted N,N-dimethylaniline, and 4 p-substituted N-methylanilines by rat liver microsomes was studied. For each compound, the apparent V_max and K_m values were determined and these parameters were correlated with their electronic, lipophilicity, and steric bulk parameters reported in the literature. Multi-parameter linear regression anal. showed a good correlation between log V_max and these parameters for the p-substituted N,N-dimethylanilines. A lower degree of correlation was observed with the m-substituted N,N-dimethylanilines. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of α-haloalkyl esters from α-arylthioalkyl esters was written by Benneche, Tore;Strande, Per;Wiggen, Unni. And the article was included in Acta Chemica Scandinavica in 1989.HPLC of Formula: 5335-05-7 This article mentions the following:

Ester R¹CO₂CHR²SR³ (R¹ = Me, Me₃C, PhCH₂, MeO₂CCH₂CH₂, MeCOCH₂CH₂, Ph, HCOC₆H₄, thienyl; R² = H, Me; R³ = ClC₆H₄, Ph) were treated with SO₂Cl₂ and Br to give R¹CO₂CHR²X (X = Cl, Br). In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7HPLC of Formula: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Design of Nonpeptide AVP V₂ Receptor Agonists: Structural Requirements for an Agonist Having 1-(4-Aminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine as a Template was written by Kondo, Kazumi;Ogawa, Hidenori;Shinohara, Tomoichi;Kurimura, Muneaki;Tanada, Yoshihisa;Kan, Keizo;Yamashita, Hiroshi;Nakamura, Shigeki;Hirano, Takahiro;Yamamura, Yoshitaka;Mori, Toyoki;Tominaga, Michiaki;Itai, Akiko. And the article was included in Journal of Medicinal Chemistry in 2000.COA of Formula: C8H6ClFO2 This article mentions the following:

The discovery of a series of nonpeptide arginine vasopressin V₂ receptor agonists is described. After identifying the aniline derivative (I) as our lead compound from the metabolites of a previously studied compound that showed antidiuretic activity by po administration to Brattleboro rats, improvements in the in vitro potency involving evaluations of the structural requirements for agonist action and optimizing the structure of the benzoyl moiety have been intensively undertaken. These studies led to a series of compounds e.g. (II) that show potent agonist activity for the V₂ receptor. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3COA of Formula: C8H6ClFO2).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C8H6ClFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Azo-functionalized microporous organic polymers: synthesis and applications in CO₂ capture and conversion was written by Yang, Zhenzhen;Zhang, Hongye;Yu, Bo;Zhao, Yanfei;Ma, Zhishuang;Ji, Guipeng;Han, Buxing;Liu, Zhimin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Product Details of 698-01-1 This article mentions the following:

Azo-functionalized MOPs (Azo-MOPs) were synthesized via oxidative polymerization of aromatic amines catalyzed by t-BuOCl/NaI (25 °C, 1 h, yield: >95%), which displayed an excellent coordinating ability with a Ru complex. The resulting Ru-coordinated Azo-MOPs displayed high CO₂ capacity and high performances for catalyzing the methylation of amines with CO₂ under low pressure (0.5 MPa). In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Product Details of 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scalable Methodology for the Catalytic, Asymmetric α-Bromination of Acid Chlorides was written by Dogo-Isonagie, Cajetan;Bekele, Tefsit;France, Stefan;Wolfer, Jamison;Weatherwax, Anthony;Taggi, Andrew E.;Lectka, Thomas. And the article was included in Journal of Organic Chemistry in 2006.Reference of 6834-42-0 This article mentions the following:

The optimization of a practical, catalytic, asym. process for the α-bromination of acid chlorides to produce synthetically versatile, optically active α-bromo esters was reported. A range of products was produced in high enantioselectivity and moderate to good chem. yields with retention of both upon scale-up. The reactions were catalyzed by cinchona alkaloid derivatives with the best performance achieved by the use of a proline cinchona alkaloid conjugate designed in a de novo fashion. Thus, PhCH₂COCl in THF containing NaH, 15-crown-5, and the ester of N-Boc-proline with quinine at -78° reacted with 1,1,3,6-tetrabromo-2(1H)-naphthalenone for five hours to give 55% of the tribromonaphthyl bromophenylacetate I with 99% enantiomeric excess. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Halogenated carbonyl ylides in the reactions of mercurial dihalocarbene precursors with substituted benzaldehydes was written by Martin, Charles W.;Lund, Paul R.;Rapp, Erich;Landgrebe, John A.. And the article was included in Journal of Organic Chemistry in 1978.Computed Properties of C9H9ClO2 This article mentions the following:

The reactions of PhHgCBrCl₂ (I) with RC₆H₄CHO [R = H (II), 3-CF₃ (III), 4-MeO (IV)] and 2,4,6-Me₃C₆H₂CHO were studied. Relative reactivities with respect to I were III (0.08), II (0.3), BuCH:CH₂ (0.3), IV (0.9), cyclohexene (1.0), and Me₂C:CMe₂ (15.0). Complexation between I and the aldehyde enhanced the rate of decomposition of I to produce :CCl₂ of the same reactivity as that from I alone. The intermediacy of dichlorocarbonyl ylides was proposed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Computed Properties of C9H9ClO2).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ni-Catalyzed Enantioselective Benzylation of Secondary Phosphine Oxide was written by Cai, Wen-Qiang;Wei, Qi;Zhang, Qing-Wei. And the article was included in Organic Letters in 2022.Product Details of 620-19-9 This article mentions the following:

A nickel-catalyzed benzylic substitution of secondary phosphine oxide was described, affording the dialkylated P-stereogenic tertiary phosphine oxides with high to excellent enantioselectivities. The reaction was performed under mild conditions with com. available benzyl chlorides and bench stable secondary phosphine oxides, exhibiting broad functional group tolerance. It represented a practical example for the preparation of P-stereogenic phosphine compounds In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Product Details of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics