Tag: 100-200

Zhang, Jin; Zhang, Pei; Shao, Lei; Wang, Ruihong; Ma, Yangmin; Szostak, Michal published an article in 2022. The article was titled 《Mechanochemical Solvent-Free Suzuki-Miyaura Cross-Coupling of Amides via Highly Chemoselective N-C Cleavage》, and you may find the article in Angewandte Chemie, International Edition.Product Details of 768-35-4 The information in the text is summarized as follows:

The first mechanochem. strategy for highly chemoselective, solvent-free palladium-catalyzed cross-coupling of amides by N-C bond activation was reported. The method was conducted in the absence of external heating, for short reaction time and shows excellent chemoselectivity for σ N-C bond activation. The reaction showed excellent functional group tolerance and could be applied to late-stage functionalization of complex APIs and sequential orthogonal cross-couplings exploiting double solventless solid-state methods. The results extend mechanochem. reaction environments to advance the chem. repertoire of N-C bond interconversions to solid-state environmentally friendly mechanochem. methods. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Runlai; Huang, Mingxin; Zhang, Shuai; Li, Long; Li, Mi; Sun, Jun; Wu, Lan; Guan, Qi; Zhang, Weige published an article in 2021. The article was titled 《Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of (3-Fluorophenyl)boronic acid The information in the text is summarized as follows:

A series of new 6- substututed phenyl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles I [R = H, 4-F, 2-F-4-Me, etc.] as tubulin polymerization inhibitors targeting the colchicine-binding site were designed to restrict bioactive configuration of (Z,E)-vinylogous CA-4. All of the target compounds I were synthesized and then evaluated for their in-vitro antiproliferative activities. Among them, compound I [R = 3-HO-4-MeO] exhibited the most potent activities against three cancer cell lines with IC50 values in the range of 0.037-0.20μM. Further mechanism studies revealed that compound I [R = 3-HO-4-MeO] inhibited tubulin polymerization, disrupted cell microtubule networks, arrested the cell cycle at G2/M phase, induced apoptosis and hindered cancer cell migration. Moreover, compound I [R = 3-HO-4-MeO] displayed significant in-vivo antitumor efficacy in 4T1-xenograft mice model with tumor growth inhibition rate of 52% at the dose of 2.5 mg/kg. Colchicine competition assay and the docking model of compound I [R = 3-HO-4-MeO] in complex with tubulin showed that compound I [R = 3-HO-4-MeO] acted at the colchicine-binding site. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Yi-Qian; Gu, Zheng-Yang; Chen, Ye; Xia, Ji-Bao published an article in 2021. The article was titled 《Pd-Catalyzed Amidation of Silyl Enol Ethers With CO and Azides via an Isocyanate Intermediate》, and you may find the article in Asian Journal of Organic Chemistry.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

An efficient Pd-catalyzed amidation of silyl enol ethers to produce β-ketoamides I [R = Me, Ph, 4-MeC6H4, etc.; R1 = n-Bu, Ph, Bn, etc.; R2 = H, Me, Et; RR2 = (CH2)3] had been developed using carbon monoxide and sulfonyl azides. The tandem reaction provided a simple and straightforward approach for the synthesis of β-ketoamides I under mild conditions without any additive. The mechanistic studies indicated that the reaction undergoes via an in situ generated isocyanate intermediate. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Catalytic synthesis of thiazolidines by the reaction of Nef-isocyanide reaction》 was written by Daghlavi, Amneh; Kowsari, Elaheh; Abdouss, Majid; Ghasemi, Mohammad Hadi; Asadi, Elham. HPLC of Formula: 5781-53-3 And the article was included in Research on Chemical Intermediates in 2020. The article conveys some information:

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H2PO4) is described. A relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, SEM, energy-dispersive x-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H2PO4 as a catalytic system, the best results were obtained. All products were characterized using m.p., FTIR, MASS, 1H NMR, and 13C NMR techniques. The use of com. available chems., reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, microwave-assisted synthesis, biological evaluation and molecular modeling studies of 4-phenylthiazoles as potent fatty acid amide hydrolase inhibitors》 was written by Wilt, Stephanie R.; Rodriguez, Mark; Le, Thanh N. H.; Baltodano, Emily V.; Salas, Adrian; Pecic, Stevan. Application of 16629-19-9 And the article was included in Chemical Biology & Drug Design in 2020. The article conveys some information:

Endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are endogenous lipids that activate cannabinoid receptors. Activation of these receptors produces anti-inflammatory and analgesic effects. Fatty acid amide hydrolase (FAAH) is a membrane enzyme that hydrolases endocannabinoids; thus, inhibition of FAAH represents an attractive approach to develop new therapeutics for treating inflammation and pain. Previously, potent rat FAAH inhibitors containing 2-naphthyl- and 4-phenylthiazole scaffolds were identified, but up to the present time, very little structure-activity relationship studies have been performed on these moieties. We designed and synthesized several analogs containing these structural motifs and evaluated their inhibition potencies against human FAAH enzyme. In addition, we built and validated a homol. model of human FAAH enzyme and performed docking experiments We identified several inhibitors in the low nanomolar range and calculated their ADME predicted values. These FAAH inhibitors represent promising drug candidates for future preclin. in vivo studies. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Metal-Free Electrochemical Coupling of Vinyl Azides: Synthesis of Phenanthridines and β-Ketosulfones》 was written by Li, Guodong; Kong, Xianqiang; Liang, Qi; Lin, Long; Yu, Ke; Xu, Bo; Chen, Qianjin. Recommanded Product: Thiophene-2-sulfonyl chloride And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

The authors reported an efficient and environmentally benign electrochem. synthesis of phenanthridines by oxidative coupling of vinyl azides with sodium azide or benzenesulfonyl hydrazides, for the first time. The reaction conditions are mild, and no addnl. metal-catalyst or exogenous oxidants are needed. The protocol has broad substrate scope and high functional group tolerance. Furthermore, this green electrochem. procedure can be readily extended to the synthesis of β-ketosulfones. Gram scale reactions further demonstrate the practicability. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Exploring the Relationship between BODIPY Structure and Spectroscopic Properties to Design Fluorophores for Bioimaging》 was published in Chemistry – A European Journal in 2020. These research results belong to Donnelly, Joanna L.; Offenbartl-Stiegert, Daniel; Marin-Beloqui, Jose M.; Rizzello, Loris; Battaglia, Guiseppe; Clarke, Tracey M.; Howorka, Stefan; Wilden, Jonathan D.. Product Details of 5781-53-3 The article mentions the following:

Designing chromophores for biol. applications requires a fundamental understanding of how the chem. structure of a chromophore influences its photophys. properties. We here describe the synthesis of a library of BODIPY dyes, exploring diversity at various positions around the BODIPY core. The results show that the nature and position of substituents have a dramatic effect on the spectroscopic properties. Substituting in a heavy atom or adjusting the size and orientation of a conjugated system provides a means of altering the spectroscopic profiles with high precision. The insight from the structure-activity relationship was applied to devise a new BODIPY dye with rationally designed photochem. properties including absorption towards the near-IR region. The dye also exhibited switch-on fluorescence to enable visualization of cells with high signal-to-noise ratio without washing-out of unbound dye. The BODIPY-based probe is non-cytotoxic and compatible with staining procedures including cell fixation and immunofluorescence microscopy. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Zhang, Wen; Wu, Lianqian; Chen, Pinhong; Liu, Guosheng. Quality Control of (3-Fluorophenyl)boronic acid. The article was titled 《Enantioselective Arylation of Benzylic C-H Bonds by Copper-Catalyzed Radical Relay》. The information in the text is summarized as follows:

A novel enantioselective copper-catalyzed arylation of benzylic C-H bonds, using alkylarenes as a limiting reagent, has been developed. A chiral bisoxazoline ligand bearing an acetate ester moiety plays a key role in both the reactivity and enantioselectivity of the reaction. The reaction provides efficient access to various chiral 1,1-diarylalkanes in good yields with good to excellent enantioselectivities, and displays excellent functional-group tolerance. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of Thiophene-2-sulfonyl chlorideIn 2020 ,《Electrochemical Oxidation-induced Difunctionalization of Alkynes and Alkenes with Sulfonyl Hydrazides: Facile Access to β-Selenovinyl Sulfones and β-Ketosulfones》 was published in Asian Journal of Organic Chemistry. The article was written by Kong, Xianqiang; Yu, Ke; Chen, Qianjin; Xu, Bo. The article contains the following contents:

Herein, an efficient electrochem. oxidative selenosulfonylation of alkynes R1CCR2 (R1 = Et, Ph, naphthalen-2-yl, etc.; R2 = H, Me, Ph, etc.) and oxysulfonylation of alkenes R3CH=CH2 (R3 = H, 4-nitrophenyl, 3,4-dichlorophenyl, etc.) without use of metal catalysts were reported. This method provides a practical access to a wide range of β-(seleno)vinyl sulfones RS(O)2C(R2)=C(R1)SePh (R = Et, 4-chlorophenyl, thiophen-2-yl, etc.) and β-keto sulfones RS(O)2CH2C(O)R3. These reactions can tolerate various functional groups and be easily scaled-up. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Safety of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Safety of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xian; Feng, Xiaoliang; Chen, Fan; Zhu, Shengqing; Qing, Feng-Ling; Chu, Lingling published an article in 2021. The article was titled 《Divergent Aminocarbonylations of Alkynes Enabled by Photoredox/Nickel Dual Catalysis》, and you may find the article in Angewandte Chemie, International Edition.Application of 5781-53-3 The information in the text is summarized as follows:

A metallaphotoredox-catalyzed strategy for the selective and divergent aminocarbonylation of alkynes with amines and 1 atm of CO was reported. This synergistic protocol not only enables the Markovnikov-selective hydroaminocarbonylation of alkynes to afford α,β-unsaturated amides, but also facilitated a sequential four-component hydroaminocarbonylation/radical alkylation in the presence of tertiary and secondary alkyl boronate esters, which allowed for straightforward conversion of alkynes into corresponding amides. Preliminary mechanistic studied disclose that a photoinduced oxidative insertion of aniline and CO into nickel followed by a migratory insertion of (carbamoyl)nickel species was involved. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics