Tag: 100-200

《Ligand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M.. Synthetic Route of C6H6BFO2 The article mentions the following:

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochem. outcome. Markovnikov hydrofunctionalization products were obtained under mild ligand-free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° vs. 2°) in the rate- and regioselectivity-determining transmetalation transition state. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Pd-Catalyzed Enantioselective Ring Opening/Cross-Coupling and Cyclopropanation of Cyclobutanones》 were Cao, Jian; Chen, Ling; Sun, Feng-Na; Sun, Yu-Li; Jiang, Ke-Zhi; Yang, Ke-Fang; Xu, Zheng; Xu, Li-Wen. And the article was published in Angewandte Chemie, International Edition in 2019. Computed Properties of C6H6BFO2 The author mentioned the following in the article:

A palladium-catalyzed enantioselective sequential ring-opening/cross-coupling of cyclobutanones is disclosed that provides chiral indanones bearing C3-quaternary stereocenters. The reaction process involves palladium-catalyzed nucleophilic addition of cyclobutanones and aryl halides, enantioselective β-carbon elimination, and intermol. trapping of a transient σ-alkylpalladium complex with boronic acids. Alternatively, an intramol. cyclopropanation is realized through C-H bond functionalization in the absence of external coupling reagents, affording chiral cyclopropane-fused-indanones in good yields and enantioselectivity.(3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents》 were Zhao, Liyu; Tian, Linfeng; Sun, Nannan; Sun, Yin; Chen, Yixuan; Wang, Xinran; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng. And the article was published in European Journal of Medicinal Chemistry in 2019. Related Products of 768-35-4 The author mentioned the following in the article:

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alc. derivatives were designed and synthesized. 3-F substituted compounds 14i(A), 14n(B), 14s(C) and 14v(D) exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03-0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1-2 μg/mL. Notably, Compounds A, B, C and D also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of D stemmed from inhibition of C. albicans CYP51. Compounds B and D were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.(3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Jadhav, Sandip B.; Thopate, Satish B.; Nanubolu, Jagadeesh Babu; Chegondi, Rambabu. Recommanded Product: 768-35-4. The article was titled 《Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization》. The information in the text is summarized as follows:

The rhodium-catalyzed arylative cyclization of enone tethered-cyclohexadienones I (R = Me, Et, i-Pr, (CH2)2OTBS; Ar = C6H5, 4-F3CC6H4, 3-BrC6H4, etc.) has been developed with high efficiency, thus providing cis-fused bicyclic enones II (R = Me, Et, i-Pr, (CH2)2OTBS; Ar = C6H5, 4-F3CC6H4, 3-BrC6H4, etc.; Ar1 = C6H5, 2-MeOC6H4, 4-ClC6H4, etc.) in good yields and with excellent diastereoselectivities. Furthermore, this mild transformation has a broad range of substrate scope and excellent functional group tolerance. In addition, bicyclic products have an enone functionality, which can be a synthetically valuable handle for further transformations. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,European Journal of Medicinal Chemistry included an article by Zhao, Liyu; Sun, Nannan; Tian, Linfeng; Sun, Yin; Chen, Yixuan; Wang, Xinran; Zhao, Shizhen; Su, Xin; Zhao, Dongmei; Cheng, Maosheng. Name: (3-Fluorophenyl)boronic acid. The article was titled 《Combating fluconazole-resistant fungi with novel β-azole-phenylacetone derivatives》. The information in the text is summarized as follows:

A series of β-azole-phenylacetone derivatives I (R1 = H, 2-F, 3-F, etc. ; R2 = 2-CH3, 4-F, 2-Cl, etc.; R3 = 3-Cl, 4-F, 4-CH3, etc.) with novel structures were designed and synthesized to combat the increasing incidence of susceptible fungal infections and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against five susceptible strains and five fluconazole-resistant strains and most of the compounds exhibited excellent antifungal activities with MIC values in the range of 0.03-1 μg/mL. Compounds I (R1 = 3-F, R2 = R3 = H), I (R1 = R2 = H; R3 = 2-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) exhibited moderate antifungal activities against fluconazole-resistant strains 17# and CaR with MIC values in the range of 1-8 μg/mL. Compounds I (R1 = 2-F; R2 = R3 = H), I (R1 = R2 = H; R3 = 2-F) and I (R1 = R3 = 2-F; R2 = H) displayed moderate to good antifungal activity against fluconazole-resistant strains 632, 901 and 904 with MIC values in the range of 0.125-4 μg/mL. Notably, I (R1 = R2 = H; R3 = 2-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) exhibited antifungal activity against five susceptible strains and five fluconazole-resistant strains. Preliminary mechanistic studies showed that the potent antifungal activity of compound I (R1 = 2-F; R2 = H; R3 = 4-CH3) stemmed from inhibition of C. albicans CYP51. Compounds I (R1 = R2 = H; R3 = 2-F), I (R1 = 3-F; R2 = H; R3 = 4-F) and I (R1 = 2-F; R2 = H; R3 = 4-CH3) were nearly nontoxic to mammalian A549 cells. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Efficient diverse approach for quinoxaline-derived glycosylated and morphinylated analogs》 were Beldi, Razika; Atta, Kamal F.; Aboul-Ela, Sallah; El Ashry, El Sayed H.. And the article was published in Journal of Heterocyclic Chemistry in 2010. Safety of 2-(2-Chloroethoxy)ethyl acetate The author mentioned the following in the article:

Sulfanyl-glycosides have been synthesized by reaction of dimercaptoquinoxaline I (R = H) with aceto-halo sugars in presence of base to give the thioglycosides-derived quinoxalines, e.g. II. Similarly, the acyclic analogs, e.g. I (R = Me), were prepared by coupling of I (R = H) with different acyclo-alkylating agents. The preparation of 3-morpholinyl quinoxalines allowed the synthesis of 3-glycosylsulfanyl-2-morpholinyl quinoxalines as well as the acyclic analogs. Microwave irradiation of the reactants turned out to be preferred over the conventional method for achieving the synthetic goals. This study made an available venue to the synthesis of diverse quinoxaline derivatives The results came from multiple reactions, including the reaction of 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Safety of 2-(2-Chloroethoxy)ethyl acetate)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of 2-(2-Chloroethoxy)ethyl acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen》 were Li, Zhen; Wang, Zhen; Chekshin, Nikita; Qian, Shaoqun; Qiao, Jennifer X.; Cheng, Peter T.; Yeung, Kap-Sun; Ewing, William R.; Yu, Jin-Quan. And the article was published in Science (Washington, DC, United States) in 2021. Safety of 2-Chloroisonicotinic acid The author mentioned the following in the article:

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. IR, x-ray, and computational anal. support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites. In addition to this study using 2-Chloroisonicotinic acid, there are many other studies that have used 2-Chloroisonicotinic acid(cas: 6313-54-8Safety of 2-Chloroisonicotinic acid) was used in this study.

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 2-Chloroisonicotinic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nafie, Mohamed S.; Elghazawy, Nehal H.; Owf, Salma M.; Arafa, Kholoud; Abdel-Rahman, Mohamed A.; Arafa, Reem K. published an article on January 5 ,2022. The article was titled 《Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives》, and you may find the article in Chemico-Biological Interactions.Category: chlorides-buliding-blocks The information in the text is summarized as follows:

New semi-synthetic effective and safe anticancer agents isoeugenol derivatives were synthesized, characterized, and screened for their cytotoxic activity against MCF-7. Moreover, their selective cytotoxicity was assessed against MCF-10A. Three derivatives, 2, 8 and 10 were significantly more active than the reference drug 5-FU with IC50 values of 6.59, 8.07 and 9.63 and 30.93 μM, resp. Also interestingly, these derivatives demonstrated some degree of selectivity to cancer cells over normal cells. Furthermore, derivative 2 was subjected to other in vitro experiments against MCF-7 where it inhibited colony formation by 87.5% and lowered ERα concentration to 395.7 pg/mL compared to 1129 pg/mL in untreated control cells. In continuation of the investigation, the apoptotic activity of compound 2, was assessed where it significantly enhanced total apoptotic cell death by 9.16-fold (18.70% compared to 1.64% for the untreated MCF-7 control cells) and arrested the cell cycle at the G2/M phase. Furthermore, the mol. mechanism of apoptotic activity was investigated at both the gene (RT-PCR) and protein (western plotting) levels where upregulation of pro-apoptotic and down regulation of anti-apoptotic genes was detected. Addnl., compound 2 treatment enhanced the antioxidant (GSH, CAT, SOD) activities. Finally, in vivo experiments verified the effective anticancer activity of compound 2 through inhibition of tumor proliferation by 47.6% compared to 22.9% for 5-FU and amelioration of the hematol., biochem., and histopathol. examinations near normal. In effect, compound 2 can be viewed as a promising semi-synthetic derivative of isoeugenol with some degree of selectivity for management of breast cancer through apoptotic induction and ERα downregulation. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kondo, Takashi; Nekado, Takahiro; Sugimoto, Isamu; Ochi, Kenya; Takai, Shigeyuki; Kinoshita, Atsushi; Hatayama, Akira; Yamamoto, Susumu; Kishikawa, Katsuya; Nakai, Hisao; Toda, Masaaki published an article on February 15 ,2008. The article was titled 《Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group》, and you may find the article in Bioorganic & Medicinal Chemistry.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole The information in the text is summarized as follows:

A series of (4β-substituted)-L-prolylpyrrolidine analogs lacking the electrophilic nitrile function were synthesized and their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and duration of ex vivo activity were evaluated. Structural optimization of the analog (I), which was found by high-speed analog synthesis, was carried out to improve the potency and duration of action. A representative compound (II) was evaluated to assess its effect on the plasma glucose level after the oGTT (oral glucose tolerance test) in normal rats. Structure-activity relationships (SAR) are also presented. The results came from multiple reactions, including the reaction of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Application In Synthesis of 5-Chloro-1,2,4-thiadiazole)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Funk, Lutz; Brehmer, Martin; Zentel, Rudolf; Kang, Huiman; Char, Kookheon published an article on January 4 ,2008. The article was titled 《Novel amphiphilic styrene-based block copolymers for induced surface reconstruction》, and you may find the article in Macromolecular Chemistry and Physics.Product Details of 14258-40-3 The information in the text is summarized as follows:

This paper describes the synthesis of amphiphilic block copolymers by living radical polymerization (NMP) of new styrene-like monomers. The polar monomers (ethylene oxide side chains and free hydroxyl- or amino-groups after deprotection) were polymerized in a “”protected form”” to adjust the solubility of the monomers. In this way high molar mass polymers with a narrow polydispersity (around or below 1.2) were accessible. By exposing thin films of these polymers to vacuum (air) or alternatively to water or a hydrophilic surface it becomes possible to switch the surface polarity reversibly between contact angles of about 105° and 83° as a result of surface reconstruction. Through side chains of different length and with different functionalities, it was possible to adjust the glass transition temperatures to values between -2° to 140° for the hydrophilic blocks and -30° to 100° for the hydrophobic block. The wide range of the glass temperatures allowed it to find a block copolymer system with a slow kinetic concerning the surface reconstruction process, so that a mechanistic examination of the process by AFM was possible. It got, thereby, possible to detect the break-up of the hydrophobic surface lamella and the upfold of the hydrophilic lamella in contact with water.2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Product Details of 14258-40-3) was used in this study.

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Product Details of 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics