Tag: 100-200

In 2022,Chang, Xiaoqiang; Chen, Xingyu; Lu, Sixian; Zhao, Yifan; Ma, Yue; Zhang, Dong; Yang, Lan; Sun, Peng published an article in Advanced Synthesis & Catalysis. The title of the article was 《Electrochemical [3+2] Cycloaddition of Anilines and 1,3-Dicarbonyl Compounds: Construction of Multisubstituted Indoles》.Category: chlorides-buliding-blocks The author mentioned the following in the article:

Herein, the intermol. electro-oxidative cycloaddition of anilines and com. available 1,3-dicarbonyl compds was reported. This method provided an alternative route for the synthesis of a broad range of multisubstituted indoles I [R1 = H, 5-EtO, 6-Cl,5-MeO, etc.; R2 = Ts, benzenesulfonyl, ethylsulfonyl, etc.; R3 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.] without a transition-metal catalyst or external chem. oxidant. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sun, Yue; Yang, Zi-Hui; Gu, Wen published an article in Chinese Journal of Structural Chemistry. The title of the article was 《Synthesis, crystal structure and antifungal activity of new furan-1,3,4-oxadiazole carboxamide derivatives》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A series of novel furan-1,3,4-oxadiazole carboxamide derivatives I (R = H, Me, Br, Cl, F) were designed, synthesized and characterized by spectroscopic methods including HR-MS, 1H- and 13C-NMR. The crystal structure of compound I (R = Br) was determined by single-crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P1 with a = 4.7261(5), b = 10.4672(11), c = 14.5886(13) Å, α = 106.081(4)°, β = 91.043(3)°, γ = 99.456(4)°, Z = 2, V = 682.48(12) Å3, Mr = 348.16, Dc = 1.694 Mg/m3, S = 1.008, μ = 3.025 mm-1, F(000) = 348, the final R = 0.0775 and wR = 0.2080 for 2774 observed reflections (I > 2σ(I)). There are two kinds of hydrogen bonds (N(3)-H(3A)…N(2) and C(8)-H(8A)…O(3)) present in its crystal structure. The preliminary antifungal assay showed that compounds I (R = Cl, F) exhibited significant antifungal activities against several plant pathogenic fungi. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Ru; Ding, Lu; Zheng, Chao; You, Shu-Li published an article in 2021. The article was titled 《Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions》, and you may find the article in Science (Washington, DC, United States).Recommanded Product: 768-35-4 The information in the text is summarized as follows:

Z-Olefins are challenging synthetic targets owing to their relative thermodn. instability. Transition metal-catalyzed asym. allylic substitution reactions are well known for installing stereocenters adjacent to branched or E-linear olefins. However, analogous reactions for the synthesis of optically active Z-olefin products are rare. Here we report iridium-catalyzed asym. allylic substitution reactions that retain Z-olefin geometries while establishing an adjacent quaternary stereocenter. The formation of transient anti-π-allyl-iridium intermediates and their capture by external nucleophiles before isomerization to the thermodynamically more stable syn-π-allyl-iridium counterparts have been observed These results provide a promising method for preparing chiral Z-olefinic compounds In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simeon, Fabrice G.; Lee, Jae-Hoon; Morse, Cheryl L.; Stukes, Ian; Zoghbi, Sami S.; Manly, Lester S.; Liow, Jeih-San; Gladding, Robert L.; Dick, Rachel M.; Yan, Xuefeng; Taliani, Sabrina; Costa, Barbara; Martini, Claudia; Da Settimo, Federico; Castellano, Sabrina; Innis, Robert B.; Pike, Victor W. published an article in 2021. The article was titled 《Synthesis and Screening in Mice of Fluorine-Containing PET Radioligands for TSPO: Discovery of a Promising 18F-Labeled Ligand》, and you may find the article in Journal of Medicinal Chemistry.HPLC of Formula: 768-35-4 The information in the text is summarized as follows:

Translocator protein 18 kDa (TSPO) is a biomarker of neuroinflammation. [11C]ER176 robustly quantifies TSPO in the human brain with positron emission tomog. (PET), irresp. of subject genotype. We aimed to develop an ER176 analog with potential for labeling with longer-lived fluorine-18 (t1/2 = 109.8 min). New fluoro and trifluoromethyl analogs of ER176 were prepared through a concise synthetic strategy. These ligands showed high TSPO affinity and low human genotype sensitivity. Each ligand was initially labeled by a generic 11C-methylation procedure, thereby enabling speedy screening in mice. Each radioligand was rapidly taken up and well retained in the mouse brain at baseline after i.v. injection. Preblocking of TSPO showed that high proportions of brain uptake were specifically bound to TSPO at baseline. Overall, the 3-fluoro analog of [11C]ER176 ([11C]3b) displayed the most promising imaging properties. Therefore, a method was developed to label 3b with [18F]fluoride ion. [18F]3b gave similarly promising PET imaging results and deserves evaluation in higher species. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wan, Hai-Lan; Guan, Zhi; He, Yan-Hong published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Electrochemically Promoted Bifunctionalization of Alkynes for the Synthesis of β-Keto Sulfones》.Name: Thiophene-2-sulfonyl chloride The article contains the following contents:

An electrochem. oxidative difunctionalization of internal and terminal alkynes with sulfonyl hydrazides for the synthesis of β-keto sulfones has been achieved. The reaction involves the addition of sulfonyl radicals to alkynes, and the resulting alkenyl radicals are oxidized to alkenyl cations, which are then nucleophilically attacked by H2O, followed by tautomerization to form β-keto sulfones. The method is green and sustainable as it is catalyst-free, oxidant-free, and additive-free. The new C-O and C-S bonds can be constructed in one-pot to directly access β-keto sulfone derivatives In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Access to galectin-3 inhibitors from chemoenzymic synthons》 was written by Dussouy, Christophe; Teletchea, Stephane; Lambert, Annie; Charlier, Cathy; Botez, Iuliana; Ceuninck, Frederic De; Grandjean, Cyrille. Quality Control of Methyl 2-chloro-2-oxoacetate And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Chemoenzymic strategies are useful for providing both regio- and stereoselective access to bioactive oligosaccharides. We show herein that a glycosynthase mutant of a Thermus thermophilus α-glycosidase can react with unnatural glycosides such as 6-azido-6-deoxy-D-glucose/glucosamine to lead to β-D-galactopyranosyl-(1→3)-D-glucopyranoside or β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-D-glucopyranoside derivatives bearing a unique azide function. Taking advantage of the orthogonality between the azide and the hydroxyl functional groups, the former was next selectively reacted to give rise to a library of galectin-3 inhibitors. Combining enzyme substrate promiscuity and bioorthogonality thus appears as a powerful strategy to rapidly access to sugar-based ligands. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Quality Control of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-Light-Driven Remote C-H Chlorination of Aliphatic Sulfonamides with Sodium Hypochlorite》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Zhu, Yanshuo; Wang, Juan-Juan; Wu, Danhua; Yu, Wei. Reference of Thiophene-2-sulfonyl chloride The article mentions the following:

The C(sp3)-H chlorination of aliphatic sulfonamides was realized by visible-light photoredox catalysis with Ru(bpy)3Cl2 as photocatalsyt and NaOCl·5H2O crystals as the chlorinating agent. The reaction proceeded in a tandem pattern of N-H chlorination and Hofmann-Loffler-Freytag chlorination. A variety of differently substituted sulfonamides were chlorinated in this way in high yield. A radical-chain mechanism was proposed for the reaction on the basis of exptl. evidence. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Mass spectra of some 1,2,4-thiadiazoles》 were Potts, K. T.; Armbruster, R.. And the article was published in Journal of Heterocyclic Chemistry in 1972. Recommanded Product: 5-Chloro-1,2,4-thiadiazole The author mentioned the following in the article:

2,4-Thiadiazoles (I, R1 = SMe, H, Ph, Me, R2 = H, Cl, SH, SCH2CO2H, EtOCH:NNH) underwent fragmentation by loss of RCN(R = R1, R3) from the mol. ion with 3- and 5-substituents involved to some extent. This was followed by loss of S to yield a nitrilium ion. With 5-hydrazino substituents, H transfer was observed from the substituent to a ring N. In addition to this study using 5-Chloro-1,2,4-thiadiazole, there are many other studies that have used 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Recommanded Product: 5-Chloro-1,2,4-thiadiazole) was used in this study.

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 5-Chloro-1,2,4-thiadiazole

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 3-ChlorobenzylchlorideOn March 15, 2022, Yang, Xi; Sun, Hang; Maddili, Swetha Kameswari; Li, Shuo; Yang, Ren-Guo; Zhou, Cheng-He published an article in European Journal of Medicinal Chemistry. The article was 《Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens》. The article mentions the following:

The health crisis caused by severe multidrug resistance increasingly compels the exploitation of new alternative antibacterial drugs. A library of structurally unique dihydropyrimidinone imidazoles as novel potential antibacterial agents was developed with the aim to confront drug resistance. Some target compounds exhibited strong antibacterial activities, especially, sulfamethoxazole hybridized dihydropyrimidinone imidazole 8b was found to be extremely active against multidrug-resistant K. pneumonia and A. baumanii at a low concentration of 0.5 μg/mL, which outperformed norfloxacin even clinafloxacin. This active compound not only exhibited low cytotoxicity to mammalian cells (human red blood cells, HepG2 and ECs), but also possessed rapid bactericidal property, good biofilm inhibition ability, and a low propensity to induce K. pneumonia and A. baumanii resistance. Further studies revealed that the inhibitory effect of the active compound 8b might be achieved by disrupting membrane integrity, increasing ROS generation, reducing GSH activity and interacting with DNA. These findings provided a bright hope for developing dihydropyrimidinone imidazoles to combat emergent drug resistance. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 3-ChlorobenzylchlorideOn June 7, 2021, An, Shaoyu; Zhang, Zhong; Li, Pingfan published an article in European Journal of Organic Chemistry. The article was 《Metal-Free Synthesis of Selenodihydronaphthalenes by Selenoxide-Mediated Electrophilic Cyclization of Alkynes》. The article mentions the following:

A transition-metal-free, selenium mediated electrophilic cyclization reaction was realized through a one-pot procedure between simple alkynes and triflic anhydride-activated selenoxides to give selenium containing dihydronaphthalene products. This method gave good to very high yields for all products, including selenium-substituted phenanthrene, dihydroquinoline, 2H-chromene, and coumarin, which can be further transformed to other functionalized compounds The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Safety of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Safety of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics