Tag: 100-200

Novel Ferulic Amide Ac6c Derivatives: Design, Synthesis, and Their Antipest Activity was written by Zhang, Renfeng;Guo, Shengxin;Deng, Peng;Wang, Ya;Dai, Ali;Wu, Jian. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Thirty-eight novel ferulic amide 1-aminocyclohexane carboxylic acid (Ac6c) derivatives D1-D19 (I) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; and E1-E19 (II) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; were designed and synthesized, and their antibacterial, antifungal, and insecticidal activities were tested. Most of the synthesized compounds displayed excellent activity against Xanthomonas oryzae pv. oryzae (Xoo), with EC₅₀ values ranging from 11.6 to 83.1μg/mL better than that of com. bismerthiazol (BMT, EC₅₀ = 84.3μg/mL), as well as much better performance compared to that of thiediazole copper (TDC, EC₅₀ = 137.8μg/mL). D6 (EC₅₀ = 17.3μg/mL), D19 (EC₅₀ = 29.4μg/mL), E3 (EC₅₀ = 29.7μg/mL), E9 (EC₅₀ = 27.0μg/mL), E10 (EC₅₀ = 18.6μg/mL), and E18 (EC₅₀ = 20.8μg/mL) showed much higher activity on Xanthomonas oryzae pv. oryzicola compared with BMT (EC₅₀ = 80.1μg/mL) and TDC (EC₅₀ = 124.7μg/mL). In relation to controlling the fungus, Rhizoctonia solani, E1, E10, and E13 had much lower EC₅₀ values of 0.005, 0.140, and 0.159μg/mL compared to hymexazol at 74.8μg/mL. Further in vivo experiments demonstrated that E6 and E12 controlled rice bacterial leaf blight disease better than BMT and TDC did. SEM studies revealed that E12 induced the Xoo cell membrane collapse. Moreover, D13 (73.7%), E5 (80.6%), and E10 (73.4%) also showed moderate activity against Plutella xylostella. These results indicated that the synthesized ferulic amide Ac6c derivatives showed promise as candidates for treating crop diseases. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of μ-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions was written by Dockendorff, Chris;Jin, Shujuan;Olsen, Madeline;Lautens, Mark;Coupal, Martin;Hodzic, Lejla;Spear, Nathan;Payza, Kemal;Walpole, Christopher;Tomaszewski, Miroslaw J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application of 6834-42-0 This article mentions the following:

A series of 1-aminotetralin scaffolds was synthesized via metal-catalyzed ring-opening reactions of heterobicyclic alkenes. Small libraries of amides and amines were made using the amino group of each scaffold as a handle. Screening of these libraries against human opioid receptors led to the identification of (S)-(S)-I as a high-affinity selective μ ligand (IC₅₀ μ = 5 nM, κ = 707 nM, δ = 3,795 nM) displaying μ-agonist/antagonist properties due to its partial agonism (EC₅₀ = 2.6 μM; E _max = 18%). In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) was written by Ali, Abdelselam;Bliese, Marianne;Rasmussen, Jo-Anne M.;Sargent, Roger M.;Saubern, Simon;Sawutz, David G.;Wilkie, John S.;Winkler, David A.;Winzenberg, Kevin N.;Woodgate, Ruth C. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Related Products of 75279-55-9 This article mentions the following:

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives, e.g., I, were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9Related Products of 75279-55-9).

2-Chloro-6-fluorophenylacetonitrile (cas: 75279-55-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 75279-55-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction was written by Kim, Seung-Hoi;Rieke, Reuben D.. And the article was included in Tetrahedron in 2010.Synthetic Route of C8H4ClNO This article mentions the following:

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides I (X = CH₂, N; Y = N, CH₂) has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, resp. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones and their anticonvulsant activities was written by Quan, Zhe-Shan;Wang, Jun-Min;Rho, Jung-Rae;Kwak, Kyung-Chell;Kang, Hee-Cheol;Jun, Chang-Soo;Chai, Kyu-Yun. And the article was included in Bulletin of the Korean Chemical Society in 2005.Application of 697-73-4 This article mentions the following:

A series of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones were synthesized through nitration, reduction, diazotization, hydrolysis, and alkylation from 3,4-dihydro-2(1H)-quinolinone. Their structures were characterized by IR, ¹H-NMR, and MS. The anticonvulsant activity was evaluated by the maximal electroshock test (MES) and the s.c. pentylenetetrazole (metrazole) test (scMet). The neurotoxicity was measured by the rotarod test (Tox). The result showed that 6-hexyloxy-3,4-dihydro-2(1H)-quinolinone was potent in anti-MES and anti-scMet test with ED₅₀ of 24.0 and 21.2 mg/kg, resp., albeit its TD₅₀ (67.6 mg/kg) revealed the high neurotoxicity. 6-Benzyloxy-3,4-dihydro-2(1H)-quinolinone was less effective against MES-induced seizure with ED₅₀ of 29.6 mg/kg, but no neurotoxicity was observed even <300 mg/kg. Its protective index (PI) was >10 preferable to phenytoin, carbamazepin, phenobarbital, and valproate. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Application of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Crystal Structure, Anti-inflammatory and Anti-hyperglycemic Activities of Novel 3,4-Disubstituted 1,2,4-Triazol-5(4H)-one Derivatives was written by Saleem, Muhammad;Yu, Seon-Mi;Rafiq, Muhammad;Kim, Song-Ja;Seo, Sung-Yum;Lee, Ki Hwan. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2014.Computed Properties of C9H9ClO2 This article mentions the following:

A new series of 3,4-disubstituted 1,2,4-triazol-5(4H)-ones I (n = 0, 1; X = 2-F, 4-F, 2-OMe, etc; Y = 3-Me, 2-OMe, 3,4-(OMe)₂, etc.) was synthesized by the dehydrocyclization of hydrazinecarboxamides by refluxing in a 2N sodium hydroxide solution Hydrazinecarboxamides were synthesized via condensation of the corresponding aralkanoic acid hydrazides, with fluoro-, tolyl- and methoxyphenylisocyanates. The structure of compound I (n = 1; X, Y = 2-F) was determined by single crystal X-ray diffraction anal. The final compounds were screened for their anti-inflammatory and anti-diabetic (α-glucosidase and α-amylase inhibition) activity to identify new drugs that might be useful in preventing damage related to diabetes and inflammation. Compounds I (n = 1; X = 3-OMe, 4-OMe, 3,4-(OMe)₂; Y = 3-F, 2-F) decrease the expression of type II collagen in a dose dependent manner; similarly I (n = 1; X = 4-MeO; Y = 3F) decrease the COX-2 expression of rabbit articular chondrocytes in a dose dependent manner possessing potent anti-inflammatory potential while some of derivatives including I (X = 4-F, 2-OMe; Y = 3,4-(OMe)₂ 2-F, 4-F)cause inflammation. Meanwhile, excellent α-glucosidase and moderate α-amylase inhibitory profiles against carbohydrate modulating enzymes were demonstrated by compounds I (n = 0, 1; X = 2-F, 2-OMe, 4-OMe; Y = 3-Me, 3-F, 2-F,) compared to the reference standard acarbose, while some exhibited moderate to low enzyme inhibition potential. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Computed Properties of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

¹⁷O NMR study of ortho and alkyl substituent effects in substituted phenyl and alkyl esters of benzoic acids was written by Nummert, Vilve;Maemets, Vahur;Piirsalu, Mare;Vahur, Signe;Koppel, Ilmar A.. And the article was included in Collection of Czechoslovak Chemical Communications in 2011.Reference of 5335-05-7 This article mentions the following:

¹⁷O NMR spectra for 44 ortho-, meta- and para-substituted Ph and alkyl benzoates (C₆H₅CO₂C₆H₄-X, C₆H₅CO₂R) at natural abundance in acetonitrile were recorded. Substituent effects on the ¹⁷O NMR chem. shifts, δ(¹⁷O), of the carbonyl oxygen and the single-bonded phenoxy (OPh) and alkoxy (OR) oxygens have been studied. The δ(¹⁷O) values of the carbonyl oxygen for para derivatives showed a good correlation with the σ° constants The δ(¹⁷O) values of carbonyl oxygen for ortho derivatives were found to be described well with the Charton equation containing the inductive, σ_I, resonance, σ°_R, and steric, E_s^B, substituent constants in case the data treatment was performed sep. for electron-donating +R and electron-attracting -R substituents. The electron-donating +R ortho and para substituents in substituted benzoates caused shielding and the electron-withdrawing -R substituents produced deshielding of the O signal. The steric interaction of ortho substituents with the ester group decreased the electron d. at the carbonyl oxygen. In alkyl benzoates the δ(¹⁷O) values were found to be described well with the inductive, σ_I, and the steric, E_s^B, substituent constants In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Reference of 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzothiazoles exhibit broad-spectrum antitumor activity: Their potency, structure-activity and structure-metabolism relationships was written by Xie, Xilei;Yan, Yu;Zhu, Ning;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Application of 1711-11-1 This article mentions the following:

An antitumor activity oriented benzothiazole sublibrary was constructed from a hit compound I via a five stepwise procedure. All target compounds were screened for their antitumor activity against 60 human cancer cell lines. Compounds II, III and IV, showing higher potency than hit I, were identified. Particularly, the compound II gave its average 50% growth inhibition (GIC₅₀) at 0.38 μM. Furthermore, incubation in human liver microsome primarily proved their metabolic stability in vitro. General structure-activity and structure-metabolism relationships were both summarized, which provides information on further strategically optimization. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of hazardous wastes by fused silica capillary gas chromatography/Fourier transform infrared spectrometry and gas chromatography/mass spectrometry was written by Shafer, K. H.;Hayes, T. L.;Brasch, J. W.;Jakobsen, R. J.. And the article was included in Analytical Chemistry in 1984.Computed Properties of C8H7ClO2 This article mentions the following:

The results of capillary gas chromatog. (GC)/Fourier transform IR (FTIR) and GC/mass spectrometry (MS) analyses of a hazardous waste sample are presented to demonstrate the high chromatog. resolution, sensitivity, and identifications possible by capillary GC/FTIR. Emphasis is placed on the use of wall-coated open tubular columns for GC/FTIR instead of support-coated open tubular or packed columns which have been more commonly used in the past. Of the 44 compounds detected by either technique, 64% were completely identified and 34% partially identified (exact structure not determined) by GC/FTIR, compared with 30% being completely identified and 52% partially identified by GC/MS. For this sample, capillary GC/FTIR anal. resulted in the characterization of 43 compounds, in contrast to only 17 compounds by packed column GC/FTIR. An automated spectral subtraction of water vapor from each sample spectrum improved spectral search results with correct identifications in some cases being made only after the subtraction procedure. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Computed Properties of C8H7ClO2).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C8H7ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Crystal Structure of Benzoyloxymethyl (4α,8β,13β)-13-methyl-16-oxo-17-norkauran-18-carbonate Ester was written by Cai, Jin;Zhou, Wen;Chen, Junqing;Sun, Min;Ji, Min. And the article was included in Journal of Chemical Crystallography in 2009.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

Isosteviol derivative: benzoyloxymethyl (4α,8β,13β)-13-methyl-16-oxo-17-norkauran-18-carbonate ester was synthesized by esterification of isosteviol with chloromethyl benzoate and its crystal structure was determined by x-ray diffraction method. The compound crystallizes in the triclinic space group P1 with a = 8.784(3) Å, b = 9.079(3) Å, c = 15.950(6) Å, α = 79.343(6)°, β = 79.061(5)°, γ = 89.849(5)°, Z = 2. The conformation of rings A and B is chair, whereas the conformation of ring C is unsym. twist chair. The carbonyl group at the C20 is coplanar with the benzene ring. The fragment of the ester group occupying the pseudoaxial site of C1 position adopts a zigzag conformation. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics