Tag: 100-200

Liu, Lixia; Wang, Chengming published their research in Reaction Chemistry & Engineering in 2021. The article was titled 《Copper-catalyzed redox-neutral regioselective chlorosulfonylation of vinylarenes》.Application of 16629-19-9 The article contains the following contents:

A copper-catalyzed redox-neutral, regioselective aromatic alkene chlorosulfonylation reaction has been developed. This protocol features simple procedure, easily accessible materials and good functional group tolerance. Moreover, it could be amplified to a gram scale and smoothly applied to the late-stage modification of bioactive mol. derivatives In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Stoichiometric Photochemical Carbene Transfer by Bamford-Stevens Reaction》 was written by Jana, Sripati; Li, Fang; Empel, Claire; Verspeek, Dennis; Aseeva, Polina; Koenigs, Rene M.. Formula: C3H3ClO3 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A protocol that takes advantage of the in-situ generation of donor-acceptor diazoalkanes from functionalized tosyl hydrazones by Bamford-Stevens reaction is described. This approach was used in C-H and N-H functionalization and cyclopropanation of nitrogen heterocycles, and the wide scope is illustrated by 51 examples. For example, irradiation of N-tosyl hydrazones RC(CO2Me):NNHTs (R = Ph, 4-MeC6H4, 3-Me-4-MeOC6H4. 4-ClC6H4, etc.) with various R1-substituted N-R2-indoles (R1 = H, 5-Br, 5-MeO2C, 6-F, 4-Br, etc.; R2 = Me, H2C:CHCH2, PhCH2, 4-MeOC6H4, 2-thienyl, etc.) under basic conditions provided the corresponding indoleacetates I in moderate to high yields. Following this strategy, the concentration of the diazoalkane reaction partner was minimized to reduce unwanted side reactions and to now conduct photochem. carbene transfer reactions under stoichiometric reaction conditions. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Hydrolysis of dihydroisoquinoline derivatives activated by sulfonyl or acyl chloride》 was published in Canadian Journal of Chemistry in 2020. These research results belong to Liu, Jianchen; Dang, Xinxin; Chen, Dan; Zhang, Xinyuan; Yang, Zhonglie; Lin, Li; Jiang, Hezhong; Li, Jiahong. Recommanded Product: 16629-19-9 The article mentions the following:

A new, efficient and mild strategy for hydrolysis of 3,4-dihydroisoquinoline imines activated by sulfonyl chloride or acyl chloride was developed, by which method ketosulfonamides I [R = CF3, Ph, 4-MeC6H4, etc.; R1 = H, 5-F, 4-MeO, 5-MeO, 6-MeO, 4,5-di-MeO; R2 = Ph, 4-Br, 2-NO2, etc.] and ketoamides II [R3 = Me, Ph, 2-furyl, etc.] were synthesized. This process tolerated broad scope with respect to both the sulfonyl chloride and acyl chloride with moderate to excellent yields. This protocol features a broad substrate scope for various kinds of 3,4-dihydroisoquinoline and mild reaction conditions without using strong acidic or basic conditions. These features showed that this user-friendly and simple system could be applied in the future to the synthesis of a broader range of amino benzophenones. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and anticancer evaluation of 1,2,4-thiadiazole linked benzoxazole-quinazoline derivatives》 was published in Chemical Data Collections in 2020. These research results belong to Perupogu, Neerada; Krishna, Ch. Murali; Ramachandran, Dittakavi. Application of 16629-19-9 The article mentions the following:

The authors designed and synthesized a series of 1,2,4-thiadiazole-incorporated benzoxazole-quinazoline derivatives I [Ar = 2-thiophenyl, 4-MeC6H4, 3,5-Cl2C6H3, etc.] and screened them for anticancer activity against human cancer cell lines that included MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) and A2780 (ovarian cancer). The clin. agent etoposide was chosen as the pos. control. Among the tested compounds, I [Ar = 5-methylisoxazol-4-yl] showed efficient anticancer activities against the four cancer cell lines. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties》 was published in Bioorganic Chemistry in 2020. These research results belong to Akin Kazancioglu, Elif; Senturk, Murat. Recommanded Product: 16629-19-9 The article mentions the following:

In this study, synthesis of nine N-phenylsulfonamide derivatives I [R = Me, 4-methoxyphenyl, 4-fluorophenyl, 2-thiophenyl, etc.] was designed by starting from aniline, which was the simplest aromatic amine. These compounds I were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds I on carbonic anhydrase I (CA I), CA II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The compound I [R = 2-naphthyl] for CA I, AChE and BChE, 2 for CA II showed a very active inhibition profile (KI 45.7 ± 0.46 for CA I, 33.5 ± 0.38 nM for CA II, 31.5 ± 0.33 nM for AChE and 24.4 ± 0.29 nM for BChE). The results indicate that these N-phenyl-sulfonamide derivatives I were potent CA and cholinesterases and new potential drugs. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids》 were Diemoz, Kayla M.; Franz, Annaliese K.. And the article was published in Journal of Organic Chemistry in 2019. Formula: C6H6BFO2 The author mentioned the following in the article:

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes, including phenols, diols, silanols, carboxylic acids, boronic acids, and phosphoric acids, were examined with a variety of steric and electronic modifications to understand how the structure and secondary effects contribute to hydrogen-bonding ability and catalysis. Hammett plots demonstrate high correlation for the Δδ 31P NMR shift to Hammett parameters, establishing the ability of TEPO binding to predict electronic trends. Upon correlation to catalytic activity in a Friedel-Crafts addition reaction, data demonstrate that 31P NMR shifts correlate to catalytic activity better than pKa values. Boronic acids were investigated, and 31P NMR binding experiments predicted strong hydrogen-bonding ability, for which catalytic activity was confirmed, resulting in the greatest rate enhancement observed in the Friedel-Crafts addition of all organocatalysts studied. A detailed investigation supports that boronic acid activation proceeds through hydrogen-bonding interactions and not coordination with the Lewis acidic boron center. Using 31P NMR spectroscopy offers a simple and rapid tool to quantify and predict hydrogen-bonding abilities for the design and applications of new organocatalysts and supramol. synthons. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Formula: C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Formula: C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum》 was written by Huang, Zhaoxiang; Pang, Daorui; Liao, Sentai; Zou, Yuxiao; Zhou, Pengfei; Li, Erna; Wang, Weifei. Formula: C7H6Cl2 And the article was included in Industrial Crops and Products on April 30 ,2021. The article conveys some information:

Cinnamon is an important spice crop that is widely cultivated in tropical regions. In this study, the antibacterial activities of four accessions of cinnamon essential oil (CEO) belonging to three different species (CEO1 and CEO4, Cinnamomum cassia Presl. (Lauraceae) bark; CEO2, Cinnamomum zeylanicum Blume (Lauraceae) bark; CEO3, Cinnamomum burmannii Blume (Lauraceae) bark) toward Salmonella enterica subsp. enterica serovar pullorum (S. pullorum) were evaluated by microdilution assay and kinetic anal. The min. inhibitory concentration (MIC) of the CEOs were all 0.31 mg/mL, and kinetic anal. suggested that the lag phase and maximum specific growth rate of bacteria were concentration dependent. Furthermore, to explore the synergistic antibacterial effects between main components and minor components, the volatile constituents of CEOs were determined by gas chromatog.-mass spectrometry (GC-MS). Cinnamaldehyde (CM) (57.73 %-91.79 %) was the principal constituent in CEO1-CEO4 (p < 0.05), with CEO3 having the highest CM contents. A synergistic effect against S. pullorum was observed when CA was combined with CM. To explore the potential synergistic mechanism, the membrane glycerophospholipid (GPL) composition of S. pullorum was characterized by ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). CM, CA, and their combination regulated the levels of most phosphatidylethanolamines (PEs), phosphatidylglycerols (PGs), phosphatidic acids (PAs), and some cardiolipins (CLs). In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria》 was published in New Journal of Chemistry in 2019. These research results belong to Nasim, Muhammad Jawad; Witek, Karolina; Kincses, Annamaria; Abdin, Ahmad Yaman; Zeslawska, Ewa; Marc, Malgorzata Anna; Gajdacs, Mario; Spengler, Gabriella; Nitek, Wojciech; Latacz, Gniewomir; Karczewska, Elzbieta; Kiec-Kononowicz, Katarzyna; Handzlik, Jadwiga; Jacob, Claus. Electric Literature of C7H6Cl2 The article mentions the following:

Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC50 = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2Electric Literature of C7H6Cl2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Electric Literature of C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 768-35-4In 2019 ,《Enantioselective Synthesis of Triarylmethanes via Organocatalytic 1,6-Addition of Arylboronic Acids to para-Quinone Methides》 appeared in Advanced Synthesis & Catalysis. The author of the article were Huang, Gong-Bin; Huang, Wei-Hua; Guo, Jing; Xu, Dong-Liang; Qu, Xiao-Chen; Zhai, Pei-Hong; Zheng, Xiu-Hua; Weng, Jiang; Lu, Gui. The article conveys some information:

A method for the preparation of chiral triarylmethanes via organocatalytic 1,6-addition of arylboronic acids to para-quinone methides (p-QMs) was established. Here the use of salicylaldehyde-derived p-QMs with an ortho-hydroxy substituent as a directing group was essential for the remote stereocontrol. In the presence of a BINOL catalyst, chiral triarylmethanes, e.g., I, can be obtained in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee). This method shows broad substrate tolerance and can be easily scaled up, both electron-rich and electron-deficient arylboronic acids are suitable substrates for this addition reaction. In the experimental materials used by the author, we found (3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《General Access to Concave-Substituted cis-Dioxabicyclo[3.3.0]octanones: Enantioselective Total Syntheses of Macfarlandin C and Dendrillolide A》 was written by Allred, Tyler K.; Dieskau, Andre P.; Zhao, Peng; Lackner, Gregory L.; Overman, Larry E.. Electric Literature of C3H3ClO3 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The evolution of a strategy to access the family of rearranged spongian diterpenoids harboring a concave-substituted cis-2,8-dioxabicyclo[3.3.0]octan-3-one fragment is described. The approach involves late-stage fragment coupling of a tertiary-carbon radical and an electron-deficient double bond to form vicinal quaternary and tertiary stereocenters with high fidelity. A stereoselective Mukaiyama hydration is the key step in the subsequent elaboration of the cis-2,8-dioxabicyclo[3.3.0]octan-3-one moiety. This strategy was utilized in enantioselective total syntheses of (-)-macfarlandin C and (+)-dendrillolide A. An efficient construction of enantiopure tetramethyloctahydronaphthalenes was developed during the construction of (-)-macfarlandin C. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Electric Literature of C3H3ClO3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Electric Literature of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics