Tag: 100-200

Duan, Shao-Bo; Gao, Xu-Jing; Zhang, Hong-Yu; Lu, Cong-Cong; Zhao, Jiquan; Han, Ya-Ping; Zhang, Yuecheng; Liang, Yong-Min published their research in Arabian Journal of Chemistry in 2021. The article was titled 《Palladium-catalyzed intramolecular tandem dearomatization of indoles for the synthesis of tetracyclic indolines》.Reference of (3-Fluorophenyl)boronic acid The article contains the following contents:

A highly diastereoselective, atom-economical, and palladium-catalyzed Heck protocol for the assembly of structurally diverse indoline scaffolds with vicinal tertiary as well as quaternary stereocenters is described, starting from readily available N-halobenzoyl o-haloaniline derivatives and phenylboronic acids. This cascade annulation reaction, which is scalable and conducts under an ambient atm., provides the valuable tetracyclic indoline derivatives in an efficient and straightforward way. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Reference of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Reference of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles》 were Guo, Yingying; Wang, Zhoulu; Zhu, Ying; Zhang, Qiaochu; Wei, Donghui; Liu, Xiang; Fu, Zhenqian. And the article was published in Organic Chemistry Frontiers in 2019. SDS of cas: 5781-53-3 The author mentioned the following in the article:

An efficient and direct strategy for the synthesis of polyfunctionalized carbazoles I [R1 = H, 2-Me, 3-Cl, etc.; R2 = Me, Et, Bn, etc.; R3 = H, 8-OMe, 9,10-di-Br; X = NTs, NSO2Ph, O, S] and II [R4 = H, 2-Me, 3-Cl, 2-NO2; R5 = OMe, OEt, OBn; X = NTs, NSO2Ph, S] was developed via formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione or dialkyl acetylene dicarboxylate in acceptable to excellent yields. This reaction featured H2O as the only byproduct, broad substrate scope and proceeded under mild conditions. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Birgul, Kaan; Uba, Abdullah Ibrahim; Cuhadar, Ozan; Sevinc, Sevgi Kocyigit; Tiryaki, Selen; Tiber, Pinar Mega; Orun, Oya; Telci, Dilek; Yilmaz, Ozgur; Yelekci, Kemal; Guniz Kucukguzel, S. published an article in Journal of Molecular Structure. The title of the article was 《Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents》.Reference of 3-Chlorobenzylchloride The author mentioned the following in the article:

New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R1 = Ph, 4-FC6H4, Bn, etc.; R2 = Bn, 3-FC6H4CH2, 4-MeOC6H4CH2, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC50 values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC50 value (IC50x1, IC50x2, IC50x3, IC50x4, and IC50x5). Next in order to determine the toxicity of the combination of compound I (R1 = Bn; R2 = 3-FC6H4CH2) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Reference of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Reference of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Abdel-Megied, Ahmed E. S.; Pedersen, Erik B.; Nielsen, Carsten M. published their research in Chemica Scripta on December 31 ,1989. The article was titled 《Synthesis and biological activity of 1-(5-hydroxy-3-oxapentyl)- and 1-(8-hydroxy-3,6-dioxaoctyl)uracils》.SDS of cas: 14258-40-3 The article contains the following contents:

Title compounds I (R = H, Me, CH2OCH2Ph, F, NO2; R1 = H; n = 2, 3) and II (R = Me, CH2OCH2Ph, R1 = H) were prepared by treating uracils III with NaH and Cl(CH2CH2O)nCOMe and then ammonolysis of I and II (R1 = Ac) with NH3-MeOH. A screen of selected compounds, including cytosine IV prepared from I (R = H, R1 = Ac, n = 2), for virucidal activity against herpes simplex virus type 1 and human immunodeficiency virus type 1 showed no significant activity. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3SDS of cas: 14258-40-3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.SDS of cas: 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 620-20-2On November 17, 2020 ,《Unsymmetrical Disulfides Synthesis via Cs2CO3-Catalyzed Three-Component Reaction in Water》 appeared in Advanced Synthesis & Catalysis. The author of the article were Wang, Dungai; Gao, Yuanji; Tong, Yunli; Xiong, Mingteng; Liang, Xiao; Zhu, Heping; Pan, Yuanjiang. The article conveys some information:

An unsym. disulfide synthesis by Cs2CO3-catalyzed three-component coupling reaction of thioacetates RSC(O)Me (R = 4-CH3OC6H4, CH2C6H5, oxolan-2-ylmethyl, etc.), sodium thiosulfate, and benzyl halide R1CH2Cl (R1 = C6H5, 4-BrC6H4, 1-naphthyl, etc.) in water has been described. The safe, stable, and non-toxic Na2S2O3 was invoked as the sulfur-source, successfully avoiding the odor generation in the process of S-S bond formation. A wide range of substrate suitability and appropriate functional group tolerance were observed for the transformation. Notably, the approach reported here was compatible with various biomols. including glucose, coumarin, and quinolinone. In addition to this study using 3-Chlorobenzylchloride, there are many other studies that have used 3-Chlorobenzylchloride(cas: 620-20-2HPLC of Formula: 620-20-2) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.HPLC of Formula: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《N-Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N-chlorosuccinimide》 was published in Organic & Biomolecular Chemistry in 2019. These research results belong to Li, Zi-Hao; Fiser, Bela; Jiang, Biao-Lin; Li, Jian-Wei; Xu, Bao-Hua; Zhang, Suo-Jiang. Recommanded Product: 620-20-2 The article mentions the following:

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with com. available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theor. anal. indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Increments of the arithmetic retention index for polyoxyethylene glycol monoalkyl ethers and their degradation products》 was written by Szymanowski, J.; Kusz, P.; Szewczyk, H.. Recommanded Product: 14258-40-3 And the article was included in Journal of Chromatography on August 30 ,1989. The article conveys some information:

The arithmetic retention indexes for CmH2m+1O(CH2CH2O)nH (m = 12, 14, 16, 18; n = 0-8) were calculated for OV 101 and Dexsil 400 columns, with average absolute and relative errors of 10 and 0.5%, resp. Chlorinated and ester degradation products were similarly assessed. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Recommanded Product: 14258-40-3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Recommanded Product: 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H6BFO2In 2021 ,《[3+2+1] Pyridine Skeleton Synthesis Using Acetonitrile as C4N1 Units and Solvent》 appeared in Journal of Organic Chemistry. The author of the article were Bai, Chaolumen; Guo, Huifang; Liu, Xin; Liu, Dan; Sun, Zhaorigetu; Bao, Agula; Baiyin, Menghe; Muschin, Tegshi; Bao, Yong-Sheng. The article conveys some information:

The first [3+2+1] methodol. for pyridine skeleton I (R = 4-isopropylphenyl, 3-fluorophenyl, 2-naphthyl, etc.; R1 = Me, Ph, furan-2-yl, etc.) synthesis via cascade carbopalladation/cyclization of acetonitrile, arylboronic acids RB(OH)2, and aldehydes R1CHO was developed. This reaction proceeds via six step tandem reaction sequences involving the carbopalladation reaction of acetonitrile, a nucleophilic addition, a condensation, an intramol. Michael addition, cyclization, and aromatization. Delightfully, both palladium acetate and supported palladium nanoparticles catalyzed this reaction with similar catalytic performance. The characterization results of the fresh and used supported palladium nanoparticle catalysts indicated that the reaction might be performed via a Pd(0)/Pd(II) catalytic cycle that began with Pd(0). Furthermore, the products showed good fluorescence characteristics. The green homogeneous/heterogeneous catalytic methodologies pave a new way for constructing the pyridine skeleton. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Yu, Xiao; Zhu, Wenjing; Liu, Hongyan; Liu, Yi; Li, Hongshuang; Han, Junfen; Duan, Guiyun; Bai, Zhushuang; Zhang, Pengfei; Xia, Chengcai published an article in Organic & Biomolecular Chemistry. The title of the article was 《Practical chemoselective aromatic substitution: the synthesis of N-(4-halo-2-nitrophenyl)benzenesulfonamide through the efficient nitration and halogenation of N-phenylbenzenesulfonamide》.SDS of cas: 16629-19-9 The author mentioned the following in the article:

A novel route involving the metal-promoted tandem nitration and halogenation of N-phenylbenzenesulfonamide to synthesize N-(4-halo-2-nitrophenyl)benzenesulfonamide derivatives has been developed. The method shows highly practical chemoselective and functional group compatibility. In addition, it employs insensitive and inexpensive Cu(NO3)2·3H2O, Fe(NO3)3·9H2O, and NH4NO3 as the nitration reagents, and it provides a direct approach for the preparation of 4-halo-2-nitroaniline, which is a crucial intermediate for the synthesis of benzimidazoles and quinoxaline derivatives In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Jiajun; Li, Guodong; Yu, Ke; Xu, Bo; Chen, Qianjin published an article in 2022. The article was titled 《Electrochemical Sulfonylation-Induced Lactonization of Alkenes: Synthesis of Sulfonyl Phthalides》, and you may find the article in Journal of Organic Chemistry.HPLC of Formula: 16629-19-9 The information in the text is summarized as follows:

An electrochem. cascade sulfonylation and lactonization process of alkenes and a most widely used arylsulfonylation reagent-sulfonyl hydrazines-was developed for the first time. This electrochem. sulfonyl lactonization avoids the use of toxic metal catalysts or stoichiometric oxidants and was carried out under mild conditions. The target product γ-sulfonylated phthalides with broad and excellent substrate tolerance were achieved. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics