Tag: 100-200

《Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types》 was written by Wang, Guan; Zhao, Yuqian; Liu, Yao; Sun, Dejuan; Zhen, Yongqi; Liu, Jie; Fu, Leilei; Zhang, Lan; Ouyang, Liang. Related Products of 620-20-2 And the article was included in Journal of Medicinal Chemistry on April 23 ,2020. The article conveys some information:

ERK1 and ERK5 are proposed to have pivotal roles in several types of cancer. Under some circumstance, ERK5 may provide a common bypass route, which rescues proliferation upon abrogation of ERK1 signaling. Thus, we accurately classified the tumor types from The Cancer Genome Atlas (TCGA) based on the expression levels of ERK1 and ERK5. We proposed a novel therapeutic strategy to overcome the above-mentioned compensatory mechanism in specific tumor types by co-targeting both ERK1 and ERK5. On the basis of the idea of overcoming ERK5 compensation mechanism, 22ac (ADTL-EI1712) as the first selective dual-target inhibitor of ERK1 and ERK5 was discovered to have potent antitumor effects in vitro and in vivo. Interestingly, this compound was found to induce regulated cell death accompanied by autophagy in MKN-74 cells. Taken together, our results warrant the potential of this dual-target inhibitor as a new candidate drug that conquers compensatory mechanism in certain tumor types. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Related Products of 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Related Products of 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C4H3ClO2S2In 2021 ,《Visible-Light-Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones》 was published in Chemistry – An Asian Journal. The article was written by Wang, Chen; Sun, Guoquan; Huang, Hong-Li; Liu, Jing; Tang, Hua; Li, Yinghua; Hu, Honggang; He, Shipeng; Gao, Fei. The article contains the following contents:

Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using com. available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C4H3ClO2S2In 2022 ,《Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group》 appeared in Advanced Synthesis & Catalysis. The author of the article were Sun, Bin; Ding, Hao; Tian, Hai-Xia; Huang, Pan-Yi; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu. The article conveys some information:

A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R1 = H, 3-F, 2-MeO, etc.; n = 0, 1].Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Gao, Yuting; Sun, Yang; Fang, Xianfu; Zhao, Guixian; Li, Xufeng; Zhang, Gong; Li, Yangfeng; Li, Yizhou published an article in Organic Chemistry Frontiers. The title of the article was 《Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries》.Synthetic Route of C4H3ClO2S2 The author mentioned the following in the article:

The DNA-encoded chem. library (DEL) technol. is a novel drug discovery tool, benefiting from its large number of compound collections with chem. space coverage. Vinyl sulfone is a privileged functional group, eliciting diverse pharmacol. activities as the covalent warhead. In this report, we incorporated vinyl sulfone into the DEL chem. field by developing a mild and efficient DNA-compatible method starting from simple sodium sulfinates and DNA-conjugated alkenes, affording a broad substrate scope with moderate-to-excellent conversions. Further chem. transformations including the thiol-Michael addition reaction, together with enzymic ligation, were also successfully implemented to demonstrate the feasibility of this DNA-compatible synthesis in DEL construction. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ji, Mingjuan; Xu, Liang; Luo, Xiangxiang; Jiang, Minghui; Wang, Siyu; Chen, Jian-Qiang; Wu, Jie published an article in 2021. The article was titled 《Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation》, and you may find the article in Organic Chemistry Frontiers.Product Details of 5781-53-3 The information in the text is summarized as follows:

Alkyloxalyl chlorides, generated from alcs. and oxalyl chlorides, were used as alkoxycarbonyl radicals in the reaction of N-acryloyl benzamides under photocatalysis at room temperature This approach could be compatible with a variety of alc.-containing pharmaceutically active compounds under visible light irradiation A variety of isoquinoline-1,3(2H,4H)-diones I [R = Me, Et, hexadecyl, etc.; R1 = H, 6-Me, 6-F, etc.; R2 = Me, cyclohexyl, Bn, etc.; R3 = Me, Ph, Bn] were prepared in moderate to good yields. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Selmani, Aymane; Darses, Sylvain. Product Details of 768-35-4. The article was titled 《Access to chiral cyano-containing five-membered rings through enantioconvergent rhodium-catalyzed cascade cyclization of a diastereoisomeric E/Z mixture of 1,6-enynes》. The information in the text is summarized as follows:

In contrast to the intermol. rhodium-catalyzed asym. 1,4-addition of organometallic reagents to activated alkenes, the asym. arylative cyclization of diastereoisomeric E/Z mixture of 1,6-enynes afforded only one major enantiomer. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Wei; Zhai, Zhi-Wen; Wedge, David E.; Duke, Stephen O.; Wu, Hong-Ke; Weng, Jian-Quan; Tan, Cheng-Xia; Zhang, Yong-Gang; Liu, Xing-Hai published their research in Research on Chemical Intermediates on December 31 ,2019. The article was titled 《Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety》.Recommanded Product: 3-Chlorobenzylchloride The article contains the following contents:

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring I (R = cyano, 3,4-dichlorophenyl, 2-chlorothiazol-5-yl, etc.) were designed and synthesized from Et acetoacetate and tri-Et orthoformate as starting materials via multi-step reactions. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 3-ChlorobenzylchlorideOn October 31, 2021 ,《CuSO4 nanoparticles loaded on carboxymethylcelulose/polyaniline composites: A highly efficient catalyst with enhanced catalytic activity in the synthesis of propargylamines, benzofurans, and 1,2,3-triazoles》 was published in Applied Organometallic Chemistry. The article was written by Xu, Zhian; Xu, Jinxi; Li, Yiqun. The article contains the following contents:

A novel and efficient heterogeneous CuSO4 nanoparticles (CuSO4 NPs) immobilized on CM-cellulose/polyaniline (CuSO4NPs@CMC/PANI) composites were prepared via one-pot and one-step interfacial oxidative polymerization of aniline with sodium CM-cellulose (CMC) as soft template and CuSO4 as catalyst. The in situ formed CuSO4 NPs were dispersed uniformly and firmly on the resultant composites and stabilized by complexation with hydroxyl groups (OH), carboxylate groups (COO-), nitrogen atoms, and delocalized π-π conjugate benzenoid and quinoid moieties of CMC/PANI composites. The morphol., composition, and structure of the as-fabricated composites were systematically characterized by XPS, transmission electron microscopy (TEM), SEM (SEM), energy-dispersive X-ray spectroscopy (EDS), Fourier transform IR spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric anal. (TGA), and derivative thermogravimetry (DTG) techniques. The CuSO4NPs@CMC/PANI composites were successfully applied as catalysts in aldehyde-alkyne-amine (A3) coupling reactions, A3-cycloisomerization tandem reactions, and Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. All reactions proceeded smoothly and afforded the desired products in excellent yields. Moreover, no significant decrease in catalytic ability was observed in A3 model reaction after 15 recycles, indicating CuSO4NPs@CMC/PANI composites exhibited easy separability and high reusability. Tolerance of wide scope of substrate, excellent catalytic activity, easy operation, recycling of catalyst, and environmental benign are the salient features of these catalytic process. The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

SDS of cas: 16629-19-9In 2021 ,《Synthesis, biological evaluation and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors》 was published in Bioorganic Chemistry. The article was written by Balaramnavar, V. M.; Srivastava, R.; Varshney, S.; Kumar, S.; Rawat, A. K.; Chandasana, H.; Chhonker, Y. S.; Bhatta, R. S.; Srivastava, A. K.; Gaikwad, A. N.; Lakshmi, V.; Saxena, A. K.. The article contains the following contents:

Rohitukine (RH) I [R = H] was derivatized to different aryl sulfonated derivatives I [R = 4-MeC6H4SO2, 2-O2NC6H4SO2, 2-thienylsulfonyl, etc.] by treating with the corresponding aryl sulfonyl chlorides. These derivatives were tested in-vitro on protein tyrosine phosphatase 1B (PTP1B) inhibition. Among these the active compounds I [R = 4-O2NC6H4SO2, 3-O2NC6H4SO2, 2,4,6-tri-MeC6H2SO2, 1-naphthylsulfonyl] significantly inhibited the PTP1B by 51.3%, 65.6%, 71.9%, and 55.9% resp. at 10μg/mL, the results were also supported by in-silico docking experiments The most potent compound I [R = 2,4,6-tri-MeC6H2SO2] was analyzed for antidiabetic and antidyslipidemic activity in vivo. It showed a marked reduction in blood glucose level (random and fasting) and serum insulin level in db/db mice. It improved glucose intolerance as ascertained by the oral glucose tolerance test (OGTT). These NCEs (New Chem. Entities) also lowered cholesterol and triglyceride profiles while improved high-d. lipoprotein cholesterol in db/db mice. The compound I [R = 2,4,6-tri-MeC6H2SO2] was further evaluated for antiadipogenic activity on MDI (Methylisobutylxanthine, dexamethasone, and insulin)-induced adipogenesis, where it significantly inhibited MDI-induced adipogenesis in 3 T3-L1 preadipocytes, at 10μM and 20μM concentration These results were compared with the parent compound I [R = H] which inhibited 35% and 45% lipid accumulation while the RH analog compound I [R = 2,4,6-tri-MeC6H2SO2] inhibited the lipid accumulation by 41% and 51% at 10 and 20μM concentration, resp. These results well corroborated with in-silico studies. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of (3-Fluorophenyl)boronic acidIn 2020 ,《Nickel(II)-catalyzed C-C, N-C cascade coupling of ketonitriles into substituted pyrroles and pyridines》 appeared in Organic Chemistry Frontiers. The author of the article were Zhen, Qianqian; Li, Renhao; Qi, Linjun; Hu, Kun; Yao, Xinrong; Shao, Yinlin; Chen, Jiuxi. The article conveys some information:

Herein, the first ever example of nickel complexes as effective catalysts to promote the C-C, N-C cascade coupling of ketonitriles with arylboronic acids, affording potentially biol. active 3-carboxylate-2,5-diaryl-pyrroles as well as 2,5-diarylpyrroles and 2,6-diarylpyridines is demonstrated. This protocol features a broad scope of substrates and excellent functional group tolerance, thus representing a highly versatile and atom-economical alternative to novel methods for the synthesis of various unsym. diarylpyrroles and diarylpyridines under manageable conditions.(3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics