Tag: 100-200

In 2022,Ishida, Toshiaki; Watanabe, Bunta; Mashiguchi, Kiyoshi; Yamaguchi, Shinjiro published an article in Phytochemistry Letters. The title of the article was 《Synthesis and structure-activity relationship of 16,17-modified gibberellin derivatives》.Related Products of 5781-53-3 The author mentioned the following in the article:

Gibberellins (GAs) are a group of diterpenoid plant hormones that control plant growth and development at various stages. Biol. active GAs share the common structures of a 3β-hydroxy group, a carboxy group at C-6, and a γ-lactone between C-4 and C-10. Hydroxylation at C-2β is a major deactivation step in many plant species, and hydroxylation at C-13 has been shown to weaken the binding affinity of GAs to their receptor proteins. In rice, bioactive GA4 has also been shown to be deactivated through 16α,17-epoxidation Moreover, 16,17-dihydro-16α,17-dihydroxy GA4 has been identified as an aglycon of its glucoside from rice. However, our knowledge on the biol. activity of 16,17-epoxidized GAs is currently limited to 16,17-dihydro-16α,17-epoxy GA4. Moreover, the bioactivity of 16,17-dihydro-16α,17-dihydroxy GA4 remains unknown. Here, we synthesized 16,17-epoxidized or dihydroxylated GA derivatives and performed a structure-activity relationship study using rice seedlings. 16,17-Epoxidation of bioactive GA1 and GA4 reduced their activity to promote elongation of rice leaf sheaths. Moreover, 16,17-dihydroxylation significantly decreased the activities of 16,17-dihydro-16α,17-epoxy GAs. These results suggest that GAs are deactivated in a stepwise manner via 16,17-epoxidation and hydrolysis of these epoxy groups. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Related Products of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Tantawy, Ahmed H.; Farag, Shaimaa M.; Abdel-Haleem, Doaa R.; Mohamed, Hany I. published an article in Bioorganic Chemistry. The title of the article was 《Facile synthesis, larvicidal activity, biological effects, and molecular docking of sulfonamide-incorporating quaternary ammonium iodides as acetylcholinesterase inhibitors against Culex pipiens L》.Electric Literature of C4H3ClO2S2 The author mentioned the following in the article:

Insecticides participate with a vital role in our lives especially in preventing the spread of human diseases via controlling the dangerous pests. It is a challenge to identify alternatives to the ordinary insecticides with new mode of action to be used for mosquitoes′ control in an environmentally sustainable manner. Using a facile two-step procedure, three novel series of sulfonamide-incorporating quaternary ammonium iodides (3a-i, 4a-i and 5a-i) were synthesized and their chem. structures were successfully characterized. The uncharged sulfonamide intermediates (2a-i) were constructed through simple amidation of the corresponding (hetero)aryl sulfonyl chlorides then the cationic target mols. were formed by quaternizing the tertiary nitrogen with Me, Et, and allyl iodides. The larvicidal activities and biol. effects of most synthesized compounds against Culex pipiens L. were extensively investigated and they exhibited good and comparable activities to temephos. Among these hybrids, 4a showed the most potent activity with LC50 = 26.71 ppm. Addnl., the developmental durations of larval and pupal stages were significantly prolonged after treatment with all concentrations of 4h. At high concentration (160 ppm) of 4a and 4b, no adults emerged due to the complete death of pupae, and consequently zero growth index. Moreover, the results of the mol. docking demonstrated that the activities of compounds correlate partially to their binding with acetylcholinesterase (AChE) and it is not the sole parameter for determining the activity. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jian, Jie; Hammink, Roel; McKenzie, Christine J.; Bickelhaupt, F. Matthias; Poater, Jordi; Mecinovic, Jasmin published their research in Chemistry – A European Journal in 2021. The article was titled 《Do Sulfonamides Interact with Aromatic Rings?》.Recommanded Product: (3-Fluorophenyl)boronic acid The article contains the following contents:

Aromatic rings form energetically favorable interactions with many polar groups in chem. and biol. systems. Recent mol. studies have shown that sulfonamides can chelate metal ions and form hydrogen bonds, however, it is presently not established whether the polar sulfonamide functionality also interacts with aromatic rings. Here, synthetic, spectroscopic, structural, and quantum chem. analyses on 2,6-diarylbenzenesulfonamides are reported, in which two flanking aromatic rings are positioned close to the central sulfonamide moiety. Fine-tuning the aromatic character by substituents on the flanking rings leads to linear trends in acidity and proton affinity of sulfonamides. This phys.-organic chem. study demonstrates that aromatic rings have a capacity to stabilize sulfonamides via through-space NH-π interactions. These results have implications in rational drug design targeting electron-rich aromatic rings in proteins. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: (3-Fluorophenyl)boronic acid) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《One-pot Cascade Reaction for the Synthesis of Phenanthridines via Suzuki Coupling/C-H Oxidation/Aromatization》 was written by Zhang, Yi; Ding, Yuxin; Chen, Rener; Ma, Yongmin. Synthetic Route of C6H6BFO2 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

A one-pot cascade coupling/annulation reaction for the synthesis of phenanthridines were developed from arylboronic acids and o-bromo arylamides with DMSO as a carbon source. The desired phenanthridines were obtained in moderate to good yields by using simple procedure. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins》 was written by Dai, Ling; Yu, Shuling; Xiong, Wenzhang; Chen, Zhongyan; Xu, Tong; Shao, Yinlin; Chen, Jiuxi. Computed Properties of C6H6BFO2 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl benzoates afforded 2,4-diaryloxazoles as products, while 2-benzoyl-substituted cyanomethyl benzoates delivered 3-benzoyl-4-aryl-isocoumarins selectively. Furthermore, a possible mechanism for the selective reaction of cyanomethyl benzoates with arylboronic acids was discussed. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and biological activity of 5-aryliden-2-thiohydantoin S-aryl derivatives》 was published in Bioorganic Chemistry in 2020. These research results belong to Finko, Alexander V.; Skvortsov, Dmitry A.; Laikov, Dimitri N.; Averochkin, Gleb M.; Dlin, Egor A.; Kalinina, Marina A.; Aladinskiy, Vladimir A.; Vorobyeva, Nataliya S.; Mironov, Andrei V.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Ivanenkov, Yan A.; Majouga, Alexander G.. Product Details of 768-35-4 The article mentions the following:

Three new and complementary approaches to S-arylation of 2-thiohydantoins I (R1 = OEt, CN, F, etc.; R2 = H, F, Cl; R3 = H, Br) have been developed: copper-catalyzed cross coupling with either arylboronic acids 4-R4,3-R5 C6H3B(OH)2 (R4 = H, Me, OMe, F, Cl, CN, NO2; R5 = H, F, OMe, CF3) or aryl iodides 2-R8-3-R7-4-R6C6H2I (R6 = OMe, Me, Cl, H, etc.; R7 = H, CF3; R8 = H, NO2) under mild conditions, or direct nucleophilic substitution in activated aryl halides 2-R10-4-R9C6H3X (X = I, F; R9 = NO2; R10 = NO2, H). For 38 diverse compounds, II reaction yields for all three methods have been determined Selected by mol. docking, they have been tested on androgen receptor activation, and p53-Mdm2 regulation, and A549, MCF7, VA13, HEK293T, PC3, LnCAP cell lines for cytotoxicity, wherein two of them are turned out to be promising as androgen receptor activators (likely by allosteric regulation), and another one is shown to activate the p53 cascade. It is hoped that 2-thiohydantoin S-arylidenes are worth for further studies as biol. active compounds After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor》 were Gonzalez-Esguevillas, Maria; Miro, Javier; Jeffrey, Jenna L.; MacMillan, David W. C.. And the article was published in Tetrahedron in 2019. Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A new visible-light photoredox catalyzed method was disclosed for the deoxyfluorination of alcs. via their corresponding oxalates, which were readily accessible in a single step and could be use without purification This radical-mediated C-F coupling was capable of fluorinating secondary and tertiary alcs. efficiently, complementing previously reported nucleophilic deoxyfluorination protocols. From a mechanistic perspective, this strategy constitute a distinct approach to the deoxyfluorination of alcs., employing an electrophilic fluorine source. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xue; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue published their research in Chemistry – A European Journal in 2021. The article was titled 《Metal-free synthesis of aryl selenocyanates and selenaheterocycles with elemental selenium》.Product Details of 768-35-4 The article contains the following contents:

This work reports a green method for the synthesis of aryl selenocyanates via a three-component reaction of arylboronic acids, Se powder, and trimethylsilyl cyanide (TMSCN) under metal-free and additive-free conditions. Remarkably, TMSCN acts as not only the substrate, but also the catalyst. Various selenaheterocycles can be also accessed with a catalytic amount of TMSCN.(3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Copper-catalyzed synthesis of N-aryl acridones from 2-amino benzophenones and aryl boronic acids via sequential double oxidative C-N coupling》 was published in Applied Organometallic Chemistry in 2020. These research results belong to He, Yang; Xu, Liang; Zhang, Jinli; Wei, Yu. Application In Synthesis of (3-Fluorophenyl)boronic acid The article mentions the following:

Pot-economic synthesis of N-aryl acridones was performed with 2-aminobenzophenones and aryl boronic acids as starting materials. Cu-catalyzed chelation-assisted oxidative C-N cross-coupling reactions were well merged with the following intra-mol. oxidative dehydrogenative C-H amination reactions under an air atm. The use of reagent capsules can further resolve the compatibility problem of reagents and simplify the operational process, providing a more straightforward access to the target products. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Pd-Catalyzed Approach for Assembling 9-Arylacridines via a Cascade Tandem Reaction of 2-(Arylamino)benzonitrile with Arylboronic Acids in Water》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ye, Xuanzeng; Xu, Beihang; Sun, Jiani; Dai, Ling; Shao, Yinlin; Zhang, Yetong; Chen, Jiuxi. Synthetic Route of C6H6BFO2 The article mentions the following:

A novel palladium-catalyzed protocol for the synthesis of 9-arylacridines via tandem reaction of 2-(arylamino)benzonitrile with arylboronic acids in water has been developed with good functional group tolerance. The present synthetic route could be readily scaled up to gram quantity without difficulty. This methodol. was further extended to the synthesis of a 4′-OH derivative, which showed estrogenic biol. activity. Preliminary mechanistic experiments showed that this transformation involves a nucleophilic addition of aryl palladium species to the nitrile to generate an aryl ketone intermediate followed by an intramol. Friedel-Crafts acylation and dehydration to acridines. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics