Tag: 100-200

COA of Formula: C6H4ClNO2On May 1, 2020 ,《A series of luminescent LnIII-based coordination polymers: Syntheses, structures and luminescent properties》 appeared in Inorganica Chimica Acta. The author of the article were Zhao, Xiaoqing; Zhang, Fenhang; Liu, Yajun; Zhao, Tianhao; Zhao, Hongyan; Xiang, Shuo; Li, Yunchun. The article conveys some information:

A series of lanthanide coordination polymers (Ln-CPs), with the formula of {[Ln(L)3(CH3OH)(H2O)]n} (Ln = Sm (1), Eu (2), HL = 2-chloroisonicotinic acid) and {[Ln(L)3(H2O)2]n} (Ln = Dy (3), Tb (4)), were synthesized under solvothermal condition. This series display two different 1D chains due to the lanthanide contraction: complexes 1 and 2, based on light Sm and Eu, resp., consist of paddle-wheel [Ln2(COO)4] dimmers through double μ2-COO bridges, and complexes 3 and 4 with heavy Dy and Tb, resp., show 1D [Ln(COO)2]n chains. The luminescent measurements indicate the typical emissions of corresponding Ln3+ ions in complexes 1-4. Furthermore, complexes 2 and 4 display significant luminescent response for Fe3+ ions with high quenching constant Complexes 2 and 4 can act as luminescent probes for Fe3+ ions with relatively high sensitivity and selectivity. In the experimental materials used by the author, we found 2-Chloroisonicotinic acid(cas: 6313-54-8COA of Formula: C6H4ClNO2)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.COA of Formula: C6H4ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《1,2,4-Thiadiazoles. IX. Synthesis and reactions of 3-alkylthio-5-chloro-1,2,4-thiadiazoles》 was published in Chemische Berichte in 1957. These research results belong to Goerdeler, Joachim; Sperling, Gerhard. Related Products of 38362-15-1 The article mentions the following:

cf. C.A. 51, 12077d. In general, 0.5 mole RSC(:NH)NH2.HBr (I) in 300 cc. H2O, 0.5 mole CCl3SCl (II), and about 0.5 g. emulsifier treated dropwise (3-5 hrs.) at 0° and with vigorous stirring with 80 g. NaOH in 320 cc. H2O, the excess II decomposed with 20-30 cc. 25% NH4OH, and the mixture neutralized and steam-distilled gave RSC:N.S.CCl:N (III) as the lower layer of the distillate, sufficiently pure for further reactions, or it could be purified by distillation in vacuo, R, % yield, b.p./mm., d18, and n21D of the III: Me, 50-5, 98°/17 (m. 29-30°), -, -; Et, 65-70, 115°/13, 1.3861, 1.58285; Pr, 45-50, 131°/18, 1.3177, 1.56865; Bu, 37, 140°/14, 1.2650, 1.55805; tert-Bu, 58, 118°/14, 1.2560, 1.55635; iso-C5H11, 36, 148°/14, 1.2233, 1.54785; PhCH2 (IV), 45-50, 120°/0.2 (m. 49-50°), -, -. The preparation of IV was modified by adding 20-30 cc. ether at first, stirring longer after neutralization, and extracting with ether instead of steam-distilling III treated with a concentrated solution of MeNH2 in MeOH, the resulting MeNH2.HCl and most of the solvent removed, and H2O added gave RSC:N.S.C(NHMe):N (R, m.p., and m.p. of picrate given): Me, 144.5-5.0°, 164.5°; Et, 101-2°, 145°; Pr, 75-6°, 128°; Bu, 89-90°, 123°; tert-Bu, 119-20°, 138°; iso-C5H11, 82-3°, 126.5°; PhCH2, 139-40°, 141.5°. Similarly, with PhCH2NH2 in place of MeNH2, the solvent not removed, and dilute HCl added in place of H2O (to keep the excess PhCH2NH2 in solution) were formed RSC:N.S.C(NHCH2Ph):N (R and m.p. given): Me, 114.5-15.5°; Et, 101-1.5°; tert-Bu, 149.5-50°. Other reagents in very similar reactions with III gave RSC:N.S.CR’:N (V) (reagent used, R, R’, % yield, and m.p. given): PhNH2, tert-Bu, NHPh, 60-5, 146-7.5°; Me2NH, Me, NMe2, -, – (picrate, m. 70.5-1.0°); Me3N, Me, NMe3.HCl, 100, 105° (decomposition) (picrate, m. 128.5-30.0°); N2H4.H2O, Et, NHNH2, 100, 112-14° (decomposition) (the product with BzH and AcONa, R’ = NHN:CHPh, m. 208°); H2S with (NH4)2CO3, Me, HS, 55 g. from 74 g. III, 150-1° (decomposition); SC(NH2)2 (followed by hydrolysis with 10% NH4OH), PhCH2, HS, -, 136° (decomposition) [the product with PhCH2Cl and NH4OH at room temperature for 2 days, R’ = SCH2Ph, m. 51°, identical with the compound from PhCH2Cl and HSC:N.C(SH):N.S (VI)]; concentrated H2SO4 (warmed 3 hrs. and poured onto ice), Me, OH, 65%, 139-40°; KOH-MeOH, Me, OMe, 100, 46-7°. MeSC:N.S.C(SH):N (VII) oxidized 15 min. with 2N HNO3 at 50-60° gave [S.N:C(SMe).N:C]2S2, m. 112.5-13°; VII kept 5 hrs. at room temperature with the calculated amount of NH3 and MeI in EtOH gave V (R = Me, R’ = SMe), m. 40-1°, formed also from III (R = Me) with NH3 and excess MeSH in MeOH, and identical with the product from methylation of VI; VII kept several hrs. at room temperature with NH3-MeOH yielded almost 100% [S.N:C(SMe).N:C]2S, m. 169.5-70°. III (R = Me) (1.7 g.) refluxed 6 hrs. with NaOCMe:CHCO2Et (from 2 cc. AcCH2CO2Et kept 4 hrs. with 0.23 g. Na in 15 cc. dry C6H6), the resulting precipitate with the residue from the filtrate extracted with dilute NH4OH, and the extract acidified yielded 85% V [R = Me, R’ = HC(Ac)CO2Et] (VIII), m. 119-20° (decomposition). Similarly, with 2.9 cc. H2C(CO2Et)2 in place of AcCH2CO2Et was obtained 60% V [R = Me, R’ = HC(CO2Et)2] (IX), m. 143° (decomposition); and with 5 cc. NCCH2CO2Et and 0.5 g. Na 1.7 g. III (R = Me) yielded 80% V [R = Me, R’ = HC(CN)CO2Et], m. above 200°. III (R = Me) (3.65 g.) kept 24 hrs. with 5 cc. Ac2CH2 and 3.5 g. powd. K2CO3 in 25 cc. MeOH, then refluxed 6 hrs. on an H2O bath, kept overnight, the MeOH largely distilled, the residue warmed to 60-70° with 40 cc. H2O containing a little NH4OH, filtered, and the filtrate acidified yielded 35% V (R = Me, R’ = HCAc2), m. 144.5-5.0°. IX (2 g.) in 5-6 cc. 75% H2SO4 heated slowly to 130°, kept at 130° until no more gas evolved (4-6 min.), cooled, H2O added cautiously, and the mixture filtered after 3 hrs. yielded 70% V (R = Me, R’ = CH2CO2H), m. about 150-60° (decomposition) (Et ester, m. 70-1°), formed also from VIII (0.4 g.) with 5 cc. concentrated H2SO4. The experimental part of the paper was very detailed, including the reaction process of 5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1Related Products of 38362-15-1)

5-Chloro-1,2,4-thiadiazole(cas: 38362-15-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Related Products of 38362-15-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 16629-19-9In 2022 ,《1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade》 appeared in Nature Communications. The author of the article were Radhoff, Niklas; Studer, Armido. The article conveys some information:

Here a simple, efficient and scalable method for the preparation of sterically hindered and valuable α-quaternary amides RNHC(O)C(R1)(R2)(R3) (R = i-Pr, Ph, 2,2-dimethyl-1,3-dioxan-5-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Ph, 4-iodophenyl, etc; R1R2 = -(CH2)6-; R3 = Ph, 4-chlorophenyl, thiophen-2-yl, etc.) via a polar-radical crossover-enolate oxidation-aryl migration pathway was reported. A variety of easily accessible N-alkyl and N-arylsulfonamides RNHS(O)2R3 is reacted with disubstituted ketenes R1(R2)C=C=O to give the corresponding amide enolates, which undergo upon single electron transfer oxidation, a 1,4-aryl migration, desulfonylation, hydrogen atom transfer cascade to provide α-quaternary amides in good to excellent yields. Various mono- and di-substituted heteroatom-containing polycyclic arenes engage in the aryl migration reaction. Functional group tolerance is excellent and substrates as well as reagents are readily available rendering the method broadly applicable. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Chen, Ying; Wang, Fei; Liu, Bo-Xi; Rao, Wei-Dong; Wang, Shun-Yi published an article in Organic Chemistry Frontiers. The title of the article was 《A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates》.Product Details of 5781-53-3 The author mentioned the following in the article:

A Ni(II)-catalyzed reductive cross-coupling reaction of oxalates and thiosulfonates/selenosulfonates to synthesize benzylic sulfides/selenides under mild conditions is developed. The oxalates prepared from the corresponding alcs. are used as carbon radical precursors to participate in the reaction. This strategy has the advantages of easy substrate availability and mild conditions, and provides a new method for the preparation of unsym. sulfides/selenides with good functional group tolerance. In the part of experimental materials, we found many familiar compounds, such as Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Che, Zhiping; Li, Yuanhao; Guo, Xiaolong; He, Jiaxuan; Zhang, Song; Zhu, Lina; Liu, Yibo; Wei, Ruxue; Yang, Yingjun; Huang, Xiaobo; Liu, Shengming; Chen, Genqiang; Tian, Yuee published an article in Chemistry & Biodiversity. The title of the article was 《Synthesis and Anti-Oomycete Activity of Sulfonate Derivatives of Fenjuntong》.Related Products of 16629-19-9 The author mentioned the following in the article:

In order to discover highly active fungicides, sixteen novel sulfonate derivatives of Fenjuntong were synthesized by structural modification of 2′-hydroxybutyrophenone, and their anti-oomycete activity against Phytophthora capsici Leonian was determined in this study. Among all tested compounds, compound I displayed more significant anti-oomycete activity than the precursor Fenjuntong against P. capsici, and the EC50 values of I and Fenjuntong were 84.50 and 517.25 mg/L, resp. By comparing the anti-oomycete activity of compounds the following conclusions were drawn: (1) Hydroxy group is well tolerated, and sulfonylation of hydroxy group enhances its anti-oomycete activity. (2) The proper length of the ketone carbonyl chain is very important for their anti-oomycete activity. (3) The presence of a site methoxy group in the structural skeleton is closely related to the anti-oomycete activity. These important results will pave the way for further modification of Fenjuntong to develop potential new fungicides. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Related Products of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Related Products of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Ying; Sheng, Daopeng; Wang, Fei; Rao, Weidong; Shen, Shu-Su; Wang, Shun-Yi published an article in 2022. The article was titled 《Nickel(II)/TPMPP catalyzed reductive coupling of oxalates and tetrasulfides: synthesis of unsymmetric disulfides》, and you may find the article in Organic Chemistry Frontiers.Application In Synthesis of Methyl 2-chloro-2-oxoacetate The information in the text is summarized as follows:

A Ni(II)/tris(para-methoxyphenyl)phosphine (TPMPP)-catalyzed reductive cross-coupling reaction of benzyl oxalates and tetrasulfides to synthesize unsym. disulfides was reported. The benzyl oxalate works as the carbon radical precursor in this reaction. This catalytic strategy has the advantages of mild reaction conditions, wide substrate range and easy operation and provided a new approach for the preparation of unsym. disulfides with good functional group tolerance. Also, this method successfully achieved the synthesis of disulfides at the gram-scale, making it highly valuable. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lv, Yunhe; Han, Wanru; Pu, Weiya; Xie, Jinhui; Wang, Axue; Zhang, Mengyue; Wang, Jin; Lai, Junrong published an article in 2022. The article was titled 《Copper-catalyzed regioselective 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN》, and you may find the article in Organic Chemistry Frontiers.Computed Properties of C4H3ClO2S2 The information in the text is summarized as follows:

A novel and practical copper-catalyzed reaction for the 1,4-sulfonylcyanation of 1,3-enynes under mild conditions was described. This protocol provided efficient and straightforward access to a variety of 5-sulfonylpenta-2,3-dienenitrile derivatives with excellent functional group tolerance and good regioselectivity from readily available 1,3-enynes and com. available sulfonyl chlorides and TMSCN. A mechanism involving sulfonyl and allenyl radical species was proposed. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors》 was written by Niu, Ao; Lin, Lizhi; Zhang, Danyang; Jiang, Kaixuan; Weng, Dan; Zhou, Wenjia; Wang, Jinxin. COA of Formula: C7H6Cl2 And the article was included in Bioorganic & Medicinal Chemistry on April 1 ,2022. The article conveys some information:

Necroptosis, a key form of programmed lytic cell death, has gained recognition as an important driver in various inflammatory diseases. Inhibition of kinase activity of receptor interaction protein kinase 1 (RIPK1), which block the activation of the necroptosis pathway has shown therapeutic potential in many human diseases. In order to find new chemotypes of RIPK1 inhibitors, a virtual screening workflow was performed and led to the discovery of 8-benzoyl-3-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione as a hit compound Further structural optimization identified a series of 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 inhibitors. Among them, compound 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one exhibited prominent inhibitory activity against RIPK1 with an IC50 value of 92 nM. Meanwhile, compound 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one showed a significant anti-necroptotic effect in a necroptosis model in U937 cells. Therefore, 2-(2,5-difluorobenzyl)-8-(1-methyl-1H-indole-6-carbonyl)-2,8- diazaspiro[4.5]decan-1-one could be employed as a lead compound of RIPK1 inhibitors for further structural optimization. In the part of experimental materials, we found many familiar compounds, such as 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity》 was written by Barrios-Rivera, Jonathan; Xu, Yingjian; Wills, Martin. COA of Formula: C7H6Cl2 And the article was included in Organic Letters on August 21 ,2020. The article conveys some information:

The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asym. transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Thiophene-2-sulfonyl chlorideIn 2022 ,《Propargyl Chalcones’ Radical Annulation/Sulfonation Reaction: Efficient Synthesis of Benzo[b]oxepin-5(2H)-one and Chromane Derivatives》 was published in Journal of Organic Chemistry. The article was written by Yu, Qiuyu; Zhang, Jinghang; Wu, Fan; Liu, Xiaoqin; Wang, Chang; Zhang, Jinpeng; Rong, Liangce. The article contains the following contents:

A novel and facile methodol. for the synthesis of sulfonated benzo[b]oxepinones I (R = H, F, Br; R1 = H, MeO; R2 = Ph, 3-methoxyphenyl, 2-thienyl, etc.; Ar = Ph, 4-methylphenyl, 4-bromophenyl, etc.) and chromane derivatives II (R3 = H, MeO, F, Cl, Br; R4 = H, MeO; R3R4 = -CH=CH-CH=CH-; R5 = Ph, 2-fluorophenyl, 4-methylphenyl; Ar1 = Ph, 2-fluorophenyl, biphenyl-4-yl, etc.) was reported by the reaction of propargyl chalcones 3-R-4-R1-6-OCH2CCHC6H2C(O)CH=CHR2/3-R3-4-R4-6-OCH2CCHC6H2CH=CHC(O)R5 with arylsulfonyl chlorides Ar/Ar1SO2Cl via radical cascade annulation/sulfonation under laboratory conditions. Readily available propargyl chalcones, commercialized arylsulfonyl chlorides, and simple reaction conditions make this six(seven)-membered oxygen-containing heterocycles’ synthetic strategy more attractive and with significant application values. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics