Tag: 100-200

In 2022,Bai, Junping; Zhou, Junliang; Ji, Xin; Wang, Nannan; Dong, Xiaochun; Wu, Wei; Zhao, Weili published an article in Chinese Chemical Letters. The title of the article was 《Development of environment-insensitive and highly emissive BODIPYs via installation of N,N’-dialkylsubstituted amide at meso position》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

Fluorescent dyes play a crucial role in fluorescence imaging and sensing technol. However, there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability. Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable. In this manuscript, we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N’-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sun, Bin; Tian, Hai-Xia; Ni, Zhi-Gang; Huang, Pan-Yi; Ding, Hao; Li, Bing-Qian; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published an article in Organic Chemistry Frontiers. The title of the article was 《Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light》.Reference of Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-Light-Enabled Paterno-Buchi Reaction via Triplet Energy Transfer for the Synthesis of Oxetanes》 was written by Rykaczewski, Katie A.; Schindler, Corinna S.. Reference of Methyl 2-chloro-2-oxoacetate And the article was included in Organic Letters in 2020. The article conveys some information:

One of the most efficient ways to synthesize oxetanes is the light-enabled [2+2] cycloaddition reaction of carbonyls and alkenes, referred to as the Paterno-Buchi reaction. The reaction conditions for this transformation typically require the use of high energy UV light to excite the carbonyl, limiting the applications, safety, and scalability. We herein report the development of a visible-light-mediated Paterno-Buchi reaction protocol that relies on triplet energy transfer from an iridium-based photocatalyst to the carbonyl substrates. This mode of activation is demonstrated for a variety of aryl glyoxylates and negates the need for both visible-light-absorbing carbonyl starting materials and UV light to enable access to a variety of functionalized oxetanes in up to 99% yield. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Reference of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Reference of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Nickel-catalyzed Suzuki Coupling of Cycloalkyl Silyl Peroxides with Boronic Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Chen, Lei; Yang, Jun-Cheng; Xu, Pengfei; Zhang, Jun-Jie; Duan, Xin-Hua; Guo, Li-Na. Synthetic Route of C6H6BFO2 The article mentions the following:

In the presence of NiBr2(diglyme) and 4,4′-di-tert-butyl-2,2′-bipyridine, cycloalkyl trimethylsilyl peroxides such as I underwent tandem ring opening and Suzuki coupling reactions with arylboronic and trans-styryl boronic acids RB(OH)2 [R = 4-R1C6H4, 2-MeOC6H4, 2-NCC6H4, 3-MeOC6H4, 3-FC6H4, 3-MeCOC6H4, 3-Cl-4-FC6H3, 1-naphthyl, 2-naphthyl, 3-furanyl, 1-Boc-3-indolyl, 9-Ph-3-carbazolyl, 2-Cl-4-pyridinyl, 2-F-5-pyridinyl, 2-F3C-5-pyridinyl, 3-quinolinyl, (E)-PhCH:CH; R1 = F, MeO, Cl, Br, F, F3C, NC, MeSO2] mediated by Et3N to yield aralkyl ketones such as PhCO(CH2)4R [R = 4-R1C6H4, 2-MeOC6H4, 2-NCC6H4, 3-MeOC6H4, 3-FC6H4, 3-MeCOC6H4, 3-Cl-4-FC6H3, 1-naphthyl, 2-naphthyl, 3-furanyl, 1-Boc-3-indolyl, 9-Ph-3-carbazolyl, 2-Cl-4-pyridinyl, 2-F-5-pyridinyl, 2-F3C-5-pyridinyl, 3-quinolinyl, (E)-PhCH:CH; R1 = F, MeO, Cl, Br, F, F3C, NC, MeSO2]. Inhibition of the reaction by TEMPO and BHT and formation of an adduct with TEMPO support a radical mechanism for the reaction. I was found to decompose at 105°.(3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Chemistry Frontiers included an article by Zu, Weisai; Liu, Shuai; Jia, Xin; Xu, Liang. Product Details of 768-35-4. The article was titled 《Chemoselective N-arylation of aminobenzene sulfonamides via copper catalysed Chan-Evans-Lam reactions》. The information in the text is summarized as follows:

Cu-Catalyzed Chan-Evans-Lam cross-coupling reactions between unprotected aminobenzene sulfonamides RS(O)2NH2 (R = 2-NH2C6H4, 3-NH2C6H4, 4-NH2C6H4) and arylboron nucleophiles ArB(OH)2 (Ar = 4-MeC6H4, 3,5-Me2C6H3, naphthalen-1-yl, etc.) are explored herein. Chemoselective N-arylation of aminobenzene sulfonamides could be simply enabled by the adjustment of reaction variables, such as the sources of aerobic oxidative Cu catalysis, solvents and bases. The arylation processes could be well regulated to occur on either amino or sulfonamide nitrogen atoms RS(O)2NHAr at room temperature under open flask conditions. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Ran; Liu, Ya-Li; Hao, Hui; Chen, Chuan-Yi; Liu, Lei; Chen, Nian-Shou; Guo, Yu; Wang, Pei-Long published an article in 2021. The article was titled 《Regioselective, copper(I)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides》, and you may find the article in Organic Chemistry Frontiers.Category: chlorides-buliding-blocks The information in the text is summarized as follows:

A copper(I)-catalyzed sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides was developed. This transformation demonstrated a broad substrate scope and presented excellent regioselectivity after radical addition and subsequent deprotonation to form the derivatized 1,5-dihydro-2H-pyrrol-2-one scaffold in one pot. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jian-Qiang; Tu, Xiaodong; Tang, Qi; Li, Ke; Xu, Liang; Wang, Siyu; Ji, Mingjuan; Li, Zhiming; Wu, Jie published an article in 2021. The article was titled 《Efficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides》, and you may find the article in Nature Communications.Related Products of 5781-53-3 The information in the text is summarized as follows:

A strategy to access aliphatic esters RC(O)OR1 (R = 2-chloro-2-(4-methylphenyl)ethyl, 2-chloroheptyl, 2-chloro-2-cyclohexylethyl, 2-chloro-3-(2,3-dihydro-1H-indol-1-yl)-2-methyl-3-oxopropyl, etc.; R1 = Et, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl, 4-phenylbutyl, etc.) from olefins RH through a photocatalyzed alkoxycarbonylation reaction was reported. Alkyloxalyl chlorides R1C(O)2C(O)Cl, generated in situ from the corresponding alcs. R1OH and oxalyl chloride, are engaged as alkoxycarbonyl radical fragments under photoredox catalysis. This transformation tolerates a broad scope of electron-rich and electron-deficient olefins and provides the corresponding β-chloro esters in good yields. Addnl., a formal β-selective alkene alkoxycarbonylation is developed. Moreover, a variety of oxindole-3-acetates I (R2 = H, t-Bu, CN, me, etc.; R3 = Me, Bn; R4 = Me, Et, Bn, i-Pr), Et 2-(1-methyl-2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetate, Et 2-(7-methyl-6-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetate, Et 2-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[g]indol-3-yl)acetate and furoindolines II are prepared in good to excellent yields. A more concise formal synthesis of (±)-physovenine is accomplished as well. With these strategies, a wide range of natural-product-derived olefins and alkyloxalyl chlorides are also successfully employed. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Related Products of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Syntheses of Pyrroles, Pyridines, and Ketonitriles via Catalytic Carbopalladation of Dinitriles》 was published in Journal of Organic Chemistry in 2020. These research results belong to Qi, Linjun; Li, Renhao; Yao, Xinrong; Zhen, Qianqian; Ye, Pengqing; Shao, Yinlin; Chen, Jiuxi. Formula: C6H6BFO2 The article mentions the following:

In the presence of Pd(O2CCF3)2 or Pd2(dba)3 and 2,2′-bipyridine, arylboronic acids underwent carbopalladation and cyclocondensation reactions with butanedinitriles and pentanedinitriles to yield 2,5-diarylpyrroles and 2,6-diarylpyridines. In the presence of Pd(acac)2 and 2,2′-bipyridine, arylboronic acids underwent chemoselective monocarbopalladation reactions with dinitriles NC(CH2)nCN (n = 2-6) to yield arylketonitriles. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Formula: C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Formula: C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,New Journal of Chemistry included an article by Jamwal, Babita; Kaur, Manpreet; Sharma, Harsha; Khajuria, Chhavi; Paul, Satya; Clark, J. H.. Application In Synthesis of (3-Fluorophenyl)boronic acid. The article was titled 《Diamines as interparticle linkers for silica-titania supported PdCu bimetallic nanoparticles in Chan-Lam and Suzuki cross-coupling reactions》. The information in the text is summarized as follows:

A series of highly efficient amine functionalized SiO2-TiO2 supported bimetallic PdCu catalysts with varied metal composition have been synthesized. Ethane-1,2-diamine, butane-1,4-diamine and hexane-1,6-diamine were employed as interparticle linkers for amine functionalization of a SiO2-TiO2 support material so as to study the effect of pendant chain length on stabilization and immobilization of bimetallic nanoparticles. The shortest carbon chain length on the support provided the best results, which may be due to the trapping of metal nanoparticles more efficiently by the basic nitrogen sites. The catalytic activities of these materials were evaluated for C-N and C-C coupling reactions. The most active catalyst, Pd1Cu1@12DA-STS was characterized by various techniques including SEM, HR-TEM, ICP-AES, XRD, FTIR, EDX, CHN anal. and TGA studies. Moreover, the synthesized catalyst was found to be recyclable for up to five runs without significant loss of activity.(3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Yun; Wang, Beilei; Wang, Junjie; Qi, Shuang; Zou, Fengming; Qi, Ziping; Liu, Feiyang; Liu, Qingwang; Chen, Cheng; Hu, Chen; Hu, Zhenquan; Wang, Aoli; Wang, Li; Wang, Wenchao; Ren, Tao; Cai, Yujiao; Bai, Mingfeng; Liu, Qingsong; Liu, Jing published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors》.Recommanded Product: 350-30-1 The author mentioned the following in the article:

Starting from our previously developed c-KIT kinase inhibitor CHMFL-KIT-8140, through a type II kinase inhibitor binding element hybrid design approach, we discovered a novel c-KIT kinase inhibitor compound 18 (CHMFL-KIT-64), which is potent against c-KIT wt and a broad spectrum of drug-resistant mutants with improved bioavailability. 18 exhibits single-digit nM potency against c-KIT kinase and c-KIT T670I mutants in the biochem. assay and displays great potencies against most of the gain-of-function mutations in the juxtamembrane domain, drug-resistant mutations in the ATP binding pocket (except V654A), and activation loops (except D816V). In addition, 18 exhibits a good in vivo pharmacokinetic (PK) profile in different species including mice, rats, and dogs. It also displays good in vivo antitumor efficacy in the c-KIT T670I, D820G, and Y823D mutant-mediated mice models as well as in the c-KIT wt patient primary cells which are known to be imatinib-resistant. The potent activity against a broad spectrum of clin. important c-KIT mutants combining the good in vivo PK/pharmacodynamic properties of 18 indicates that it might be a new potential therapeutic candidate for gastrointestinal stromal tumors. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Recommanded Product: 350-30-1)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Recommanded Product: 350-30-1 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics