Tag: 100-200

In 2017,ChemPlusChem included an article by Champagne, Pier-Luc; Ester, David; Ward, Sandra; Williams, Vance E.; Ling, Chang-Chun. Related Products of 14258-40-3. The article was titled 《A family of amphiphilic cyclodextrin liquid crystals governed by dipole-dipole interactions》. The information in the text is summarized as follows:

A novel family of amphiphilic cyclodextrin (CD)-based liquid crystals that bear O-acetylated oligoethylene glycol chains at the secondary face is reported. Unlike most of the previously reported liquid crystals (LC) based on chem. modified CDs, which depend on H-bonding as the primary intermol. forces, the present CD derivatives self-assemble into highly ordered smectic liquid crystal phases via the weaker dipole-dipole intermol. interactions. The obtained materials are found to display much improved properties such as improved thermostability, reduced clearing temperatures, and better fluidity. The present work opens up new possibilities to design CD-based LC materials. In the experimental materials used by the author, we found 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Related Products of 14258-40-3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Related Products of 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksOn May 31, 2021, Cao, Chaotun; Cao, Chenzhong; Qu, Junyan published an article in Journal of Luminescence. The article was 《Quantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene》. The article mentions the following:

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Category: chlorides-buliding-blocks)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Effect of alkyl substitution in drugs. XVII. Synthesis on pharmacological properties of alkyl-substituted benzhydryl derivatives of piperazine》 was written by Gootjes, J.; Funcke, A. B. H.; Tersteege, H. M.; Nauta, Wijbe T.. Product Details of 14258-40-3 And the article was included in Arzneimittel-Forschung in 1966. The article conveys some information:

Benzhydryl piperazin-2-ylmethyl ethers, benzhydryl 2-(4-phenylpiperazino)ethyl ethers, benzhydryl 2-(2-piperazinoethoxy)ethyl ethers, and bis(benzhydryl ethers) of 1,4-bis(hydroxyethoxyethyl)piperazines are prepared Benzhydryl 1,4-dimethylpiperazin-2-ylmethyl ether (I) shows papaverine-like action on isolated guinea pig ileum. The compounds prepared are (b.p./mm. and m.p. given): 1,4-bis(p-toluenesulfonyl)-2-piperazinemethanol, -, 174-5°; 2-piperazinemethanol, 140-1°/15, – (maleate m. 149.5-50°); 1,4-dimethyl-2-piperazinemethanol (II), 102-4°/15, -, (maleate m. 144-6°); 4-diphenylmethyl-1-phenylpiperazine, -, -; ClCH2CH2OCH2CH2OAc, 97°/10, -; 2-(2-piperazinoethoxy)ethanol, 150-5°/2, – (maleate m. 121.5-3°); 2-[2-(4-methylpiperazino)ethoxy]ethanol, 115-20°/2, – (HCl salt m. 213-15°); 2,2′-[1,4-piperazinediylbis(ethyleneethoxy)]diethanol, 180-210°/0.1, – (HCl salt m. 179-81°); trans-2,2′-[2,5-dimethyl-1,4-piperazinediylbis(ethyleneoxy)]diethanol, 192-6°/3, 57-60°. A mixture of Ph2CHOH, II, and K2CO3 is heated 1 hr. at 180° to give 47% I di-oxalate, m. 185.5-6°. Similarly prepared are (m.p. and % yield given): o-methylbenzhydryl 1,4-dimethylpiperazin-2-ylmethyl ether di-oxalate hydrate, 119-20°, 31; o-tert-butylbenzhydryl, 1,4-dimethylpiperazin-2-ylmethyl ether di-oxalate, 184.5-5°, 27; III (n = 0, R1 = R2 = R3 = R4 = R5 = R6 = R8 = H), 125-6°, 49; the following III (n = 1, R7 = OCH2CH2)(R1, R2, R3, R4, R5, R6, R8, m.p., and salt m.p. given): H, H, H, H, H, H, H, -, oxalate hemihydrate 177-9°; Me, H, H, H, H, H, H, -, oxalate hemihydrate 162-3°; H, MeO, H, H, MeO, H, H, -, hemioxalate 197-8°; Me, H, Me, Me, H, Me, H, 98-9°, -; H, H, H, H, H, H, Me, -, HCl 153-4°; the following IV (R1, R2, R3, R4, R5, R6, R7, R8, and salt m.p. given): H, H, H, H, H, H, H, Me, 2HCl 179-81.5°; Me, H, H, H, H, H, H, Me, 2HCl 180-2°; H, Me, H, H, H, H, H, Me, 2HCl 137-9°; Me, H, Me, Me, Me, H, H, Me, -; Et, H, Et, Et, Et, H, H, Me, -; H, H, H, H, H, Me, Me, Me, 2HCl 177-9° (trans); Me, H, H, H, H, Me, Me, Me, 2HCl 167-8.5° (trans); H, H, H, H, H, H, H, O(CH2CH2O)2H, dimaleate 137.5-9°; Me, H, H, H, H, H, H, O(CH2CH2O)2H, dimaleate 138.5-40°; Me, H, Me, Me, Me, H, H, O(CH2CH2O)2H, dimaleate 143-4°; the following V (R1, R2, R3, R4, and m.p. salt given): tert-Bu, H, H, H, dimaleate 150-1.5°; Me, Me, H, H, dimaleate 153.5-5°; H, H, Me, Me, 2HCl 186-7.5° (trans); Me, H, Me, Me, 2HCl 182-3° (trans). In the part of experimental materials, we found many familiar compounds, such as 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Product Details of 14258-40-3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Product Details of 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Carbene-catalyzed atroposelective synthesis of axially chiral styrenes》 was written by Yan, Jia-Lei; Maiti, Rakesh; Ren, Shi-Chao; Tian, Weiyi; Li, Tingting; Xu, Jun; Mondal, Bivas; Jin, Zhichao; Chi, Yonggui Robin. Synthetic Route of C4H3ClO2S2This research focused onynal sulfinic acid phenol heterocyclic carbene catalyst addition; axially chiral styrene preparation enantioselective click chem. The article conveys some information:

Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to prepare due to the low rotational barrier of the axis. Disclosed here is an N-heterocyclic carbene (NHC) catalytic asym. solution to this problem. The reaction involves ynals, sulfinic acids, and phenols as the substrates with an NHC as the catalyst. Key steps involve selective 1,4-addition of sulfinic anion to acetylenic acylazolium intermediate and sequential E-selective protonation to set up the chiral axis. The reaction affords axially chiral styrenes bearing a chiral axis as the product with up to > 99:1 e.r., > 20:1 E/Z selectivity, and excellent yields. The sulfone and carboxylic ester moieties in the styrene products are common moieties in bioactive mols. and asym. catalysis.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formula: C3H3ClO3In 2019 ,《Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay》 appeared in ACS Infectious Diseases. The author of the article were Lee, Minhee; Zhao, Jinshi; Kwak, Seung-Hwa; Cho, Jae; Lee, Myungju; Gillespie, Robert A.; Kwon, Do-Yeon; Lee, Hyunji; Park, Hyun-Ju; Wu, Qinglin; Zhou, Pei; Hong, Jiyong. The article conveys some information:

The UDP-2,3-diacylglucosamine pyrophosphatase LpxH in the Raetz pathway of lipid A biosynthesis is an essential enzyme in the vast majority of Gram-neg. pathogens and an excellent novel antibiotic target. The 32P-radioautog. thin-layer chromatog. assay has been widely used for anal. of LpxH activity, but it is inconvenient for evaluation of a large number of LpxH inhibitors over an extended time period. Here, we report a coupled, nonradioactive LpxH assay that utilizes the recently discovered Aquifex aeolicus lipid A 1-phosphatase LpxE for quant. removal of the 1-phosphate from lipid X, the product of the LpxH catalysis; the released inorganic phosphate is subsequently quantified by the colorimetric malachite green assay, allowing the monitoring of the LpxH catalysis. Using such a coupled enzymic assay, we report the biochem. characterization of a series of sulfonyl piperazine LpxH inhibitors. Our anal. establishes a preliminary structure-activity relationship for this class of compounds and reveals a pharmacophore of two aromatic rings, two hydrophobic groups, and one hydrogen-bond acceptor. We expect that our findings will facilitate the development of more effective LpxH inhibitors as potential antibacterial agents. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Ran; Fu, Jian-Ming; Tian, Hai-Yu; Chen, Nian-Shou; Liu, Lei; Guo, Yu; Wang, Pei-Long published their research in New Journal of Chemistry in 2021. The article was titled 《Sulfonyl radical-induced regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides to produce 1,2-dihydropyridines by copper catalysis》.Recommanded Product: Thiophene-2-sulfonyl chloride The article contains the following contents:

A Cu-catalyzed regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides for the synthesis of 1,2-dihydropyridines I [R = 4-MeC6H4, 3-ClC6H4, 2-thienyl, etc.; R1 = Me, Ph, 3-MeC6H4, 4-MeOC6H4, 2-NCC6H4, 2-thienyl; R2 = H, Me, Et; R3 = Ph, 4-BrC6H4, 2-naphthyl, etc.] was described. This present method provided a new pathway for the construction of 1,2-dihydropyridines from 3-aza-1,5-enynes in reasonable yields and an alternative method for the synthesis of 3-functionalized multi-substituted pyridines. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schirmer, Tobias E.; Rolka, Alessa B.; Karl, Tobias A.; Holzhausen, Ferdinand; Koenig, Burkhard published their research in Organic Letters in 2021. The article was titled 《Photocatalytic C-H Trifluoromethylthiolation by the Decatungstate Anion》.Application of 5781-53-3 The article contains the following contents:

A broadly applicable method for the trifluoromethylthiolation of methylene C(sp3)-H, methine C(sp3)-H, α-oxygen C(sp3)-H, and formyl C(sp2)-H bonds is presented using the decatungstate anion as the sole catalyst. By adjusting the substrate ratio and reaction concentration, this method was applied to 40 examples in good regioselectivities, including the derivatization of natural products. Furthermore, SCF3-drug analogs were synthesized by subsequent functionalization of the SCF3 products, highlighting the importance of this photocatalyzed C-H functionalization. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe》 were Ding, Lele; Tian, Zhenhao; Hou, Jie; Dou, Tongyi; Jin, Qiang; Wang, Dandan; Zou, Liwei; Zhu, Yadi; Song, Yunqing; Cui, Jingnan; Ge, Guangbo. And the article was published in Chinese Chemical Letters in 2019. Application of 5781-53-3 The author mentioned the following in the article:

Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiol. processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biol. systems, a practical and isoform-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity, sensitivity, enzymic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CES1 activities in several biol. systems including tissue preparations, living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biol. systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clin. practice and fundamental research. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Akkarasamiyo, Sunisa; Margalef, Jessica; Samec, Joseph S. M.. Formula: C6H6BFO2. The article was titled 《Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Naphthyl and Quinolyl Alcohols with Boronic Acids》. The information in the text is summarized as follows:

A nickel-catalyzed C(sp3)-C(sp2) Suzuki cross-coupling of arylboronic acids and (hetero)naphthyl alcs. has been developed. A Ni(dppp)Cl2 complex showed the highest efficiency and broadest substrate scope. High functional group tolerance has been achieved where 35 compounds could be generated in good to excellent yields, including both primary and secondary benzylic alcs. Mechanistic studies using multiple NMR techniques as well as ESI-HRMS showed that the C-O cleavage is facilitated by an activation of the benzylic alc. through formation of a boronic ester intermediate. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Formula: C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Formula: C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 620-20-2On November 30, 2019 ,《An improved method for the synthesis of phenylacetic acid derivatives via carbonylation》 appeared in Journal of Chemical Research. The author of the article were Li, He; Zhang, Yijun; Liu, Dinghua; Liu, Xiaoqin. The article conveys some information:

A series of phenylacetic acid derivatives RCH2CO2H [R = 2-ClC6H4, 4-MeC6H4, 2,4-Cl2C6H3, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics