Tag: 100-200

Zhang, Yurong; Liu, Yafei; Zhang, Jun; Gu, Ren; Han, Shiqing published their research in Tetrahedron Letters on December 5 ,2019. The article was titled 《An alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur》.Quality Control of 3-Chlorobenzylchloride The article contains the following contents:

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines was developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that was metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system was used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equiv to 5 equivalent The results came from multiple reactions, including the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C6H6BFO2In 2019 ,《Bis-N,N-aminophosphine (PNP) crosslinked poly(p-tert-butyl styrene) particles: A new support for heterogeneous palladium catalysts for Suzuki coupling reactions》 appeared in Catalysis Communications. The author of the article were Vece, Vito; Szeto, Kai C.; Charlin, Marc O.; Rouge, Pascal; De Mallmann, Aimery; Taam, Manel; Dugas, Pierre-Yves; Lansalot, Muriel; D’Agosto, Franck; Taoufik, Mostafa. The article conveys some information:

Crosslinked polymer particles carrying hemilabile bis-N,N-aminophosphine (PNP) moieties were obtained by the copolymerization of a PNP-derived monomer bearing four vinyl fragments as cross-linkers, with para-tert-butylstyrene and divinylbenzene, using free radical copolymerization in presence of AIBN, performed in aqueous dispersed medium. This new support was characterized by thermogravimetric anal., elemental anal., laser diffraction, solid state NMR. The PNP moiety allowed monochelation to palladium. The resulting insoluble Pd-catalyst revealed to be very active for Suzuki cross-coupling with several substrates, allowing separation of the product from the catalyst by filtration. The final palladium PS-PNP catalyst was reused for several catalytic cycles. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Electric Literature of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Electric Literature of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sheng, Cheng; Ling, Zheng; Luo, Yicong; Zhang, Wanbin published an article in Nature Communications. The title of the article was 《Cu-Catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters for the construction of linear chiral N,O-ketals》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

Herein, a Cu-catalyzed asym. addition of alcs. to β,γ-alkynyl-α-imino esters was developed under mild conditions, providing the corresponding linear chiral N,O-ketals I [R1 = n-Bu, Ph, 2-thienyl, etc.; R2 = Me, Et, n-Pr, n-Bu; R3 = Me, Et, cyclobutyl, Bn, etc.] with up to 96% ee. The method tolerated some variation in the β,γ-alkynyl-α-imino esters and alc. scope, including some glucose and natural amino acid derivatives Computational results indicated that the Boc group of the substrates assist in the extraction of hydrogen atoms from the alcs. to promote the addition reactions. These products could be synthesized on a gram-scale and can be used in several transformations. This asym. addition system provided an efficient, mild, gram-scale, and transition-metal-catalyzed synthesis of linear chiral N,O-ketals. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Zhuoxiong; Yu, Hui published an article in 2022. The article was titled 《Synthesis of (E)-α-chloromethyl vinyl sulfones by 1, 2-radical difunctionalization of allenes with sodium sulfinates and iron(III) chloride hexahydrate》, and you may find the article in Tetrahedron Letters.Formula: C4H3ClO2S2 The information in the text is summarized as follows:

An efficient radical chlorosulfonylation of allenes was disclosed and vinylsulfones were prepared smoothly under mild conditions. By using sodium sulfinates as radical precursors, iron(III) chloride hexahydrate (FeCl3.6H2O) as oxidant and chloride source, allenes were converted into (E)-α-chloromethyl vinylsulfones I [R = Me, Ph, 4-FC6H4, etc., R1 = Ph, R2 = H, X = Cl, Br; R = Ph, R1 = 2-MeC6H4, 4-FC6H4, 4-ClC6H4, etc., R2 = H, Me, X = Cl] via regioselective 1,2-radical difunctionalization process in moderate to good yields. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Straccia C., Vianni G.; Lugo, Pedro L.; Rivela, Cynthia B.; Blanco, Maria B.; Wiesen, Peter; Teruel, Mariano A. published an article in 2021. The article was titled 《OH-initiated degradation of methyl 2-chloroacetoacetate and ethyl 2-chloroacetoacetate: Kinetics, products and mechanisms at 298 K and atmospheric pressure》, and you may find the article in Chemosphere.Application of 5781-53-3 The information in the text is summarized as follows:

Rate coefficients for the gas-phase reactions of OH radicals with CH3C(O)CHClC(O)OCH3 (k1) and CH3C(O)CHClC(O)OCH2CH3 (k2) were measured using the relative technique with different reference compounds The experiments were performed at (298 ± 2) K and 750 Torr of nitrogen or synthetic air by in situ FTIR spectroscopy and GC-FID chromatog. The following rate coefficients (in units of cm3mol.-1 s-1) were obtained: k1FTIR= (2.70 ± 0.51) x 10-11; k1GC-FID= (2.30 ± 0.71) x 10-11 and k2FTIR= (3.37 ± 0.62) x 10-11; k2GC-FID= (3.26 ± 0.85) x 10-11. This work reports the first kinetic study for the reactions of OH radicals with the mentioned chloroacetoacetates. Addnl., product studies are reported in similar conditions of the kinetic experiments Acetic acid, acetaldehyde, formyl chloride, and Me 2-chloro-2-oxoacetate were pos. identified and quantified as degradation products. According to the identified products, atm. chem. mechanisms were proposed. The environmental implications of these reactions were assessed by the tropospheric lifetimes calculations of the title chloroesters. Significant average ozone production of 4.16 ppm for CH3C(O)CHClC(O)OCH3 and 5.98 ppm for CH3C(O)CHClC(O)OCH2CH3, resp. were calculated In the experimental materials used by the author, we found Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sharland, Jack C.; Wei, Bo; Hardee, David J.; Hodges, Timothy R.; Gong, Wei; Voight, Eric A.; Davies, Huw M. L. published their research in Chemical Science in 2021. The article was titled 《Asymmetric synthesis of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates》.Formula: C3H3ClO3 The article contains the following contents:

This study described general methods for the enantioselective syntheses of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates through dirhodium tetracarboxylate-catalyzed asym. cyclopropanation of vinyl heterocycles with aryldiazoacetates. The reactions were highly diastereoselective and high asym. induction could be achieved using either (R)-pantolactone as a chiral auxiliary or chiral dirhodium tetracarboxylate catalysts. For meta- or para-substituted aryl- or heteroaryldiazoacetates the optimum catalyst was Rh2(R-p-Ph-TPCP)4. In the case of ortho-substituted aryl- or heteroaryldiazoacetates, the optimum catalyst was Rh2(R-TPPTTL)4. For a highly enantioselective reaction with the ortho-substituted substrates, 2-chloropyridine was required as an additive in the presence of either mol. sieves or 1,1,1,3,3,3-hexafluoroisopropanol (HFIP). Under the optimized conditions, the cyclopropanation could be conducted in the presence of a variety of heterocycles, such as pyridines, pyrazines, quinolines, indoles, oxadiazoles, thiophenes and pyrazoles. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jianrong; Ma, Ling; Song, Chang; Xing, Hui; Cen, Shan; Lin, Wenhan published their research in ACS Chemical Biology in 2021. The article was titled 《Anti-HIV Effects of Baculiferins Are Regulated by the Potential Target Protein DARS》.HPLC of Formula: 5781-53-3 The article contains the following contents:

Baculiferins are a group of marine sponge-derived polycyclic alkaloids with anti-HIV (human immunodeficiency virus) activities. To identify addnl. baculiferin-based congeners for SAR anal. and to investigate the mode of action, a total of 18 new baculiferin-type derivatives were synthesized. The inhibitory activities of the congeners against the HIV-1 virus were evaluated in vitro, and the relevant SAR was discussed. Compound 18 exerted the most potent activity toward VSV-G-pseudotyped HIV-1 (IC50 of 3.44μM) and HIV-1 strain SF33 (IC50 of 2.80μM) in vitro. To identify the cellular targets, three photoaffinity baculiferin probes were simultaneously synthesized. Photoaffinity labeling experiments together with LC-MS/MS data identified aspartate-tRNA ligase (DARS) as a putative target protein of 18. The overexpression and knockdown of DARS in HEK293T cells provided addnl. data to demonstrate that DARS is a potential target protein in the regulation of HIV virus infection. The modes of antiviral baculiferins 13 and 18 binding to DARS were determined by a mol. docking simulation. Thus, baculiferin 18 is considered a promising lead as a new mol. target for the development of anti-HIV agents. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Palladium supported on N-Heterocyclic carbene functionalized hydroxyethyl cellulose as a novel and efficient catalyst for the Suzuki reaction in aqueous media》 was written by Dong, Yahao; Bi, Jiajun; Zhang, Shoute; Zhu, Dajian; Meng, Di; Ming, Shujun; Qin, Kaiwei; Liu, Qian; Guo, Lei; Li, Tao. Related Products of 768-35-4 And the article was included in Applied Surface Science in 2020. The article conveys some information:

Bearing an intrinsic green nature, biopolymers are expected to serve as ideal alternatives in the sustainable conversion process. A N-Heterocyclic carbene functionalized hydroxyethyl cellulose supported palladium catalyst (HEC-NHC-Pd) was successfully prepared through a surface functionalization approach. The as-prepared catalyst was characterized through TEM, CP/MAS 13C NMR, and XPS analyses, etc. The new and eco-friendly catalyst was effectively employed in Suzuki reactions in ethanol aqueous solution Dependent on dual coordination sites (-OH and N-Methylimidazole) binding to the active component (Pd), the palladium complex exhibited high stability and low metal leaching (<1%). Addnl., the environmental friendliness catalyst could be retrieved through simple centrifugation within a few cycles. This study also offers a new pathway for the application of such biopolymer surface functionalization in organic transformations. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Transient-axial-chirality controlled asymmetric rhodium-carbene C(sp2)-H functionalization for the synthesis of chiral fluorenes》 was published in Nature Communications in 2020. These research results belong to Dong, Kuiyong; Fan, Xing; Pei, Chao; Zheng, Yang; Chang, Sailan; Cai, Ju; Qiu, Lihua; Yu, Zhi-Xiang; Xu, Xinfang. Recommanded Product: 768-35-4 The article mentions the following:

In catalytic asym. reactions, the formation of chiral mols. generally relies on a direct chirality transfer (point or axial chirality) from a chiral catalyst to products in the stereo-determining step. Herein, a transient-axial-chirality transfer strategy to achieve asym. reaction is disclosed. This method relies on transferring point chirality from the catalyst to a dirhodium carbene intermediate with axial chirality, namely a transient-axial-chirality since this species is an intermediate of the reaction. The transient chirality is then transferred to the final product by C(sp2)-H functionalization reaction with exceptionally high enantioselectivity. This strategy is also generalized for the asym. cascade reaction involving dual carbene/alkyne metathesis (CAM), a transition-metal-catalyzed method to access chiral 9-arylfluorene frameworks in high yields with up to 99% ee. Detailed DFT calculations shed light on the mode of the transient-axial-chirality transfer and the detailed mechanism of the CAM reaction. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《New synthesis of 4-acetoxy-2-azetidinones by use of electrochemical oxidation》 were Mori, Miwako; Kagechika, Katsuji; Tojima, Ko; Shibasaki, Masakatsu. And the article was published in Tetrahedron Letters in 1988. Application of 98019-65-9 The author mentioned the following in the article:

Optically pure 4-acetoxy-3-[1(t-butyldimethylsilyloxy)ethyl]-2-azetidinone, which is a highly versatile intermediate for the synthesis of thienamycin and other biol. active β-lactam analogs, was synthesized from 4-carboxy-3-[1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone by Kolbe type electrolysis. The results came from multiple reactions, including the reaction of 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9Application of 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics