Tag: 100-200

Zhu, Haiqian; Zheng, Hanliang; Zhang, Junhua; Feng, Jian; Kong, Lichun; Zhang, Fang; Xue, Xiao-Song; Zhu, Gangguo published their research in Chemical Science in 2021. The article was titled 《Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols》.Application of 16629-19-9 The article contains the following contents:

Divergent synthesis is a powerful strategy for the fast assembly of different mol. scaffolds from identical starting materials. Herein, a solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes with sulfonyl chlorides for the direct construction of highly functionalized cyclopentenones and dihydropyranols that widely exist in bioactive mols. and natural products has been described. D. functional theory calculations suggest that a unique N,N-dimethylacetamide-assisted 1,2-hydrogen transfer of alkoxy radicals is responsible for the cyclopentenone formation, whereas a C-C cleavage accounts for the selective production of dihydropyranols in acetonitrile and water at 50°C. Given the simple and mild reaction conditions, excellent functional group compatibility, forming up to four chem. bonds, and tunable selectivity, it may find wide applications in synthetic chem. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes under photocatalyst- and additive-free conditions》 was written by Meng, Xiao-Xiao; Kang, Qing-Qing; Zhang, Jun-Yao; Li, Qiang; Wei, Wen-Ting; He, Wei-Min. Application In Synthesis of Thiophene-2-sulfonyl chloride And the article was included in Green Chemistry in 2020. The article conveys some information:

Without employing any photocatalyst and additive, an economical, eco-friendly and practical strategy was developed for the visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes in a biomass-derived green solvent 2-methylTHF from easily accessible sulfonyl chlorides under open-air conditions at room temperature Compared with conventional heating conditions, the use of a 3 W blue light-emitting diode (LED) or sunlight not only reduces energy consumption but also minimizes side reactions. This transformation showed excellent regioselectivity, mild reaction conditions, broad substrate scope and ease of scale-up. Moreover, mechanistic studies indicated that a sulfonyl radical pathway was involved in this reaction. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Two-channel responsive fluorescent probe of meso carboxylate of BODIPY with AIE characteristics for fast detection of palladium》 were Zhou, Junliang; Xu, Shuang; Yu, Zhiliang; Ye, Xufeng; Dong, Xiaochun; Zhao, Weili. And the article was published in Dyes and Pigments in 2019. HPLC of Formula: 5781-53-3 The author mentioned the following in the article:

The wide use of palladium species may cause palladium pollution in medicine, food and water, which raises risks on environment and health due to the latent hazard of palladium species. In this work, two BODIPY-based fluorescent probes (BDP-COOen and BDP-COOyn) for the detection of palladium have been developed. Both probes displayed strong AIE fluorescence and exhibited selective response to Pd0 in aqueous buffer. Notably, BDP-COOen showed a favorable two-channel responsive manner as well as preferred reaction kinetics (<6 min). Furthermore, the probe BDP-COOen was successfully applied for two channel fluorescence imaging of intracellular Pd0. The results came from multiple reactions, including the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yuan, Huihui; Wang, Mingyue; Fan, Lei; Yang, Jia; Wang, Shuai; Zhong, Hong published their research in Tetrahedron Letters on December 21 ,2021. The article was titled 《A solvent-free method for the preparation of phosphinates from P(O)-OH compounds with alkyl chlorides》.Formula: C7H6Cl2 The article contains the following contents:

Herein, a new solvent-free synthetic method using P(O)-OH compound and alkyl chloride for phosphinate compounds is disclosed. This transformation proceeds smoothly under the promotion of a lone base and presents the advantages of an easily available raw material source, a simple post treatment process, good functional group tolerance and high reaction efficiency. Good yield was obtained when the reaction was magnified to gram scale(coating), and the molar ratio of P(O)-OH compounds and alkyl chlorides can be decreased to 1:2. This protocol provides a practical method for the preparation of phosphorus derivatives Furthermore, the reaction mechanism was explored by 31P NMR. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Deracemization of axially chiral nicotinamides by dynamic salt formation with enantiopure dibenzoyltartaric acid (DBTA)》 were Yagishita, Fumitoshi; Kamataki, Norifumi; Okamoto, Kazuma; Kanno, Shota; Mino, Takashi; Masu, Hyuma; Sakamoto, Masami. And the article was published in Molecules in 2013. Category: chlorides-buliding-blocks The author mentioned the following in the article:

The dynamic atroposelective resolution of chiral salts derived from oily racemic nicotinamides (RS)-I (R = pyrrolidino, piperidino, morpholino) and enantiopure dibenzoyltartaric acid (DBTA) was achieved by crystallization The absolute structures of the axially chiral nicotinamides were determined by X-ray structural anal. The chirality could be controlled by the selection of enantiopure DBTA as a chiral auxiliary. The axial chirality generated by dynamic salt formation was retained for a long period after dissolving the chiral salt in solution even after removal of the chiral acid. The rate of racemization of nicotinamides could be controlled based on the temperature and solvent properties, and that of the salts were prolonged compared to free nicotinamides, as the mol. structure of the pyridinium ion in the salts was different from that of acid-free nicotinamides. In the experimental materials used by the author, we found 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Category: chlorides-buliding-blocks)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 5781-53-3In 2019 ,《Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes》 was published in ACS Catalysis. The article was written by Pitre, Spencer P.; Muuronen, Mikko; Fishman, Dmitry A.; Overman, Larry E.. The article contains the following contents:

Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited. This report describes the use of tert-alkyl oxalate salts, derived from tertiary alcs., to introduce tertiary substituents into a variety of heterocyclic substrates. This reaction has reasonably broad scope, proceeds rapidly under mild conditions, and is initiated by either photochem. or thermal activation. Insights into the underlying mechanism of the higher yielding visible-light initiated process were obtained by flash photolysis studies, whereas computational studies provided insight into the reaction scope. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Ji, Dong-Sheng; Liang, Hui; Yang, Kai-Xuan; Feng, Zhi-Tao; Luo, Yong-Chun; Xu, Guo-Qiang; Gu, Yucheng; Xu, Peng-Fei published an article in Chemical Science. The title of the article was 《Solvent directed chemically divergent synthesis of β-lactams and α-amino acid derivatives with chiral isothiourea》.HPLC of Formula: 5781-53-3 The author mentioned the following in the article:

A protocol for the chem. divergent synthesis of β-lactams I (R1 = Ph, 3-ClC6H4, 2-thienyl, etc.; R2 = Ph, 1-naphthyl, 3-thienyl, 3-indolyl, etc.; R3 = Me, Et, PhCH2) and α-amino esters II with isothiourea catalysis by switching solvents has been developed. The stereospecific Mannich reaction occurring between imines III and zwitterionic enolate intermediates, generated from the catalyst and perfluorophenyl esters IV, followed by intramol. lactamization afforded β-lactams I when dichloromethane and acetonitrile were used as solvents. However, when EtOH was used as the solvent, the intermediates underwent an intermol. esterification reaction, and α-amino acid derivatives II were produced. Detailed mechanistic experiments were conducted to prove that these two kinds of products came from the same intermediates. Furthermore, chem. diversified transformations of β-lactam and α-amino acid derivatives were achieved. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kamoshita, Masahiro; Kosaka, Koji; Endo, Osamu; Asami, Mari; Aizawa, Takako published an article on January 31 ,2010. The article was titled 《Mutagenic activities of a chlorination by-product of butamifos, its structural isomer, and their related compounds》, and you may find the article in Chemosphere.Quality Control of 2-Methyl-5-nitro-6-chlorophenol The information in the text is summarized as follows:

The mutagenic activities of 5-methyl-2-nitrophenol (5M2NP), a chlorination byproduct of butamifos, its structural isomer 2-methyl-5-nitrophenol (2M5NP), and related compounds were evaluated by the Ames assay. The mutagenic activities of 5M2NP and 2M5NP were neg. or not particularly high. However, those of their chlorinated derivatives were increased in Salmonella typhimurium strain TA100 and the overproducer strains YG1026, and YG1029 in the absence and/or presence of a rat liver metabolic activation system (S9 mix), particularly for YG1029. The mutagenic activities of 6-chloro-2-methyl-5-nitrophenol (6C2M5NP) in YG1029 in the absence and presence of S9 mix were 70 000 and 110 000 revertants mg-1, resp. When nitro functions of 6C2M5NP and 4-chloro-5-methyl-2-nitrophenol (4C5M2NP) were reduced to amino functions, their mutagenic activities were markedly decreased. The mutagenic activities of 5M2NP and 4C5M2NP were lower than those of 2M5NP and 6C2M5NP, resp. Thus, it was shown that substituent position is a key factor for the mutagenic activities of methylnitrophenols (MNPs) and related compounds The mutagenic activities of the extracts of 2M5NP in chlorination increased early during the reaction time and then decreased. The main chlorination byproduct contributing to the mutagenic activities of the extracts of 2M5NP in chlorination was 6C2M5NP. The results of chlorination of 2M5NP suggested that MNPs were present as their dichlorinated derivatives or further chlorination byproducts in drinking water. In addition to this study using 2-Methyl-5-nitro-6-chlorophenol, there are many other studies that have used 2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Quality Control of 2-Methyl-5-nitro-6-chlorophenol) was used in this study.

2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Quality Control of 2-Methyl-5-nitro-6-chlorophenol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fu, Dong-Jun; Cui, Xin-Xin; Zhu, Ting; Zhang, Yan-Bing; Hu, Yang-Yang; Zhang, Li-Rong; Wang, Sheng-Hui; Zhang, Sai-Yang published their research in Bioorganic Chemistry on February 28 ,2021. The article was titled 《Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells》.Name: 3-Chlorobenzylchloride The article contains the following contents:

A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogs, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)acetamide (I) showed the best inhibitory activity against MGC803 cells with an IC50 value of 1.59μM. Cellular mechanisms elucidated that I inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analog I inhibited NEDDylation pathway and MAPK pathway against MGC803 cells. In the experiment, the researchers used many compounds, for example, 3-Chlorobenzylchloride(cas: 620-20-2Name: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Name: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cha, J. K. published their research in Science of Synthesis on August 10 ,2005. The article was titled 《Product class 3: N-[α-(Heteroatom)alkyl]-substituted alkanamides》.HPLC of Formula: 98019-65-9 The article contains the following contents:

A review of the preparation of N-[α-(heteroatom)alkyl]-substituted alkanamides and applications to organic synthesis. The experimental part of the paper was very detailed, including the reaction process of 4-Oxo-2-azetidinecarboxylic acid(cas: 98019-65-9HPLC of Formula: 98019-65-9)

4-Oxo-2-azetidinecarboxylic acid(cas:98019-65-9) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 98019-65-9 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics