Tag: 100-200

In 2022,Zhu, Wenjuan; Xi, Hui; Jiao, Wenyang; Huang, Lihua; Wang, Lianjie; Wu, Junliang published an article in Organic Letters. The title of the article was 《Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones》.Name: Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

Visible-light-promoted R1CH=CF2 (R1 = 2H-1,3-benzodioxol-5-yl, 3-bromo-4-methoxyphenyl, 4-(benzyloxy)phenyl, etc.) using sulfonyl chlorides R2S(O)OCl (R2 = 4-tert-butylphenyl, naphthalen-1-yl, thiophen-2-yl, cyclopropyl, etc.) and alcs. R3OH (R3 = Me, Bn, i-Pr, etc.) has been developed. The reaction exhibits a relatively broad substrate scope with excellent functional group compatibility. This synthesis method includes an atom transfer radical addition-like process. The products R1CH(O)R2CF2S(O)OR3 can be used as platform mols. for further modification. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Rhodium(III) Catalyzed Regioselective and Stereospecific Allylic Arylation in Water by β-Fluorine Elimination of the Allylic Fluoride: Toward the Synthesis of Z-Alkenyl-Unsaturated Amides》 was published in Organic Letters in 2020. These research results belong to Casalta, Clement; Bouzbouz, Samir. Name: (3-Fluorophenyl)boronic acid The article mentions the following:

A direct coupling of arylboronic acids with allylic fluorides was carried out in water without additives using a rhodium(III) catalyst (Cp*RhCl2)2. The transformation proceeded with excellent γ-selectivity to afford major allyl-aryl coupling products (Z) γ-substituted α,β-unsaturated amides. The reactions of α-chiral allylic fluorides took place with excellent α-to-γ chirality transfer to give allylated arenes with a stereogenic center at the benzylic and allylic position. After reading the article, we found that the author used (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Palladium immobilized on functionalized hypercrosslinked polymers: a highly active and recyclable catalyst for Suzuki-Miyaura coupling reactions in water》 were Liu, Xi; Xu, Wei; Xiang, Dexuan; Zhang, Zaixing; Chen, Dizhao; Hu, Yangjian; Li, Yuanxiang; Ouyang, Yuejun; Lin, Hongwei. And the article was published in New Journal of Chemistry in 2019. HPLC of Formula: 768-35-4 The author mentioned the following in the article:

Heterogeneous catalysts have shown advantages such as high stability, good recyclability and easy separation from reactants over homogeneous catalysts in recent years. In this paper, three pyridine-functionalized N-heterocyclic carbene-palladium complexes (HCP-Pd) were successfully synthesized via a simple external crosslinking reaction. In each catalyst (i.e., complex), palladium (Pd) was immobilized on the hypercrosslinked polymer (HCP) via formation of a six-membered ring by Pd2+ and the bidentate ligands of NHC and pyridine. The structure and composition of HCP-Pd were characterized by SEM, TEM, N2 sorption, FT-IR, TGA and XPS. The catalytic performances of these catalysts in a Suzuki-Miyaura coupling reaction were also studied. The results prove that HCP-Pd is a very effective heterogeneous catalyst for the Suzuki-Miyaura coupling reaction of various aryl halides with aryl boronic acid in an aqueous medium under mild conditions. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nambo, Masakazu; Ghosh, Koushik; Yim, Jacky C.-H.; Tahara, Yasuyo; Inai, Naoto; Yanai, Takeshi; Crudden, Cathleen M. published their research in ACS Catalysis on August 5 ,2022. The article was titled 《Desulfonylative Coupling of Alkylsulfones with gem-Difluoroalkenes by Visible-Light Photoredox Catalysis》.Computed Properties of C5H3ClOS The article contains the following contents:

The desulfonylative radical addition of tertiary alkyl groups I [R1 = 2-phenylethyl, 1,3-dioxolan-2-ylmethyl, prop-2-en-1-yl, etc. R2 = Me, 3-chloropropyl, 2-(tert-butoxy)-2-oxoethyl, etc.; R1 = R2 = -(CH2)5-, -(CH2)2O(CH2)2-, 2,3-dihydro-1H-inden-2-ylidene; R3 = H, Me] to gem-difluoroalkenes F2C=CHR4 (R4 = 4-(4-chlorophenyl)phenyl, naphthalen-2-yl, 1-benzothiophen-3-yl, etc.) by photoredox Ir-catalyst was described. This method exhibits broad substrate scope, affording structurally diverse (E)-fluoroalkene derivatives (R1)(R2)R3CC(F)=CHR4 in a highly stereoselective manner. The resulting (E)-fluoroalkenes were converted into complex fused cyclic compounds e.g., II by intramol. cyclization reactions. Control experiments and theor. calculations are consistent with a single Ir catalyst playing the dual role of generating radical species from sulfones via single electron transfer and mediating Z/E isomerization via energy transfer. A subset of fluoroalkenes provided Z stereoisomers with <90% selectivity, but the same alkenes could also be obtained as E isomers (R1)(R2)R3CC(F)=CHR4 (R1 = 2-phenylethyl, R2 = R3 = Me, R4 = m-OMe, m-Br, p-Me.) with high selectivity by taking advantage of a secondary Z to E photoisomerization. The experimental process involved the reaction of 5-Chlorothiophene-3-carbaldehyde(cas: 36155-85-8Computed Properties of C5H3ClOS)

5-Chlorothiophene-3-carbaldehyde(cas: 36155-85-8) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C5H3ClOS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nakamura, Takumi; Ishikawa, Hiroki; Ban, Kazuma; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published an article on January 31 ,2022. The article was titled 《Attrition-Enhanced Asymmetric Transformation of Axially Chiral Nicotinamides by Dynamic Chiral Salt Formation》, and you may find the article in ChemPlusChem.HPLC of Formula: 66662-48-4 The information in the text is summarized as follows:

Atroposelective resolution for axially chiral nicotinamides was achieved by dynamic chiral salt formation with L-DBTA (dibenzoyl-L-tartaric acid) using six types of nicotinamides that could not be optically resolved by the preferential crystallization method. Kinetic studies of the racemization indicated that the chiral conformation was retained for a significant period of time. Two methods of crystallization-induced asym. transformation were examined by dynamic diastereomeric salt formation: solvent evaporation from a supersaturated solution, and attrition-enhanced asym. transformation. The attrition method was more effective for asym. amplification of diastereomeric salts of axially chiral materials. Attrition of an equimolar amount of the nicotinamide salts with L-DBTA converged to one diastereomeric salt; and the corresponding enantiomers in 87-99% ee were obtained after the chiral acid was removed. Changing the ratio of two of the nicotinamides with L-DBTA to 1:2 inverted the axial chirality. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4HPLC of Formula: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,ChemMedChem included an article by Schwarze, Benedikt; Jelaca, Sanja; Welcke, Linda; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Hey-Hawkins, Evamarie. Computed Properties of C6H4ClNO2. The article was titled 《2,2′-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes》. The information in the text is summarized as follows:

Investigations on the antitumor activity of metallacarboranes are sparse in the literature and limited to a handful of ruthena- and molybdacarboranes. In this study, the molybdacarborane fragment [3-(CO)2-closo-3,1,2-MoC2B9H11] was combined with a vector mol., inspired by the well-known drug tamoxifen or 4,4′-dihydroxytamoxifen (TAM-diOH). The molybdacarborane derivative [3,3-{4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine-κ2N,N′}-3-(CO)2-closo-3,1,2-MoC2B9H11] (10), as well as the ligand itself 4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine (6) showed cytotoxic activities in the low micromolar range against breast adenocarcinoma (MDA-MB-231, MDA-MB-361 and MCF-7), human glioblastoma (LN-229) and human glioma (U-251) cell lines. In addition, compounds 6 and 10 were found to induce senescence and cytodestructive autophagy, lower ROS/RNS levels, but only the molybdacarborane 10 induced a strong increase of nitric oxide (NO) concentration in the MCF-7 cells. In the experiment, the researchers used many compounds, for example, 2-Chloroisonicotinic acid(cas: 6313-54-8Computed Properties of C6H4ClNO2)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C6H4ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol》 was written by Chen, Yi-Xuan; Wang, Zhu-Jun; Xiao, Jun-An; Chen, Kai; Xiang, Hao-Yue; Yang, Hua. Computed Properties of C4H3ClO2S2This research focused ontrifluoromethyl sulfonyl tertiary alc preparation; sodium sulfinate trifluoromethylstyrene sulfonation. The article conveys some information:

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcs. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant mols. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: (3-Fluorophenyl)boronic acidIn 2019 ,《New approach to unsymmetrical 1,3-diazatriphenylenes through intramolecular oxidative cyclodehydrogenation》 appeared in Tetrahedron. The author of the article were Verbitskiy, Egor V.; Eltsov, Oleg S.; Zhilina, Ekaterina F.; Pakhomov, Ilya M.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.. The article conveys some information:

An efficient synthetic route towards previously inaccessible dibenzo[f,h]quinazolines and [1]benzothieno[3,2-f]benzo[h]quinazolines through FeCl3-mediated intramol. oxidative cyclodehydrogenation of readily available 5-([1,1′-biphenyl]-2-yl)pyrimidines and 5-(2-phenylbenzo[b]thiophen-3-yl)pyrimidines was described. MO calculations (DFT), as well as redox and photophys. measurements for all new compounds was performed. The data showed that the reported polycyclic systems have a potential to use in organic electronic applications. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Kim, Thomas T.; Lee, Chungwoo; Kim, Dongwook; Lee, Hee-Seung; Han, Sunkyu published an article in Organic Letters. The title of the article was 《Synthesis and Reactivity of 1-Hydroxyherquline A》.Application of 5781-53-3 The author mentioned the following in the article:

Herein, we present the synthesis of 1-hydroxyherquline A and describe its reactivity discovered during its attempted conversion to herquline A, a long-sought natural product target in the synthetic chem. community. The strategic installation of the C1 hydroxyl group enabled the key aza-Michael addition-mediated N10-C2 bond formation and eventually access to 1-hydroxyherquline A, the most advanced herquline A congener reported to date. Our attempted reductive transformation of 1-hydroxyherquline A to herquline A was challenged by the extremely strained bowl-shaped pentacyclic structures of key precursors that prevented either radical formation at C1 or protonation (or hydrogenation) from the desired face. These discoveries regarding the innate chem. reactivities of advanced intermediates toward herquline A may prove useful in efforts toward this formidable target. After reading the article, we found that the author used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Jin-Lin; Liu, Mei-Ling; Zou, Jian-Yu; Sun, Wen-Hui; Liu, Xue-Yuan published an article in 2022. The article was titled 《Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration》, and you may find the article in Organic Letters.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

A new strategy for aminoarylation of alkenes by copper-catalyzed Smiles rearrangement using O-benzoylhydroxylamines as the amine reagent was described.. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics