Tag: 100-200

Liu, Qian; Zhao, Xiaoqian; Xu, Feng; Li, Gaoqiang published an article on February 13 ,2020. The article was titled 《Metal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides》, and you may find the article in Tetrahedron Letters.COA of Formula: C7H6Cl2 The information in the text is summarized as follows:

An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I2O5 and DBU via direct oxidative coupling was described. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2COA of Formula: C7H6Cl2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.COA of Formula: C7H6Cl2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jian-Ping; Li, Yi; Liu, Chao; Wang, Tianyi; Chung, Lung Wa; Xu, Ming-Hua published their research in Organic Letters in 2021. The article was titled 《Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic β2/γ2/δ2-Amino Acid Derivatives》.Recommanded Product: 768-35-4 The article contains the following contents:

A highly enantioselective rhodium-catalyzed intermol. hydroarylation of α-aminoalkyl acrylates using water as a direct proton source was realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of α-aryl-methyl-substituted β2- γ2- δ2-amino esters I [Ar = Ph, 2-ClC6H4, 2-naphthyl, etc.] with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions. By utilizing this method, a series of structurally interesting benzo-fused heterocyclic mols. and corresponding β2- γ2- and δ2-amino esters II [R = 2-ylisoindoline-1,3-dione, NHBoc; Ar = Ph, 3-ClC6H4, 4-F3CC6H4, etc.; n = 2,3] were facilely constructed. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《C- to N-Center Remote Heteroaryl Migration via Electrochemical Initiation of N Radical by Organic Catalyst》 was written by Liu, Chengkou; Jiang, Qiang; Lin, Yang; Fang, Zheng; Guo, Kai. Electric Literature of C4H3ClO2S2 And the article was included in Organic Letters in 2020. The article conveys some information:

Herein an exogenous oxidant- and metal-free electrochem. heteroaryl migration triggered by N radicals to construct new N-C bonds was developed. This methodol. features a high atom economy and utilization rate of energy, and it is insensitive to water and air. Moreover, a user-friendly undivided cell was employed. The use of an organic catalyst makes it more efficient, green, and practical. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Electron-Deficient Alkynes as Dipolarophile in Pd-Catalyzed Enantioselective (3 + 2) Cycloaddition Reaction with Vinyl Cyclopropanes》 were Ding, Wen-Ping; Zhang, Gao-Peng; Jiang, Yang-Jie; Du, Juan; Liu, Xiu-Yan; Chen, Di; Ding, Chang-Hua; Deng, Qing-Hai; Hou, Xue-Long. And the article was published in Organic Letters in 2019. SDS of cas: 5781-53-3 The author mentioned the following in the article:

The activated alkynes have been used successfully for the first time as the dipolarophile in the palladium-catalyzed asym. (3 + 2) cycloaddition, affording highly functionalized cyclopentenes in good to high yields with high chemoselectivities and good to high enantioselectivities. The introduction of an addnl. carbonyl group at the α-position of the alkynyl esters is the key to activating the carbon-carbon triple bond. The reaction process was investigated, and an inverse process of Pd-catalyzed (3 + 2) cycloaddition was observed In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Chen, Zhixiang; Ma, Dawei. COA of Formula: C3H3ClO3. The article was titled 《Cu/N,N’-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines》. The information in the text is summarized as follows:

N,N’-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For (hetero)aryl bromides/iodides, coupling reaction took place at 80-100 °C with 1 mol % CuI and 2 mol % DBO. A variety of heteroanilines worked well to afford the arylation products in good to excellent yields. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3COA of Formula: C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Heavier chalcogenone complexes of bismuth(III)trihalides: potential catalysts for acylative cleavage of cyclic ethers》 were Srinivas, Katam; Suresh, Paladugu; Babu, Chatla Naga; Sathyanarayana, Arruri; Prabusankar, Ganesan. And the article was published in RSC Advances in 2015. Computed Properties of C6H11ClO3 The author mentioned the following in the article:

Heavier chalcogenones (S, Se and Te) of imidazole act as versatile ligands to yield a series of mononuclear and dinuclear bismuth(III)complexes of heavier chalcogenones in excellent yield. These new bismuth heavier chalcogen derivatives are the first structurally characterized mols., where the bismuth and heavier chalcogen ratio is 1 : 1. There is only one previous report of a crystal structure of a bismuth(III)-imidazol selone compound and none with bismuth(III)-imidazol tellone. The bismuth center in monomeric bismuth chalcogen trihalides depicts pseudo trigonal bipyramidal geometry, while the dimeric bismuth chalcogen trihalides demonstrate distorted square pyramidal geometry. The solid state structures of bismuth chalcogenone derivatives feature rare Bi···π(aryl) interactions. Thus, the centroid of the C6-ring suggests a half sandwich type of bismuth environment in mononuclear and dinuclear bismuth(III) chalcogenone complexes. Notably, the Bi···π(aryl) interaction is not often noticed for mononuclear bismuth chalcogen compounds Some of the bismuth(III) chalcogenone complexes also exhibit C-H···π(aryl), C-H···S and C-H···Cl types of hydrogen bonding. The bismuth-chalcogen bond distance in mononuclear bismuth(III) tribromide chalcogenone complexes is slightly longer than in mononuclear bismuth(III) trichloride chalcogenone complexes. A gradual increase in carbon-chalcogen bond distance was observed from the free imidazole-chalcogenone to mononuclear bismuth(III) trichloride chalcogenones, dinuclear bismuth(III) trichloride chalcogenones and mononuclear bismuth(III) tribromide chalcogenones and dinuclear bismuth(III) tribromide chalcogenones. The UV-vis absorption properties and thermal decomposition properties of imidazol chalcogenones and their bismuth derivatives were investigated. Furthermore, the O-acylative cleavage of cyclic ethers was demonstrated using mononuclear and dinuclear bismuth(III) complexes of heavier chalcogenones as catalysts. In contrast to bismuth(III) trichloride and bismuth(III) tribromide catalysts, mononuclear and dinuclear bismuth(III) complexes of heavier chalcogenones are very active towards an acylative cleavage of cyclic ethers through a mild and regioselective strategy. In particular, mononuclear imidazolthione-bismuth(III) trichloride is very active towards O-acylative cleavage of 2-Me THF. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Computed Properties of C6H11ClO3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Computed Properties of C6H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《A novel series of [1,2,4]triazolo[4,3-a]pyridine sulfonamides as potential antimalarial agents: in silico studies, synthesis and in vitro evaluation》 were Karpina, Veronika R.; Kovalenko, Svitlana S.; Kovalenko, Sergiy M.; Drushlyak, Oleksandr G.; Bunyatyan, Natalya D.; Georgiyants, Victoriya A.; Ivanov, Vladimir V.; Langer, Thierry; Maes, Louis. And the article was published in Molecules in 2020. SDS of cas: 620-20-2 The author mentioned the following in the article:

For the development of new and potent antimalarial drugs, the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment, e.g., I has been described. The library of 1561 compounds has been investigated by both virtual screening and mol. docking methods using falcipain-2 as a target enzyme. 25 Chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98μM, resp. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs. After reading the article, we found that the author used 3-Chlorobenzylchloride(cas: 620-20-2SDS of cas: 620-20-2)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.SDS of cas: 620-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Pharmaceuticals included an article by Juhas, Martin; Bachtikova, Andrea; Nawrot, Daria Elzbieta; Hatokova, Paulina; Pallabothula, Vinod Sukanth Kumar; Diepoltova, Adela; Jandourek, Ondrej; Barta, Pavel; Konecna, Klara; Paterova, Pavla; Sestak, Vit; Zitko, Jan. Product Details of 6313-54-8. The article was titled 《Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole》. The information in the text is summarized as follows:

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stages of the drug discovery pipeline due to their unspecific reactivity (PAINS), toxicity, insufficient stability, or low water solubility In this work, we investigated a series of substituted N-oxazolyl- and N-thiazolylcarboxamides of various pyridinecarboxylic acids. Final compounds were tested against several microbial species. In general, oxazole-containing compounds showed high activity against mycobacteria, especially Mycobacterium tuberculosis (best MICH37Ra = 3.13 μg/mL), including the multidrug-resistant strains. Promising activities against various bacterial and fungal strains were also observed None of the compounds was significantly cytotoxic against the HepG2 cell line. Exptl. measurement of lipophilicity parameter log k′w and water solubility (log S) confirmed significantly (typically two orders in logarithmic scale) increased hydrophilicity/water solubility of oxazole derivatives in comparison with their thiazole isosteres. Mycobacterial β-ketoacyl-acyl carrier protein synthase III (FabH) was suggested as a probable target by mol. docking and mol. dynamics simulations. In the part of experimental materials, we found many familiar compounds, such as 2-Chloroisonicotinic acid(cas: 6313-54-8Product Details of 6313-54-8)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 6313-54-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Chemical Science included an article by Joung, Seewon; Bergmann, Allison M.; Brown, M. Kevin. Quality Control of 3-Chlorobenzylchloride. The article was titled 《Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes》. The information in the text is summarized as follows:

Nickel-catalyzed 1,2-carboboration of alkenes is emerging as a useful method for chem. synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1,2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochem. The utility of the products as well as the mechanistic details of the process are also presented.3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride) was used in this study.

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

El Ashry, E. S. H.; Abdel-Rahman, A. A.-H.; Rashed, N.; Rasheed, H. A. published their research in Pharmazie on December 31 ,1999. The article was titled 《Homoacyclovir analogs of unnatural bases and their activity against hepatitis B virus》.HPLC of Formula: 14258-40-3 The article contains the following contents:

The ambident nucleophilic nature of the sodium salts of 2(1H)-quinoxalinone and 2-phenylphthalazinedione has been realized from their alkylation with 2-(2-chloroethoxy)ethyl acetate to afford N- and O-alkylated derivatives, e.g., I and II. Four addnl. N-alkylated heterocycles were similarly prepared from unnatural bases. Treatment of the alkylated derivatives with methanolic ammonia solution (1:1) at room temperature gave the hydroxyalkyl derivatives The site of alkylation was deduced from the spectral characteristics of the products. The activity of several compounds against hepatitis B virus in HepG2 cells has been tested. Some of the compounds showed high viral replication inhibition with low cytotoxicity. In the experiment, the researchers used many compounds, for example, 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3HPLC of Formula: 14258-40-3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.HPLC of Formula: 14258-40-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics