Tag: 100-200

Xie, Wenjiao; Ma, Pengju; Zhang, Yujun; Xi, Longyi; Qiu, Shengqi; Huang, Xuan; Yang, Bo; Gao, Yuan; Zhang, Junmin published an article in 2022. The article was titled 《Visible Light-Induced Highly Regioselective and Stereoselective Oxysulfonylation of Alkynes for the Synthesis of (E)-β-Phenoxy Vinylsulfones》, and you may find the article in Organic Letters.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

A highly efficient visible light-induced regioselective and stereoselective oxysulfonylation of alkynes with arylsulfonate phenol esters was developed. This photocatalyst- and metal-free method proceeded smoothly under very mild conditions and exhibits a broad substrate scope, providing (E)-β-phenoxy vinylsulfones in moderate to excellent yields. Mechanistic studies indicated the involvement of an electron donor-acceptor complex-mediated radical process. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saranya, Salim; Radhika, Sankaran; Anilkumar, Gopinathan published their research in ChemistrySelect in 2021. The article was titled 《Ligand- and Base-Free Cu-Catalyzed C-N Coupling of Aminoquinolines with Boronic Acids》.Application In Synthesis of (3-Fluorophenyl)boronic acid The article contains the following contents:

A ligand- and base-free Cu-catalyzed protocol for the synthesis of N-arylquinolin-8-amine and N-arylquinolin-3-amine derivatives has been developed. A wide range of N-aryl heterocycles were synthesized in moderate to good yields under the mild condition of 10 mol% Cu(OAc)2 in 3 mL methanol at room temperature in presence of air. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Catalytic enantioselective synthesis of tetrasubstituted chromanones via palladium-catalyzed asymmetric conjugate arylation using chiral pyridine-dihydroisoquinoline ligands》 was written by Baek, Doohyun; Ryu, Huijeong; Ryu, Ji Yeon; Lee, Junseong; Stoltz, Brian M.; Hong, Sukwon. Quality Control of (3-Fluorophenyl)boronic acid And the article was included in Chemical Science in 2020. The article conveys some information:

Highly enantioselective conjugate addition reactions of arylboronic acids to 2-substituted chromones catalyzed by palladium complexes with new chiral pyridine-dihydroisoquinoline (PyDHIQ) ligands was developed. These reactions provide highly enantioselective access to chromanones containing tetrasubstituted stereocenters. Various arylboronic acids and 2-substituted chromones were used in the catalytic reaction which afforded the chiral tetrasubstituted chromanones in good yields and excellent enantioselectivities (25 examples, up to 98% yields, up to 99% ee). The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Quality Control of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Quality Control of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Dearomative 1,4-difunctionalization of naphthalenes via palladium-catalyzed tandem Heck/Suzuki coupling reaction》 was published in Nature Communications in 2020. These research results belong to Zhou, Bo; Wang, Hongliang; Cao, Zhong-Yan; Zhu, Jia-Wen; Liang, Ren-Xiao; Hong, Xin; Jia, Yi-Xia. Application of 768-35-4 The article mentions the following:

Reported herein is an application of naphthalenes I [R = 2-bromophenyl, N-(2-bromophenyl)-N-methylcarbamoyl, 2-bromo-5-(methoxycarbonyl)phenoxymethyl, N-(3-bromopyridin-2-yl)-N-methylcarbamoyl, etc.; R1 = H, OMe; R2 = H, Br; R3 = H, OMe; R4 = H; R3R4 = -CH=CH-CH=CH-] as a masked conjugated diene in a palladium-catalyzed dearomative 1,4-diarylation or 1,4-vinylarylation reaction via tandem Heck/Suzuki sequence. Three types of 1,4-dihydronaphthalene-based spirocyclic compounds II [X = N, CH; R5 = Me, Bn; R6 = H, 4-F, 5-OMe, 6-CF3, etc.; R7 = Ph, 4-ethenylphenyl, 3,4-difluorophenyl, etc.; R8 = H, Ph]/III [R9 = H, 4-Me, 4-OMe, 4-F, 5-Me, 5-F; R10 = Et, n-Pr, Ph, etc.; R11 = Ph, 3-methylphenyl, naphthalen-2-yl] are achieved in excellent regio- and diastereoselectivities. Key to this transformation is the inhibition of a few competitive side reactions, including intramol. naphthalenyl C-H arylation, intermol. Suzuki cross-coupling, dearomative 1,2-difunctionalization, and dearomative reductive-Heck reaction. D. functional theory (DFT) calculations imply that the facile exergonic dearomative insertion of a naphthalene double bond disrupts the sequence of direct Suzuki coupling, leading to the tandem Heck/Suzuki coupling reaction. The observed regioselectivity towards 1,4-difunctionalization is due to the steric repulsions between the introduced aryl group and the spiro-scaffold in 1,2-difunctionalization. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Application of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Thiosulfonylation of Unactivated Alkenes with Visible-Light Organic Photocatalysis》 was published in ACS Catalysis in 2020. These research results belong to Gadde, Karthik; Mampuys, Pieter; Guidetti, Andrea; Ching, H. Y. Vincent; Herrebout, Wouter A.; Van Doorslaer, Sabine; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.. Application of 16629-19-9 The article mentions the following:

A metal-free method for the vicinal thiosulfonylation of unactivated alkenes R1CH=CHR (R = H, Me; R1 = benzyl, (trimethylsilyl)methyl, (prop-2-en-1-yloxy)methyl, 3-cyanopropyl, etc.; RR1 = -(CH2)4-, -(CH2)3-, -(CH2)2(O)-, etc.) with thiosulfonates R2S(O)2SR3 (R2 = Me, 4-methylphenyl, 4-fluorophenyl, thiophen-2-yl, etc.; R3 = Ph, Bu, 2-[methoxy(oxo)methane]phenyl, thiophen-2-yl, etc.) using 9-mesityl-10-methylacridinium perchlorate as photo-organocatalyst with visible-light irradiation has been developed. The method can be performed in di-Me carbonate under air at room temperature and features a broad functional group compatibility. Metrics indicate the green potential of the developed vs. the state-of-the-art methodologies. Mechanistic studies revealed no single electron transfer but involvement of an energy transfer from the excited photo-organocatalyst to thiosulfonate reactant, subsequently providing a sulfenyl and a sulfonyl radical via homolytic cleavage. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Cu-Catalyzed Dehydrogenative Olefinsulfonation of Alkyl Arenes》 was published in Organic Letters in 2020. These research results belong to Li, Fangfang; Zhang, Guang-an; Liu, Yingguo; Zhu, Bingke; Leng, Yuting; Wu, Junliang. Application of 16629-19-9 The article mentions the following:

A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This reaction procedure proceeded well under mild reaction conditions, providing a practical and efficient strategy for the rapid assembly of biol. and pharmaceutically significant mols., such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in the presence of N-sulfonylbenzo[d]imidazole with broad substrate scope and good functional group tolerance. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《δ C-H (hetero)arylation via Cu-catalyzed radical relay》 were Zhang, Zuxiao; Stateman, Leah M.; Nagib, David A.. And the article was published in Chemical Science in 2019. HPLC of Formula: 768-35-4 The author mentioned the following in the article:

A Cu-catalyzed strategy was developed that harnesses a radical relay mechanism to intercept a distal C-centered radical for C-C bond formation. This approach enabled selective δ C-H (hetero)arylation of sulfonamides via intramol. hydrogen atom transfer (HAT) by an N-centered radical. The radical relay was both initiated and terminated by a Cu catalyst, which enabled incorporation of arenes and heteroarenes by cross-coupling with boronic acids. The broad scope and utility of this catalytic method for δ C-H arylation was showed, along with mechanistic probes for selectivity of the HAT mechanism. A catalytic, asym. variant was also presented, as well as a method for accessing 1,1-diaryl-pyrrolidines via iterative δ C-H functionalizations. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Polymer Chemistry included an article by Pan, Haiyan; Chen, Siqi; Jin, Ming; Malval, Jean-Pierre; Wan, Decheng; Morlet-Savary, Fabrice. Application In Synthesis of Methyl 2-chloro-2-oxoacetate. The article was titled 《A substituent para-to-ortho positioning effect drives the photoreactivity of a dibenzothiophene-based oxalate series used as LED-excitable free radical photoinitiators》. The information in the text is summarized as follows:

Four dibenzothiophene (DBT)-based Me oxalates, synthesized through a one-step Friedel-Crafts acylation reaction, were developed as high-performance photoinitiators (PIs) for the free radical polymerization of acrylate resins excitable using LED sources that emit in the near-UV and visible region (i.e. 365-425 nm). These type I PIs show good optical absorption properties (ε365nm = 1 000-5300 M-1 cm-1). Their resp. photophys. properties, as well as the sequential photocleavage mechanism, were investigated using a large set of theor. and exptl. methods. A relevant structure/reactivity relationship opening the way to enhancing the PI performance is highlighted. Indeed, a para-to-ortho positioning effect of the oxalate-based substituent regulates both the absorption and photocleavage abilities within this DBT series. Para-isomers consequently exhibit a photoinitiating reactivity, whose efficiency is more than one order of magnitude higher than that of their ortho homologues. Associated with a H-donor alkylamine co-reactant, these photoinitiating efficiencies can be amplified even more due to an addnl. reaction pathway that judiciously assigns a new role to the aryloyl radical byproducts. These results correlate the PI photopolymerization performance with the photoinduced processes occurring in the excited states. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Methyl 2-chloro-2-oxoacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Cell Chemical Biology included an article by Ohki, Yu; Sakurai, Hidetaka; Hoshino, Madoka; Terashima, Hideki; Shimizu, Hiroki; Ishikawa, Tomio; Ogiyama, Tomoko; Muramatsu, Yasunori; Nakanishi, Toshiyuki; Miyazaki, Shojiro; Tsuruoka, Hiroyuki; Kobayashi, Hideki; Kubota, Kazuishi. Recommanded Product: 768-35-4. The article was titled 《Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology》. The information in the text is summarized as follows:

Mol. target identification of small mols., so-called target deconvolution, is a major obstacle to phenotype-based drug discovery. Here, we developed an approach called perturbation-based proteomic correlation profiling (PPCP) utilizing the correlation between protein quantity and binding activity of compounds under cellular perturbation by gene silencing and successfully identified lanosterol synthase as a mol. target of TGF-β pathway inhibitor. This PPCP concept was extended to the use of a cell line panel and provides a new option for target deconvolution. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Liang, Junqing; Han, Jie; Wu, Jingjing; Wu, Pingjie; Hu, Jian; Hu, Feng; Wu, Fanhong. Application In Synthesis of (3-Fluorophenyl)boronic acid. The article was titled 《Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones》. The information in the text is summarized as follows:

A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents α-bromo-α-fluoroketones by using a trifluoroacetate release protocol. Mechanistic investigation indicated that a monofluoroalkyl radical is involved in the catalytic circle. Moreover, an important medical intermediate of flindokalner was synthesized via a nickel-catalyzed coupling reaction of α-bromo-α-fluoro-2-indolone and boronic ester. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Application In Synthesis of (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Application In Synthesis of (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics