Tag: 100-200

Category: chlorides-buliding-blocksIn 2020 ,《Ruthenium(II)-Catalyzed C-H Arylation of N,N-Dialkyl Thiobenzamides with Boronic Acids by Sulfur Coordination in 2-MeTHF》 was published in Organic Letters. The article was written by Zhang, Jin; Liu, Ying; Jia, Qiangqiang; Wang, Yue; Ma, Yangmin; Szostak, Michal. The article contains the following contents:

We report ruthenium(II)-catalyzed ortho-C-H arylation of N,N-dialkylthiobenzamides with boronic acids. The method employs [RuCl2(p-cym)]2 in the presence of Cu(OTf)2 and Ag2O oxidant. The reaction represents the first example of Ru-catalyzed C-H arylation directed by sulfur-containing groups and a rare example of C-H arylation directed by the versatile thiobenzamide moiety. As a further advantage, the method is performed in sustainable and eco-friendly 2-MeTHF as a solvent. In the experiment, the researchers used many compounds, for example, (3-Fluorophenyl)boronic acid(cas: 768-35-4Category: chlorides-buliding-blocks)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xi; Wang, Qiang; Zhang, Zhe; Niu, Zhi-Jie; Shi, Wei-Yu; Gong, Xiao-Ping; Jiao, Rui-Qiang; Gao, Ming-Hui; Liu, Xue-Yuan; Liang, Yong-Min published an article in 2022. The article was titled 《Copper-Catalyzed Hydrogen Atom Transfer and Aryl Migration Strategy for the Arylalkylation of Activated Alkenes》, and you may find the article in Organic Letters.Recommanded Product: Thiophene-2-sulfonyl chloride The information in the text is summarized as follows:

Herein, the copper-catalyzed arylalkylation of activated alkenes, e.g., N-(benzenesulfonyl)-N-(4-methoxyphenyl)-2-methylprop-2-enamide via hydrogen-atom transfer and aryl migration strategy were described. The reaction was carried out through a radical-mediated continuous migration pathway using N-fluorosulfonamides, e.g., N-fluoro-4-methyl-N-octylbenzene-1-sulfonamide as the alkyl source. The primary, secondary, and tertiary alkyl radicals formed by intramol. hydrogen-atom transfer proceeded smoothly. This methodol. is an efficient approach for the synthesis of various amide derivatives possessing a quaternary carbon center, e.g., I with good yields and high regioselectivity. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides》 was written by Luo, Ziwei; Yang, Xinkan; Tsui, Gavin Chit. Recommanded Product: 16629-19-9 And the article was included in Organic Letters in 2020. The article conveys some information:

A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with com. nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Palladium Immobilized on 2,2′-Dipyridyl-Based Hypercross linked Polymers as a Heterogeneous Catalyst for Suzuki-Miyaura Reaction and Heck Reaction》 was written by Liu, Cijie; Xu, Wei; Xiang, Dexuan; Luo, Qionglin; Zeng, Shunqin; Zheng, Lijuan; Tan, Yujie; Ouyang, Yuejun; Lin, Hongwei. Recommanded Product: 768-35-4 And the article was included in Catalysis Letters in 2020. The article conveys some information:

2,2′-Bipyridine was successfully integrated into the skeleton of hypercrosslinked polymers networks (HCPs-bipy) via Friedel-Crafts reaction and Scholl coupling reaction, and PdCl2 was locked in this network polymers by coordination with pyridine motif. The preparation of HCPs-bipy has the advantages of low cost, mild conditions, easy separation and high yield. FT-IR, TGA, N2 sorption, ICP, XPS, SEM, EDX and TEM was employed to characterize the structure and composition of the heterogeneous catalysts. The result indicates that HCPs-bipy-Pd possess high sp. surface areas, large microporous volume, thermal stability, and highly dispersion of palladium species. HCPs-bipy-Pd can be applied in Suzuki-Miyaura reactions and Heck reactions as robust heterogeneous catalyst to afford high yield. The reusability test demonstrates that HCPs-bipy-Pd could be recovered and reused for at least five times without losing catalytic activity. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Insight into catalytic properties of supported palladium nanoparticles catalyzed ortho-directed sulfonylation》 was published in Youji Huaxue in 2020. These research results belong to Li, Pengshuai; Wu, Yun; Bai, Chaolumen; Bao, Yongsheng. Product Details of 16629-19-9 The article mentions the following:

Catalyzed by supported palladium nanoparticles, an ortho-directed sulfonylation reaction between 2-phenylpyridine and arylsulfonyl chlorides has been developed. The full oxidation-state change of palladium was detected in the XPS anal. of the supported palladium nanoparticles catalyst before and after reaction, which confirmed that Pd-catalyzed ortho-directed sulfonylation reaction was performed via a PdII/IV catalytic cycle instead of Pd0/II. The hot filtration test and other tests of catalysts further confirmed the hypothesis. This report afforded the most straightforward approach to confirm the variation of valence of palladium in ortho-directed sulfonylation reaction. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Product Details of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Product Details of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guo, Haichang; Zheng, Renhua; Jiang, Huajiang; Xu, Zhenyuan; Xia, Aibao published their research in BMC Chemistry on December 31 ,2019. The article was titled 《Preparation of sub-microspherical Fe3O4@PDA-Pd NPs catalyst and application in catalytic hydroreduction reaction of halogenated aromatic nitro compounds to prepare halogenated aromatic amines》.Safety of 3-Chloro-4-fluoronitrobenzene The article contains the following contents:

A promising method for preparation of the superparamagnetic and strongly magnetic Fe3O4@PDA core-shell sub-microsphere-supported nano-palladium catalyst for catalyzing the hydrogenation reduction of halogenated aromatic nitro compds was reported. The catalyst showed a high selectivity of greater than 96% and effectively inhibited the occurrence of the side reactions of dehalogenation and C-N coupling. The optimum condition of the hydroredn. reaction was when THF is used as solvent and the reaction occurred at 50° for 5 h. The selectivity of the chlorinated aromatic amine and the fluorinated aromatic amine products exceeded 99% and the yield exceeds 90%. Only a small amount of dehalogenated products and C-N coupling byproducts were produced in the brominated aromatic compound and the iodinated aromatic compound In the experiment, the researchers used many compounds, for example, 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Safety of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Safety of 3-Chloro-4-fluoronitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 3-Chloro-4-fluoronitrobenzeneOn May 31, 2022, Li, Dingzhong; Zhang, Wensheng; Zhu, Longzhi; Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua published an article in ChemistryOpen. The article was 《FeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones》. The article mentions the following:

An efficient hydrazine substitution of p-nitro-aryl fluorides viz., 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 2-fluoro-5-nitroaniline, etc. with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. These hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups such as 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 1-bromo-2,4-difluoro-5-nitrobenzene, etc. proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups such as 2-fluoro-5-nitroaniline, 1-fluoro-2-methyl-4-nitrobenzene, 2-bromo-4-fluoro-1-nitrobenzene, etc. also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines viz., (2-chloro-4-nitrophenyl)hydrazine, (3-fluoro-4-nitrophenyl)hydrazine, (2-bromo-4-nitrophenyl)hydrazine, (2,3-difluoro-4-nitrophenyl)hydrazine, (2-chloro-3-fluoro-4-nitrophenyl)hydrazine, some phthalazinones I (R = H, 4-hydroxyphenyl; R1 = 2-Cl, 2-Br, 3-F, 2-Cl-3-F, 2,3-F2), interesting as potential structures for pharmaceuticals, have been successfully synthesized in high yields. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Reference of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Reference of 3-Chloro-4-fluoronitrobenzene The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Computed Properties of C6H11ClO3On May 6, 2016 ,《Synthesis Toward and Stereochemical Assignment of Clathsterol: Exploring Diverse Strategies to Polyoxygenated Sterols》 appeared in Organic Letters. The author of the article were Zhou, Tao; Feng, Feng; Shi, Yong; Tian, Wei-Sheng. The article conveys some information:

Herein we describe a synthesis of the trisulfate derivative I of clathsterol (II), a marine sterol endowed with impressive structural features and moderate inhibitory activity against HIV-1 reverse transcriptase. By synthesizing two possible isomers of the side chain, the stereochem. of II is assigned. In creating chiral side chains from steroidal lactone, our strategies, including an addition/reduction procedure to give C22R-OH, an epoxide-opening reaction, and a [3.3]-rearrangement to induce the generation of C24S-Et and C24R-Et resp., are highly flexible and complementary to each other. After reading the article, we found that the author used 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Computed Properties of C6H11ClO3)

2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Computed Properties of C6H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 5781-53-3In 2020 ,《Facile Access to 1,4-Disubstituted Pyrrolo[1,2-a]pyrazines from α-Aminoacetonitriles》 appeared in Synthesis. The author of the article were Karmakar, Ananta; Ramalingam, Sridharan; Basha, Mushkin; Indasi, Gopi Kumar; Belema, Makonen; Meanwell, Nicholas A.; Dhar, T. G. Murali; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha; Gupta, Arun Kumar. The article conveys some information:

An efficient and practical synthetic protocol for synthesis of 1,4-disubstituted pyrrolo[1,2-a]pyrazine derivatives I (R = Ph, pyridin-3-yl, cyclohexyl, t-Bu, etc.) that originate from α-substituted pyrroloacetonitriles II (R1 = H) which, in turn, are readily available from aryl and alkyl aldehydes RCHO is described . The α-pyrroloacetonitriles II were subjected to a Friedel-Crafts acylation with Me chlorooxoacetate followed by reduction of the nitrile group under Pd-catalyzed hydrogenation conditions and finally aromatization with DDQ leading to the desired pyrrolo[1,2-a]pyrazine derivatives I. This method was generalized and successfully applied to various substrates. The developed protocol provides direct and convenient access to 1,4-disubstituted ring systems in moderate to good overall yields (51-68%) without the need for purification of the intermediates II (R1 = 2-methoxy-2-oxoacetyl). Further functionalization via the stepwise halogenation (bromination, iodination) and nitration was also demonstrated. In addition, the potential of the ester functionality for elaboration was demonstrated by manipulating into heterocyclic ring systems, exemplified by conversion into 2-(4-phenylpyrrolo[1,2-a]pyrazin-1-yl)benzo[d]oxazole.Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application of 5781-53-3) was used in this study.

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application of 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zhao, Shizhen; Wang, Le; Wang, Jie; Wang, Chenwei; Zheng, Shaowei; Fu, Yajie; Li, Yunfu; Chen, Wei-Dong; Hou, Ruifang; Yang, Dongbin; Wang, Yan-Dong published an article in RSC Advances. The title of the article was 《Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists》.HPLC of Formula: 5781-53-3 The author mentioned the following in the article:

TGR5 is emerging as an important and promising target for the treatment of non-alc. steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated in vitro and in vivo. The most potent compounds 18g and 18k exhibited excellent hTGR5 agonist activity, which was superior to those of the reference drug INT-777. In addition, compound 18k could significantly reduce blood glucose levels in C57 BL/6 mice and stimulate GLP-1 secretion in NCI-H716 cells and C57 BL/6 mice. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3HPLC of Formula: 5781-53-3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 5781-53-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics