Tag: 100-200

《Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides》 was written by Zhang, Guofu; Fan, Qiankun; Zhao, Yiyong; Wang, Huimin; Ding, Chengrong. Synthetic Route of C4H3ClO2S2This research focused onthiosulfonate preparation; sulfonyl hydrazide reductive coupling. The article conveys some information:

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO2.CH2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates RSO2SR (R = Ph, 3-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) using sulfonyl hydrazides RSO2NHNH2 with the assistance of reductant. Addnl., the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Design, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives》 was published in Youji Huaxue in 2020. These research results belong to Wu, Bowen; Cui, Xinxin; Zhu, Ting; Wang, Shenghui; Lu, Chaofan; Wang, Jinjie; Dang, Hexiang; Zhang, Saiyang; Ding, Li-na; Jin, Chengyun. Recommanded Product: 3-Chlorobenzylchloride The article mentions the following:

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC6H4, 4-FC6H4, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH2C6H4] showed the most potent antitumor activity against PC-3 cells with IC50 value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH2C6H4] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH2C6H4] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway. In the experimental materials used by the author, we found 3-Chlorobenzylchloride(cas: 620-20-2Recommanded Product: 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Recommanded Product: 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Miki, Ryotaro; Yamauchi, Tomoya; Kawashima, Kosuke; Egawa, Yuya; Seki, Toshinobu published their research in Langmuir in 2021. The article was titled 《Multinuclear NMR Study on the Formation and Polyol-Induced Deformation Mechanisms of Wormlike Micelles Composed of Cetyltrimethylammonium Bromide and 3-Fluorophenylboronic Acid》.Computed Properties of C6H6BFO2 The article contains the following contents:

We had previously confirmed a glucose-responsive decrease in the viscosity of cetyltrimethylammonium bromide (CTAB) and phenylboronic acid (PBA) wormlike micelle (WLM) systems. However, the mechanisms of the formation of WLMs and the decrease in viscosity with glucose addition have not been determined In this study, we elucidated the mechanisms using 3-fluorophenylboronic acid (3FPBA) based on 11B NMR and 19F NMR analyses. The system in 60 mM CTAB/60 mM 3FPBA at pH 7.4 demonstrated high viscoelasticity, and the formation of WLMs in the system was confirmed by rheol. characteristics. The 11B NMR spectrum at pH 7.4 revealed that 3FPBA existed in a neutral form with sp2-hybridized boron; however, the 11B signal disappeared in the presence of CTAB. In contrast, 19F NMR studies indicated that the quaternary ammonium ion of CTAB interacts with the Ph group of 3FPBA in the sp2 form via cation-π interactions. PBA derivatives react with various polyols; thus, we investigated the change in the viscous system after the addition of sugar and sugar alcs. The viscosity of the WLMs decreased with increased polyol concentration, especially those of fructose and mannitol, in which the decrease was apparent at 40-160 mM polyols. The 19F NMR spectra revealed that polyol addition induced decrease in the sp2 form of 3FPBA and increase in the sp3 form of 3FPBA. Based on the results, we propose the following mechanism of the polyol response: (1) The WLMs are stabilized by CTAB and 3FPBA in the sp2 form using cation-π interactions as the driving force. (2) When polyol is added to the system, the sp2 form of 3FPBA decreases and its sp3 form increases. (3) This change means that the structural component of WLMs decreases, which induces the disruption of WLMs, and the viscosity decreases. The formation and deformation mechanisms of the WLMs determined in this study are notable because 3FPBA interacts as a neutral compound, whereas CTAB often interacts with anionic aromatic compounds to form WLMs. Without 19F NMR measurements, these mechanisms would not have been discovered. In the experiment, the researchers used (3-Fluorophenyl)boronic acid(cas: 768-35-4Computed Properties of C6H6BFO2)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Computed Properties of C6H6BFO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Through-Space Polar-π Interactions in 2,6-Diarylthiophenols》 was published in ChemPhysChem in 2020. These research results belong to Jian, Jie; Poater, Jordi; Hammink, Roel; Tinnemans, Paul; McKenzie, Christine J.; Bickelhaupt, F. Matthias; Mecinovic, Jasmin. Related Products of 768-35-4 The article mentions the following:

Mol. recognition between polar groups and aromatic mols. is fundamentally important to rational drug design. Although it has been well established that many polar functionalities interact with electron-rich aromatic residues through energetically favorable polar-π interactions, there is a limited understanding of the association between thiols and aromatic systems. Herein we report phys.-organic chem. studies on 2,6-diarylthiophenols that possess the central thiophenol ring and two flanking aromatic rings with tunable electronic properties caused by substituents at distant para position. Hammett anal. revealed that pKa values and proton affinities correlate well with Hammett sigma values of substituents. Addnl. energy decomposition anal. supported the conclusion that both through-space SH-π interactions and S–π interactions contribute to intramol. stabilization of 2,6-diarylthiophenols. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Rhodium-Catalyzed Diverse Arylation of 2,5-Dihydrofuran: Controllable Divergent Synthesis via Four Pathways》 was published in ACS Catalysis in 2020. These research results belong to Xing, Junhao; Zhu, Wanjiang; Ye, Bihai; Lu, Tao; Hayashi, Tamio; Dou, Xiaowei. Product Details of 768-35-4 The article mentions the following:

The rhodium-catalyzed controllable diverse arylation of 2,5-dihydrofuran with arylboronic acids was reported. By fine-tuning of the reaction conditions, four different ring-opening or oxidative arylation pathways were controlled in the rhodium-catalyzed arylation of 2,5-dihydrofuran, granting selective access to 2-aryl or 3-aryl homoallylic alcs. and 3-aryl or 4-aryl-2,3-dihydrofurans. The catalytic asym. ring-opening arylation of 2,5-dihydrofuran was also realized. Four plausible reaction pathways were proposed, based on the exptl. results. In the experimental materials used by the author, we found (3-Fluorophenyl)boronic acid(cas: 768-35-4Product Details of 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Product Details of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones》 was published in Synthesis in 2020. These research results belong to Dar’in, Dmitry; Kantin, Grigory; Bakulina, Olga; Krasavin, Mikhail. SDS of cas: 16629-19-9 The article mentions the following:

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones R1SO2C(=N2)C(O)R2 [R1 = Me, cyclohexyl, Ph, etc.; R2 = Me, Ph, 4-FC6H4, etc.] from sulfonyl chlorides was described. It involved the conversion of sulfonyl chloride to sodium sulfinate, alkylation of latter with α-haloketones followed by diazo transfer using ‘sulfonyl-azide-free’ (SAFE) protocol in aqueous medium. The simple and expedient method relied on readily available starting materials and provided facile access to a wide variety of valuable diazo reagents for organic synthesis. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 3-Chloro-4-fluoronitrobenzeneOn September 16, 2021 ,《Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents》 was published in ChemMedChem. The article was written by Fujii, Shinya; Kikuchi, Eriko; Suzuyama, Honoka; Watanabe, Yuko; Ishigami-Yuasa, Mari; Masuno, Hiroyuki; Mori, Takayasu; Isobe, Kiyoshi; Uchida, Shinichi; Kagechika, Hiroyuki. The article contains the following contents:

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative I, and the veterinary anthelmintic closantel (II) led to the discovery of compound III as a potent SPAK inhibitor with reduced toxicity. Compound III decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Quality Control of 3-Chloro-4-fluoronitrobenzene)

3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 3-Chloro-4-fluoronitrobenzene Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Song, Xuyan; He, Yunlu; Wang, Bo; Peng, Sanwen; Pan, Xi; Wei, Min; Liu, Qiang; Qin, Hua-Li; Tang, Haolin published an article in Tetrahedron. The title of the article was 《Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO2F2) as fluoride provider》.Name: Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO2F [Ar = 4-MeC6H4, 4-PhC6H4, 4-ClC6H4, etc.] was developed from aryl sulfonyl chlorides using SO2F2 as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lin, Li; Yang, Zhonglie; Liu, Jianchen; Wang, Jingxia; Zheng, Jiale; Li, Jun-Long; Zhang, Xiaobin; Liu, Xiang-Wei; Jiang, Hezhong; Li, Jiahong published an article in 2021. The article was titled 《Visible-light-induced surfactant-promoted sulfonylation of alkenes and alkynes with sulfonyl chloride by the formation of an EDA-complex with NaI in water at room temperature》, and you may find the article in Green Chemistry.HPLC of Formula: 16629-19-9 The information in the text is summarized as follows:

A green and efficient visible-light-induced iodosulfonyl reaction of alkenes, e.g., cyclohexene in water using an EDA complex strategy at room temperature has been disclosed. The addition of a cationic surfactant allows for the easy formation of colored EDA complexes in water. The hydrophobic effect of the core in the surfactant aggregates, which act as a reaction medium formed by the surfactants themselves in water, plays a significant role in stabilizing the transition state and decreasing the activation energy of the reaction. Remarkably, transition-metal catalysts and organic solvents were not required in this transformation. Moreover, it displayed a broad substrate scope, good functional group tolerance, simple operation, scalability and high chem. selectivity. Thus, it not only provided a green and efficient synthetic strategy for the preparation of β-iodo-substituted sulfone derivatives, e.g., 1-((2-iodocyclohexyl)sulfonyl)-4-methylbenzene but also enriched the investigation of visible-light-induced reactions in water. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Phosphate-sensing with (di-(2-picolyl)amino)quinazolines based on a fluorescence on-off system》 was written by Aoki, Kazusa; Osako, Ryuji; Deng, Jiahui; Hayashita, Takashi; Hashimoto, Takeshi; Suzuki, Yumiko. HPLC of Formula: 768-35-4 And the article was included in RSC Advances in 2020. The article conveys some information:

Detection and visualization of phosphates such as ATP in living organisms can facilitate the elucidation of various biol. events. Although substantial efforts had been made in this area, present methods have disadvantages such as the need for specialized equipment and poor sensitivities. To address these limitations, novel fluorescent probes, (di-(2-picolyl)amino)quinazolines, were developed for application in ATP detection. They selectively recognized copper ions by fluorescence quenching, and their copper complexes displayed fluorescence enhancement in the presence of phosphoric acid derivatives This fluorescence on-off system enabled highly sensitive fluorescence detection of ATP when combined with a Ph boronic acid-modified γ-cyclodextrin through a plausible multipoint recognition system. The experimental part of the paper was very detailed, including the reaction process of (3-Fluorophenyl)boronic acid(cas: 768-35-4HPLC of Formula: 768-35-4)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.HPLC of Formula: 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics