Tag: 100-200

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Reference of 4-Chloro-2-fluorotoluene The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Reference of 4-Chloro-2-fluorotoluene

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Reference of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 30, 1981, Jurga, S.; Jurga, K.; Pajak, Z. published an article.Related Products of 5034-06-0 The title of the article was NMR study of molecular motion in solid trimethyloxosulfonium halides. And the article contained the following:

NMR 2nd moments M2 and spin-lattice relaxation times in the laboratory and rotating frame (T1 and T1ρ) for Me3SOF, Me3SOCl, Me3SOBr, and Me3SOI were measured over a wide temperature range. The variations of M2, T1, and T1ρ for each of these salts were interpreted in terms of Me group reorientation about its C3 axis and reorientation of the trimethyloxosulfonium ion about its C3′ symmetry axis; the resp. activation parameters were also estimated (CH3)3SOCl contains 2 types of Me groups statistically weighted in the ratio 2:1, reorienting with different frequencies about their C3 axes. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Related Products of 5034-06-0

The Article related to methyloxosulfonium halide nmr relaxation, fluoride trimethyloxosulfonium nmr relaxation, chloride trimethyloxosulfonium nmr relaxation, bromide trimethyloxosulfonium nmr relaxation, iodide trimethyloxosulfonium nmr relaxation, methyl reorientation trimethyloxosulfonium halide, oxosulfonium methyl halide nmr, sulfonium oxo methyl halide nmr and other aspects.Related Products of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yamazoe, Sayumi; Liu, Qingyang; McQuade, Lindsey E.; Deiters, Alexander; Chen, James K. published an article in 2014, the title of the article was Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.SDS of cas: 35444-44-1 And the article contains the following content:

Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chem. probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).SDS of cas: 35444-44-1

The Article related to wavelength selective caged morpholino oligonucleotide preparation gene targeting zebrafish, mesoderm patterning gene targeting wavelength selective caged morpholino oligonucleotide, nb deacm mn bifunctional linker caged morpholino oligonucleotide, antisense agents, cage compounds, developmental biology, gene expression, oligonucleotides and other aspects.SDS of cas: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 16, 2020, Wang, Peng-Fei; Jensen, Anders A.; Bunch, Lennart published an article.Related Products of 89-77-0 The title of the article was From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors. And the article contained the following:

Methaqualone (2-methyl-3-(o-tolyl)-quinazolin-4(3H)-one, MTQ) is a moderately potent pos. allosteric modulator (PAM) of GABAA receptors (GABAARs). In a previous structure-activity relationship (SAR) study probing the importance of 2- and 3-substituents in the quinazolin-4(3H)-one scaffold, several potent GABAAR PAMs were identified, including 2,3-diphenylquinazolin-4(3H)-one (PPQ) and 3-(2-chlorophenyl)-2-phenylquinazolin-4(3H)-one (Cl-PPQ). Here, PPQ was applied as lead in a SAR study of 6-, 7-, and 8-substituents in the quinazolin-4(3H)-one by synthesis and functional characterization of 36 PPQ analogs at various GABAAR subtypes. While none of the new analogs were significantly more potent than PPQ or displayed pronounced subtype selectivity across the GABAARs tested, several interesting SAR observations were extracted from the study. In an in silico study, the putative binding modes of MTQ, PPQ, and Cl-PPQ in the transmembrane β2(+)/α1(-) interface of the α1β2γ2S GABAAR were predicted. Several plausible binding modes were identified for the three PAMs, and rationalization of the mol. basis for their different modulatory potencies was attempted. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Related Products of 89-77-0

The Article related to quinazolinone preparation gaba receptor allosteric modulator, structure quinazolinone binding selectivity gaba receptor, mol docking complex quinazolinone gabaa transmembrane domain, gabaa positive allosteric modulators (pams), gabaa receptors, docking, methaqualone, structure−activity relationship (sar) study, transmembrane domain and other aspects.Related Products of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 1983, Jones, Gurnos; Tonkinson, Daryl J.; Hayes, Peter C. published an article.Application of 5034-06-0 The title of the article was Reactions between 4-pyrimidones and sulfur ylides: cyclopropanation and ring opening reactions. And the article contained the following:

Reaction of pyrimidones I (R = H, R1 = Me, CH2Ph) with C-H2S+(O)Me2 (II) gave the corresponding (Z)-R1NHCOCH:CHNHCHO and cyclopropapyrimidones III in 32, 24, 8, and 27% yield, resp. Analogous reaction of I (R = SMe, R1 = Me) (IV) with II in DMSO gave 7.5% III (R = SMe, R1 = Me) and iodide V. Under certain conditions 41% methylide VI was obtained from IV and II. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to pyrimidone reaction methylsulfoxonium methylide, sulfoxonium methylide dimethyl reaction pyrimidone, cyclopropanation pyrimidone dimethylsulfoxonium methylide, ring cleavage pyrimidone dimethylsulfoxonium methylide, cyclopropapyrimidone, formylaminoacrylamide, acrylamide formylamino, methyloxopyrimidinylmethylide methylsulfoxonium and other aspects.Application of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and Characterization of Novel Thiazolidinones and Thioxothiazolidinones Derived from Substituted Indole》 were Rekiba, Nawel; Benmohammed, Abdelmadjid; Khanoussi, Sofiane; Djafri, Ayada; Thibonnet, Jerome. And the article was published in Molbank in 2021. Quality Control of 3-Chlorobenzylchloride The author mentioned the following in the article:

Based on recent discoveries concerning the numerous biol. properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives I [R = F, H, 3-Cl, 3-CF3, 2-C≡N], II and III had been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or thiosemicarbazone. Thus, a series of new thioxothiazolidinone, thiazolidinone, or thiosemicarbazone derivatives I, II and III bearing indole-based moiety have been designed, synthesized, and developed in good yields. The experimental part of the paper was very detailed, including the reaction process of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 3-ChlorobenzylchlorideOn September 30, 2019 ,《Sodium Selenosulfate from Sodium Sulfite and Selenium Powder: An Odorless Selenylating Reagent for Alkyl Halides to Produce Dialkyl Diselenide Catalysts》 was published in Synlett. The article was written by Liu, Yonghong; Ling, Hai; Chen, Chao; Xu, Qing; Yu, Lei; Jiang, Xuefeng. The article contains the following contents:

Na2SeSO3, which can be generated in situ by the reaction of Na2SO3 with Se power, was found to be an odorless reagent for the selenenylation of alkyl halides RX (R = Bu, cyclohexyl, 3-fluorobenzyl, etc.; X = Cl, Br) to produce dialkyl diselenides RSeSeR. By using aqueous EtOH as the solvent and avoiding the generation of a malodorous selenol intermediate, the selenylation reaction with Na2SeSO3 is much more environmentally friendly than conventional methods. Owing to the cheap and abundant starting materials and selenium reagents, the novel synthetic method reduces the production costs of dialkyl diselenides as organoselenium catalysts, thereby advancing practical applications of organoselenium-catalysis technologies. In the experiment, the researchers used 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)

3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: (3-Fluorophenyl)boronic acidIn 2019 ,《Palladium catalyst immobilized on functionalized microporous organic polymers for C-C coupling reactions》 appeared in RSC Advances. The author of the article were Xu, Wei; Liu, Cijie; Xiang, Dexuan; Luo, Qionglin; Shu, You; Lin, Hongwei; Hu, Yangjian; Zhang, Zaixing; Ouyang, Yuejun. The article conveys some information:

Two microporous organic polymer immobilized palladium (MOP-Pd) catalysts were prepared from benzene and 1,10-phenanthroline by Scholl coupling reaction and Friedel-Crafts reaction, resp. The structure and composition of the catalyst were characterized by FT-IR, TGA, N2 sorption, SEM, TEM, ICP-AES and XPS. MOP-Pd catalysts were found to possess high sp. surface areas, large pore volume and low skeletal bone d. Moreover, the immobilized catalyst also had advantages, such as readily available raw materials, chem. and thermal stability, and low synthetic cost. The Pd catalyst is an effective heterogeneous catalyst for carbon-carbon (C-C) coupling reactions, such as the Heck reaction and Suzuki-Miyaura reaction, affording good to high yields. In these reactions, the catalyst was easily recovered and reused five times without significant activity loss. In the part of experimental materials, we found many familiar compounds, such as (3-Fluorophenyl)boronic acid(cas: 768-35-4Name: (3-Fluorophenyl)boronic acid)

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Name: (3-Fluorophenyl)boronic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Ye, Cheng; Tong, Weiqi; Wu, Fan published an article in Synthesis. The title of the article was 《Nickel-Catalyzed Reductive Cross-Coupling of Oxalates Derived from α-Hydroxy Carbonyls with Vinyl Bromides》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:

A nickel-catalyzed cross-electrophile coupling was disclosed in which a range of vinyl bromides were utilized as electrophiles with oxalates derived from α-hydroxy carbonyls as precursors to carbonyl radical coupling partners. This method was compatible with a broad range of functional groups, providing a complementary solution for the construction of β,γ-unsaturated carbonyl compounds The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)

Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Computed Properties of C3H3ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Mingguang; Gao, Huan; Yu, Longsheng; Tang, Senlin; Peng, Ying; Zheng, Chao; Xu, Ligang; Tao, Ye; Chen, Runfeng; Huang, Wei published an article in 2021. The article was titled 《Simultaneously Enhancing Efficiency and Stability of Perovskite Solar Cells Through Crystal Cross-Linking Using Fluorophenylboronic Acid》, and you may find the article in Small.Related Products of 768-35-4 The information in the text is summarized as follows:

Organic-inorganic metal halide perovskites are regarded as one of the most promising candidates in the photovoltaic field, but simultaneous realization of high efficiency and long-term stability is still challenging. Here, a one-step solution-processing strategy is demonstrated for preparing efficient and stable inverted methylammonium lead iodide (MAPbI3) perovskite solar cells (PSCs) by incorporating a series of organic mol. dopants of fluorophenylboronic acids (F-PBAs) into perovskite films. Studies have shown that the F-PBA dopant acts as a cross-linker between neighboring perovskite grains through hydrogen bonds and coordination bonds between F-PBA and perovskite structures, yielding high-quality perovskite crystalline films with both improved crystallinity and reduced defect densities. Benefiting from the repaired grain boundaries of MAPbI3 with the organic cross-linker, the inverted PSCs exhibit a remarkably enhanced performance from 16.4% to approx. 20%. Meanwhile, the F-PBA doped devices exhibit enhanced moisture/thermal/light stability, and specially retain 80% of their initial power conversion efficiencies after more than two weeks under AM 1.5G one-sun illumination. This work highlights the impressive advantages of the perovskite crystal crosslinking strategy using organic mols. with strong intermol. interactions, providing an efficient route to prepare high-performance and stable planar PSCs. In addition to this study using (3-Fluorophenyl)boronic acid, there are many other studies that have used (3-Fluorophenyl)boronic acid(cas: 768-35-4Related Products of 768-35-4) was used in this study.

(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Related Products of 768-35-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics