Tag: 100-200

On December 31, 2018, Sakhautdinov, I. M.; Mukhamet’yanova, A. F. published an article.Product Details of 35444-44-1 The title of the article was Cycloaddition of Bromo(chloro)methyl Ketones and Allenoates of Adipic Acid Monoesters to Fullerene C60. And the article contained the following:

Chloro- and bromoketones XCH2CO(CH2)4CO2R (R = Me, Et; X = Cl, Br) and allenoates MeO2CCH:C:CH(CH2)3CO2R (R = Me, Et) were prepared from monomethyl and monoethyl adipates and subjected to Bingel cyclopropanation and phosphine-catalyzed cycloaddition reactions, resp., with fullerene-C60 to yield cyclopropa- and cyclopentenofullerenes. The use of chloroketones in the Bingel reaction gave higher product yields than the use of bromoketones; the cycloaddition of allenoates to C60 gave products in higher yields than the Bingel cycloadditions The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Product Details of 35444-44-1

The Article related to chlorooxoheptanoate bromooxoheptanoate preparation bingel cyclopropanation reaction c60, octadienoate preparation phosphine catalyzed cycloaddition c60, cyclopropafullerene cyclopentenofullerene preparation, bingel cyclopropanation chlorooxoheptanoate bromooxoheptanoate c60, cycloaddition octadienoate c60 and other aspects.Product Details of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 29, 1992, Shibayama, Katsuhiro; Makino, Tetsuya; Imaoka, Takayuki; Katou, Tetsuya; Kaneko, Masayuki published a patent.Formula: C7H6ClNO2 The title of the patent was Preparation of tricyclic triazole derivatives as antiinflammatory, antiallergic, and anti-platelet activating factor (PAF) drugs. And the patent contained the following:

The title compounds [I; R1 = H, alkyl, C3-5 cycloalkyl; R2, R3 = H, alkyl, alkoxy, halo; W = CO, CR4R5; R4, R5 = H, alkyl; A = C1-5 linear or branched (un)saturated alkylene optionally containing heteroatoms; l = 0-2; n = 1-3; Y = N, C; Z = C(B)Ar1Ar2, CAr1Ar2, OCHAr1Ar2, fused aromatic ring; B = H, HO, MeO; Ar1, Ar2 = H, (un)substituted aryl] are prepared Thus, cyclocondensation of 4-(3-ethoxypropyl)-2-chloroquinoxaline (preparation given) with acetohydrazide in BuOH under reflux and bromination of the the resulting [1,2,4]triazolo[4,3-a]quinoxaline derivative (II; R6 = OEt) with 48% HBr followed by condensation with 4-(diphenylmethylene)piperidine and NaCO3 in DMF at 60-70° gave a title compound (II; R6 = Q). I at 50 mg/kg p.o. inhibited 44-75% passive cutaneous anaphylaxis and 19-87% histamine-induced allergy in rats. I showed IC50 of 0.013-5.4 μg/mL for inhibiting PAF-induced rabbit’s blood platelet aggregation. A tablet formulation containing II (R6 = Q1) was given. A total of 121 I were prepared The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2

The Article related to tricyclic triazole preparation antiinflammatory, antiallergic triazoloquinoxaline triazolobenzodiazepine, platelet activating factor antagonist triazoloquinoxaline, paf antagonist triazoloquinoxaline, blood platelet aggregation inhibitor triazoloquinoxaline, triazolobenzimidazole antiinflammatory and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 17, 2020, Chen, Kai-Chi; Barve, Indrajeet J.; Sun, Chung-Ming published an article.Formula: C7H6ClNO2 The title of the article was Catalyst-Controlled Regioselective Synthesis of Benzotriazolodiazepin-7-ones and Benzotriazolodiazocin-8-ones. And the article contained the following:

A catalyst-controlled highly chemoselective and regioselective intramol. cycloamidation of triazol-1-ylbenzamides toward the synthesis of scarcely known heterocycles is reported. In the presence of a palladium catalyst, this cycloisomerization reaction afforded substituted benzotriazolodiazepin-7-ones via intramol. insertion of a palladium into C-C triple bond in a 7-exo-dig way. Alternatively, the use of a silver catalyst in the reaction produced substituted benzotriazolodiazocin-8-ones in a highly regioselective manner through 8-endo-dig intramol. ring closure. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to palladium catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazepinone preparation, silver catalyst triazolylbenzamide diastereoselective chemoselective regioselective intramol cycloamidation, benzotriazolodiazocinone preparation and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 3, 2020, Song, Bichao; Xie, Peipei; Li, Yingzi; Hao, Jiping; Wang, Lu; Chen, Xiangyang; Xu, Zhongliang; Quan, Haitian; Lou, Liguang; Xia, Yuanzhi; Houk, K. N.; Yang, Weibo published an article.COA of Formula: C7H6ClNO2 The title of the article was Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors. And the article contained the following:

The efficient and stereoselective synthesis of polysubstituted butadienes, especially the multifunctional butadienes, represents a great challenge in organic synthesis. Herein, we wish to report a distinctive Pd(0) carbene-initiated decarboxylative olefination approach that enables the direct coupling of diazo esters with vinylethylene carbonates (VECs), vinyl oxazolidinones, or vinyl benzoxazinones to afford alc.-, amine-, or aniline-containing 1,3-dienes in moderate to high yields and with excellent stereoselectivity. This protocol features operational simplicity, mild reaction conditions, a broad substrate scope, and gram-scalability. Notably, a structurally unique allylic Pd(II) intermediate was isolated and characterized. DFT calculation and control experiments demonstrated that a rare Pd(0) carbene intermediate could be involved in this reaction. Moreover, the polysubstituted butadienes as novel building blocks were unprecedentedly assembled into macrocycles, which efficiently inhibited the P-glycoprotein and dramatically reversed multidrug resistance in cancer cells by 190-fold. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).COA of Formula: C7H6ClNO2

The Article related to vinylethylene carbonate diazo ester palladium decarboxylative olefination catalyst, vinyloxazolidinone diazo ester palladium decarboxylative olefination catalyst, vinylbenzoxazinone diazo ester palladium decarboxylative olefination catalyst, butadiene polysubstituted stereoselective preparation and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 30, 2022, Watanabe, Akio; Hirooka, Yasuo; Tsuboi, Kazuma published a patent.SDS of cas: 59833-69-1 The title of the patent was Preparation of N-phenyl-1H-pyrazolecarboxamides, N-phenyl-1H-pyrrolecarboxamides, and N-phenylbenzamides as prostanoid receptor EP2 antagonists. And the patent contained the following:

The title anilides represented by formula I [R1 = CO2 R101, SO3H, SO2NHR102, CONHSO2R103, SO2NHCOR104, CONR105R106, tetrazolyl, or cyano; R101-R106 = each independently H, C1-4 alkyl, C1-4 alkoxy, C1-4 halo alkyl, or dimethylamino; R8, R9 = each independently H, halo, C1-4 alkyl, or HO; when R8 = R9 = C1-4 alkyl, R8 and R9 are bonded to the adjacent benzene ring at o-position to form a C3-7 carbocyclic ring; R2 = H or C1-4 alkyl; R3 = halo, HO, cyano, or each (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, 3-6 membered ring group,NH2, or SH, etc.; R4 = halo or each (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, 3-6 membered ring group, O-(3-6 membered ring group), C1-4 alkylene-(3-5 membered ring group); R5 = CF3 or each (un)substituted C3-10 carbocyclyl or 3-10 membered heterocyclyl; Y = a bond, O, or optionally oxidized S; L = each (un)substituted C1-8 alkylene, C2-8 alkenylene, or C2-8 alkynylene each optionally having the CH2 group replaced with O, S, S(O), or SO2; ring 1 = nitrogen-containing mono- or bicyclic ring; n = 1, 2, 3, or 4; m = 0, 1, 2, or 3] or pharmaceutically acceptable salts thereof are prepared The compounds I have an antagonistic activity against EP2 receptor, good solubility, and high stability against human liver microsome and provide medicines for the prevention and/or treatment of a disease caused by activation of an EP2 receptor. The disease includes endometriosis, uterine myoma, menorrhagia, adenomyosis, dysmenorrhea, chronic pelvic pain syndrome, cancer, inflammatory pain, neuropathic pain, headache, migraine, postoperative pain, interstitial cystitis, leiomyoma, irritable colon syndrome, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, rheumatism, osteoarthritis, gout, allergic disease, hypertension, brain damage, ischemia , Stroke, renal disease, transplant rejection, atherosclerosis, ischemic heart disease, acne vulgaris, asthma, prostatitis, glomerulonephritis, sarcoidosis, vasculitis, or autoimmune disease. More specifically the cancer is breast cancer, ovarian cancer, colon cancer, lung cancer, prostate cancer, head and neck cancer, lymphoma, uveal melanoma, thymoma, mesoderma, esophageal cancer, gastric cancer, duodenal cancer, hepatocellular carcinoma, bile duct cancer, gallbladder cancer cancer, pancreatic cancer, renal cell carcinoma , renal and urinary tract cancer, bladder cancer, penis cancer, testis cancer, uterine cancer, vaginal cancer, genital cancer, skin cancer (For example, malignant melanoma), malignant bone tumor, Soft tissue sarcoma, chondrosarcoma, leukemia, myelodysplastic syndrome, brain tumor or multiple myeloma. Thus, etherification of Me 2-[3-[[[1-(sec-butyl)-5-[2-[(2-fluoropyridin-4-yl)oxy]ethyl]-1H-pyrrol-2-yl]carbonyl]amino]-4-(trifluoromethyl)phenyl]acetate with 2-fluoro-4-hydroxypyridine using cyanomethylenetributylphosphorane in toluene at 90° for 2.5 h gave Me 2-[3-[[[1-(sec-butyl)-5-[2-[(2-fluoropyridin-4-yl)oxy]ethyl]-1H-pyrrol-2-yl]carbonyl]amino]-4-(trifluoromethyl)phenyl]acetate which underwent alkali hydrolysis in a mixture of 5 N aqueous NaOH solution and methanol at room temperature for 30 min followed by acidification with 2 N aqueous HCl solution to give [3-[[[1-sec-Butyl-5-[2-[(2-fluoro-4-pyridinyl)oxy]ethyl]-1H-pyrrol-2-yl]carbonyl]amino]-4-(trifluoromethyl)phenyl]acetic acid (II). II and [3-[[[1-((2S)-2-butyl)-5-[2-[(2-chloro-6-fluoro-4-pyridinyl)oxy]ethyl]-1H-pyrrol-2-yl]carbonyl]amino]-4-(trifluoromethyl)phenyl]acetic acid (III) inhibited the PGE2-induced production of cAMP in CHO cells expressing human EP2 receptor with IC50 of 2.5 and 0.3 nM, resp., and exhibited a selective EP2 selectivity over production DP receptor with a DP/EP2 receptor inhibition selectivity ratio of 2,565 and 3,681, resp. A tablet formulation containing II was described. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).SDS of cas: 59833-69-1

The Article related to anilide preparation prostanoid receptor ep2 selective antagonist, anticancer phenylpyrazolecarboxamide phenylpyrrolecarboxamide phenylbenzamide preparation, cancer endometriosis uterine myoma menorrhagia adenomyosis dysmenorrhea treatment, phenylpyrazolecarboxamide phenylpyrrolecarboxamide phenylbenzamide preparation prostanoid receptor ep2 selective antagonist and other aspects.SDS of cas: 59833-69-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:

In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 1998, Kawanishi, Hiroyuki; Morimoto, Hiroshi; Nakano, Takao; Watanabe, Tatsuya; Oda, Kuniyuki; Tsujihara, Kenji published an article.Category: chlorides-buliding-blocks The title of the article was Stereoselective synthesis of antifungal sulfoximines, novel triazoles II. And the article contained the following:

Novel triazole derivatives I (R = H, MeCO, MeNHCO, Me, MeO2CCH2) with an N-substituted sulfoximine moiety were synthesized and evaluated for antifungal activity. These compounds showed significantly weaker activity than I (R = H); the N-H moiety of the sulfoximine was extremely important for the activity. A practical and effective stereoselective synthesis of (-)-I (R = H), considered to be the most promising antifungal compound, has been developed. (-)-I (R = H) is prepared in seven steps, including two resolution steps, from the methylthiodifluoropropiophenone II, by epoxidation with Me3SO+ Cl-, diastereoselective sulfimine formation with chloramine T, addition of 1,2,4-triazole to the epoxide, oxidation of the sulfimine, acid hydrolysis of toluenesulfonyl group of the sulfoximine, and resolution with the novel resolving agent 1-(2,3,4-trichlorophenyl)ethanesulfonic acid [(+)-TCPES] III. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to triazole sulfoximine derivative preparation, sulfoximine triazole prospective antifungal agent nonracemic stereoselective practical preparation, stereoselective synthesis antifungal sulfoximine novel triazole, antifungal activity triazole sulfoximine nitrogen substitution, chlorophenylethanesulfonic acid tcpes novel resolving agent sulfoximine triazole and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 31, 1999, Shea, Kenneth J.; Staiger, Chad L.; Lee, Sun Y. published an article.Synthetic Route of 5034-06-0 The title of the article was Synthesis of Polymethylene Block Copolymers by the Polyhomologation of Organoboranes.. And the article contained the following:

AB and ABA block copolymers of poly(ethylene glycol-b-methylene) and poly(dimethylsiloxane-b-methylene) were prepared by hydroboration polyhomologation protocol. Control over the chain length of the polymethylene block was achieved by adjusting the initial molar ratio of ylide to organoborane. ABA block copolymers of polymethylene-polydimethylsiloxane-polymethylene were synthesized by a similar approach using thexyl borane as the difunctional hydroboration agent. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to polymethylene block copolymer polyethylene glycol synthesis hydroboration polyhomologation, polysiloxane polymethylene block copolymer synthesis thexyl borane hydroboration agent, dimethylsulfoxonium methylide block polymer oxirane dimethylsiloxane synthesis hydroboration polyhomologation, ylide polymerization polymethylene block copolymer synthesis and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 4, 1999, Shea, Kenneth J.; Staiger, Chad L.; Lee, Sun Y. published an article.Application In Synthesis of trimethyloxosulphonium chloride The title of the article was Synthesis of Polymethylene Block Copolymers by the Polyhomologation of Organoboranes.. And the article contained the following:

AB and ABA block copolymers of poly(ethylene glycol-b-methylene) and poly(dimethylsiloxane-b-methylene) were prepared by hydroboration polyhomologation protocol. Control over the chain length of the polymethylene block was achieved by adjusting the initial molar ratio of ylide to organoborane. ABA block copolymers of polymethylene-polydimethylsiloxane-polymethylene were synthesized by a similar approach using thexyl borane as the difunctional hydroboration agent. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application In Synthesis of trimethyloxosulphonium chloride

The Article related to polymethylene block copolymer polyethylene glycol synthesis hydroboration polyhomologation, polysiloxane polymethylene block copolymer synthesis thexyl borane hydroboration agent, dimethylsulfoxonium methylide block polymer oxirane dimethylsiloxane synthesis hydroboration polyhomologation, ylide polymerization polymethylene block copolymer synthesis and other aspects.Application In Synthesis of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 29, 1993, Axelsson, Oskar; Peters, Dan; Nielsen, Elsebet Ostergaard; Christophersen, Palle published a patent.Electric Literature of 38939-88-7 The title of the patent was Imidazole compounds, their preparation and use. And the patent contained the following:

The title compounds, particularly the benzimidazole derivatives and 3H-imidazo[4,5-b]pyridine derivatives, I (X, Y = carbon, nitrogen; R12, R13 = alkyl; R4-R7 = H, halo, amino, cyano, etc.) and their uses for the treatment of diseases responsive to blocking of calcium channels of the central nervous system are claimed. Such diseases include degenerative changes associated with stroke, ischemia, migraine, psychosis, Parkinson’s disease, depression, epilepsy, or convulsive disorders. For example, 1-(4-iodophenyl)-4-fluorobenzimidazole (II) had an in vitro activity as L-type calcium channel blocker. Other I were tested for activity as N-type and P-type calcium channel blockers. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7

The Article related to ischemia benzimidazole imidaopyridine phenyl, migraine benzimidazole imidaopyridine phenyl, antipsychotic benzimidazole imidaopyridine phenyl, antidepressant benzimidazole imidaopyridine phenyl, antiepileptic benzimidazole imidaopyridine phenyl, anticonvulsant benzimidazole imidaopyridine phenyl, calcium channel blocker benzimidazole imidaopyridine and other aspects.Electric Literature of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics