Tag: 100-200

On February 1, 2021, Kadaiahgari, Chandra Sekhar; Saha, Moumita; Ravuri, Srinath; Nandigama, Sandeep; Saha, Krishna Das; Banerji, Biswadip published an article.Formula: C7H6ClNO2 The title of the article was Sulphonamide-Containing Oxazoline Hybrids as New Class of Neuroprotective Agents and Lead Molecule as Autophagy Inducer. And the article contained the following:

In the present study, a series of sulfonamide containing oxazoline hybrids I [R1 = 2-NH2, 3-NH2, 4-NH2; R2 = H, Cl, MeO; R3 = H, MeO; R2R3 = HC=CHCH=CH] were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds I showed moderate to good neuroprotection against adrenal medulla cell lines (PC 12). Compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] had good neuroprotective activity against PC 12 cell lines showing increased expression of autophagy regulatory proteins (ATG7, LC 3B, p62, Beclin-1) and anti-apoptotic proteins (Bcl-2) and also decreased expression of pro-apoptotic proteins (Bax and Bad). This study demonstrated clearly that compound I [R1 = 4-NH2; R2R3 = HC=CHCH=CH] showed neuroprotective effect through the induction of autophagy and opens up new avenues for a new class of compounds as neuroprotective therapeutic agents. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to amino dihydrooxazolyl aryl benzenesulfonamide preparation neuroprotective agent autophagy human, aminophenyl sulfonylamino hydroxyethyl aryl carboxamide preparation mitsunobu reaction, hydroxyethyl nitrophenyl sulfonylamino aryl carboxamide preparation reduction catalyst iron, nitrophenyl sulfonylamino aryl carboxylic acid preparation aminoethanol coupling and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 1998, Kawanishi, Hiroyuki; Morimoto, Hiroshi; Nakano, Takao; Watanabe, Tatsuya; Oda, Kuniyuki; Tsujihara, Kenji published an article.Category: chlorides-buliding-blocks The title of the article was Stereoselective synthesis of antifungal sulfoximines, novel triazoles II. And the article contained the following:

Novel triazole derivatives I (R = H, MeCO, MeNHCO, Me, MeO2CCH2) with an N-substituted sulfoximine moiety were synthesized and evaluated for antifungal activity. These compounds showed significantly weaker activity than I (R = H); the N-H moiety of the sulfoximine was extremely important for the activity. A practical and effective stereoselective synthesis of (-)-I (R = H), considered to be the most promising antifungal compound, has been developed. (-)-I (R = H) is prepared in seven steps, including two resolution steps, from the methylthiodifluoropropiophenone II, by epoxidation with Me3SO+ Cl-, diastereoselective sulfimine formation with chloramine T, addition of 1,2,4-triazole to the epoxide, oxidation of the sulfimine, acid hydrolysis of toluenesulfonyl group of the sulfoximine, and resolution with the novel resolving agent 1-(2,3,4-trichlorophenyl)ethanesulfonic acid [(+)-TCPES] III. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Category: chlorides-buliding-blocks

The Article related to triazole sulfoximine derivative preparation, sulfoximine triazole prospective antifungal agent nonracemic stereoselective practical preparation, stereoselective synthesis antifungal sulfoximine novel triazole, antifungal activity triazole sulfoximine nitrogen substitution, chlorophenylethanesulfonic acid tcpes novel resolving agent sulfoximine triazole and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 31, 1999, Shea, Kenneth J.; Staiger, Chad L.; Lee, Sun Y. published an article.Synthetic Route of 5034-06-0 The title of the article was Synthesis of Polymethylene Block Copolymers by the Polyhomologation of Organoboranes.. And the article contained the following:

AB and ABA block copolymers of poly(ethylene glycol-b-methylene) and poly(dimethylsiloxane-b-methylene) were prepared by hydroboration polyhomologation protocol. Control over the chain length of the polymethylene block was achieved by adjusting the initial molar ratio of ylide to organoborane. ABA block copolymers of polymethylene-polydimethylsiloxane-polymethylene were synthesized by a similar approach using thexyl borane as the difunctional hydroboration agent. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Synthetic Route of 5034-06-0

The Article related to polymethylene block copolymer polyethylene glycol synthesis hydroboration polyhomologation, polysiloxane polymethylene block copolymer synthesis thexyl borane hydroboration agent, dimethylsulfoxonium methylide block polymer oxirane dimethylsiloxane synthesis hydroboration polyhomologation, ylide polymerization polymethylene block copolymer synthesis and other aspects.Synthetic Route of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 4, 1999, Shea, Kenneth J.; Staiger, Chad L.; Lee, Sun Y. published an article.Application In Synthesis of trimethyloxosulphonium chloride The title of the article was Synthesis of Polymethylene Block Copolymers by the Polyhomologation of Organoboranes.. And the article contained the following:

AB and ABA block copolymers of poly(ethylene glycol-b-methylene) and poly(dimethylsiloxane-b-methylene) were prepared by hydroboration polyhomologation protocol. Control over the chain length of the polymethylene block was achieved by adjusting the initial molar ratio of ylide to organoborane. ABA block copolymers of polymethylene-polydimethylsiloxane-polymethylene were synthesized by a similar approach using thexyl borane as the difunctional hydroboration agent. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application In Synthesis of trimethyloxosulphonium chloride

The Article related to polymethylene block copolymer polyethylene glycol synthesis hydroboration polyhomologation, polysiloxane polymethylene block copolymer synthesis thexyl borane hydroboration agent, dimethylsulfoxonium methylide block polymer oxirane dimethylsiloxane synthesis hydroboration polyhomologation, ylide polymerization polymethylene block copolymer synthesis and other aspects.Application In Synthesis of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 29, 1993, Axelsson, Oskar; Peters, Dan; Nielsen, Elsebet Ostergaard; Christophersen, Palle published a patent.Electric Literature of 38939-88-7 The title of the patent was Imidazole compounds, their preparation and use. And the patent contained the following:

The title compounds, particularly the benzimidazole derivatives and 3H-imidazo[4,5-b]pyridine derivatives, I (X, Y = carbon, nitrogen; R12, R13 = alkyl; R4-R7 = H, halo, amino, cyano, etc.) and their uses for the treatment of diseases responsive to blocking of calcium channels of the central nervous system are claimed. Such diseases include degenerative changes associated with stroke, ischemia, migraine, psychosis, Parkinson’s disease, depression, epilepsy, or convulsive disorders. For example, 1-(4-iodophenyl)-4-fluorobenzimidazole (II) had an in vitro activity as L-type calcium channel blocker. Other I were tested for activity as N-type and P-type calcium channel blockers. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7

The Article related to ischemia benzimidazole imidaopyridine phenyl, migraine benzimidazole imidaopyridine phenyl, antipsychotic benzimidazole imidaopyridine phenyl, antidepressant benzimidazole imidaopyridine phenyl, antiepileptic benzimidazole imidaopyridine phenyl, anticonvulsant benzimidazole imidaopyridine phenyl, calcium channel blocker benzimidazole imidaopyridine and other aspects.Electric Literature of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 7, 2020, Yuen, Tsz Ying; Brown, Christopher J.; Tan, Yaw Sing; Johannes, Charles W. published an article.Application of 5034-06-0 The title of the article was Synthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides. And the article contained the following:

α,α’-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α’-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure. Herein, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting helical peptides. The increased potency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by a combined effect of net hydrophobicity and enhanced protein association rates. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Application of 5034-06-0

The Article related to chiral cyclopropane alkenyl amino acid synthesis stapled peptide, solid phase peptide synthesis macrocyclization conformation helix, mdm2 binding fluorescence md simulation enthalpy free energy cluster, glycine derivative horner wadsworth emmons olefination alkenyl aldehyde, condensation reaction stereoselective cyclopropanation and other aspects.Application of 5034-06-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 8, 2019, Liu, Guiyan; Han, Fangwai; Liu, Chengxin; Wu, Hongli; Zeng, Yongfei; Zhu, Rongjiao; Yu, Xia; Rao, Shuang; Huang, Genping; Wang, Jianhui published an article.Category: chlorides-buliding-blocks The title of the article was A Highly Active Catalyst System for Suzuki-Miyaura Coupling of Aryl Chlorides. And the article contained the following:

New Pd(II) complexes with simple structures were designed and synthesized for Suzuki-Miyaura coupling reactions of aryl chlorides. The new Pd(II) complexes contain bidentate amine ligands, and their structures were characterized by single-crystal x-ray diffraction. They are highly efficient for Suzuki-Miyaura coupling reactions of aryl chlorides with low catalyst loadings (0.01 mol %) in aqueous media at room temperature Two possible reaction pathways involving a Pd(II)/(0)/(II) and a Pd(II)/(IV)/(II) catalytic cycle are proposed, and the mechanism was further studied using d. functional theory (DFT) calculations The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Category: chlorides-buliding-blocks

The Article related to mesitylethanediamine palladium bromide chloride iodide preparation catalyst suzuki coupling, crystal structure mesitylethanediamine palladium bromide chloride iodide, mol structure mesitylethanediamine palladium bromide chloride iodide, potential energy surface suzuki coupling mesitylethanediamine palladium bromide catalyst and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 25, 2010, Kajino, Masahiro; Imaeda, Toshihiro; Ono, Koji; Aso, Kazuyoshi; Tarui, Naoki published a patent.Synthetic Route of 38939-88-7 The title of the patent was Preparation of 2-aminobenzimidazole derivatives as gastric acid secretion inhibitors. And the patent contained the following:

There are disclosed acid secretion inhibitors containing compounds represented by formula [I; R1’s may be the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted alkoxy group, a hydroxy group or an optionally substituted amino group; R2 represents a hydrogen atom or a substituent; R3 represents a hydrogen atom or a substituent; ring A represents an optionally substituted carbon ring or an optionally substituted heterocyclic ring; and n represents an integer of 1-4], salts thereof, or prodrugs of the compounds or salts. These compounds inhibit proton,potassium-ATPase (H+/K+-ATPase) and are useful as gastric acid secretion inhibitors. There is also provided the preventive or therapeutic method for peptic ulcer, Zollinger-Ellison syndrome, gastritis, gastroesophageal reflux disease (GERD), symptomatic gastroesophageal reflux disease (symptomatic GERD), Barrett esophagus, functional dyspepsia, gastric cancer (stomach cancer), gastric MALT lymphoma, ulcer caused by nonsteroidal antiinflammatory agents, ulcer or hyper-gastric acidity (excessive acid secretion) caused by postsurgical stress, acute stress ulcer, hemorrhagic gastritis, stress, or upper digestive tract hemorrhage by administering the compound in mammals. Thus, a solution of 666 mg benzene-1,2-diamine in 30 mL THF was treated with 1.08 g 2-isothiocyanato-1,3,5-trimethyl benzene, refluxed for 4 h, treated with 2.24 g 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and refluxed for 50 min to give, after workup and recrystallization from EtOAc/hexane, 253 mg N-(2,4,6-trimethylphenyl)-1H-benzimidazol-2-amine (II). II N-(4-fluoro-2,6-dimethylphenyl)-5-methoxy-4-methyl-1H-benzimidazol-2-amine (III) showed IC50 of 970 and 14 nM, resp., against H+/K+-ATPase. A tablet formulation containing I was described. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Synthetic Route of 38939-88-7

The Article related to aminobenzimidazole preparation gastric acid secretion inhibitor, proton potassium atpase inhibitor aminobenzimidazole preparation, peptic ulcer zollinger ellison syndrome prevention treatment aminobenzimidazole preparation, gastritis gastroesophageal reflux disease gerd prevention treatment aminobenzimidazole preparation and other aspects.Synthetic Route of 38939-88-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 8, 2011, LaMarche, Matthew J.; Leeds, Jennifer A.; Amaral, Kerri; Brewer, Jason T.; Bushell, Simon M.; Dewhurst, Janetta M.; Dzink-Fox, JoAnne; Gangl, Eric; Goldovitz, Julie; Jain, Akash; Mullin, Steve; Neckermann, Georg; Osborn, Colin; Palestrant, Deborah; Patane, Michael A.; Rann, Elin M.; Sachdeva, Meena; Shao, Jian; Tiamfook, Stacey; Whitehead, Lewis; Yu, Donghui published an article.HPLC of Formula: 35444-44-1 The title of the article was Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: Identification of the cycloalkylcarboxylic acids. And the article contained the following:

4-Aminothiazolyl analogs of the antibiotic natural product GE2270 A were designed, synthesized, and optimized for their activity against Gram pos. bacterial infections. Optimization efforts focused on improving the physicochem. properties (e.g., aqueous solubility and chem. stability) of the 4-aminothiazolyl natural product template while improving the in vitro and in vivo antibacterial activity. Structure-activity relationships were defined, and the solubility and efficacy profiles were improved over those of previous analogs and GE2270 A. These studies identified novel, potent, soluble, and efficacious elongation factor-Tu inhibitors, which bear cycloalkylcarboxylic acid side chains, and culminated in the selection of development candidates amide (I) (R1 = C:O) and urethane I (R1 = OC:O). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).HPLC of Formula: 35444-44-1

The Article related to antibiotic natural product ge2270a aminothiazolyl analog synthesis structure activity, macrocyclic peptidomimetic antibacterial structure activity solubility stability pharmacokinetic, elongation factor tu inhibitor aminothiazolyl ge2270a analog cycloalkylcarboxylic acid, ge2270a acylation azidation curtius rearrangement and other aspects.HPLC of Formula: 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Chang-Liang; Fuerstner, Alois published an article in 2013, the title of the article was Formal Ring-Opening/Cross-Coupling Reactions of 2-Pyrones: Iron-Catalyzed Entry into Stereodefined Dienyl Carboxylates.COA of Formula: C7H11ClO3 And the article contains the following content:

In the presence of Fe(acac)3, α-pyrones such as 4,6-dimethyl-2-pyrone underwent stereoselective and chemoselective ring opening reactions with MeMgBr in Et2O at -60° to give (2Z)-2,4-pentadienoic acids such as (Z)-Me2C:CHCMe:CHCO2H in 68-94% yields and in 7:1->20:1 diastereoselectivities; if the reactions were warmed to ambient temperature during reaction, (E)-alkadienoic acids were isolated stereoselectively. The method was used to prepare the dodecadienamide natural product granulatamide B and a fragment of the marine natural product pateamine A. The structure of (Z)-Me2C:CHCMe:CHCO2H was determined by X-ray crystallog. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3

The Article related to alkadienoic acid stereoselective preparation, pateamine a fragment stereoselective preparation, granulatamide b stereoselective preparation, alpha pyrone stereoselective ring opening iron catalyst methyl grignard, methylhexadienoic acid mol crystal structure, cross-coupling, dienes, heterocycles, iron, natural products and other aspects.COA of Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics